Vol 7 korvaa täysin Vol 6:n Linkit, joiden täydentäminen alkoi 7.2.2021. Uusimmat linkit ovat ylimpänä. Tämä nopeuttaa kiinnostavimpien, usein uusimpien linkkien löytämistä. Jatkuvasti päivittyvät löytyvät edelleen alimpana.
Disclaimer: Tästä ja edellisistä viidestä linkkikokoelmasta löytyvät artikkelit eivät muodosta täydellistä, edustavaa, suositeltua eikä luotettavaksi varmennettua koostetta eri medioissa julkaistuista SARS-CoV-2 virukseen, Covid-19 sairauteen, sen hoitoon tai estämiseen liittyvistä artikkeleista.
December 21-31
SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons. Experimental and Molecular Pathology. Dec. 2023. https://www.sciencedirect.com/science/article/pii/S0014480023000254
December 11-20
December 1-10
November 21-30
Cognitive decline in older adults in the UK during and after the COVID-19 pandemic: a longitudinal analysis of PROTECT study data (Pre-pandemic data were included for 3142 participants, of whom 1696 (54·0%) were women and 1446 (46·0%) were men, with a mean age of 67·5 years (SD 9·6, range 50–96). Significant worsening of executive function and working memory was observed in the first year of the pandemic across the whole cohort (effect size 0·15 [95% CI 0·12–0·17] for executive function and 0·51 [0·49–0·53] for working memory), in people with mild cognitive impairment (0·13 [0·07–0·20] and 0·40 [0·36–0·47]), and in people with a history of COVID-19 (0·24 [0·16–0·31] and 0·46 [0·39–0·53]). Worsening of working memory was sustained across the whole cohort in the second year of the pandemic (0·47; 0·44–0·49). Regression analysis indicated that cognitive decline was significantly associated with reduced exercise (p=0·0049; executive function) and increased alcohol use (p=0·049; working memory) across the whole cohort, as well as depression (p=0·011; working memory) in those with a history of COVID-19 and loneliness (p=0·0038; working memory) in those with mild cognitive impairment. In the second year of the pandemic, reduced exercise continued to affect executive function across the whole cohort, and associations were sustained between worsening working memory and increased alcohol use (p=0·0040), loneliness (p=0·042), and depression (p=0·014) in those with mild cognitive impairment, and reduced exercise (p=0·0029), loneliness (p=0·031) and depression (p=0·036) in those with a history of COVID-19.). Lancet / Healthy Longevity. Nov. 2023. https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00187-3/fulltext
November 11-20
Koronalääke Paxlovid uhkaa loppua Suomesta – nelikymppinen riskiryhmäläinen metsästi korkeassa kuumeessa itselleen lääkettä. Seuraava normaalierä Paxlovidia saataneen Suomeen aikaisintaan vasta joulukuun puolivälissä. Ennen sitä lääkeyritys Pfizer yrittää tuoda pienen lisäerän lääkettä Ruotsista. YLE. 3.11.2023. https://yle.fi/a/74-20058398
At least 14% of Americans have long COVID, research suggests by University College London (The researchers found that nearly half (47%) of people surveyed reported having had COVID-19 at some point, while 14% of the total had had long COVID at some point, half of whom (7% of the total) still had long COVID symptoms when answering the survey. The findings suggest that one in three people who contract COVID-19 may end up with long COVID symptoms. The researchers caution that a limitation of their study is that it relies on people self-reporting symptoms, while some people surveyed may have had COVID-19 without knowing it.). MedicalXpress. 2.11.2023. https://medicalxpress.com/news/2023-11-americans-covid.html
Kansanedustajat tekivät kirjallisen kysymyksen koronarokotteista ja Paxlovidista – ”Hallituksen kanta hyvä saada mustaa valkoisella”. (Edustajat pohtivat, onko Paxlovid-koronaviruslääkkeen panttaus syynä Suomen korkeaan ylikuolleisuuteen pandemian alkamisen jälkeen. Terhi Koulumies (kok) kysyy kirjallisessa kysymyksessään muun muassa, kuinka paljon koronarokotteita on tuhottu Suomessa käyttämättöminä tai lahjoitettu pois. ”Minulla on sellainen mielikuva, että edellinenkin hallitus oli rokote- ja lääkemyönteinen, mutta poliittinen tahto ei oikein kanavoitunut käytäntöön.”) Mediuutiset. 1.11.2023. https://www.mediuutiset.fi/uutiset/mu/0225a552-47ed-40c4-baf2-6d4dc7e7e8f8
The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID (Although COVID-19 was initially considered an acute respiratory illness, recent evidence suggests that manifestations including but not limited to those of the cardiovascular, respiratory, neuropsychiatric, gastrointestinal, reproductive, and musculoskeletal systems may persist long after the acute phase. These persistent manifestations, also referred to as long COVID, could impact all patients with COVID-19 across the full spectrum of illness severity. Herein, we comprehensively review the current literature on long COVID, highlighting its epidemiological understanding, the impact of vaccinations, organ-specific sequelae, pathophysiological mechanisms, and multidisciplinary management strategies. In addition, the impact of psychological and psychosomatic factors is also underscored.). Signal Transduction and Targeted Therapy. 1.11.2023. https://www.nature.com/articles/s41392-023-01640-z
Boris Johnson suggested he thought COVID was ‘nature’s way of dealing with old people’
The COVID inquiry has heard evidence about Boris Johnson’s attitude to older people when making crunch decisions over lockdown. Sir Patrick Vallance wrote in one of his notebooks in August 2020 that Mr Johnson was “obsessed with older people accepting their fate and letting the young get on with life and the economy going. Quite bonkers set of exchanges”. Sky news. 1.11.2023. https://news.sky.com/story/boris-johnson-suggested-he-thought-covid-was-natures-way-of-dealing-with-old-people-12997032
SARS-CoV-2 infection leads to sustained testicular injury and functional impairments in K18 hACE2 mice. bioRxiv. 1.11.2023. https://www.biorxiv.org/content/10.1101/2023.10.31.565042v1
A Storm Is Gathering Around A CDC Committee For Its Controversial Infection Control Guidance (The Healthcare Infection Control Advisory Committee of the CDC is revising infection control guidelines for healthcare facilities throughout the country. They have come under considerable criticism from several national advocacy groups over their draft guidelines, which suggest they will weaken protections, particularly for respiratory protection. Members of the World Health Network looked into the HICPAC’s charter and, as a result, have filed a complaint with the Office of the Inspector General charging … ). Forbes. 1.11.2023. https://www.forbes.com/sites/judystone/2023/11/01/a-storm-is-gathering-around-a-cdc-committee/
Nov. 1-10
Some common deleterious mutations are shared in SARS-CoV-2 genomes from deceased COVID-19 patients across continents. Scientific Reports. 30.10.2023. https://www.nature.com/articles/s41598-023-45517-1
Ilmavälitteisyyden merkitys on luultua suurempi. Pandemia loi tarpeen infektioiden ilmavälitteisyyden tutkimukselle (Lotta Oksanen, Anne Seppänen. Ennen koronaa ajateltiin, että ilmavälitteinen tartunta on harvinainen ja koskee lähinnä tuberkuloosia ja tuhkarokkoa. Pandemia loi tarpeen infektioiden ilmavälitteisyyden tutkimukselle ja nyt aiheesta tiedetään enemmän. Luontainen hiukkastuotto, jota tapahtuu hengitysteissä, kun hengitämme, puhumme, nauramme tai laulamme, synnyttää ilmaan sen kokoisia hiukkasia, että on riski saada tartunta, jos hengitysteissä on infektio, Oksanen kertoo.). Lääkärilehti. 27.10.2023. https://www.laakarilehti.fi/tieteessa/ilmavalitteisyyden-merkitys-on-luultua-suurempi/?public=10fceb88e8e3074c0e00ed113fdf709a
SARS-CoV-2 virus found to migrate within neurons and infect the brain. MedicalXpress. 27.10.2023. https://medicalxpress.com/news/2023-10-sars-cov-virus-migrate-neurons-infect.html
COVID-19 vaccine-induced adaptive immunity against SARS-CoV-2 variants (…a two-dose mRNA vaccine regimen leads to consistent and high production of S-specific antibodies across all studied age groups. Vaccinated individuals exhibit the ability to neutralize the SARS-CoV-2 Alpha variant, while neutralization against the Beta and Delta variants is reduced. Furthermore, a majority of vaccinated participants display the presence of SARS-CoV-2 S-specific memory CD4+ and CD8+ T cells, which exhibit cross-recognition of the different SARS-CoV-2 variants. S-specific antibody levels were found to decline within months following vaccination, while T cell responses remained stable for at least six months.). Turun yliopisto. 27.10.2023. https://www.utupub.fi/handle/10024/175883
Quantitative errors in the Cochrane review on “Physical interventions to interrupt or reduce the spread of respiratory viruses” (There are extensive studies validating scientific understanding about the behavior of larger (droplets) and smaller (aerosols) particles in disease transmission and the dosimetry of particles in the respiratory track. Similarly, modalities for respiratory protection against particles in the size range spanned by infectious particles, such as N95 respirators, are available and known to be efficacious with tested standards for harm reduction across environments including physical, chemical and biological hazards. Even though multiple studies also confirm their protective effect when adopted in healthcare and public settings for infection prevention, overall, studies of protocols of their adoption over the last several decades in both clinical trials and observational studies have not provided as clear an understanding. Here we demonstrate that these studies are strongly biased towards the null by infections resulting from transmission outside of the investigated environments and study participants. Such study limitations are frequently mis-stated as not influencing the conclusions of research on respiratory protection. The reason for the failure to properly analyze the studies is that the standard analytical equations used do not correctly represent the random variables that play a role in the study results. By correcting the mathematical representation and the equations that result from them, we demonstrate that conclusions drawn from these studies are strongly biased and much more uncertain than is acknowledged, providing almost no useful information. Even with all these limitations, we show that existing results, when outcome measures are properly analyzed, consistently point to the benefit of precautionary measures such as N95 respirators over medical masks, and masking over its absence. We also show that correcting manifest errors of widely reported meta-analyses also leads to statistically significant estimates. Our results have implications for the design of studies and analyses on the effectiveness of respiratory protection and on using existing evidence for policy guidelines for infection control.). Research Square. 26.10.2023. https://www.researchsquare.com/article/rs-3486610/v1
SIDE EFFECT Children infected with Covid at risk of blood vessel damage that can trigger clots, scientists warn. (VIRTUALLY all children infected with Covid suffer from serious blood vessel damage, scientists have warned. The US study found a “high proportion” of kids with the bug had elevated levels of a biomarker tied to this type of cardiovascular injury. And this was even the case for those who only had mild symptoms. Originally Published on 8.12.2020!) The Sun 26.10.2023. https://www.thesun.co.uk/health/24519378/blood-vessel-damage-children/
Dopaminergic systems create reward seeking despite adverse consequences (). nature. 25.10.2023. https://www.nature.com/articles/s41586-023-06671-8
Koronatilanne pahenee? – Koronapotilaiden määrä ruuhkautti yhteispäivystyksen Etelä-Karjalassa (Kun viikolla 2.-8.10. todennettujen tartuntojen määrä oli samalla tasolla kuin millä se oli pysytellyt viikkoja ja kuukausia eli 175, niin seuraavalla viikolla 9.-15.10. se oli noussut lukemaan 414.). Mediuutiset. 25.10.2023. https://www.mediuutiset.fi/uutiset/koronatilanne-pahenee-koronapotilaiden-maara-ruuhkautti-yhteispaivystyksen-etela-karjalassa/508f1650-1fa1-4384-a8ec-7431b599b970
Japan faces flu medicine ‘shortage’ as case surge leads to closure of thousands of schools
Flu cases per medical institution in Japan exceeds warning level (“Several factors are believed to have played a role in the current spread of the flu, including a decline in immunity as (the flu) had not spread for a long time, and an increase in travel between Japan and overseas,” a health ministry official was quoted as saying by the outlet. The official advised residents to continue efforts to prevent infection as they did for Covid.). Independent. 23.10.2023. https://www.independent.co.uk/asia/japan/japan-flu-outbreak-influenza-b2434297.html
October 21-31
Schools cut covid-19 sick days by 20 per cent using HEPA air filters. Placing HEPA air filters into classrooms in the Bradford area of the UK reduced the number of covid-19-related absences among students by more than 20 per cent. New Scientist. 20.10.2023. https://www.newscientist.com/article/2398713-schools-cut-covid-19-sick-days-by-20-per-cent-using-hepa-air-filters/
Tutkimus: Rakennusten jäähdytyksellä ja riittävällä ilmanvaihdolla voidaan torjua helteen terveyshaittoja ja hengitystieinfektioita (Tuoreen tutkimuksen mukaan rakennukset Suomessa ylilämpenevät merkittävästi kuuman hellekesän aikana. Tämä lisää huomattavasti ennenaikaisia kuolemia ja sairaalahoitojaksoja. Lisäksi riittämätön ilmanvaihto voi kasvattaa hengitystieinfektioriskiä ja infektioista johtuvia terveysvaikutuksia.). THL. 19.10.2023. https://thl.fi/fi/-/tutkimus-rakennusten-jaahdytyksella-ja-riittavalla-ilmanvaihdolla-voidaan-torjua-helteen-terveyshaittoja-ja-hengitystieinfektioita-
Ilmanvaihto- ja jäähdytysjärjestelmien resilienssi lämpöaaltojen ja hengitystieinfektioiden suhteen.
Uudis- ja korjausrakennusten teknisten ratkaisujen toiminta muuttuvissa olosuhteissa. Valtioneuvoston selvitys- ja tutkimustoiminnan julkaisusarja 2023:56. 19.10.2023. https://julkaisut.valtioneuvosto.fi/bitstream/handle/10024/165209/VNTEAS_2023_56.pdf
COVID’s Damage Lingers in the Heart. Researchers increasingly find that the effects of infection by SARS-CoV-2 extend to the cardiovascular system (But COVID-19 patients are also unusually prone to a different type of heart attack called a type 2 myocardial infarction. In these cases, the problem isn’t a blockage in the arteries, but rather a mismatch between oxygen supply and oxygen demand. Fever and inflammation accelerate heart rate and increase metabolic demands on many organs, including the heart. If infected lungs are incapable of effectively exchanging oxygen and carbon dioxide, then stressed hearts might suffer damage due to insufficient oxygen.). Harvard Medicine. October 2023. https://magazine.hms.harvard.edu/articles/covids-damage-lingers-heart
Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent? Biochimie. Oct 2023. https://www.sciencedirect.com/science/article/pii/S0300908423001360
October 11-20
Hospital trust apologises for telling staff not to test for Covid-19. Shropshire Community Health NHS Trust said it prioritises the wellbeing and safety of its patients and staff (A hospital trust has apologised for telling staff they “should not be testing for Covid-19”. An email sent by Shropshire Community Health NHS Trust said testing for the virus could “result in having to remain at home for longer than their symptoms persist”. The communication sparked outrage online after a screenshot was posted on social media site X, formerly Twitter. It was branded a “callous approach to staff and patient safety”, leading many to question whether it was a hoax.). BirminghamLive. 10.10.2023. https://www.birminghammail.co.uk/black-country/hospital-trust-apologises-telling-staff-27882146
Not ‘little adults’: Experts say long COVID undercounted, misdiagnosed in kids (Research on long COVID in children is limited, and reported prevalences range widely, from less than 1% to 70%. And while it’s a relatively new condition in an evolving field, experts say it could be better defined and measured through well-designed longitudinal studies that take children’s unique presentations into account.) CIDRAP. 10.10.2023. https://www.cidrap.umn.edu/covid-19/not-little-adults-experts-say-long-covid-undercounted-misdiagnosed-kids
Miksi vain jotkut saavat pian uuden koronarokotteen? Yhdysvalloissa annetaan paikoin taas koronarokote kaikille, mutta Suomessa tehdään toisin (Tänä syksynä uusia koronarokotetehosteita annetaan vain osalle suomalaisista. Tähän ratkaisuun vaikuttaa raha. On odottavissa, että jo lähiaikoina on mahdollista ostaa Suomessa koronarokote omalla rahalla.). Iltalehti. 9.10.2023. https://www.iltalehti.fi/terveysuutiset/a/b8d9adfd-6191-4e65-b8cb-7ea8e85de82e
Trial By Error: More of the Same Old Nonsense from the “Oslo Chronic Fatigue Consortium”. Virology Blog by David Tuller. 8.10.2023. https://virology.ws/2023/10/09/trial-by-error-more-of-the-same-old-nonsense-from-the-oslo-chronic-fatigue-consortium/
New Zealand’s Covid-19 response saved 20,000 lives – research (Lead author and Otago University public health professor Michael Baker [actually the mastermind of the NZ strategy] said it was a “strange paradox” of preventative medicine that its success could work against it in people’s minds. “We have an expression in public health: ‘A public health triumph: nothing happened’. “If you stop a pandemic, or greatly blunt it, people may say ‘well, what was all the fuss about?’). RNZ. 7.10.2023. https://www.rnz.co.nz/news/national/499516/new-zealand-s-covid-19-response-saved-20-000-lives-research
People may suffer ‘long colds’ more than four weeks after infection, study shows. Results in the Lancet’s EClinicalMedicine journal found a ‘similar risk’ of long-term symptoms as those with Covid. Guardian. 6.10.2023. https://www.theguardian.com/science/2023/oct/06/people-may-suffer-long-colds-more-than-four-weeks-after-infection-study-shows
Long-term symptom profiles after COVID-19 vs other acute respiratory infections: an analysis of data from the COVIDENCE UK study (Participants with SARS-CoV-2 infection had increased odds of problems with taste/smell (odds ratio 19.74, 95% CI 10.53–37.00) and lightheadedness or dizziness (1.74, 1.18–2.56) compared with participants with non-COVID-19 ARIs. Separate LCA models identified three symptom severity groups for each infection type. In the most severe groups (representing 22% of participants for both SARS-CoV-2 and non-COVID-19 ARI), SARS-CoV-2 infection presented with a higher probability of problems with taste/smell (probability 0.41 vs 0.04), hair loss (0.25 vs 0.16), unusual sweating (0.38 vs 0.25), unusual racing of the heart (0.43 vs 0.33), and memory problems (0.70 vs 0.55) than non-COVID-19 ARI.). eClinicalMedicine. 6.10.2023. DOI:https://doi.org/10.1016/j.eclinm.2023.102251
Effective Health Care and Global Pandemic Preparedness. Policy paper for G20 (Well-functioning health systems are a pre-requisite for achieving Sustainable Development Goal 3 (SDG 3) Good Health and Wellbeing. The COVID-19 pandemic demonstrated that the global health system should become more effective and equitable. The World Health Organization (WHO) serves as a vital resource for countries to enhance their national public health systems, and as a catalyst and enabler of multilateral cooperation for addressing global health-related threats. This policy paper proposes several key recommendations that, in the view of an expert panel, could be implemented in the near term to further strengthen and empower the WHO.). IIASA. 6.10.2023. https://pure.iiasa.ac.at/id/eprint/19119/
Autoimmune and Autoinflammatory Connective Tissue Disorders Following COVID-19 (This cohort study including 354 527 individuals with COVID-19 and 6 134 940 controls identified a significant elevation in the risk of multiple incident autoimmune and autoinflammatory disorders subsequent to COVID-19. Notably, certain disease risks exhibited a positive association with the severity of COVID-19.). JAMA Network Open. 6.10.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2810259
Covid-19 : l’Etat condamné à indemniser des plaignants qui dénonçaient le manque de masques
(La justice administrative a confirmé en appel la responsabilité des autorités dans la constitution d’un stock de masques insuffisant avant l’épidémie.). franceinfo. 6.10.2023. https://www.francetvinfo.fr/sante/maladie/coronavirus/masques-sanitaires/covid-19-l-etat-condamne-a-indemniser-des-plaignants-qui-denoncaient-le-manque-de-masques_6105522.html
A next-generation intranasal trivalent MMS vaccine induces durable and broad protection against SARS-CoV-2 variants of concern (By expressing the six-proline-stabilized prefusion spikes from three diverse SARS-CoV-2 strains in the MeV, MuV-JL1, and MuV-JL2 vaccine strains from MMR, we generated a MMS trivalent vaccine candidate. Intranasally delivered MMS induced strong SARS-CoV-2-specific neutralizing antibody, mucosal IgA, and systemic and lung resident T cell immune responses that provide broad protection against challenge with each of these three strains. Therefore, MMS is a highly promising next-generation vaccine candidate against COVID-19. Furthermore, any of the three component vaccine viruses can be quickly modified when a new important SARS-CoV-2 variant appears.). PNAS. 5.10.2023. https://www.pnas.org/doi/10.1073/pnas.2220403120
Lääketieteen Nobelin voittaneen Katalin Karikón työ mahdollisti koronarokotteet – Ennen läpimurtoa häntä uhattiin karkoituksella Yhdysvalloista ja alennettiin rivitutkijaksi.
Mediuutiset julkaisee Kauppalehden Faktassa helmikuussa 2021 julkaistun laajan Katalin Karikón haastattelun. Karikón tutkimukset avasivat tien Modernan ja Pfizerin koronarokotteille. Mediuutiset. 3.10.2023. https://www.mediuutiset.fi/uutiset/laaketieteen-nobelin-voittaneen-katalin-karikon-tyo-mahdollisti-koronarokotteet-ennen-lapimurtoa-hanta-uhattiin-karkoituksella-yhdysvalloista-ja-alennettiin-rivitutkijaksi/b47bd6b0-c126-463a-a257-c9f24747ed48
If you have COVID-19 we recommend you isolate for at least 5 days, even if you only have mild symptoms. Find out what else you need to do (Start your recommended 5 day isolation period / Report your test result / Get antiviral medicine [You can get free antiviral medicines if you: have COVID-19 and symptoms or you are a Household Contact and have symptoms, and became sick within the last 5 days, and meet one of the additional antiviral eligibility criteria. Eligible people include: Māori or Pacific people aged 50 or over / everyone aged 65 or over / anyone aged 50 or over, who has not completed a primary course of vaccination / anyone with a severely weakened immune system / anyone with Down syndrome / anyone with sickle cell disease / anyone who has previously been in critical high dependency hospital care from COVID-19 / anyone with a disability who is at high risk of severe illness from COVID-19 / anyone with frailty or vulnerability due to one or more severe health conditions / You are also eligible if you have 3 or more high-risk factors for severe illness from COVID-19.]/ Monitor and manage your symptoms / Finish your recommended isolation period / More information). 2.10.2023. https://covid19.govt.nz/testing-and-isolation/if-you-have-covid-19/
Medicines to treat COVID-19. COVID-19 antiviral medicines can help people who are at risk of becoming very sick with COVID-19. These medicines are free. You must start taking them within the first 5 days of becoming unwell. Unite against COVID. 2.10.2023. https://covid19.govt.nz/testing-and-isolation/if-you-have-covid-19/medicines-to-treat-covid-19/
October 1-10
T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19 (In the case of a pediatric patient with SARS-CoV-2 infection, the liver biopsy showed acute submassive hepatocyte necrosis, accompanied by a significant increase in T cell infiltration. Furthermore, CD8 T-cell dominant hepatitis induced by coronavirus disease 2019 (COVID-19) vaccination has also been recently reported. Although it is known that T cell receptors (TCRs) can discriminate between self- and non-self-antigens, it is now well-accepted that TCRs exhibit cross-reactivity toward similar and even distinct antigen peptides. Thus, we hypothesized that following SARS-CoV-2 infection or vaccination, T cells carrying TCRs that recognize self-antigens undergo clonal expansion, which could eventually result in the onset of autoimmune-like hepatitis). hLife. 28.9.2023. https://www.sciencedirect.com/science/article/pii/S2949928323000093
Long Covid Is Real. Now the Evidence Is Piling Up. A new study finds evidence of hormone imbalances and other biomarkers that can cause symptoms to linger. Bloomberg. 27.9.2023. https://www.bloomberg.com/opinion/articles/2023-09-27/long-covid-is-real-now-the-evidence-is-piling-up
Vaccine Effectiveness Against Long COVID in Children: A Report from the RECOVER EHR Cohort (The vaccination rate was 56% in the cohort of 1,037,936 children. The incidence of probable long COVID was 4.5% among patients with COVID-19, while diagnosed long COVID was 0.7%. Adjusted vaccine effectiveness within 12 months was 35.4% (95 CI 24.5 – 44.5) against probable long COVID and 41.7% (15.0 – 60.0) against diagnosed long COVID. VE was higher for adolescents 50.3% [36.3 – 61.0]) than children aged 5-11 (23.8% [4.9 – 39.0]). VE was higher at 6 months (61.4% [51.0 – 69.6]) but decreased to 10.6% (–26.8 – 37.0%) at 18-months.). medRxiv. 27.9.2023. https://www.medrxiv.org/content/10.1101/2023.09.27.23296100v2
Community Mobility and Depressive Symptoms During the COVID-19 Pandemic in the United States (In this survey study with 192 271 respondents, individuals who lived in communities where fewer individuals left home on a daily basis during the pandemic reported greater levels of depression on average. These differences were not directly attributable to COVID-19 pandemic restrictions, nor to county-level differences in COVID-19 cases or deaths, weather, or county-level economic features; the association persisted after widespread COVID-19 vaccine availability.). JAMA Network. 27.9.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809947
Has the risk of getting long covid been overestimated? Long covid, the experience of lingering symptoms after a covid-19 infection, remains a poorly understood condition, and researchers disagree on how common it is. New Scientist. 27.9.2023. https://www.newscientist.com/article/2393962-has-the-risk-of-getting-long-covid-been-overestimated/
Long COVID has affected nearly 7% of American adults, CDC survey data finds (In reports published Tuesday using data from 2022 National Health Interview Survey, the agency said 6.9% of U.S. adults reported ever having long COVID, while 3.4% said they currently had the condition at the time of interview. Based on U.S. Census data, that would mean nearly 18 million have suffered from the condition at some point since the pandemic began, and almost 9 million did at the time of the survey.). CBS News. 26.9.2023. https://www.cbsnews.com/news/long-covid-americans-new-cdc-survey-data/
Long Covid treatment breakthrough as study finds abnormalities in blood of patients
A new study has found that Long Covid sufferers have unusual hormone and immune systems – spotting abnormalities in patients could offer medics an early-warning sign of the condition’s presence. Mirror. 25.9.2023. https://www.mirror.co.uk/news/us-news/long-covid-treatment-breakthrough-study-31023408
A blood test for long Covid is possible, a study suggests. Scientists can now show key differences in the blood of those who recover from Covid — and those who don’t. NBC News. 25.9.2023. https://www.nbcnews.com/health/health-news/long-covid-differences-blood-test-study-finds-rcna116871
Distinguishing features of Long COVID identified through immune profiling (273 individuals with or without LC were enrolled in a cross-sectional study that included multi-dimensional immune phenotyping and unbiased machine learning methods to identify biological features associated with LC. Marked differences were noted in circulating myeloid and lymphocyte populations relative to matched controls, as well as evidence of exaggerated humoral responses directed against SARS-CoV-2 among participants with LC. Further, higher antibody responses directed against non-SARS-CoV-2 viral pathogens were observed among individuals with LC, particularly Epstein-Barr virus. Levels of soluble immune mediators and hormones varied among groups, with cortisol levels being lower among participants with LC. Integration of immune phenotyping data into unbiased machine learning models identified key features most strongly associated with LC status.). nature.25.9.2023. https://www.nature.com/articles/s41586-023-06651-y
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study (Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.). Lancet Respiratory Medicine. 22.9.2023. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00262-X/fulltext
Prion Disease After COVID-19: A Case Report. Unknown etiology, Challenging differential diagnosis, Rare disease. Am J Case Reports. 21.9.2023. https://amjcaserep.com/abstract/full/idArt/940564
September 21-30
COVID-19 is more lethal in hemodialysis chronic kidney disease patients with low physical capacity (112 patients were submitted to a physical, 31 patients contracted symptomatic COVID-19, 20 recovered and 11 died (lethality rate of 35.5%). There was a difference between survivors and non-survivors on six-minutes-walking-test (6MWT) 386.1 ± 112.8 versus 296.9 ± 103.3 meters (p = 0.04), 30 s sit-to-stand test (30CST) score 11.7 ± 3.1 versus 7.7 ± 4.1 (p = 0.006), and timed up and go test (TUG) 9.4 versus 13.6 s (p = 0.009). There was also an association between percentages of predicted 6MWT, 30CST, and TUG with COVID-19 lethality.). Therapeutic Apheresis and Dialysis. 20.9.2023. https://onlinelibrary.wiley.com/doi/10.1111/1744-9987.14069
Critical care, maternal and neonatal outcomes of pregnant women with COVID-19 admitted to eight intensive care units during the wildtype, alpha and delta waves of the pandemic across the North West of England—a retrospective review (Of the women admitted to ICU antepartum, 40% were discharged while remaining pregnant and 60% had expedited delivery. Antepartum women who were discharged from ICU without giving birth may receive lower rates of mechanical ventilation than those who delivered in ICU or admitted postpartum; however, further studies are needed to confirm or refute this association). Obstetrics & Gynaecology. 20.9.2023. https://obgyn.onlinelibrary.wiley.com/doi/10.1111/aogs.14681
Does the risk of getting long Covid increase each time you get reinfected? (Ziyad Al-Aly, each time you are infected with Covid, you are rolling the dice on long Covid, whether it’s a first infection or second or third or so on) STAT. 20.9.2023. https://www.statnews.com/2023/09/20/do-long-covid-odds-increase-with-second-infection/
Opinion: The mistake hospitals made on Covid-19. CNN Opinnion. 19.9.2023. https://edition.cnn.com/2023/09/19/opinions/covid-19-hospital-policies-pak-jirmanus-wang/index.html
Interview with Finnish pulmonologist Dr. Alexander van Assendelft on airborne transmission during the COVID-19 pandemic (I would like to say that even if it’s not possible anymore to get rid of this pandemic because of the extremely transmissible Omicron mutations, it would still make a great difference if people realized that the most dangerous part in encountering others is when they are talking. By minimizing discussions indoors, maintaining distance and wearing good masks, then it is possible to decrease your risks considerably from getting COVID. Everybody can do something to protect themselves and others. ). World Socialist Web Site. 18.9.2023.https://www.wsws.org/en/articles/2023/09/19/otlo-s19.html
Cambridge Health Alliance to require masks again starting Monday. Boston Nusiness Journal (Cambridge Health Alliance will reinstate mask mandate for its patients, visitors and employees on Monday, according to a memo from CEO Dr. Assaad Savah.). 15.9.2023. https://www.bizjournals.com/boston/news/2023/09/15/cha-reinstates-mask-mandate.html
Covid-19 ökar i Stockholms län (Ökningen i Stockholm följer samma trend som resten av landet. Samtidigt ser man även tecken på ökad smittspridning i flera länder inom Europa och i andra delar av världen, enligt statistik från Folkhälsomyndigheten. / Ökningen förväntas att fortsätta under hösten och vintern. Covid-19 är ett luftvägsvirus och de brukar spridas mer under höst och vinter. Men en annan anledning kan vara Eris, som den nya varianten som cirkulerar i landet kallas.). SVT Nyheter. 15.9.2023. https://www.svt.se/nyheter/lokalt/stockholm/covid-19-okar-i-stockholms-lan–fw669x
Modernan päivitetty koronarokote sai vihreää valoa EMAsta. Spikevax-rokote räätälöitiin torjumaan koronan omikron XBB.1.5-varianttia vastaan, mutta sen kerrotaan tepsivän myös XBB.1.16 -alavarianttia eli Arcturusta vastaan. Mediuutiset. 15.9.2023. https://www.mediuutiset.fi/uutiset/modernan-paivitetty-koronarokote-sai-vihreaa-valoa-emasta/ab88b52f-3918-45c7-bd31-b1333bfc079c
”Tavallinen flunssa” kaataa nyt ihmisiä petiin hurjaa tahtia ympäri Suomen. Tavallinen flunssa on palannut niin kuin oli lomilta paluun jälkeen tapana ennen koronapandemiaa. Seuraukset ovat harvoin vakavia, ja käsien pesu on paras ehkäisykeino, sanoo erikoislääkäri Petja Orre Päijät-Hämeen alueelta. Helsingin Sanomat. 15.9.2023. https://www.hs.fi/kotimaa/art-2000009855784.html
Addressing Education and Health Inequity: Perspective from the North of England. A report prepared for the Child of the North All-Party Parliamentary Group. Health Equity North. Sept. 2023. https://www.healthequitynorth.co.uk/app/uploads/APPG-REPORT-SEPT-23.pdf
Long COVID in Adults: United States, 2022. NCHS Data Brief No. 480. Sept.2023. https://www.cdc.gov/nchs/data/databriefs/db480.pdf
Long COVID in Chuildren: United States, 2022. NCHS Data Brief No. 479. Sept.2023. https://www.cdc.gov/nchs/data/databriefs/db479.pdf
Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium (COVID-19 containment measures were associated with a sustained decrease in the incidence of invasive disease caused by S pneumoniae, H influenzae, and N meningitidis during the first 2 years of the pandemic, but cases began to increase in some countries towards the end of 2021 as pandemic restrictions were lifted. These IRIS data provide a better understanding of microbial transmission, will inform vaccine development and implementation, and can contribute to health-care service planning and provision of policies.). Lancet Digital Health. Sept. 2023. https://www.sciencedirect.com/science/article/pii/S2589750023001085
New Study Detects Spike Protein 6 Months After COVID-19 Vaccination. (According to CDC, mRNA from COVID-19 vaccines is “broken down within a few days after vaccination and doesn’t last long in the body”—a position it has adhered to since the pandemic’s beginning, despite research suggesting otherwise (pdf). The CDC refers to mRNA as “messenger RNA,” whereas regulatory documents and Pfizer refer to the mRNA in COVID-19 vaccines as “modified RNA.” However.
A study in Proteomics Clinical Applications found spike protein in individuals six months after vaccination, challenging claims mRNA in COVID-19 vaccines break.) EPOCH Health. 14.9.2023. https://www.theepochtimes.com/health/new-study-detects-spike-protein-in-vaccinated-6-months-after-covid-19-vaccination-researchers-suggest-3-possible-reasons-5488364/
Covid may have permanently damaged people’s immunity (New Zealand. Several international studies – involving millions of people, mainly from before vaccines became widely available – found a Covid infection doubled the risk of developing heart disease and increased the chance of stroke 1.6 fold. It was also associated with higher rates of both type 1 and type 2 diabetes. “There are a lot of long-term sequelae to Covid that we don’t really know yet and we may not know for years,” Payinda said. “Post polio syndromes were not identified for literally decades after polio infections. The same with the 1918 flu epidemic – people born during the 1918 Spanish flu epidemic had a two- to three-fold increased risk of later developing Parkinson’s Disease.” The latest research showed vaccination halved the risk of cardiac problems post-infection, he said.). 1 news. 13.9-2023. https://www.1news.co.nz/2023/09/13/covid-may-have-permanently-damaged-peoples-immunity/
“Absolut erschreckend” Corona-Gefahr: Ärzte schreiben Brandbrief (“16 österreichische Ärzte haben sich in einem Brandbrief an die Österreichische Ärztekammer gewandt. Ihr Anliegen: Der Schutz der Patienten vor einer Corona-Infektion. Sie schreiben: “Wir können eine ständige, unmitigierte Durchseuchung der Bevölkerung mit einem Gefäß-schädigenden, neurotropen Virus wie SARS-CoV-2, bei dem eine frühere Infektion nicht längerfristig vor einer weiteren Infektion schützt, NICHT verantworten!” / Der Umgang mit der Pandemie und das Management dieser Gesundheitskrise sei “absolut erschreckend”. “Durch Infektionen und Reinfektionen sehen wir bereits jetzt, dass den Menschen gesunde Lebensjahre verloren gehen, die Übersterblichkeit anhaltend zu hoch ist, und alleine in Europa 36 Millionen Menschen als Folge einer SARS-CoV-2-Infektion chronisch krank geworden sind. COVID-19 ist kein Schnupfen. Es ist kein grippaler Infekt. Es ist eine systemische, Gefäß-schädigende Erkrankung, die sich lediglich über den respiratorischen Weg, über Aerosole, ausbreitet.” / Zur Infektionsprävention schlagen sie eine Reihe von Maßnahmen vor:
-Einsatz von Kohlendioxid-Messgeräten in Innenräumen
-Gute Ventilation mittels Lüftungsanlagen bzw. offene Fenster
-Luftreinigung mit HEPA-Filtern (im Winter oder wo Ventilation nur eingeschränkt möglich ist)
-Testungen und Isolation bei Symptomen, Testung bei Kontakt mit COVID-19-Erkrankten
-COVID-19 als meldepflichtige Erkrankung beibehalten und Einsicht ins Vigilanz-System (Überwachungssystem) ermöglichen (z. B. Abwasserdaten, Hospitalisierungen, Todesfälle)
-FFP2-Masken
-Geblockte Zeitfenster an definierten Tagen für vulnerable Personen reservieren
-Freiwillige Ärzteliste erstellen, wo präventive Maßnahmen eingehalten werden
Ein Arzt sollte Respekt vor Patienten haben. Ein Mensch kann entscheiden, ob er in eine Diskothek geht oder nicht. In eine Arztpraxis oder in ein Spital muss er gehen.”). t-online. 12.9.2023. https://www.t-online.de/gesundheit/krankheiten-symptome/coronavirus/id_100241686/corona-gefahr-aerzte-warnen-in-brandbrief-vor-folgenschweren-infektionen.html
When Did “Herd Immunity” Become a Taboo Phrase (Doctors who repeatedly predicted herd immunity in 2020 and 2021, mocking and berating those who disagreed, now treat herd immunity as a taboo phrase. Jonathan Howard, GBD, Martin Kulldorf, Jay Bhattacharya:
- Herd immunity for coronaviruses means a widescale decoupling of cases from deaths caused by the virus due to immunity.
However, most doctors who spoke ceaselessly about herd immunity in 2020 and 2021, refuse to do so today. In fact, they act as if they had never mentioned herd immunity at all. There has been scant acknowledgement that their preposterous predictions of the pandemic’s end failed to arrive. They’ve made made no effort to grapple with the real-world consequences of telling people herd immunity was around the corner, when in fact the worst was yet to come. Instead of reflecting on their previous claims of herd immunity, these doctors now encourage repeat mass infection, saying:
- Repeat infections are inevitable. More the longer you live. Nothing can be done about it.
And thus it becomes clear, doctors who previously mocked and berated those who supposedly treated herd immunity as a taboo phrase, now treat herd immunity, as they defined it in 2021, as a taboo phrase. As cases and hospitalizations rise once again, I wonder why that is). Science Based Medicine. 12.9.2023. https://sciencebasedmedicine.org/when-did-herd-immunity-become-a-taboo-phrase/
How evasive and transmissible is the newest omicron offshoot, BA.2.86, that causes COVID-19? 4 questions answered. The Conversation. 12.9.2023. https://theconversation.com/how-evasive-and-transmissible-is-the-newest-omicron-offshoot-ba-2-86-that-causes-covid-19-4-questions-answered-212453
Updated COVID-19 Vaccine Recommendations are Now Available (On September 12, 2023, CDC recommended a COVID-19 vaccine updated for 2023-2024 for everyone aged 6 months and older to protect against serious illness. / The main reason to get vaccinated against COVID-19 is to protect yourself against severe illness, hospitalization, and even death. COVID-19 vaccines also reduce the chance of having Long COVID. This vaccine is expected to provide better protection against variants that are currently making people sick.). CDC Respiratory Viruses. 12.9.2023. https://www.cdc.gov/respiratory-viruses/whats-new/covid-vaccine-recommendations-9-12-2023.html
Satoja tutkimuksia läpikäynyt raportti: Kasvomaskit ja sulut vaikuttivat kiistattomasti koronaviruksen leviämisen hallintaan. (Asiantuntijatyöryhmää johtaneen Mark Walportin mukaan tutkimustulokset ovat tärkeitä, koska jossain vaiheessa tulee taas uusi pandemia, joka voi olla jotain paljon pahempaa kuin sars-CoV-2). Mediuutiset. 11.9.2023. https://www.mediuutiset.fi/erikoistumispaikat
Is COVID back in Germany? Summer is coming to an end in Germany and the number of COVID-19 cases is starting to increase again. Is this the beginning of a new post-pandemic wave of infection? DW. 11.9.2023. https://www.dw.com/en/is-covid-back-in-germany/a-66781061
September 11-20
Comparative study showed that children faced a 78% higher risk of new-onset conditions after they had COVID-19 (We compared 1656 exposed and 1656 unexposed children from 1 February 2020 to 30 November 2021. the excess risk of new-onset conditions after COVID-19 was 78% higher in the exposed children when we compared them to the unexposed cohort, with an aHR of 1.7 (95% CI 1.4–2.3) (data not shown). The risk was significantly increased after COVID-19 for mental health disorders (aHR 1.8, 95% CI 1.1–3.0), neurological diseases (aHR 2.4, 95% CI 1.4–4.1), and other conditions, including skin rashes and taste and smell alterations (aHR 2.0, 95% CI 1.0–3.8)). Acta Paediatrica. 9.9.2023. https://onlinelibrary.wiley.com/doi/10.1111/apa.16966
SARS-CoV-2-Infektion: Das Post-COVID-Syndrom bei Kindern und Jugendlichen.
Long COVID und das Post-COVID-Syndrom (PCS) bei Kindern und Jugendlichen bestehen aus mehreren Untergruppen mit unterschiedlichem klinischem Verlauf und vermutlich unterschiedlicher Pathogenese. Welche sind die häufigsten Symptome, und wie ist diagnostisch und therapeutisch jeweils vorzugehen? Kinderärztliche Praxis. 8.9.2023. https://www.kinderaerztliche-praxis.de/a/sars-cov-infektion-das-post-covid-syndrom-bei-kindern-und-jugendlichen-2492148
SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood (In this longitudinal cohort study of 885 infants with an elevated genetic risk of type 1 diabetes, the incidence rate of islet autoantibodies developing concurrently with or soon after SARS-CoV-2 antibodies were detected was 7.8 per 100 person-years and was 3.5 per 100 person-years in children without SARS-CoV-2 antibodies, a significant difference.). JAMA Network. 8.9.2023. https://jamanetwork.com/journals/jama/fullarticle/2809621
Covid-19 linked to elevated risk of type 1 diabetes in young children (Children between the ages of 4 months and 2 years seem more likely to have antibodies that attack insulin-producing cells, a feature of type 1 diabetes, if they have had covid-19, which may show how viral infections can lead to this type of diabetes). New Scientist. 8.9.2023. https://www.newscientist.com/article/2391359-covid-19-linked-to-elevated-risk-of-type-1-diabetes-in-young-children/
COVID patients breathe large amounts of virus early on. Northwestern investigators collect samples over the entire course of infection to determine when a person is most infectious (On day eight, exhaled levels of virus drop steeply, down to near the limit of detection — an average of two copies exhaled per minute. / Mild and moderately symptomatic patients with COVID still exhale large amounts of virus, though severely symptomatic cases exhale higher levels on average, the study reports. / Vaccinated and unvaccinated patients exhale similar levels of virus over the course of infection, the research shows. / The amount of virus being exhaled while infected was the same no matter which variant a person was infected with — people infected with Alpha exhaled just as much as those infected with Omicron, the study reports.). Northwestern Now. 8.9.2023. https://news.northwestern.edu/stories/2023/09/covid-patients-exhale-up-to-1000-copies-of-virus-per-minute-during-first-eight-days-of-symptoms/
Quantity of SARS-CoV-2 RNA copies exhaled per minute during natural breathing over the course of COVID-19 infection (…numbers of exhaled SARS-CoV-2 RNA copies during COVID-19 infection do not decrease significantly until day 8 from symptom-onset. COVID-19-positive participants exhaled an average of 80 SARS-CoV-2 viral RNA copies per minute during the first 8 days of infection, with significant variability both between and within individuals, including spikes over 800 copies a minute in some patients.). medRxiv. 8.9.2023. https://www.medrxiv.org/content/10.1101/2023.09.06.23295138v1
Global Trends in Highly Cited Studies in COVID-19 Research (This cross-sectional study found that the number of highly cited studies peaked at 1292 studies at the end of 2021 and declined to 649 studies at the end of 2022. Highly cited studies from China showed a decreasing trend, while those from the US and UK showed an increasing trend. These findings suggest that as the COVID-19 pandemic evolved in the 3 years since its outbreak, there were important shifts in trends of the number and origin of high-profile COVID-19 studies.). JAMA Network Open. 8.9.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809120/
Determinants of the onset and prognosis of the post-COVID-19 condition: a 2-year prospective observational cohort study (The study included 548 individuals, 341 with PCC, followed for a median of 23 months (IQR 16.5–23.5), and 207 subjects fully recovered. In the model with the best fit, subjects who were male and had tertiary studies were less likely to develop PCC, whereas a history of headache, or presence of tachycardia, fatigue, neurocognitive and neurosensitive complaints and dyspnea at COVID-19 diagnosis predicted the development of PCC. The cluster analysis revealed the presence of three symptom clusters with an additive number of symptoms. Only 26 subjects (7.6%) recovered from PCC during follow-up; almost all of them (n = 24) belonged to the less symptomatic cluster A, dominated mainly by fatigue. Recovery from PCC was more likely in subjects who were male, required ICU admission, or had cardiovascular comorbidities, hyporexia and/or smell/taste alterations during acute COVID-19. Subjects presenting with muscle pain, impaired attention, dyspnea, or tachycardia, conversely, were less likely to recover from PCC.). The Lancet Regional Health – Europe. 5.9.2023. https://www.sciencedirect.com/science/article/pii/S2666776223001436
Neutralization Escape by SARS-CoV-2 Omicron Subvariant BA.2.86 (The ability of BA.2.86 to evade NAbs compared with other currently circulating Omicron variants remains unknown. Our data show that NAb responses to BA.2.86 were lower than to BA.2 but were comparable or slightly higher than to the current circulating recombinant variants XBB.1.5, XBB.1.16, EG.5, EG.5.1, and FL.1.5.1). bioRxiv. 4.9.2023. https://www.biorxiv.org/content/10.1101/2023.09.04.556272v1.full.pdf
Bird flu is undergoing changes that could increase the risk of widespread human transmission. EurekAlert AAAS. 4.9.2023. https://www.eurekalert.org/news-releases/1000437
Fauci Touts Face Masks While Admitting to Ineffectiveness (Dr. Anthony Fauci said that face masks may not be effective on populations when looking at the “pandemic as a whole” but persists in his stance that people need to follow authorities’ recommendations and wear them.). The Epoch Times. 4.9.2023. https://www.theepochtimes.com/us/fauci-touts-face-masks-while-admitting-to-ineffectiveness-5485677/
September 1-10
Scientists Sound the Alarm: COVID-19 Virus Is Rapidly Evolving in White-Tailed Deer (Genomic analysis showed that at least 30 infections in deer had been introduced by humans – a figure that surprised the research team. “We generally talk about interspecies transmission as a rare event, but this wasn’t a huge sampling, and we’re able to document 30 spillovers. It seems to be moving between people and animals quite easily,” said Andrew Bowman, associate professor of veterinary preventive medicine at The Ohio State University and co-senior author of the study. “And the evidence is growing that humans can get it from deer – which isn’t radically surprising. It’s probably not a one-way pipeline.”). SciTechDaily. 29.8.2023. https://scitechdaily.com/scientists-sound-the-alarm-covid-19-virus-is-rapidly-evolving-in-white-tailed-deer/
Opinion Everyone should know the dangers of long covid (Given these [Long Covid] findings, I am confused as to why CDC and our local public health authorities in Montgomery County and elsewhere in Maryland are not widely sharing information about the risks of long covid, encouraging us to prevent every possible infection and mandating — or at the very least encouraging — universal masking protections in health-care settings. … High-quality masks and ventilation can help us reduce the likelihood of these serious health outcomes and are especially important in essential spaces such as health-care settings.). Washington Post. 27.8.2027. https://www.washingtonpost.com/opinions/2023/08/27/long-covid-dangers-awareness/
Hundreds of hospital wards closed due to Covid outbreaks (At least 237 wards were closed to new admissions – typically for periods of around seven to 10 days – in a bid to prevent the virus spreading to other patients. That compares to a total of 93 ward closures up to the end of July for all other infection control incidents combined, including cases of norovirus, flu, RSV, or gastroenteritis.). The Herald/Scotland. 25.8.2023. https://www.heraldscotland.com/news/23746393.hundreds-hospital-wards-closed-due-covid-outbreaks/
As schools resume, CDC reports new rise in COVID emergency room visits from adolescents (The increase comes as schools and businesses are now weighing a return to masks and other precautions to curb the virus, amid a weeks-long rise in new COVID-19 hospitalizations nationwide that is projected to continue. Officials are also now tracking a new, highly-mutated COVID-19 variant called BA.2.86 that experts think might fuel further spread.). CBC News. 25.8.2023. https://www.cbsnews.com/news/cdc-reports-new-rise-covid-er-visits-adolescents-as-schools-resume/
Public Pushes Back On CDC’s Plan To Weaken Infection Control (“This is eugenics. I’m Jewish, and I see the writing on the wall. The history of not only the Holocaust but many genocides.” They continued, “They target disabled people first, and I’m literally begging for something to be done.”). Forbes. 25.8.2023. https://www.forbes.com/sites/judystone/2023/08/25/public-pushes-back-on-cdcs-plan-to-weaken-infection-control/
Ilma elintarvikkeena (Ilmastointialan eurooppalainen kattojärjestö Eurovent on käynnistänyt Air as food -viestintäkampanjan. Idea on osuva. Terveelliseen elämään tarvitaan monipuolisen ruoan ja liikunnan lisäksi puhdasta ilmaa. / Keuhkoihin pääsevien pienhiukkasten tiedetään olevan usean sairauden takana. Sisäilman liian korkea hiilidioksidipitoisuus väsyttää ja laskee työ- sekä oppimistehoa. Haihtuvilla yhdisteillä on omat haittavaikutuksensa ja niin edelleen. Myös yleistyvät korkeat sisälämpötilat kesäisin ovat terveysriski. / Erikoistilojen ilmastoinnin ammattilaiset ovat jo pitkään tunteneet virusten ja bakteerien ilmavälitteisyyden riskit. Laajaan tietoisuuteen se on tullut tuskaisen hitaasti Covid19-pandemian jyllätessä. Jos nyt jotain myönteistä tästä pandemiasta yrittää löytää, niin se on tutkimuksen ja sen myötä tiedon lisääntyminen tartuntamekanismeista ja suojauskeinoista.). Sähkömaailma. 24.8.2023. https://www.sahkomaailma.fi/ilma-elintarvikkeena/
Lockdowns and face masks really did help to control covid-19.
(Non-vaccine measures such as social distancing and wearing face masks have been “unequivocally effective” at preventing the spread of the SARS-CoV-2 coronavirus, according to a major report by the UK’s Royal Society). New Scientist. 24.8.2023. https://www.newscientist.com/article/2388929-lockdowns-and-face-masks-really-did-help-to-control-covid-19/
Effectiveness of social distancing measures and lockdowns for reducing transmission of COVID-19 in non-healthcare, community-based settings (Re. masks/schools: Four of the six observational studies assessed individual schools between the end of 2020 and early 2021. Three did not quantify the effect but observed minimal transmission in schools with SDMs and universal masking interventions in place despite substantial community transmission . The remaining study that examined the effect of multiple distancing measures in 36 schools in Italy (including limited capacity, distanced student desks and minimized crowding and entry and exits) observed that the overall secondary transmission rate was 3.8%, although there was no comparator without the interventions in place. Two other observational studies had similar findings. One that used data from 35 school outbreaks across 12 countries from 2020 to July 2021 suggested that distancing and masking were both associated with a lower risk of SARS-CoV-2 infection in schools (adjusted odds ratio (aOR): 0.30, 95% CI: 0.25, 0.37). Another ecological study examining schools in North Carolina and Wisconsin, US, from 2020 to 2021 did not observe an increase in the secondary transmission rate in schools after distancing measures were relaxed, indicating they had no effect on transmission in these schools . The remaining simulation studies found that school measures were associated with reductions in public health impacts of COVID-19, both in the schools and the community.). Philosophical Transactions of the Royal Society. 24.8.2023. https://royalsocietypublishing.org/doi/10.1098/rsta.2023.0132
Medical News in Brief: Two New Analyses Add to Long COVID Understanding (Overall, the prevalence of post–COVID-19 condition, or long COVID (LC), has declined among US adults. In June 2023, 11% of participants with a previous SARS-CoV-2 infection reported currently having LC, compared with 19% at 12 months prior. Prevalence of LC among all US adults also decreased, from 7.5% to 6%. / The decline in prevalence plateaued by this January. Among those who reported having LC this June, 1/4 said they had a significant activity limitation (MMWR). / Another study in MMWR found that LC-like symptoms may not be unique to COVID-19. It used data from the CDC-funded Innovative Support for Patients with SARS-CoV-2 Infections Registry, or INSPIRE, multicenter cohort study. / This analysis looked at the prevalence over time of LC-like symptoms among 1296 adults who had a COVID-like illness. A substantial proportion of both those who had a positive SARS-CoV-2 PCR or antigen test result and those who tested negative reported symptoms at 3 months—about 48% and 38%, respectively. Both groups also reported symptoms that emerged or reemerged over the following 9 months. /Persistent symptoms decreased over time in both groups. By month 12, the prevalence of long COVID-like symptoms was similar between the groups, reported by about 18% of people with a positive test result and about 16% of people with a negative test result.). JAMA. 23.8.2023. https://jamanetwork.com/journals/jama/fullarticle/2808856/
A new Covid variant (EG.5) is on the rise – how worried should we be? It is important we stay level-headed as new subvariants emerge and mutate in the coming weeks and months. Guardian. 23.8.2023. https://www.theguardian.com/commentisfree/2023/aug/18/new-covid-variant-worried-subvariants-mutate
Hospitals are killing patients because they don’t feel like doing infection control (We now know COVID is fully airborne. We also know how to control airborne disease. So why are vulnerable people still dying of hospital-acquired COVID?). The Gauntlet. 23.8.2023. https://www.thegauntlet.news/p/hospitals-are-killing-patients-because
Small study suggests long COVID may affect more people than previously thought (). American Academy of Neurology. 23.8.2023. https://www.eurekalert.org/news-releases/998924
Anders Tegnell släpper bok om pandemin. Tegnell säger att han vill bidra med lärdomar inför nästa pandemi. HBL. 23.8.2023. https://www.hbl.fi/artikel/05d03ec6-d1c9-5cf7-8003-21cf59fc8c35
Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration (In summary, the enhancement and reduction of ACE2 will be beneficial for the prevention/treatment of chronic disease and COVID-19, respectively. Post-translational modifications of ACE2 protein in chronic diseases are different from those in COVID-19; therefore, regulation of ACE2 protein modification will help develop the prevention or treatment for COVID-19 without the induction of chronic disease risks.)? Journal of Biomedical Science. 22.8.2023. https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-023-00965-9
SARS-CoV-2 can cause lasting damage to cells’ energy production (“The continued dysfunction we observed in organs other than the lungs suggests that mitochondrial dysfunction could be causing long-term damage to the internal organs of these patients”) . NIH. 22.8.2023. https://www.nih.gov/news-events/nih-research-matters/sars-cov-2-can-cause-lasting-damage-cells-energy-production
Neuro-ophthalmic complications of varicella-zoster virus (Despite varicella vaccination, the incidence of herpes zoster continues to rise, potentially leading to devastating consequences when ocular complications occur.). Current Opinion in Ophthalmology. 22.8.2023. https://journals.lww.com/co-ophthalmology/abstract/9900/neuro_ophthalmic_complications_of_varicella_zoster.116.aspx
Sosiaali- ja terveysministeri Juuso: Koronarajoitusten järkevyyttä pitää selvittää.
(Sosiaali- ja terveysministeri Kaisa Juuson (ps) mukaan tulisi miettiä, pitäisikö Pohjoismaiden kesken sopia yhteisistä käytännöistä mahdollisissa tulevissa pandemiatilanteissa. ”Tutkimushankkeessa käsitellään ainakin kriisin johtamista, varautumista ja perusoikeusrajoituksia”, hallitusohjelmassa todetaan.) Helsingin Sanomat. 22.8.203. https://www.hs.fi/politiikka/art-2000009801386.html
Long COVID still worrisome 2 years after infection. Virus continues to pose risk of diabetes, lung problems, blood clots, GI issues, other conditions [sama tutkimus kuin edellinen] (Ziyad Al-Aly. …during the two-year study period, some COVID-related health risks among the nonhospitalized — the majority of people infected with the virus — declined and became insignificant. Such risks included death, hospitalization and disorders associated with the brain, heart, kidneys and mental health. For example, risks of death and hospitalization became insignificant at six and 19 months, respectively. But those hospitalized within 30 days of being infected with the virus fared worse. Two years after infection, their risk of death and hospitalization remained elevated, and their risk of adverse health conditions remained significant across all organ systems.). Washington University School of Medicine. MedicalXpress. 21.8.2023. https://medicalxpress.com/news/2023-08-covid-worrisome-years-infection.html
Postacute sequelae of COVID-19 at 2 years [sama tutkimus kuin edellinen] (Ziyad Al-Aly. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to postacute sequelae in multiple organ systems, but evidence is mostly limited to the first year postinfection. We built a cohort of 138,818 individuals with SARS-CoV-2 infection and 5,985,227 noninfected control group from the US Department of Veterans Affairs and followed them for 2 years to estimate the risks of death and 80 prespecified postacute sequelae of COVID-19 (PASC) according to care setting during the acute phase of infection. The increased risk of death was not significant beyond 6 months after infection among nonhospitalized but remained significantly elevated through the 2 years in hospitalized individuals. Within the 80 prespecified sequelae, 69% and 35% of them became not significant at 2 years after infection among nonhospitalized and hospitalized individuals, respectively. Cumulatively at 2 years, PASC contributed 80.4 (95% confidence interval (CI): 71.6–89.6) and 642.8 (95% CI: 596.9–689.3) disability-adjusted life years (DALYs) per 1,000 persons among nonhospitalized and hospitalized individuals; 25.3% (18.9–31.0%) and 21.3% (18.2–24.5%) of the cumulative 2-year DALYs in nonhospitalized and hospitalized were from the second year. In sum, while risks of many sequelae declined 2 years after infection, the substantial cumulative burden of health loss due to PASC calls for attention to the care needs of people with long-term health effects due to SARS-CoV-2 infection. nature medicine- 21.8.2023. https://www.nature.com/articles/s41591-023-02521-2
Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history (We find that most individuals increase BA.1/BA.2/BA.5-specific neutralizing antibodies following infection, but confirm that the magnitude of increase and post-omicron titres are higher in the infection-naive. In contrast, significant increases in nasal responses, including neutralizing activity against BA.5 spike, are seen regardless of infection history. Spike-specific T cells increase only in infection-naive vaccinees; however, post-omicron T cell responses are significantly higher in the previously-infected, who display a maximally induced response with a highly cytotoxic CD8+ phenotype following their 3rd mRNA vaccine dose. Responses to non-spike antigens increase significantly regardless of prior infection status. These findings suggest that hybrid immunity induced by omicron breakthrough infections is characterized by significant immune enhancement that can help protect against future omicron variants.). nature communications. 21.8.2023. https://www.nature.com/articles/s41467-023-40592-4
International Pediatric COVID-19 Severity Over the Course of the Pandemic (This cohort study including 31 785 hospitalized children with SARS-CoV-2 infection suggested that while intensive care unit admission decreased over the course of the pandemic in all age groups, ventilatory and oxygen support did not decrease over time in children aged younger than 5 years.). JAMA Pediatrics. 21.8.2023. https://jamanetwork.com/journals/jamapediatrics/article-abstract/2808592
COVID-19 boosts risks of health problems 2 years later, giant study of veterans says. SARS-CoV-2’s public health impact is worse than that of heart disease or cancer, study claims; others say the work may overestimate harm for the general population (Now, researchers have attempted to quantify this long-term harm using a massive database of U.S. veterans’ health records. They found a dramatically increased risk of dozens of conditions including heart failure and fatigue, sometimes years postinfection. Overall, the team estimates, COVID-19’s public health impact is more than 50% greater than that of cancer or heart disease.). Science. 21.8.2023. https://www.science.org/content/article/covid-19-boosts-risks-health-problems-2-years-later-giant-study-veterans-says
Postacute sequelae of COVID-19 at 2 years (The increased risk of death was not significant beyond 6 months after infection among nonhospitalized but remained significantly elevated through the 2 years in hospitalized individuals. Within the 80 prespecified sequelae, 69% and 35% of them became not significant at 2 years after infection among nonhospitalized and hospitalized individuals, respectively. Cumulatively at 2 years, PASC contributed 80.4 (95% confidence interval (CI): 71.6–89.6) and 642.8 (95% CI: 596.9–689.3) disability-adjusted life years (DALYs) per 1,000 persons among nonhospitalized and hospitalized individuals; 25.3% (18.9–31.0%) and 21.3% (18.2–24.5%) of the cumulative 2-year DALYs in nonhospitalized and hospitalized were from the second year). nature medicine, 21.8.2023. https://www.nature.com/articles/s41591-023-02521-2
August 21-31
Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes (The hypothesis is consistent with the mutagenic deriving observed on the in-silico assay, which reveals that genotypes N/120 and N/152 are determinant to reduce the Immune Response of the host infecting lymphocytes, allowing the virus persists indefinitely and causing an Acquire Immune Deficiency Syndrome = AIDS). Biomedical Journal. 19.8.2023. https://www.sciencedirect.com/science/article/pii/S2319417023000872
Infection prevention and control in the context of coronavirus disease (COVID-19): a living guideline, 10 August 2023. WHO. 19.8.2023. https://www.who.int/publications/i/item/WHO-2019-nCoV-IPC-guideline-2023.2
Evidence of leaky protection following COVID-19 vaccination and SARS-CoV-2 infection in an incarcerated population (Although associations may not have been thoroughly adjusted due to dataset limitations, the findings suggest that prior infection and vaccination may be leaky, highlighting the potential benefits of pairing vaccination with non-pharmaceutical interventions in crowded settings.). nature. 19.8.2023. https://www.nature.com/articles/s41467-023-40750-8
Risk assessment for SARS-CoV-2 variant V-23AUG-01 (or BA.2.86). Gov.uk. 18.8.2023. https://www.gov.uk/government/publications/investigation-of-sars-cov-2-variants-of-concern-variant-risk-assessments/risk-assessment-for-sars-cov-2-variant-v-23aug-01-or-ba286
How Bad Is a Second (or Third or Fourth) Case of Covid? Reinfections are becoming more common. Experts are still unsure about how damaging they can be. NYTimes. 17.8.2023. https://www.nytimes.com/2023/08/17/well/live/covid-reinfection.html
There are a couple of simple ways to see whether herd immunity has been achieved. twitter. 17.8.2023. https://twitter.com/adamhamdy/status/1692056008389247046
Data on COVID-19 vaccination in the EU/EEA. ECDC.17.8.2023. https://www.ecdc.europa.eu/en/publications-data/data-covid-19-vaccination-eu-eea
Risk of autoimmune diseases following COVID-19 and the potential protective effect from vaccination: a population-based cohort study (Compared with non-COVID controls, patients with COVID-19 presented an increased risk of developing pernicious anaemia [adjusted Hazard Ratio (aHR): 1.72; 95% Confidence Interval (CI): 1.12–2.64]; spondyloarthritis [aHR: 1.32 (95% CI: 1.03–1.69)]; rheumatoid arthritis [aHR: 1.29 (95% CI: 1.09–1.54)]; other autoimmune arthritis [aHR: 1.43 (95% CI: 1.33–1.54)]; psoriasis [aHR: 1.42 (95% CI: 1.13–1.78)]; pemphigoid [aHR: 2.39 (95% CI: 1.83–3.11)]; Graves’ disease [aHR: 1.30 (95% CI: 1.10–1.54)]; anti-phospholipid antibody syndrome [aHR: 2.12 (95% CI: 1.47–3.05)]; immune mediated thrombocytopenia [aHR: 2.1 (95% CI: 1.82–2.43)]; multiple sclerosis [aHR: 2.66 (95% CI: 1.17–6.05)]; vasculitis [aHR: 1.46 (95% CI: 1.04–2.04)].). eClinicalMedicine. 16.8.2023. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00331-0/fulltext
Outpatient Treatment for COVID-19. JAMA Patient Page. 16.8. 2023. https://jamanetwork.com/journals/jama/fullarticle/2808687?guestAccessKey=3ef6c699-3c89-4843-9008-03433769bb45&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=081623&adv=000004416804
Viral emissions into the air and environment after SARS-CoV-2 human challenge: a phase 1, open label, first-in-human study (). The Lancet Microbe. 16.8.2023. https://www.sciencedirect.com/science/article/pii/S2666524723001015
Why Blood Type Seems to Be Linked With COVID-19 Risk (…given the earlier SARS observations, Stowell said that most studies of the relationship between SARS-CoV-2 and blood group have found that, all other things being equal, people with type A were more likely to become infected than people with type O. Although some studies have found no relationship between blood type and COVID-19 risk, none has linked type O to a higher risk of SARS-CoV-2 infection.). JAMA. 16.8.2023. https://jamanetwork.com/journals/jama/fullarticle/2808688?guestAccessKey=010c32e6-deee-4499-a180-94aee45e5885&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=081623&adv=000004416804
Communication of COVID-19 Misinformation on Social Media by Physicians in the US. JAMA Network. (The propagation of COVID-19 misinformation was attributed to 52 physicians in 28 different specialties across all regions of the country. General misinformation categories included vaccines, medication, masks, and other (ie, conspiracy theories). Forty-two physicians (80.8%) posted vaccine misinformation, 40 (76.9%) propagated information in more than 1 category, and 20 (38.5%) posted misinformation on 5 or more platforms. Major themes identified included (1) disputing vaccine safety and effectiveness, (2) promoting medical treatments lacking scientific evidence and/or US Food and Drug Administration approval, (3) disputing mask-wearing effectiveness, and (4) other (unsubstantiated claims, eg, virus origin, government lies, and other conspiracy theories).) 15.8.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2808358
Protection against COVID-19 hospitalisation conferred by primary-series vaccination with AZD1222 in non-boosted individuals: first vaccine effectiveness results of the European COVIDRIVE study and meta-regression analysis (Primary-series AZD1222 vaccination confers protection against COVID-19 hospitalisation with enduring levels of VE through ≥6 months. AstraZeneca.) Science Direct. August 2023. https://www.sciencedirect.com/science/article/pii/S2666776223000947
Changes in SARS-CoV-2 seroprevalence and population immunity in Finland, 2020-2022. Helsingi Yliopisto. 12.8.2023. https://helda.helsinki.fi/items/e7895157-bce5-4f6f-b151-3886d9986fa9
Group Life COVID-19 Mortality Survey Report. SOA Research Institute 11.8.2023. https://www.soa.org/49b504/globalassets/assets/files/resources/experience-studies/2022/group-life-covid-19-mortality-12-2022.pdf
More young Americans are dying – and it’s not COVID. Why aren’t we searching for answers?
Without a thorough and collaborative exploration, we can’t know what’s killing us – or how to stop it. USA Today Opinnion. 11.8.2023. https://eu.usatoday.com/story/opinion/2023/08/11/more-americans-dying-than-before-pandemic-covid-deaths/70542423007/
Bird flu researchers turn to Finland’s mink farms, tracking a virus with pandemic potential. STAT 11.8.2023. https://www.statnews.com/2023/08/11/bird-flu-researchers-finland-mink-farms/
August 11-20
Treaqtment of ME/CFS and Long COVID in Finland and from a broader perspective. The treatment of Long COVID and ME/CFS based on biopsychosocial approach in Finland has raised international criticism. There is no scientific evidence of this approach, and it does not represent the current guidelines. COMMENTARY 10.8.2023. https://slme.fi/wp-content/uploads/2023/08/Commentary_Treatment_of_ME_CFS_and_Long_COVID_in_Finland_and_from_a_broader_perspective_10_Aug_2023.pdf
Opinion: Long covid has derailed my life. Make no mistake: It could yours, too. The Washington Post. 9.8.2023. https://www.washingtonpost.com/opinions/2023/08/09/madeline-miller-long-covid-post-pandemic/
Italy abandoning all COVID mitigation measures. World Socialist Web Site. 9.8.2023. https://www.wsws.org/en/articles/2023/08/09/izva-a09.html
Long Covid May Affect Organs Like The Heart And Kidneys After Lungs Recover, New Research Says.
Forbes. 9.8.2023. https://www.forbes.com/sites/ariannajohnson/2023/08/09/long-covid-may-affect-organs-like-the-heart-and-kidneys-after-lungs-recover-new-research-says/?sh=128a8f975466
Vaccines & Immunizations, 6 Things to Know. Information for parents and caregivers: For the best protection, CDC recommends COVID-19 vaccines for everyone 6 months and older (1. COVID-19 vaccination for children is safe. 2. Getting vaccinated helps protect children against COVID-19. 3. Children may have some side effects after COVID-19 vaccination. 4. Children receive a smaller dose of COVID-19 vaccine than teens and adults. 5. Children who have already had COVID-19 should still get vaccinated. 6. Children can safely receive other vaccines the same day they receive their COVID-19 vaccine.) CDC. 8.8.2023.https://www.cdc.gov/vaccines/covid-19/planning/children/6-things-to-know.html
Antiviral efficacy of the SARS-CoV-2 XBB breakthrough infection sera against Omicron subvariants including EG.5. (the NT50 of the BTI sera of XBB1.5/1.9 and XBB.1.16 against the variant infected were 8.7- and 8.3-fold lower than that against the B.1.1 variant. These results suggest that XBB BTI cannot efficiently induce antiviral humoral immunity against XBB subvariants.) bioRxiv. 8-8.2023. https://www.biorxiv.org/content/10.1101/2023.08.08.552415v1
Case Report of Leprosy in Central Florida, USA, 2022. CDC Research Letter. August 2023
Diabetes following SARS-CoV-2 infection: Incidence, persistence, and implications of COVID-19 vaccination. A cohort study of fifteen million people (In the pre-vaccination cohort, adjusted hazard rations (aHRS) for type 2 diabetes (T2DM) incidence after COVID-19 (compared to before or without diagnosis) declined from 3.01 (95% CI: 2.76,3.28) in weeks 1-4 to 1.24 (1.12,1.38) in weeks 53-102. aHRS were higher in unvaccinated than vaccinated people (4.86 (3.69,6.41)) versus 1.42 (1.24,1.62) in weeks 1-4) and for hospitalised COVID-19 (pre-vaccination cohort 21.1 (18.8,23.7) in weeks 1-4 declining to 2.04 (1.65,2.51) in weeks 52-102), than non-hospitalised COVID-19 (1.45 (1.27,1.64) in weeks 1-4, 1.10 (0.98,1.23) in weeks 52-102). T2DM persisted for 4 months after COVID-19 for ∼73% of those diagnosed. Patterns were similar for Type 1 diabetes, though excess incidence did not persist beyond a year post-COVID-19.). medRxiv. 7.8.2023. https://www.medrxiv.org/content/10.1101/2023.08.07.23293778v1
The Economic Cost of Long COVID: An Update – David Cutler (per cap. $11 189, 17% of 2019 GDP). Harvard Kennedy School. 7.8.2023. https://scholar.harvard.edu/files/cutler/files/long_covid_update_7-22.pdf
The Effects of Vaccines on the Sequelae Rates of Recurrent Infections and the Severity of Pulmonary COVID-19 Infection by Imaging. MDPI. 4.8.2023. https://www.mdpi.com/2076-393X/11/8/1321
Notes from the Field: Safety Monitoring of Novavax COVID-19 Vaccine Among Persons Aged ≥12 Years — United States, July 13, 2022–March 13, 2023. (Although postauthorization safety data after receipt of a primary Novavax dose are limited by the low number of doses administered (0.01% of total COVID-19 vaccine doses administered) (2), available data are consistent with those from preauthorization clinical trials.§ No new safety concerns were identified. ) CDC MMWR. 3.8.2023. https://www.cdc.gov/mmwr/volumes/72/wr/mm7231a4.htm?s_cid=mm7231a4_w
We’re now finding out the damaging results of the mandated return to the office–and it’s worse than we thought. Fortune. 1.8.2023. https://fortune.com/2023/08/01/research-damaging-results-mandated-return-to-office-worse-than-we-thought-rto-remote-work-careers-leadership-gleb-tsipursky/
August 1-10
Covid-19: Leaked cremation data hint at true scale of China’s death rate (In the relatively wealthy and developed eastern province, where more than 99% of all deaths end in cremation, the number of cremations in the first quarter of 2023 was just under 171 000, compared with 99 000 in the first quarter of 2022 and 90 000 in the first quarter of 2021. Extrapolated across China, this 72% rise in mortality would translate to about 1.5 million excess deaths in the first quarter of 2023, closely matching predictions of several models developed by epidemiologists). BMJ. 31.7.2023. https://www.bmj.com/content/382/bmj.p1760
Three myths about COVID-19 — and the biggest challenge that lies ahead (1: It’s just a cold now so let’s get it over with, 2: Being fully immunised stops infection, 3: Variant-specific vaccines are the answer. Making COVID-19 personal). ABC Health & Wellbeing. 28.7.2023. https://www.abc.net.au/news/health/2022-07-29/covid-19-three-myths-challenge-lies-ahead/101274980
Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19. medRxiv. 27.7.2023. https://www.medrxiv.org/content/10.1101/2023.07.27.23293177v1
Open data for COVID-19 policy analysis and mapping. Scientific data. 27.7.2023. https://www.nature.com/articles/s41597-023-02398-3
Highly pathogenic avian influenza A(H5N1) virus infection on multiple fur farms in the South and Central Ostrobothnia regions of Finland, July 2023 separator. Eurosurveillance. 27.7.2023. https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.31.2300400
Research uncovers new insights into post-COVID-19 syndrome (PCS) phenotypes and impact on quality of life (clinical PCS phenotypes were identified: chronic fatigue-like syndrome (CF: memory loss, fatigue, and headaches, 42%, 757 individuals); respiratory syndrome (RE: dyspnea and cough, 23%, 502 individuals); neurosensorial syndrome (NS: altered smell and taste, 11%, 197 individuals); and chronic pain syndrome (CPs: myalgia and arthralgia, 22%, 399 individuals. The largest decrease in quality of life was observed in CPs and REs (44 and 44 versus 57 among control controls, respectively).).). News Medical. 26.7.2023. https://www.news-medical.net/news/20230726/Research-uncovers-new-insights-into-post-COVID-19-syndrome-(PCS)-phenotypes-and-impact-on-quality-of-life.aspx
Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants. nature. 26.7.2023. https://www.nature.com/articles/s41467-023-40228-7
Opinion: Accountability for Canada’s Covid-19 Response. We can learn from the covid-19 pandemic management strategy of First Nations communities in Canada. BMJ. 24.7.2023. https://www.bmj.com/content/382/bmj.p1675
Number needed to vaccinate with a COVID-19 booster to prevent a COVID-19-associated hospitalization during SARS-CoV-2 Omicron BA.1 variant predominance, December 2021–February 2022, VISION Network: a retrospective cohort study (Median estimated number neede to vaccinate (NNV) to prevent one hospitalization was 205 (range 44–615) and NNV was lower across study periods for adults aged ≥65 years (110, 46, and 88, respectively) and those with underlying medical conditions (163, 69, and 131, respectively). Median estimated NNV to prevent one emergency department encounter was 156 (range 75–592).). The Lancet Regional Health – Americas. 23.7.2023. https://www.sciencedirect.com/science/article/pii/S2667193X23001047?via%3Dihub
Association Between Duration of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Positivity and Long COVID (In an observational study, we analyzed 1293 healthcare workers previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), of which 34.1% developed postacute sequelae of SARS-CoV-2 infection (also known as long COVID). Using a multivariate logistic regression model, we demonstrate that the likelihood of developing long COVID in infected individuals rises with the increasing of duration of infection and that 3 doses of the BNT162b2 vaccine are protective, even during the Omicron wave.). Clinical Infectious Diseases. 22.7.2023. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad434/7227950?login=false
Study: 1 in 6 kids have persistent COVID symptoms for 3 months after infection. CIDRAP, UoMi. 21.7.2023. https://www.cidrap.umn.edu/covid-19/study-1-6-kids-have-persistent-covid-symptoms-3-months-after-infection
A Systematic Review of Persistent Clinical Features After SARS-CoV-2 in the Pediatric Population (27 cohorts and 4 cross-sectional studies met the inclusion criteria and involved over 15 000 pediatric participants. A total of more than 20 persistent symptoms and clinical features were reported among children and adolescents. 16.2% (95% confidence interval 8.5% to 28.6%) of the pediatric participants experienced 1 or more persistent symptom(s) at least 3 months post COVID-19. Female gender might be associated with developing certain long COVID symptoms.). Pediatrics. 21.7.2023. https://publications.aap.org/pediatrics/article/152/2/e2022060351/192816/A-Systematic-Review-of-Persistent-Clinical?autologincheck=redirected
The effects of COVID-19 on cognitive performance in a community-based cohort: a COVID symptom study biobank prospective cohort study (3335 individuals completed Round 1, of whom 1768 also completed Round 2. At Round 1, individuals with previous positive SARS-CoV-2 tests had lower cognitive accuracy (N = 1737, β = −0.14 standard deviations, SDs, 95% confidence intervals, CI: −0.21, −0.07) than negative controls. Deficits were largest for positive individuals with ≥12 weeks of symptoms (N = 495, β = −0.22 SDs, 95% CI: −0.35, −0.09). Effects were comparable to hospital presentation during illness (N = 281, β = −0.31 SDs, 95% CI: −0.44, −0.18), and 10 years age difference (60–70 years vs. 50–60 years, β = −0.21 SDs, 95% CI: −0.30, −0.13) in the whole study population. Stratification by self-reported recovery revealed that deficits were only detectable in SARS-CoV-2 positive individuals who did not feel recovered from COVID-19, whereas individuals who reported full recovery showed no deficits. Longitudinal analysis showed no evidence of cognitive change over time, suggesting that cognitive deficits for affected individuals persisted at almost 2 years since initial infection.). eClinicalMedicine. 21.7.2023. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00263-8/fulltext
As COVID-19 cases rose, so did diabetes — no one knows why. The spike in childhood type 1 diabetes opened new avenues for researchers to explore the cause of the disease. nature. 21.7.2023. https://www.nature.com/articles/d41586-023-02322-0
July 21-31
Official Data Hinted at China’s Hidden Covid Toll. Then It Vanished. Epidemiologists say a rise in cremations in an eastern province was the latest indication that the country’s official death toll from Covid is a vast undercount. NYTimes. 19.7.2023. https://www.nytimes.com/2023/07/19/world/asia/china-covid-data-toll.html
The Challenges of Defining, Understanding, and Addressing Long COVID. Pfizer. 18.7.2023. https://www.pfizer.com/news/articles/the_challenges_of_defining_understanding_and_addressing_long_covid
Epigenetic Age Acceleration in Surviving versus Deceased COVID-19 Patients with Acute Respiratory Distress Syndrome following Hospitalization (Our analysis revealed significant accelerated epigenetic aging but no telomere attrition acceleration in severe COVID-19 cases. … The DNAmTL measurements revealed telomere attrition acceleration in deceased COVID19 patients between inclusion and end of follow-up as well as a significant change in dynamic telomere attrition acceleration when comparing patients who recovered vs those who died. In conclusion, EAA and telomere attrition acceleration was associated with treatment outcome in hospitalized COVID-19 Patients with ARDS.). bioRxiv. 18.7.2023. https://www.biorxiv.org/content/10.1101/2023.07.18.549478v1
Healthcare group calls for return of face mask guidance (A lobby group of healthcare workers has warned against the decision to remove face mask guidance in healthcare settings. The Scottish Healthcare Workers Coalition (SHWC) has written to ministers, claiming “very serious flaws” in changing the guidance. The group is made up of medical professionals who worked throughout the pandemic. All members have long Covid or another chronic post-viral illness.Face mask guidance was withdrawn in May in hospitals, dentists and GP surgeries having been in place since June 2020. The decision came after the World Health Organization declared Covid-19 was no longer a global emergency.) BBC News. 17.7.2023. https://www.bbc.com/news/uk-scotland-66215539
News: Covid-19: Bring back mandatory mask wearing in health settings, say Scottish workers. BMJ. 17.7.2023. https://www.bmj.com/content/382/bmj.p1648
Immunogenicity and efficacy of vaccine boosters against SARS-CoV-2 Omicron subvariant BA.5 in male Syrian hamsters. ( In a comprehensive, experimental vaccination study using male Syrian hamsters, we evaluate neutralizing antibody responses and efficacy against BA.5 challenge after primary vaccination with Ad26.COV2.S (Janssen) or BNT162b2 (Pfizer/BioNTech) followed by a homologous or heterologous booster with mRNA-1273 (Moderna) or NVX-CoV2373 (Novavax). Notably, one high or low dose of Ad26.COV2.S provides more durable immunity than two primary doses of BNT162b2, and the NVX-CoV2373 booster provides the strongest augmentation of immunity, reduction in BA.5 viral replication, and disease. ) nature communications. 17.7.2023. https://www.nature.com/articles/s41467-023-40033-2
COVID-19 Severity and Waning Immunity After up to 4 mRNA Vaccine Doses in 73 608 Patients With Cancer and 621 475 Matched Controls in Singapore – A Nationwide Cohort Study. (Each booster COVID-19 vaccine dose was associated with significant clinical protection in patients with cancer, lasting at least 5 months in actively treated patients with cancer and cancer survivors, underscoring the benefit of boosters.) JAMA Network. 13.7.2023. https://jamanetwork.com/journals/jamaoncology/fullarticle/2807035
Novavax Intends to Deliver Protein-based XBB COVID Vaccine as Specified in U.S. HHS Letter to COVID Manufacturers. Novavax News&Media. 13.7.2023. https://ir.novavax.com/press-releases/Novavax-Intends-to-Deliver-Protein-based-XBB-COVID-Vaccine-as-Specified-in-U-S-HHS-Letter-to-COVID-Manufacturers
Determinants of the Onset and Prognosis of the Post-COVID-19 Condition: 2-Year Prospective Cohort Study (Preexisting medical and socioeconomic factors, as well as acute COVID-19 symptoms, predict the development of and recovery from the PCC. Recovery is extremely rare during the first 2 years, posing a major challenge to healthcare systems.). Preprint Lancet. 12.7.2023. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4505315
Gene linked to long COVID found in analysis of thousands of patients. The first genome-wide search for long-COVID risk factors could pave the way for larger studies. Nature 11.7.2023. https://www.nature.com/articles/d41586-023-02269-2
Immunogenicity of NVX-CoV2373 heterologous boost against SARS-CoV-2 variants. NPJ Vaccines. 11.7.2023. https://pubmed.ncbi.nlm.nih.gov/37433788/
The immunology of long COVID (of all those who had COVID-19 globally, at least 10% have long COVID. The disease burden spans from mild symptoms to profound disability, the scale making this a huge, new health-care challenge. Long COVID will likely be stratified into several more or less discrete entities with potentially distinct pathogenic pathways.). nature reviews, immunology- 11.7.2023. https://www.nature.com/articles/s41577-023-00904-7
July 11-20
These Schools Across the US Have Brought Back Mask Mandates. The Epoch Times. 9.7.2023. https://www.theepochtimes.com/us/these-schools-across-the-us-have-brought-back-mask-mandates-5487628/
Devastating COVID-19 surge in Okinawa exposes lies that the pandemic is over (The situation is not so much a medical crisis as a collapse of the system). World Socialist Web Site. 7.7.2023. https://www.wsws.org/en/articles/2023/07/08/okin-j08.html
An analysis of studies pertaining to masks in Morbidity and Mortality Weekly Report: Characteristics and quality of all studies from 1978 to 2023 (MMWR publications pertaining to masks drew positive conclusions about mask effectiveness over 75% of the time despite only 30% testing masks and <15% having statistically significant results. No studies were randomized, yet over half drew causal conclusions. The level of evidence generated was low and the conclusions drawn were most often unsupported by the data. Our findings raise concern about the reliability of the journal for informing health policy.). medRxiv. 7.7.2023. https://www.medrxiv.org/content/10.1101/2023.07.07.23292338v1.full
Novavax COVID-19 vaccine as a second dose generates high immune response in young people, finds study (“Of particular interest is the enhanced performance of Novavax’s protein subunit vaccine following a dose of Pfizer-BioNTech’s mRNA, compared to the standard two doses of Pfizer-BioNTech mRNA. Among participants who had not been infected with COVID-19 before, those in the Novavax group were less likely to report a breakthrough infection than those in the standard Pfizer-BioNTech group…). MedicxalXpress by UoOxford. 6.7.2023. https://medicalxpress.com/news/2023-07-novavax-covid-vaccine-dose-generates.html
UK doctors demand re-introduction of infectious disease controls. Earlier this week the trade union for doctors and medical students in the UK issued a warning about the number of doctors that have had to quit or reduce their hours due to long covid – the number was one in five. Nate Bear Ko-fi. 6.7.2023. https://ko-fi.com/Post/UK-doctors-demand-the-re-introduction-of-infectiou-U7U0MY54T
How to Protect Yourself & Others. CDC. 6.7.2023. https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html
Hospital admissions linked to SARS-CoV-2 infection in children and adolescents: cohort study of 3.2 million first ascertained infections in England (Most SARS-CoV-2 associated hospital admissions in children and adolescents in England were due to SARS-CoV-2 or SARS-CoV-2 was a contributory factor. These results should inform future public health initiatives and research.). The BMJ. 5.7.2023. https://www.bmj.com/content/382/bmj-2022-073639
First major survey of doctors with Long Covid reveals debilitating impact on health, life and work (-(-Doctors reported a wide range of symptoms, including fatigue, headaches, muscular pain, nerve damage, joint pain, ongoing respiratory problems and many more.
-60% told the BMA that post-acute Covid ill health has impacted on their ability to carry out day-to-day activities on a regular basis;
-18% reported that they were now unable to work due to their post-acute Covid ill-health;
-31% said they were working full-time, compared to 57% before the onset of their illness;
-48% have experienced some form of loss of earnings as a result of post-acute Covid;
-54% acquired Covid-19 during the first wave of the pandemic in 2020, and 77% of these believed that they contracted Covid -19 in the workplace;
-A small minority had access to respiratory protective equipment (RPE) around the time that they contracted Covid-19, with only 11% having access to an FFP2 respirator and 16% an FFP3 respirator;
-65% said their post-acute Covid symptoms had not been investigated thoroughly and effectively by an NHS long Covid clinic or centre. Almost half reported not even being referred to an NHS long Covid clinic at all.). BMA. 4.7.2023. https://www.bma.org.uk/bma-media-centre/first-major-survey-of-doctors-with-long-covid-reveals-debilitating-impact-on-health-life-and-work-and-wider-implications-for-workforce-and-health-services
Rare link between coronavirus vaccines and Long Covid–like illness starts to gain acceptance
Studies probe unusual cases of neurologic complications, blood pressure swings, and other side effects. Science. 3.7.2023. https://www.science.org/content/article/rare-link-between-coronavirus-vaccines-and-long-covid-illness-starts-gain-acceptance
July 1-10
SHEDDING OF INFECTIOUS SARS-COV-2 IN TWO ASYMPTOMATIC CHILDREN. Medicina (Buenos Aires) 2023. https://www.medicinabuenosaires.com/PMID/37094186.pdf
COVID-19 cases continue to rise, straining health care system in Okinawa. The Japan Times. 30.6.2023. https://archive.is/fOo1M
Incidence of Diabetes in Children and Adolescents During the COVID-19 Pandemic
A Systematic Review and Meta-Analysis (…a higher incidence rate during the first year of the pandemic compared with the prepandemic period (incidence rate ratio [IRR], 1.14; 95% CI, 1.08-1.21). There was an increased incidence of diabetes during months 13 to 24 of the pandemic compared with the prepandemic period (IRR, 1.27; 95% CI, 1.18-1.37)). JAMA. 30.6.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2806712?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=063023
Covid pandemic linked to surge in child and teen diabetes (There has been an unusual rise in the number of children and teenagers around the world diagnosed with type 1 diabetes since Covid, say researchers.) BBC News. 30.6.2023. https://www.bbc.com/news/health-66054946
Immunogenicity and safety of a fourth homologous dose of NVX-CoV2373. (A fourth dose of NVX-CoV2373 enhanced immune response to SARS-CoV-2 variants. / An NVX-CoV2373 fourth dose induced robust immunogenicity in those aged 18–84 years./ Correlates of protection imply post-boost efficacy of ≥ 82% for Omicron variants.) Vaccine. 29.6.2023. https://www.sciencedirect.com/science/article/pii/S0264410X23006126?via%3Dihub
New research finds that COVID-19 can cause cancer, Alzheimer’s disease and thyroid disfunction- World Socialist Web Site. 28.6.2023. https://www.wsws.org/en/articles/2023/06/29/1e81-j29.html
Reduction of SARS-CoV-2 intra-household child-to-parent transmission associated with ventilation: results from a case–control study. BMC Public Health. 26.6.2023. https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-023-16144-2
New onset or relapsing neuromyelitis optica temporally associated with SARS-CoV-2 infection and COVID-19 vaccination: a systematic review. Frontiers in neurology. 22.6.2023. https://www.frontiersin.org/articles/10.3389/fneur.2023.1099758/full
June 21-30
The Covid Inquiry is Ignoring the Biggest Lesson: COVID-19 is Airborne. In the first week of the Covid Inquiry, the importance of aerosols has been ignored, and the WHO’s disastrous initial claim Covid ‘is not airborne’ has been overlooked.(GB) Byline Times. 20.6.2023. https://bylinetimes.com/2023/06/20/the-covid-inquiry-is-ignoring-the-biggest-lesson-covid-19-is-airborne/
Study Reveals 23 Percent Lower COVID Risk in Those ‘Not Up-to-Date’ With Vaccinations. The Epoch Times. 17.6.2023. https://www.theepochtimes.com/health/study-reveals-23-percent-lower-covid-risk-in-those-not-up-to-date-with-vaccinations-5339850
Lessons From COVID-19 for Protecting Workers in the Next Pandemic (COVID-19 is an occupational disease that sickened and killed countless workers in health care and long-term care, and in meat processing, agriculture, warehousing, transportation, corrections, and other “essential” industries. Nonetheless, COVID-19 has rarely been treated or tracked as an occupational disease by public health agencies, particularly in non–health care workplaces. The lessons from the failure to protect workers during the COVID-19 pandemic can be helpful as the nation anticipates and prepares for the next public health emergency.). JAMA. 16.6.2023. https://jamanetwork.com/journals/jama/article-abstract/2806496
Reactogenicity, immunogenicity and breakthrough infections following heterologous or fractional second dose COVID-19 vaccination in adolescents (Com-COV3): A randomised controlled trial. (Novavax. Heterologous and fractional dose COVID-19 vaccine schedules in adolescents are safe, well-tolerated and immunogenic. NVXCoV2373 following 30µg BNT162b2 as a first dose elicited the highest humoral and peak cellular immune responses. Neutralising antibodies against Omicron BA.1 and BA.2 were higher after NVXCoV2373 than a two-dose 30µg BNT162b2 schedule. The lowest rate of SARS-CoV-2 breakthrough infections occurred in participants who received NVXCoV2373 as their second dose. Enhanced protection may be provided by heterologous vaccine schedules using NVXCoV2373 than the homologous BNT162b2 schedule.) J Infect. 16.6.2023. https://www.journalofinfection.com/article/S0163-4453(23)00330-4/fulltext
Why our family is covid cautious (extensive list of LC &Covid sequelae). 16.6.2023. https://sites.google.com/view/why-we-are-covid-cautious/home
Tutkimus: Yli 70 prosentilla suomalaisista on sairastetun koronan tuottamia viruksen vasta-aineita. THL. 16.6.2023. https://thl.fi/fi/-/tutkimus-yli-70-prosentilla-suomalaisista-on-sairastetun-koronan-tuottamia-viruksen-vasta-aineita
Notes from the Field: Comparison of COVID-19 Mortality Rates Among Adults Aged ≥65 Years Who Were Unvaccinated and Those Who Received a Bivalent Booster Dose Within the Preceding 6 Months — 20 U.S. Jurisdictions, September 18, 2022–April 1, 2023. CDC MMWR Weekly. 16.6. 2023. https://www.cdc.gov/mmwr/volumes/72/wr/mm7224a6.htm?s_cid=mm7224a6_w
Wavelength dependence of ultraviolet light inactivation for SARS-CoV-2 omicron variants (The inactivation efficacy of 220 nm light, which is considered safe for the human body, was approximately the same as that of health hazardous 260 nm light for both BA.2 and BA.5.). Nature 15.6.2023. https://www.nature.com/articles/s41598-023-36610-6
Maternal COVID-19 infection and the fetus: Immunological and neurological perspectives (Pregnant women with male fetuses have been reported to have decreased maternal and placental humoral responses. This suggests that in pregnancies with a male fetus, fewer antibodies may be transferred to the fetus and contribute to males’ increased susceptibility/vulnerability to infectious diseases compared to female infants.). New Microbes and New Infections. June 2023. https://www.sciencedirect.com/science/article/pii/S2052297523000549
Immunogenicity and safety of a fourth homologous dose of NVX-CoV2373 ( Novavax. In conclusion, despite the call for variant-specific vaccines, an increase in number of vaccine booster doses with NVX-CoV2373 enhances immunogenicity for the ancestral SARS-CoV-2 strain and its variants without a notable increase in reactogenicity. Therefore, these data suggest that further boosting with the ancestral sequence used in NVX-CoV2373 should retain meaningful utility in preventing variant virus-associated illness.). Vaccine. June 2023. https://www.sciencedirect.com/science/article/pii/S0264410X23006126
Viral emissions into the air and environment after SARS-CoV-2 human challenge: a phase 1, open label, first-in-human study (…a minority of participants were high airborne virus emitters, giving support to the notion of superspreading individuals or events. Our data implicates the nose as the most important source of emissions. Frequent self-testing coupled with isolation upon awareness of first symptoms could reduce onward transmissions.). The Lancet Microbe. 16.6.2023. https://www.sciencedirect.com/science/article/pii/S2666524723001015
For Patient Safety, It Is Not Time to Take Off Masks in Health Care Settings. Annals of Internal Medicine. June 2023. https://www.acpjournals.org/doi/10.7326/M23-1190
Long covid ja keho-mielihoidot (Juhani Knuuti: Covid-infektion laukaisemien pitkäaikaisoireiden hoito on edelleen suuri haaste. Toistaiseksi täsmähoitoa ei ole ja hoito perustuu toisaalta elinjärjestelmän vaurioiden hoitoon ja toisaalta moniammatilliseen kuntoutukseen, jossa tavoitteena on tukea oireiden kanssa pärjäämistä ja toipumista. Onneksi valtaosin potilaat toipuvat. / Perehdyttyäni huolellisesti tutkimusnäyttöön ja kuunneltuani luennon ja tutkittuani sen lähteitä, jää mieltäni edelleen askarruttamaan kysymys: Annetaanko Suomessa jo nyt covidin pitkäaikaisoireisiin muun kuntoutuksen ohessa hoitoa, josta tutkimusnäyttö kokonaan puuttuu ja jota vasta pyritään tutkimaan? Se, että ”kahden vuoden aikana [ei] ole jätetty yhtään muistutusta hoidon sisällöstä tai laadusta” ei mielestäni käy perusteeksi tutkimattoman hoidon antamiselle.). TS Blogit. 14.5.2023. https://blogit.ts.fi/terveys-tiede/long-covid-ja-keho-mielihoidot/
Over 20 Million Americans Struggle To Regain Smell and Taste After COVID. Sci Tech Daily. 14.6.2023. https://scitechdaily.com/over-20-million-americans-struggle-to-regain-smell-and-taste-after-covid/
Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2 VUMC researchers study long term neurological impacts of COVID. NewsChannel5. 15.5.2023. https://www.newschannel5.com/news/vumc-researchers-study-long-term-neurological-impacts-of-covid
Sunday Timesin selvitys: Koronavirus karkasi wuhanilaboratoriosta, jossa kehitettiin ihmisiin herkemmin tarttuvia virusmuunnoksia. Tekniikan Maailma. 13.6.2023. https://tekniikanmaailma.fi/sunday-timesin-selvitys-koronavirus-karkasi-wuhanilaboratoriosta-jossa-kehitettiin-ihmisiin-herkemmin-tarttuvia-virusmuunnoksia/
“The idea that the pandemic is over… The virus hasn’t gotten that memo.” An interview with Arijit Chakravarty on ending of the COVID-19 Public Health Emergency: Part 1. World Socialist Web Site. 11.6.2023. https://www.wsws.org/en/articles/2023/06/12/ddzg-j12.html
June 11-20
Evaluation of Mask-Induced Cardiopulmonary Stress. A Randomized Crossover Trial. (… wearing the N95 mask for 14 hours significantly affected the physiological, biochemical, and perception parameters.4,5 The effect was primarily initiated by increased respiratory resistance and subsequent decreased blood oxygen and pH, which contributed to sympathoadrenal system activation and epinephrine as well as norepinephrine secretion elevation. The extra hormones elicited a compensatory increase in heart rate and blood pressure. Although healthy individuals can compensate for this cardiopulmonary overload, other populations, such as elderly individuals, children, and those with cardiopulmonary diseases, may experience compromised compensation.) JAMA. 8.6.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805809
Prusty on Herpesviruses, Messed Up Mitochondria and a Biomarker for ME/CFS and Long COVID (?). HealthRising. 9.6.2023. https://www.healthrising.org/blog/2023/06/09/prusty-on-herpesviruses-messed-up-mitochondria-and-a-biomarker-for-me-cfs-and-long-covid/
Association of COVID-19 Government-Instituted Mask Mandates With Incidence of Mask Use Among Children in Alberta, Canada (This cohort study of 939 children (age, 8-13 years) from August 2020 to June 2022 examined government masking mandates and child mask use; the odds of parents’ report of child mask use (often or always) was 18.3 times higher during the mask mandate compared with when there was no mandate, which was a significant difference. Each day without the mask mandate was associated with a 1.6% decrease in mask use). JAMA. 8.6.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805784
Long COVID. National Instiututes of Health 8.6.2023. https://covid19.nih.gov/covid-19-topics/long-covid
Researchers discover that COVID-19 can cause brain cells to fuse. MedicalXpress- 7.6.2023. https://medicalxpress.com/news/2023-06-covid-brain-cells-fuse.html
SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity. Science Advances. 7.6.2023. https://www.science.org/doi/10.1126/sciadv.adg2248
Causal associations and genetic overlap between COVID-19 and intelligence. QJM: An International Journal of Medicine. 7.6.2023. https://academic.oup.com/qjmed/advance-article/doi/10.1093/qjmed/hcad122/7191821
Discontinuation of Universal Admission Testing for SARS-CoV-2 and Hospital-Onset COVID-19 Infections in England and Scotland (in England, the same mean (SD) rate increased from 0.64 (0.14) to 1.00 (0.17) to 1.39 (0.34) (Figure, B). The immediate level change was significant after admission testing ended (26% relative increase; 95% CI, 8%-45%)). JAMA. 5.6.2023. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2805585
Study finds 27% rate of long COVID in infected health workers. CIDRAP. 5.6.2023. https://www.cidrap.umn.edu/covid-19/study-finds-27-rate-long-covid-infected-health-workers
Risk factors for long coronavirus disease 2019 (long COVID) among healthcare personnel, Brazil, 2020–2022. (Of 7,051 HCP diagnosed with COVID-19, 1,933 (27.4%) who developed long COVID were compared to 5,118 (72.6%) who did not. The majority of those with long COVID (51.8%) had 3 or more symptoms.) Cambridge Univ Press, 5.6.2023. https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/abs/risk-factors-for-long-coronavirus-disease-2019-long-covid-among-healthcare-personnel-brazil-20202022/AA01F17E1C8A33C07457914E63AB3EEE
Post-COVID-19 Syndrome in Non-Hospitalized Individuals: Healthcare Situation 2 Years after SARS-CoV-2 Infection. (Of the 304 non-hospitalized participants (58.2% female, median age 53.5), 210 (69.1%) had a PCS. Among these, 18.8% had slight to moderate functional limitations. Participants with PCS showed a significantly higher utilization of healthcare and a large proportion complained about lacking information on persistent COVID-19 symptoms and problems finding competent healthcare providers) MDPI. 5.6.2023. https://www.mdpi.com/1999-4915/15/6/1326
US CDC announces indoor air guidance for COVID-19 after 3 years. (The announcement calls for indoor air to be completely replaced at least five times every hour and cleaned with minimum efficiency reporting value (MERV)-13 air filters.) Lancet. 5.6.2023. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00229-1/fulltext?s=08
Dutch Survey Data Shows Significant Increase In Memory And Concentration Problems Among Adults Since Start Of Covid-19 Pandemic. Forbes. 4.6.2023. https://www.forbes.com/sites/joshuacohen/2023/06/04/dutch-survey-data-shows-significant-increase-in-memory-and-concentration-problems-among-adults-since-start-of-covid-19-pandemic/
Australia records 37,448 new Covid-19 cases as winter begins. A winter warning for Covid-19 is under way across Australia as tens of thousands of people contract the virus. 4.6.2023. https://www.news.com.au/lifestyle/health/health-problems/australia-records-37448-new-covid19-cases-as-winter-begins/news-story/737a2b783ba14c5a7a58a323e8f4b187
More than 70% of US household COVID spread started with a child, study suggests (“More than 70% of transmissions in households with adults and children were from a pediatric index case, but this percentage fluctuated weekly,” the study authors wrote. “Once US schools reopened in fall 2020, children contributed more to inferred within-household transmission when they were in school, and less during summer and winter breaks, a pattern consistent for 2 consecutive school years.”). CIDRAP. 2.6.2023. https://www.cidrap.umn.edu/covid-19/more-70-us-household-covid-spread-started-child-study-suggests
Lapsilla on oltava oikeus puhtaaseen hengitysilmaan. Ilmahygienia on seuraava suuri kansanterveydellinen murros, kolme kirjoittajaa sanoo. Suomen Kuvalehti 1.6.2023. https://suomenkuvalehti.fi/mielipide/puheenvuoro-suomi-on-epaonnistunut-hengitysteitse-leviavien-tautien-ehkaisemisessa/
More than 70% of US household COVID spread started with a child, study suggests (Children aged 8 years and younger were more likely to be the source of transmission than those aged 9 to 17 (7.6% vs 5.8%). During most of the pandemic, the proportion of transmission from children was negatively correlated with new community COVID-19 cases). CIDRAP. 2.6.2023. https://www.cidrap.umn.edu/covid-19/more-70-us-household-covid-spread-started-child-study-suggests
Smart Thermometer–Based Participatory Surveillance to Discern the Role of Children in Household Viral Transmission During the COVID-19 Pandemic (In a cohort study of 166 170 households with adults and children using smart thermometers, among 38 787 inferred household transmissions over 3 years, 70.4% had a pediatric index case. Rates dropped during school breaks.). JAMA. 1.6.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805468
COVID-19 delirium and encephalopathy: Pathophysiology assumed in the first 3 years of the ongoing pandemic (Among COVID-19 patients, delirium and encephalopathy have been observed / Cytokine storms and CNS damage result from viral induced hyperinflammation / BBB failure and elevated microglia activation may be signs of COVID encephalopathy / COVID-19 can result in cognitive impairment, starting with delirium). Brain Disorders. June 2023. https://www.sciencedirect.com/science/article/pii/S2666459323000112
June 1-10
Recovery and symptom trajectories up to two years after SARS-CoV-2 infection: population based, longitudinal cohort study (22.9% (95% confidence interval 20.4% to 25.6%) of individuals infected with SARS-CoV-2 did not fully recover by six months. The proportion of individuals who had an infection who reported not having recovered decreased to 18.5% (16.2% to 21.1%) at 12 months and 17.2% (14.0% to 20.8%) at 24 months after infection. ). BMJ. 31.5.2023. https://www.bmj.com/content/381/bmj-2022-074425
Opmerkelijke groei aantal volwassenen met geheugenproblemen na coronapandemie. NOS Nieuws. 31.5.2023. https://nos.nl/artikel/2477146-opmerkelijke-groei-aantal-volwassenen-met-geheugenproblemen-na-coronapandemie
Why the world needs more transparency on the origins of novel pathogens. Collaboration and openness are essential to minimize the risks of future pandemics, says the World Health Organization’s scientific advisory group, SAGO. Nature. 30.5.2023. https://www.nature.com/articles/d41586-023-01722-6
Oral Fungal Alterations in Patients with COVID-19 and Recovered Patients. Advanced Science. 29.4.2023. https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202205058
EMA Panel Endorses Novavax’s (NVAX) COVID Jab for Full Approval. yahoo!finance. 29.5.2023. https://finance.yahoo.com/news/ema-panel-endorses-novavaxs-nvax-134800731.html
Immunologist Akiko Iwasaki: ‘We are not done with Covid, not even close’. The Yale professor and long Covid expert on why the virus is causing ongoing illness for so many, and the challenges she faces as a woman of colour in science. The Guardian. 27.5.2023. https://www.theguardian.com/society/2023/may/27/immunologist-akiko-iwasaki-we-are-not-done-with-covid-not-even-close
Case report: Post-COVID new-onset neurocognitive decline with bilateral mesial-temporal hypometabolism in two previously healthy sisters. Front. Pediatr. 26.5.2023. https://www.frontiersin.org/articles/10.3389/fped.2023.1165072/full
1 in 10 People Get Long COVID After Omicron. Time. 26.5.2023. https://time.com/6283028/long-covid-after-omicron/
Estimates of Bivalent mRNA Vaccine Durability in Preventing COVID-19–Associated Hospitalization and Critical Illness Among Adults with and Without Immunocompromising Conditions — VISION Network, September 2022–April 2023. (Among adults aged ≥18 years without immunocompromising conditions, bivalent booster vaccine effectiveness (VE) against COVID-19–associated hospitalization declined from 62% at 7–59 days postvaccination to 24% at 120–179 days compared with VE among unvaccinated adults. Among immunocompromised adults, lower bivalent booster VE was observed. However, bivalent booster VE was sustained against critical COVID-19–associated outcomes, including intensive care unit admission or death.) CDC MMWR. 26.5.2023. https://www.cdc.gov/mmwr/volumes/72/wr/mm7221a3.htm
Disentangling the Postacute Sequelae of SARS-CoV-2. E Unibus Pluram (From One, Many) (This first RECOVER adult cohort study report provides an important initial framework for defining the sequelae that manifest after acute SARS-CoV-2 infection. The research exemplifies the benefits of multidisciplinary collaboration informed by extensive input from patient representatives. These efforts will continue to be needed to determine whether this phenomenon represents one entity with a single definition or multiple phenotypes that arise after COVID-19 infection requiring separate case definitions (ie, E unibus pluram [from one, many]). Addressing this question and finalizing the definitions of these postacute sequelae should facilitate more robust research that ultimately leads to high-quality care and treatment for patients with late effects of SARS-CoV-2 infection.). JAMA Editorial. 25.5.2023. https://jamanetwork.com/journals/jama/fullarticle/2805541
Historiallinen käänne Suomessa: vastasyntyneen elinajanodote lyheni. Elinajanodotteemme on 50 vuotta vain pidentynyt, mutta viime vuonna se kääntyi selvään laskuun (n 1,1 v). Tutkimusprofessori Seppo Koskinen ei pidä tilastovirhettä mahdollisena. Mediuutiset. 25.5.2023. https://www.mediuutiset.fi/uutiset/historiallisen-huono-kaanne-suomessa-vastasyntyneen-elinajanodote-lyheni/5cba8c8f-4a08-4491-bcac-26f23f174cf0
Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection. (In this analysis of data from 9764 participants in the RECOVER adult cohort, a prospective longitudinal cohort study, 37 symptoms across multiple pathophysiological domains were identified as present more often in SARS-CoV-2–infected participants at 6 months or more after infection compared with uninfected participants. A preliminary rule for identifying PASC was derived based on a composite symptom score.) JAMA. 25.5.2023. https://jamanetwork.com/journals/jama/fullarticle/2805540
‘Millions of Lives Lost’ in Pandemic Mainly From Pharma-Government Nexus, Says Critical Care Expert. The Epoch Times. 24.5.2023. https://www.theepochtimes.com/article/millions-of-lives-lost-in-pandemic-mainly-from-pharma-government-nexus-says-critical-care-expert-5280075
Nouvelle baisse de l’espérance de vie au Québec en 2022. (La surmortalité liée à la pandémie de COVID-19 est en cause. L’espérance de vie a de nouveau baissé au Québec l’année dernière, et de façon notable, selon le bilan démographique publié ce mercredi par l’Institut de la statistique du Québec. En cause : la COVID-19.) Pivot. 24.5.2023. https://pivot.quebec/2023/05/24/nouvelle-baisse-de-lesperance-de-vie-au-quebec-en-2022/
Cognitive dysfunction of patients infected with SARS-CoV-2 omicron variant in Shanghai, China. Translational Neurodegeneration. 24.5.2023. https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-023-00357-x
Estimation of Excess Mortality in Germany During 2020-2022 (In 2020, the observed number of deaths was extremely close to the expected number, but in 2021, the observed number of deaths was far above the expected number in the order of twice the empirical standard deviation, and in 2022, above the expected number even more than four times the empirical standard deviation. The analysis of the age-dependent monthly excess mortality showed that high excess mortality starting from spring 2021 is responsible for the excess mortality in 2021 and 2022.). Cureus. 23.5.2023. https://www.cureus.com/articles/149410-estimation-of-excess-mortality-in-germany-during-2020-2022#!/
COVID-19 vaccines may undergo major overhaul this fall. As Omicron persists, consensus grows for abandoning the ancestral coronavirus strain to improve immune responses. Science. 23.5.2023. https://www.science.org/content/article/covid-19-vaccines-may-undergo-major-overhaul-fall
COVID-19 hospitalisations and all-cause mortality by risk group in Finland. PLOS One. 23.5.2023. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0286142
Kyselytutkimus: Suomen koronauutisoinnissa painottui vallanpitäjien ääni. JSN:n puheenjohtaja Eero Hyvönen huomauttaa, että vallanpitäjien näkyvyys mediassa ei välttämättä tarkoita heidän myötäilyään. Helsingin Sanomat. 23.5.2023. https://www.hs.fi/kotimaa/art-2000009604014.html?s=03
Editorials: Vaccine effectiveness against delta and omicron variants of SARS-CoV-2 (…omicron (78%) periods, along with 61% protection against admission to hospital. …the duration of protection appeared to wane after three months in the omicron period. Compared with the first 90 days, the odds of death increased by 30% during the period 91-150 days after three vaccine doses (adjusted odds ratio 1.31 (95% confidence interval 1.09-1.58)), and the odds of hospital admission increased by 16% (1.16 (1.07 to 1.25)).). BMJ. 23.5.2023. https://www.bmj.com/content/381/bmj.p1111
Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues. Front Microbiol. 22.5.2023. https://www.frontiersin.org/articles/10.3389/fmicb.2023.1192832/full
Näin sairastettu korona kasvattaa riskiä sairastua muihin sairauksiin.
Korona eli sairastettu SARS-CoV-2-infektio lähes kaksinkertaisti tutkimuksissa riskin sairastua muistisairauteen, ja riski oli huomattavasti korkeampi naisilla kuin miehillä. Iltalehti. 22.5.2023. https://www.iltalehti.fi/terveysuutiset/a/a8929512-451f-4139-bba9-968afcc4e730
Lung aerosol particle emission increases with age at rest and during exercise (the elderly subjects emitted on average more than twice as many aerosol particles per minute and five times as much dry volume than those of subjects aged 20 to 39 y, whereas there was only a small difference between women and men.). PNAS. 22.5.2023. https://www.pnas.org/doi/10.1073/pnas.2301145120
No time for complacency on COVID-19 in Europe. Lancet. 22.5.2023. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01012-7/fulltext
Prepare for disease deadlier than COVID – WHO chief. SciDevNet. 22.5.2023. https://www.scidev.net/global/news/prepare-for-disease-deadlier-than-covid-who-chief/
Sairauspoissaolot kääntyivät kunta-alalla jyrkkään nousuun – syy ei yllätä. MTV Uutiset. 22.5.2023. https://www.mtvuutiset.fi/artikkeli/sairauspoissaolot-kaantyivat-kunta-alalla-jyrkkaan-nousuun-syy-ei-yllata/8703496
Kunta-alan sairauspoissaolot kääntyivät jyrkkään kasvuun.
Vuonna 2022 kuntatyöntekijät olivat keskimäärin 20,7 päivää poissa töistä oman sairauden takia. Kaikkien ammattiryhmien sairauspoissaolot ovat lisääntyneet. Todennäköinen syy on koronaviruksen aiheuttamat poissaolot. Työterveyslaitos. 22.5.2023. https://www.sttinfo.fi/tiedote/kunta-alan-sairauspoissaolot-kaantyivat-jyrkkaan-kasvuun?publisherId=69819005&releaseId=69979473
May 21-31
Urgent action needed to tackle stalled progress on health-related Sustainable Development Goals. WHO. 19.5.2023. https://www.who.int/news/item/19-05-2023-urgent-action-needed-to-tackle-stalled-progress-on-health-related-sustainable-development-goals
Wuhan lab experienced a ‘serious biocontainment’ incident in 2019 and first COVID death in China was two months EARLIER than first thought: New Senate report shares more evidence on leak theory and Beijing’s cover-up. ‘Reports from the WIV spanning more than a three-year period yielded a picture of a struggling institution: underfunded, underregulated, and understaffed’
The report admits that it does not contain any one ”smoking gun’ – which matters most when assessing the origin question’ Mail Online. 18.5.2023. https://www.dailymail.co.uk/news/article-12094249/MORE-evidence-Wuhan-leak-revealed-Senate-report.html
New study shows masks and air cleaners were associated with stopping COVID-19 in two Swiss schools (“Although our study has several limitations, including the observational nature of our study and that detecting SARS-CoV-2 in the air or aerosols does not necessarily mean transmission, we found that mask mandates reduced transmission in classrooms, and both masks and air cleaners reduced aerosol concentrations.”). MedivalXpress. 18.5.2023. https://medicalxpress.com/news/2023-05-masks-air-cleaners-covid-swiss.html
SARS-CoV-2 transmission with and without mask wearing or air cleaners in schools in Switzerland: A modeling study of epidemiological, environmental, and molecular data (Molecular detection of airborne and human SARS-CoV-2 indicated sustained transmission in schools. Mask mandates were associated with greater reductions in aerosol concentrations than air cleaners and with lower transmission. ) . PLOS Medicine. 18.5.2023. https://journals.plos.org/plosmedicine/article?id=10.1371%2Fjournal.pmed.1004226
Pivotal points in the COVID-19 pandemic – 5 essential reads (1. A whole new vocabulary, 2. Comparisons to the 1918 flu ran rife, 3. How and when pandemics end, 4. The midway point, 5. How omicron altered the course of the pandemic). The Conversation. 17.5.2023. https://theconversation.com/pivotal-points-in-the-covid-19-pandemic-5-essential-reads-205722
Why is COVID life-threatening for some people? Genetics study offers clues. Immune genes could play a part in the risk of needing intensive care when infected with SARS-CoV-2. () nature news. 17.5.2023. https://www.nature.com/articles/d41586-023-01655-0
Heart Transplants From Active COVID Donors Linked With Higher Mortality.
— Outcomes from donors with recently resolved COVID similar to those without SARS-CoV-2, however. Medpage Today 17.5.2023. https://www.medpagetoday.com/cardiology/hearttransplantation/104555
Record numbers not working due to ill health. (More than two and a half million are not working due to health problems, the Office for National Statistics said. … Since the start of the Covid pandemic, there were “well over 400,000 more people outside of the labour market due to ill health,” Darren Morgan, director of economic statistics at the ONS, told the BBC’s Today Programme.) BBC News. 16.5.2023. https://www.bbc.com/news/business-65596283
Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in non-human primates. Science Immunology 16.5.2023. https://www.science.org/doi/10.1126/sciimmunol.adg7015
VUMC researchers study long term neurological impacts of COVID. NewsChannel5. 15.5.2023. https://www.newschannel5.com/news/vumc-researchers-study-long-term-neurological-impacts-of-covid
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy. nature communications.15.5.2023. https://www.nature.com/articles/s41467-023-36120-z
Post–COVID Conditions Among Adult COVID-19 Survivors Aged 18–64 and ≥65 Years — United States, March 2020–November 2021. MMWR Morb Mortal Wkly Rep 2022;71:713–717. 14.5.2023. DOI: http://dx.doi.org/10.15585/mmwr.mm7121e1
Are repeat COVID infections dangerous? What the science says. Researchers disagree over how bad it is to be reinfected, and whether COVID-19 can cause lasting changes to the immune system. nature. 11.5.2023. https://www.nature.com/articles/d41586-023-01371-9
Parents Don’t Understand How Far Behind Their Kids Are in School. New York Times. 11.5.2023. https://www.nytimes.com/interactive/2023/05/11/opinion/pandemic-learning-losses-steep-but-not-permanent.html
Covid-19 Patients Flung Out Hospital Windows As Public Emergency Ends. the ONION. 11.3.2023. https://www.theonion.com/covid-19-patients-flung-out-hospital-windows-as-public-1850419502
As Emergency Ends, a Look at Covid’s U.S. Death Toll. NYTimes. 11.5.2023. https://www.nytimes.com/interactive/2023/05/11/us/covid-deaths-us.html
May 11-20
Diabetes symptoms as deaths caused by the disease triple across the UK
Deaths related to diabetes have increased throughout the UK as check up appointments have been missed or delayed amid a crippling NHS backlog. Daily Record. 10.5,2023. https://www.dailyrecord.co.uk/lifestyle/diabetes-symptoms-deaths-caused-disease-29944903
Novavax Announces Positive Flu/COVID-19 Vaccine Data. The combination shot showed a ‘robust’ immune response in the company’s phase two trial. USNews. 9.5.2023. https://www.usnews.com/news/health-news/articles/2023-05-09/novavax-announces-positive-flu-covid-19-vaccine-data
Long-term symptoms after SARS-CoV-2 infection in a cohort of hospital employees: duration and predictive factor (About half of the HEs suffered from long lasting symptoms over 90 days after almost entirely mild acute COVID-19.). BMC Infectious Diseases. 8.5.2023. https://www.researchsquare.com/article/rs-2812977/v1
The plasma metabolome of long COVID-19 patients two years after infection. Scientific Reports. 05.03.2023. https://www.medrxiv.org/content/10.1101/2023.05.03.23289456v1
COVID’s future: mini-waves rather than seasonal surges. Three years after the start of the pandemic, SARS-CoV-2 shows no signs of settling into a seasonal pattern of spread, like influenza has. nature news. 4.5.2023. https://www.nature.com/articles/d41586-023-01437-8
Lack of association between vaccination rates and excess mortality in Cyprus during the COVID-19 pandemic (No relationship was found between vaccination rates and all-cause mortality, demonstrating the excellent safety profile of COVID-19 vaccines.). Vaccine. 2.5.2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066729/
Intrinsic factors behind long-COVID: I. Prevalence of the extracellular vesicles (Is long-COVID caused by the continued presence of the virus or one/several of its components in the recovering individual body for long periods of time, which urges the body to respond in a way that leads to long-COVID development? Or are there some latent and limited reasons related to the recovering patients themselves? Or is it a sum of both?). J Cell Biochem. 1.5.2023. https://pubmed.ncbi.nlm.nih.gov/37126363/
Study of Novavax COVID vaccine estimates 100% efficacy against hospitalizations (A post hoc analysis of a phase 3 randomized, controlled trial estimates that two doses of the Novavax (NVX-CoV2373) COVID-19 vaccine were 100% effective against hospitalization by 95 days during a period dominated by the SARS-CoV-2 Alpha variant.) CIDRAP. 1.5.2023. https://www.cidrap.umn.edu/covid-19/study-novavax-covid-vaccine-estimates-100-efficacy-against-hospitalizations
May 1-10
Mild Covid can lead to long-term impact on cardiovascular health, study claims. Scientists compared pre- and post-Covid infection levels of arterial stiffness, which can indicate cardiovascular health. Independenty Premium. 28.4.2023. https://www.independent.co.uk/independentpremium/uk-news/scientists-university-of-portsmouth-b2327081.html
Female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders: a literature review (LC may be associated with disruptions to the menstrual cycle, gonadal function, ovarian insufficiency, premature menopause, and fertility problems. RH conditions connected to associated illnesses (e.g., ME/CFS, POTS, EDS) include dysmenorrhea, amenorrhea, oligomenorrhea, dyspareunia, endometriosis, infertility, vulvodynia, intermenstrual bleeding, ovarian cysts, uterine fibroids and bleeding, pelvic congestion syndrome, and adverse pregnancy complications, such as maternal mortality, preeclampsia, and premature birth.). Frontiers Rehab Sci. 28.4.2023. https://www.frontiersin.org/articles/10.3389/fresc.2023.1122673/full
Characterising subgroups of people with severe COVID anxiety by latent profile analysis (People living with severe COVID anxiety are a heterogenous group. This analysis adds to evidence that certain health behaviours and demographic factors are inextricably linked to poor mental health in people with COVID anxiety, and that targeting health behaviours with specific intervention might be beneficial.). medRxiv. 28.4.2023. https://www.medrxiv.org/content/10.1101/2023.04.28.23289248v1
Novavax COVID-19 vaccine 80% effective among US teens (The vaccine effectiveness (VE) of the Novavax COVID-19 vaccine was 79.5% among US adolescents before the SARS-CoV-2 Omicron variant emerged, but the monoclonal antibody combo tixagevimab and cilgavimab showed little benefit for nonhospitalized COVID patients, according to two randomized, controlled trials published today in JAMA Network Open.) CIDRAP 26.4.2023. https://www.cidrap.umn.edu/covid-19/novavax-covid-19-vaccine-80-effective-among-us-teens
Doctors are more extroverted and neurotic than their patients, researchers find. BMJ. 24.4.2023. https://www.bmj.com/content/381/bmj.p927
Why long COVID could be a ticking time bomb for public health. Long COVID isn’t novel: other viruses in history have had similar “long” arcs — with devastating repercussions. Salon. 24.4.2023. https://www.salon.com/2023/04/24/long-parkinsons/
Explanation proposed for long-COVID symptoms in the CNS. Neurology Reviews. 24.4.2023. https://www.mdedge.com/neurology/article/262566/long-covid/explanation-proposed-long-covid-symptoms-cns?icd=login_success_email_match_norm
Foibekartanossa on maskipakko – Näin sitä perustellaan vuosi yleisen maskisuosituksen poistumisen jälkeen. (ikäihmisten asuinkeskus Foibekartano pitää kiinni maskipakosta, vaikka yleinen maskisuositus poistui jo vuosi sitten huhtikuussa.) Iltalehti. 23.4.2023. https://www.iltalehti.fi/kotimaa/a/78d2efd4-83f4-45e3-9c1c-c629b3195202
Kuolleisuus kasvoi historiallisesti Suomessa vuonna 2022, kuolleiden määrä korkein sitten sotavuosien. Turun Sanomat. 22.4.2023. https://www.ts.fi/uutiset/5972790
Flera covidpatienter blir inte friska – oron (Överläkare i Stockholm märker att vissa postcovidpatienter inte tillfrisknar – trots att det gått flera år. Det rapporterar Sveriges radio. Efter tre år hade man hoppats att många fler skulle vara långt mer återställda, säger överläkare Christer Lidman.). Expressen. 22.4.22023. https://www.expressen.se/nyheter/flera-covidpatienter–blir-inte-friska-oron-/
Elinajanodotteiden lasku oli vuonna 2022 suurinta 50 vuoteen. Syntyvyys oli mittaushistorian matalin. ilta=sanomat. 21.4.2023. https://www.is.fi/kotimaa/art-2000009533904.html
April 21-30
Covid-Welle in China: Daten deuten auf gewaltige Übersterblichkeit hin. Hochrechnungen gehen von bis zu 2,4 Millionen Covid-Toten in China aus. Was die Daten aber auch zeigen: Die chinesische Impfung schützt wohl besser als erwartet. Felix Straumann. 20.4.2023. https://www.bazonline.ch/daten-deuten-auf-gewaltige-uebersterblichkeit-hin-131669464296
Widespread household transmission of SARS-CoV-2 B.1.1.529 (Omicron) variant from Children, South Korea, 2022. Yonsei Med J. 20.4.2023. https://eymj.org/DOIx.php?id=10.3349/ymj.2022.0608
Persistence of immune responses after heterologous and homologous third COVID-19 vaccine dose schedules in the UK: eight-month analyses of the COV-BOOST trial. (Heterologous third doses with viral vector vaccines [e.g., Novavax] following two doses of mRNA achieve more durable humoral responses compared with three doses of mRNA vaccines. Lower doses of mRNA vaccines could be considered for future booster campaigns.) J Infect. 19.4.2023. https://www.journalofinfection.com/article/S0163-4453(23)00247-5/fulltext
Long COVID Is Being Erased—Again. What was once outright denial has morphed into a subtler dismissal. (). The Atlantic. 19.4.2023. https://www.theatlantic.com/health/archive/2023/04/long-covid-symptoms-invisible-disability-chronic-illness/673773/
Increased sick leave over a long period after covid-19 infection. A survey from Statens Serum Institut showed that people who were infected with SARS-CoV-2 early on during the pandemic took substantially more sick leave over a long period of time compared to those who were not infected. Statens Serum Institut. 19.4.2023. https://en.ssi.dk/news/news/2023/increased-sick-leave-over-a-long-period-after-covid-19-infection
Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine. Oxford Academic (The estimated vaccine effectiveness was 29% (95% confidence interval, 21%–37%), 20% (6%–31%), and 4% (−12% to 18%), during the BA.4/5-, BQ-, and XBB-dominant phases, respectively). 19.4.2023. https://academic.oup.com/ofid/article/10/6/ofad209/7131292
Ajantasaista tietoa aiheina Long COVID, ME/CFS ja niiden liitännäissairaudetKatsaus kliinisiin Long Covid -tutkimuksiin OSA 1. Toipuminen tauolla. 19.4.2023. https://melc.fi/2023/04/19/katsaus-kliinisiin-long-covid-tutkimuksiin-osa1/
Cognitive impairment in young adults with post COVID-19 syndrome (Patients’ processing speed, attention, executive functions and various language modalities were examined online using a comprehensive task protocol designed for this research. Alteration in some of the tasks was observed in 85% of the participants, being the attention and executive functions tests the ones that show the highest percentage of patients with severe impairment. Positive correlations were observed between the age of the participants in almost all the tasks assessed, implying better performance and milder impairment with increasing age. In the comparisons of patients according to age, the oldest patients were found to maintain their cognitive functions relatively preserved, with only a mild impairment in attention and speed processing, while the youngest showed the most marked and heterogeneous cognitive impairment.). Scientific Reports. 19.4.2023. https://www.nature.com/articles/s41598-023-32939-0
Memory loss in patients with long COVID can be due to reduced hippocampal neurogenesis (Therefore, the reduced neurogenesis, which was shown in the COVID-19 group, could be due to microglial activation and the subsequent production of inflammatory cytokines, such as TNF-α, IL-6, and IL-1β, causing neuroinflammation and the resultant impaired neurogenesis. This eventually results in cognitive decline due to the destruction of spatial memory and learning. These implications on the hippocampus, especially the loss of hippocampal neurogenesis in the brains of COVID-19 patients, elucidate learning, memory, and executive impairments in COVID-19 patients compared with uninfected healthy controls). European Archives of Psychiatry and Clinical Neuroscience. 18.4.2023. https://link.springer.com/article/10.1007/s00406-023-01610-0
Completeness and Spin of medRxiv Preprint and Associated Published Abstracts of COVID-19 Randomized Clinical Trials (Preprints are increasingly important in medical research communication. In rapidly evolving areas such as COVID-19, preprints, which by definition have not been peer reviewed, can influence practice and potentially cause harm. We examined publication timelines, completeness, and spin in the abstracts of all randomized clinical trials (RCTs) related to COVID-19 posted to medRxiv during the first 2 years of the pandemic and compared the latter 2 with their published counterparts.). JAMA. 18.4.2023.
Long COVID is hurting business (“I would like the government to do anything more than the bare minimum that they’re doing right now and I think ‘bare minimum’ is generous. I think we are witnessing the complete abandonment of the disability community at an alarming and inexcusable rate from all levels of government and elected leadership.”). New Orleans City Business. 17.4.2023. https://neworleanscitybusiness.com/blog/2023/04/17/long-covid-is-hurting-business/
Saliva and Plasma Antibody Levels in Children and Adolescents After Primary Infection With Omicron Variants of SARS-CoV-2 Infection in Germany (). JAMA Pediatrics. 17.4.2023. https://jamanetwork.com/journals/jamapediatrics/fullarticle/2804012
Suomalaiset ovat luopuneet koronavarotoimista – kasvomaskeja ei käytä enää juuri kukaan.
Tuoreen kansalaiskyselyn mukaan suomalaiset ovat jo lähes kokonaan hylänneet maskit ja turvavälit. THL on viimeksi maaliskuussa päivittänyt ohjeitaan siitä, miten koronainfektioon pitää suhtautua. YLE- uutiset. 17.4.2023. https://yle.fi/a/74-20025560
Effectiveness of Molnupiravir and Nirmatrelvir–Ritonavir in Hospitalized Patients With COVID-19. A Target Trial Emulation Study. Annals of Internal Medicine. April 2023. https://www.acpjournals.org/doi/10.7326/M22-3057
Epidemiological Analysis of Nitric Oxide Nasal Spray (VirX) Use in Students Exposed to COVID-19 Infected Individuals (Of the 203 students who used VirX™, 190 tested negative for
SARS-CoV-2 on all test days, and 13 tested positive on at least one test day. Of the 422 students who did not use VirX™, 314 students tested negative on all test days and 108 tested positive on at least one test day. These results demonstrated a statistically significant difference at the p<0.0001 level in infection rate of 6.40% (13/203) in the VirX™ group versus 25.59% (108/422) in the group that did not use VirX™.). Respiratory Therapy (pp 40-42). Spring 2023. https://www.respiratorytherapy.ca/pdf/RT-18-2-Spring-2023-R17-web.pdf
SARS-CoV-2 Reinfection and Severity of the Disease: A Systematic Review and Meta-Analysis. MDPI. 14.4.2023. https://www.mdpi.com/1999-4915/15/4/967
SARS-CoV-2 and type 1 diabetes in children in Finland: an observational study (The children diagnosed during the COVID-19 pandemic had more often diabetic ketoacidosis (p<0·001), had a higher HbA1c (p<0·001), and tested more frequently positive for glutamic acid debarboxylase antibodies at diagnosis (p<0·001) than those diagnosed before the pandemic. There were no significant differences in the distribution of HLA genotypes between the two periods. Only five of those diagnosed during the pandemic (0·9%) of 583 tested positive for infection-induced SARS-CoV-2 antibodies.). Lancet Diabetes & Endochrinology. April 2023. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(23)00041-4/fulltext
Suomalaiset ovat luopuneet koronavarotoimista – kasvomaskeja ei käytä enää juuri kukaan. Tuoreen kansalaiskyselyn mukaan suomalaiset ovat jo lähes kokonaan hylänneet maskit ja turvavälit. THL on viimeksi maaliskuussa päivittänyt ohjeitaan siitä, miten koronainfektioon pitää suhtautua. YLE Uutiset 14.4.2023. https://yle.fi/a/74-20025560
High risk of autoimmune diseases after COVID-19 (Two studies that use large cohorts now highlight that SARS-CoV-2 infection is linked to a substantially increased risk of developing a diverse spectrum of new-onset autoimmune diseases.). Nature Reviews Rheumatology. 12.4.2023. https://www.nature.com/articles/s41584-023-00964-y
Editorial: Lack of Benefit of Renin-Angiotensin System Inhibitors in COVID-19 (Neither the ACTIV-4 trials nor REMAP-CAP lend any support to the hypothesis that SARS-CoV-2 infection results in harmful unopposed angiotensin II activity that might be mitigated by RAS inhibition. The totality of evidence shows that ACE inhibitors and ARBs should not be initiated as a treatment for COVID-19, especially in patients who are critically ill. Conversely, the evidence from the randomized withdrawal trials suggests that existing treatment with an RAS inhibitor does not need to be stopped in non–critically ill patients with COVID-19 if prescribed for an important indication (eg, heart failure).). JAMA. 11.4.2023. https://jamanetwork.com/journals/jama/fullarticle/2803540
SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase.Virology. 11.4.2023. https://journals.asm.org/doi/10.1128/jvi.00144-23
Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection (T cells are a critical component of the response to SARS-CoV-2, but their kinetics after infection and vaccination are insufficiently understood. Using “spheromer” peptide-MHC multimer reagents, we analyzed healthy subjects receiving two doses of the Pfizer/BioNTech BNT162b2 vaccine. Vaccination resulted in robust spike-specific T cell responses for the dominant CD4+ (HLA-DRB1∗15:01/S191) and CD8+ (HLA-A∗02/S691) T cell epitopes. Antigen-specific CD4+ and CD8+ T cell responses were asynchronous, with the peak CD4+ T cell responses occurring 1 week post the second vaccination (boost), whereas CD8+ T cells peaked 2 weeks later. These peripheral T cell responses were elevated compared with COVID-19 patients. We also found that previous SARS-CoV-2 infection resulted in decreased CD8+ T cell activation and expansion, suggesting that previous infection can influence the T cell response to vaccination.). Immunity. 11.4.2023. https://www.cell.com/immunity/fulltext/S1074-7613(23)00125-5
April 11-20
Switzerland Stops Recommending COVID-19 Vaccination (). The Epoch Times. 8.4.2023. https://www.theepochtimes.com/article/switzerland-stops-recommending-covid-19-vaccination-5180835
Risk of Death in Patients Hospitalized for COVID-19 vs Seasonal Influenza in Fall-Winter 2022-2023 (The death rate at 30 days was 5.97% for COVID-19 and 3.75% for influenza, with an excess death rate of 2.23% (95% CI, 1.32%-3.13%). Compared with hospitalization for influenza, hospitalization for COVID-19 was associated with a higher risk of death (hazard ratio, 1.61 [95% CI, 1.29-2.02]). The risk of death decreased with the number of COVID-19 vaccinations (P = .009 for interaction between unvaccinated and vaccinated; P < .001 for interaction between unvaccinated and boosted)). JAMA. 6.4.2023. https://jamanetwork.com/journals/jama/fullarticle/2803749
New study shows COVID-19 infections in 2 pregnant women caused brain damage in newborns. Contemporary Pediatrics. 6.4.2023. https://www.contemporarypediatrics.com/view/new-study-shows-covid-19-infections-in-2-pregnant-women-caused-brain-damage-in-newborns
Study sheds new light on the spread of COVID-19 in households (The research sheds new light on the spread of COVID-19 in households, where most transmission of SARS-CoV-2 occurs, and it is the first to link the presence of SARS-CoV-2 on people’s hands and frequently touched household surfaces to the risk of infection among contacts. The findings support the use of interventions at home when someone has an infection, in particular frequent handwashing, regular surface disinfection, and physical distancing as well as the use of masks to curb the spread of COVID-19.). News Medical. 6.4.2023. https://www.news-medical.net/news/20230406/Study-sheds-new-light-on-the-spread-of-COVID-19-in-households.aspx
Post-COVID less common after Omicron infection. (Because Omicron is more infectious than Delta, it caused more people to become ill overall. As a result, the total number of people with long-term symptoms after an Omicron infection may be higher, despite the milder course of illness.) RIVM. 6.4.2023. https://www.rivm.nl/en/news/post-covid-less-common-after-omicron-infection
Why the WHO took two years to say COVID is airborne. Early in the pandemic, the World Health Organization stated that SARS-CoV-2 was not transmitted through the air. That mistake and the prolonged process of correcting it sowed confusion and raises questions about what will happen in the next pandemic.nature. 6.4.2023. https://www.nature.com/articles/d41586-022-00925-7
WHO says COVID-19 health emergency is over as mortality rates reach all-time low. Medical News Today. 5.5.2023. https://www.medicalnewstoday.com/articles/who-declares-end-to-covid-health-emergency-downgrade-pandemic
COVID-origins data from Wuhan market published: what scientists think. First peer-reviewed analysis of the Chinese swabs confirms animal DNA was present in samples that tested positive for SARS-CoV-2. nature news. 5.4.2023. https://www.nature.com/articles/d41586-023-00998-y?
Breath analysis by ultra-sensitive broadband laser spectroscopy detects SARS-CoV-2 infection. J Breath Research 5.4.2023. https://iopscience.iop.org/article/10.1088/1752-7163/acc6e4
Physio-metabolic and clinical consequences of wearing face masks—Systematic review with meta-analysis and comprehensive evaluation. Frontiers in Public Health, 05 April 2023
Sec. Environmental health and Exposome. 5.4.2023. https://www.frontiersin.org/articles/10.3389/fpubh.2023.1125150/full
COVID-19 Infection Accelerates the Progression of Dementia (“Increasing epidemiological evidence of the association of COVID-19 and AD is the heightened risk of AD with COVID-19, and of increased COVID-19 in patients with AD points to shared pathogenesis. Dubey et al further clarify this connection in demonstrating COVID-19 fundamentally alters the course of dementia no matter the cause,” remarked George Perry, PhD, Editor-in-Chief, Journal of Alzheimer’s Disease). Neuroscience. 4.4.2023. https://neurosciencenews.com/covid-19-dementia-22938/
Wuhan market samples fail to shed further light on COVID origins. New analysis of genomic data from market swabs highlights their limitations. nature. 4.5.2023. https://www.nature.com/articles/d41586-023-01483-2
Disentangling the rhythms of human activity in the built environment for airborne transmission risk: An analysis of large-scale mobility data (We find the proportion of indoor to outdoor activity during a baseline year is seasonal, peaking in winter months. The measure displays a latitudinal gradient with stronger seasonality at northern latitudes and an additional summer peak in southern latitudes. We statistically fit this baseline indoor-outdoor activity measure to inform the incorporation of this complex empirical pattern into infectious disease dynamic models. However, we find that the disruption of the COVID-19 pandemic caused these patterns to shift significantly from baseline and the empirical patterns are necessary to predict spatiotemporal heterogeneity in disease dynamics.). eLife. 4.4.2023. https://elifesciences.org/articles/80466
Danish study finds sharp rise in extended sick leave after COVID infection (Danish researchers today reported a threefold increase in extended sick leave, defined as lasting longer than 30 days, in people who had recovered from COVID, compared to workers who weren’t infected.). CIDRAP /UoMinnesota. 3.4.2023. https://www.cidrap.umn.edu/covid-19/danish-study-finds-sharp-rise-extended-sick-leave-after-covid-infection
IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein. MDPI. 2.4.2023. https://www.mdpi.com/2076-393X/11/5/991
Miten Suomi voi voittaa koronan (Miksi tilannetta ei ole korjattu? hallitus, joka teki päätöksen purkaa suojatoimet ennenaikaisesti / oppositio, joka syytti hallitusta hidastelusta suojatoimien purkamisessa / johtavat terveysviranomaiset, jotka vakuuttivat, että suojatoimille ei ole enää tarvetta / useat median edustajat, jotka tietoisesti vähensivät tiedottamista koronasta ja alkoivat sen sijaan keskittyä ”koronapelon” hälventämiseen joko vähättelemällä tai vaikenemalla nopeasti kasvavista koronakuolemien määrästä ja sen aiheuttamista merkittävistä terveysriskeistä). Uusi Suomi. 1.4.2023. https://puheenvuoro.uusisuomi.fi/jln/miten-suomi-voi-voittaa-koronan/
April 1-10
Long COVID exercise trials proposed by NIH raise alarm. Advocates ask the US biomedical agency to rethink the design of its RECOVER initiative, citing possible harm and funding waste. nature news. 31.3.2023. https://www.nature.com/articles/d41586-023-00900-w
Increased neurovirulence of omicron BA.5 over BA.1 in human brain organoids and K18-hACE2 mice. Research Square. 31.3.2023. https://www.researchsquare.com/article/rs-2702556/v1
CARDIOVASCULAR COMPLICATIONS OF COVID-19. •Cardiovascular complications are a common manifestation of acute and post-acute COVID-19 infection.
•Complications include cardiomyopathy, myocardial infarction, arrhythmias, heart failure, and deep venous thrombosis.
•Pathophysiology remains poorly defined and complex.
•No single study has proven a distinct treatment for post COVID-19 associated cardiovascular disease; therefore, it is recommended to follow established guidelines for treating specific cardiovascular conditions.
•Cardiac rehabilitation program is advised for individuals who meet the established criteria for cardiac rehabilitation. Phys Med Rehabil Clin N Am. 31.3.2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063539/
Protect yourself and others. COVID-19 is in the community. To slow the spread and continue to protect yourself, your whānau, and your community, it is important to keep up the healthy habits we know. (Stay up to date with your vaccinations. Stay home if you are sick. Limit time in crowded places. Wear a face mask. Keep your distance from others when indoors. Improve ventilation. Cough or sneeze into your elbow. Keep your hands clean. Clean surfaces. Keep track of where you have been.) Unite against COVID-19. 31.3.2023. https://covid19.govt.nz/prepare-and-stay-safe/protect-yourself-and-others-from-covid-19/
Study identifies SARS-CoV-2 variants with antiviral resistance mutations (“We are optimistic that ongoing studies will develop additional compounds to avoid cross-resistance and help combat the current COVID-19 pandemic and future coronavirus outbreaks,”). CIDRAP / UoMinnesota. 30.3.2023. https://www.cidrap.umn.edu/antimicrobial-stewardship/study-identifies-sars-cov-2-variants-antiviral-resistance-mutations
Groundbreaking new nasal spray protects against all SARS-CoV-2 variants (TriSb92 was confirmed to offer effective protection against coronavirus infection by identifying a region in the spike protein of the coronavirus that is common to all current variants of the virus and inhibiting its functioning. The molecule is effective in preventing infection when administered nasally, even after a few hours of exposure, unlike face masks.). Brighter Side of News. 25.3.2023. https://www.thebrighterside.news/post/groundbreaking-new-nasal-spray-protects-against-all-sars-cov-2-variants
Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants (The potency and robust biochemical properties of TriSb92 together with its resistance against viral sequence evolution suggest that TriSb92 could be useful as a nasal spray for protecting susceptible individuals from SARS-CoV-2 infection.). nature communications. 24.3.2023. https://www.nature.com/articles/s41467-023-37290-6
Three years on, there is a new generation of lockdown sceptics – and they’re rewriting history. Guardian. 23.3.2023. https://www.theguardian.com/commentisfree/2023/mar/23/lockdown-sceptics-history-academics-left-covid?CMP=Share_iOSApp_Other
Covid-19 Surveillance Testing and Resident Outcomes in Nursing Homes (Greater surveillance testing of staff members at skilled nursing facilities was associated with clinically meaningful reductions in Covid-19 cases and deaths among residents, particularly before vaccine availability.). NEJM. 23.3.2023. https://www.nejm.org/doi/full/10.1056/NEJMoa2210063
SARS‐CoV‐2 infection during pregnancy linked to higher risk of neurodevelopmental disorders in male infants (“The neurodevelopmental risk associated with maternal SARS-CoV-2 infection was disproportionately high in male infants, consistent with the known increased vulnerability of males in the face of prenatal adverse exposures”). Medical Xpress. 23.3.2023. https://medicalxpress.com/news/2023-03-sarscov2-infection-pregnancy-linked-higher.html
Sex-Specific Neurodevelopmental Outcomes Among Offspring of Mothers With SARS-CoV-2 Infection During Pregnancy (Question: Is in utero exposure to maternal SARS-CoV-2 infection associated with greater rates of neurodevelopmental disorder diagnoses in male or female offspring, compared with controls with no such exposure? Findings This cohort study of 18 355 infants delivered after February 2020 found that male but not female offspring born to mothers with a positive SARS-CoV-2 polymerase chain reaction test result during pregnancy were more likely to receive a neurodevelopmental diagnosis in the first 12 months after delivery, even after accounting for preterm delivery.). JAMA. 23.3.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802745
Assessing COVID-19 pandemic policies and behaviours and their economic and educational trade-offs across US states from Jan 1, 2020, to July 31, 2022: an observational analysis (COVID-19 magnified the polarisation and persistent social, economic, and racial inequities that already existed across US society, but the next pandemic threat need not do the same. US states that mitigated those structural inequalities, deployed science-based interventions such as vaccination and targeted vaccine mandates, and promoted their adoption across society were able to match the best-performing nations in minimising COVID-19 death rates. These findings could contribute to the design and targeting of clinical and policy interventions to facilitate better health outcomes in future crises.). Lancet. 23.3.2023. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00461-0/fulltext?utm_campaign=trials23&utm_content=242521453&utm_medium=social&utm_source=twitter&hss_channel=tw-27013292&s=08
SARS-CoV-2 restructures host chromatin architecture (In conclusion, we provide much needed additional evidence for the presence of replicating SARS-CoV-2 virions in bioaerosols . Our results highlight the possibility to recover replicative virus particles in air samples after freezing at -80°C in VTM and storage for several months. Our results are important as they provide rationale for retrospective evaluation of the presence of infectious SARS-CoV-2 in samples collected during the different waves since 2020). nature microbiology. 23.3.2023. https://www.nature.com/articles/s41564-023-01344-8
Koronavirus ei todennäköisesti aiheuta tyypin 1 diabetesta. Tutkijat selvittivät asiaa, koska ilmaantuvuus kasvoi koronapandemian aikana (Tavallista useampi lapsi ja nuori sairastui tyypin 1 diabetekseen Suomessa ja maailmalla koronapandemian ensimmäisten 18 kuukauden aikana. Tuoreen Suomea koskevan tutkimuksen mukaan syynä ei kuitenkaan ollut koronavirus vaan muuttuneet ympäristötekijät (Knip M ym. Lancet Diabetes Endocrinol 22.3.2023). Asiaa selvitti Helsingin yliopiston PEDIA-tutkimusryhmä.). Lääkärilehti. 22.3.2023. https://www.laakarilehti.fi/tieteessa/koronavirus-ei-todennakoisesti-aiheuta-tyypin-1-diabetesta/?public=e2dae4ba7eaf4b7fab92890a8ef62048
Työikäisten aivoinfarktit lisääntyvät, ja yksi syy on liika istuminen – 37-vuotiaana sairastunut Krista Leppänen ei toipunut ennalleen. Alle 50-vuotiaiden aivoverenkierron häiriöt ovat lisääntyneet. Valtaosa kuntoutuu fyysisistä haitoista hyvin, mutta kognitiivisia vaikeuksia jää edelleen monelle. Alle puolet palaa töihin. YLE-Uutiset. 22.3.2023. https://yle.fi/a/74-20022554
Detection of viable SARS-CoV-2 in retrospective analysis of aerosol samples collected from hospital rooms of patients with COVID-19 (). CMI Clinical Microbiology and Infection. 22.3.2023. https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00135-0/fulltext
Diabetes Risk After COVID-19 Infection Still a Concern (…the rates of new-onset diabetes, hypertension, hyperlipidemia, and benchmark diagnoses were higher in the 90 days after versus before a COVID-19 infection. Post-infection, the highest odds were seen for diabetes, hypertension, benchmark diagnoses, and hyperlipidemia.). Forum Extended Care Services. 21.3.2023. https://www.forumpharmacy.com/education-resources/diabetes-risk-after-covid-19-infection-still-a-concern/
Researchers say newly posted analysis supports natural origin for Covid-19 pandemic (Swabs collected from stalls and equipment at the Huanan Market in Wuhan, China, that tested positive for traces of the virus that causes Covid-19 also, in some cases, contained traces of DNA from animals known to be susceptible to infection, according to a new analysis by an international team of researchers.). CNN Health. 21.3.2023. https://edition.cnn.com/2023/03/21/health/coronavirus-origin-market-animals-preprint/index.html
HUSin Long Covid -symposiumissa mielipiteet ohittivat tieteen (Symposiumissa ei esitetty Long Covidin hoitoon lainkaan sellaisia hoitomenetelmiä, jotka pohjautuvat kattavaan tutkimustietoon Long Covidin biologisista mekanismeista. Pääviestinä oli, että potilaita tulee ohjata ajattelemaan, että heidän oireensa johtuvat heidän omista haitallisista ajatus- ja käyttäytymismalleistaan. Näitä malleja muokkaamalla potilaat voivat luennoitsijoiden mukaan (A. Nathia lukuunottamatta) parantua täysin. Hoitoa käsittelevissä luennoissa luennoitsijoiden henkilökohtaiset mielipiteet ja asenteet ohittivat täysin tieteellisen konsensuksen ja aiheesta tehdyt tuhannet tutkimukset ja hoitosuositukset. ). Toipuminen tauolla. 21.3.2023. https://melc.fi/2023/03/21/husin-long-covid-symposiumissa-mielipiteet-ohittivat-tieteen/
SARS-CoV-2 infection induces dopaminergic neuronal loss in midbrain organoids during short and prolonged cultures. BioRxiv.21.3.2023. https://www.biorxiv.org/content/10.1101/2023.03.20.533485v1
March 21-31
Fast-tracking progress to End TB: high-level opportunities for investment and action (). Lancet. 20.3.2023. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00460-9/fulltext
SARS-CoV-2 infection weakens immune-cell response to vaccination. NIH-funded study suggests need to boost CD8+ T cell response after infection (The magnitude and quality of a key immune cell’s response to vaccination with two doses of the Pfizer-BioNTech COVID-19 vaccine were considerably lower in people with prior SARS-CoV-2 infection compared to people without prior infection, a study has found. In addition, the level of this key immune cell that targets the SARS-CoV-2 spike protein was substantially lower in unvaccinated people with COVID-19 than in vaccinated people who had never been infected. ). NIH News Releases. 20.3.2023. https://www.nih.gov/news-events/news-releases/sars-cov-2-infection-weakens-immune-cell-response-vaccination
SARS-CoV-2 variant-related abnormalities detected by prenatal MRI: a prospective case–control study (…the first study showing reduced fetal lung volume in otherwise healthy pregnant women with SARS-CoV-2 infection. This reduction was dependent on the timepoint of infection, indicating that the most significant results occurred in the third trimester, thereby overlapping with the saccular stage of lung development dedicated to the expansion of (future) air spaces). Lancet. 20.3.2023. https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(23)00005-4/fulltext#secsectitle0065
W.H.O. Accuses China of Hiding Data That May Link Covid’s Origins to Animals
Genetic research from China suggests to some experts that the coronavirus may have sprung from a seafood market in Wuhan. Now the data are missing from a scientific database. NYTimes. 17.3.2023. https://www.nytimes.com/2023/03/17/health/covid-origins-who.html?smid=nytcore-ios-share&referringSource=articleShare
COVID-19-tautiin liittyvien kuolemien tilastointi. THL. 17.3.2023. https://thl.fi/fi/web/infektiotaudit-ja-rokotukset/ajankohtaista/ajankohtaista-koronaviruksesta-covid-19/tilannekatsaus-koronaviruksesta/covid-19-tautiin-liittyvien-kuolemien-tilastointi
Addressing the Long-term Effects of the COVID-19 Pandemic on Children and Families.
A Report From the National Academies of Sciences, Engineering, and Medicine (“My mom lost her business…we were trying to maintain everything but the bills just kept piling up. Food prices went up, rent, everything went up.…We didn’t know if we were gonna get food the next day, if we were even going to have our place.…It got to the point where I wasn’t able to sleep properly anymore or eat properly anymore, and I did gain a lot of anxiety and depression.” / This is just one of many stories from children and youth who experienced the worst pandemic in US history. Although the COVID-19 Public Health Emergency is set to end on May 11, 2023, it is clear it has, and will continue to have, deleterious effects on the children and youth who experienced the pandemic during sensitive periods of their development.). JAMA Viewpoint. 16.3.2023. https://jamanetwork.com/journals/jama/article-abstract/2802732
Effects of SARS-CoV-2 on prenatal lung growth assessed by fetal MRI (). Lancet Respiratory Medicine. 16.3.2023. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00060-1/fulltext
Researchers Are Getting Closer to Learning How to Treat and Prevent Long COVID (The latest hopeful news relates to metformin, an accessible and affordable drug that’s been U.S. Food and Drug Administration (FDA)-approved to treat Type 2 diabetes since the 1990s. Metformin, which belongs to a class of drugs called biguanides, is taken as a liquid or pill and works by controlling the amount of sugar in the blood. It also decreases inflammation in the body.). TIME- 16.3.2023. https://time.com/6263356/long-covid-treatment-prevention/
New T Cell Antibody Treatment Improves Outcomes For Covid Patients (). Forbes. 16.3.2023. https://www.forbes.com/sites/williamhaseltine/2023/03/16/new-t-cell-antibody-treatment-improves-outcomes-for-covid-patients/?sh=27d9d696670f
Mortality and life expectancy statistics. EUROSTAT. March 2023. https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Mortality_and_life_expectancy_statistics
“Erittäin haitallinen potilaille”: Husin long covid -linja mitätöi potilaita, kriitikot sanovat – Yhdestä asiasta on yksimielisyys (Hus järjestää tällä viikolla pitkittyneestä koronasta, long covidista, koulutustilaisuuden, jonka näkökulma on saanut ristiriitaisen vastaanoton. Näkökulma on biopsykososiaalinen. Sen mukaan sairaudella on biologinen perusta, mutta oireita ylläpitävät psykososiaaliset mekanismit. Esimerkiksi Suomen long covid -asiantuntijaryhmän puheenjohtaja, neurologian professori Risto O. Roine pitää valittua näkökulmaa erikoisena. Hänen mukaansa symposiumin puhujien ajatussuunnassa lähdetään siitä, että long covid -potilaiden oireita ylläpitää kielteinen ajattelu. Tälle näkökulmalle ei hänen mukaansa ole tieteellistä pohjaa.
– Tällainen lähestymistapa on potilaita syyllistävä. Sosiaalisessa mediassa symposiumin puhujalistaa ovat arvostelleet myös potilaat.). Helsingin Uutiset. 15.3.2023. https://www.helsinginuutiset.fi/paikalliset/5790973
Insändare. ”Sveriges coronahantering är en skamfläck i vår historia” (Den tidigare statsepidemiologen på Folkhälsomyndigheten Anders Tegnell efter en presskonferens den 4 mars 2020. Siffror på överdödligheten kan inte dölja att den svenska pandemihanteringen var ett stort misslyckande, anser insändarskribenten.). Dagens Nyheter. 15.3.2023. https://www.dn.se/insandare/sveriges-coronahantering-ar-en-skamflack-i-var-historia/
Efectos económicos de un posible deterioro duradero en la salud general de la población española (El último barómetro sanitario del Centro de Investigaciones Sociológicas (CIS) pone de manifiesto
que, en los últimos trimestres, se ha producido un aumento sustancial en la demanda de servicios
sanitarios en España. Así, por ejemplo, entre el promedio de 2018-2019 y noviembre de 2022, el
porcentaje de la población que había acudido al médico de cabecera, al especialista o a urgencias
en los doce últimos meses aumentó en 12,1 puntos porcentuales (pp), 21,5 pp y 14,8 pp,
respectivamente (véase cuadro 1). Estos incrementos han sido especialmente acusados entre los
grupos de población más joven.). Bancode España. 15.3.2023. https://www.bde.es/f/webbde/SES/Secciones/Publicaciones/InformesBoletinesRevistas/BoletinEconomico/23/T1/Fich/be2301-art20.pdf
Dopamine Transmission Imbalance in Neuroinflammation: Perspectives on Long-Term COVID-19. MDPI. 15.3.2023. https://www.mdpi.com/1422-0067/24/6/5618
Silent Silenced Doctors (Jonathan Howard). The healthcare workers who died from COVID have been silenced (). Science-Based Medicine. 14.3.2023. https://sciencebasedmedicine.org/silenced-doctors/
FDA authorizes Pfizer’s Covid omicron booster as fourth shot for kids under 5. CNBC. 14.3.2023. https://www.cnbc.com/2023/03/14/fda-authorizes-pfizers-covid-omicron-booster-as-fourth-shot-for-kids-under-5.html
Rekord-Krankenstand belastet die deutsche Wirtschaft (Grippe, Corona, Bronchitis: Der höchste Krankenstand seit der Wiedervereinigung durch Atemwegs- und Erkältungskrankheiten kommt die deutsche Wirtschaft einer Studie zufolge teuer zu stehen. Er dürfte im vergangenen Jahr rund 27 bis 42 Milliarden Euro gekostet haben, wie aus einer am Dienstag veröffentlichten Untersuchung des Kieler Instituts für Volkswirtschaft (IfW) hervorgeht. Das Bruttoinlandsprodukt (BIP) hätte damit statt um 1,8 Prozent zwischen 2,5 und 2,9 Prozent zulegen können. Demnach stieg der Krankenstand von gut 68 Stunden je Arbeitnehmer im Jahr 2021 sprunghaft auf gut 91 Stunden. “Seit der Wiedervereinigung ist dies der mit Abstand stärkste Anstieg des Krankenstands binnen eines Jahres und auch das höchste Krankheitsniveau”, hieß es dazu. Ursache waren in erster Linie Atemwegsinfekte und Erkältungskrankheiten.). Deutsche Wirtschaftsnachrichten. 14.3.2023. https://deutsche-wirtschafts-nachrichten.de/702659/Rekord-Krankenstand-belastet-die-deutsche-Wirtschaft
Number of Britons off work due to long-term sickness hits record high – figures (The number of Britons off work due to long-term sickness has reached record levels the latest official figures show, ramping up pressure on the Chancellor ahead of his “back-to-work Budget” on Wednesday. Data from the Office for National Statistics (ONS) revealed that there were 2.52 million people off work due to long-term sickness in the three months to January – up 2.6% quarter-on-quarter and 7.9% year-on-year and the highest since record began in 1993.). Evening Standard. 14.3.2023. https://www.standard.co.uk/business/business-news/number-of-britons-off-work-due-to-longterm-sickness-hits-record-high-figures-b1067158.html
Researchers model possible COVID-19 trajectories for 2023 (Notably, increasing mask usage was associated with substantial reductions in infections and mortality rates, whereas [social distancing] mandate reimposition mildly/moderately reduced future COVID-19 burden. Combining these two interventions led to an even more significant impact than individually. Above all, the analysis showed that simple interventions, including masking and social distancing mandates, could be critical tools against COVID-19.). News Medical. 14.3.2023. https://www.news-medical.net/news/20230314/Researchers-model-possible-COVID-19-trajectories-for-2023.aspx
More than 14,000 people in England and Wales died with Covid after catching the viru s in hospital (According to official NHS data in England and Wales, 14,047 Brits died in hospital after they caught the virus following admission, whilst at least 69,337 people caught the virus only after having been admitted.). Mirror. 13.3.2023. https://www.mirror.co.uk/news/uk-news/we-need-better-over-14000-28046576
Health system characteristics and COVID-19 performance in high-income countries (We find that the COVID-19 excess mortality and case fatality rates [in 43 OECD and selected non-member coutries] were systematically associated with healthcare system financing and organizational structures, as well as performance regarding other health outcomes besides COVID-19 health outcomes. NOTE! This is a study by Finnish authors. According to its results Finland fared among the very best. The data, however, ends in September 2021, 18 months before publication. In the beginning of those 18 months Finland quit all COVID restriction and most recommendations, restricted vaccinations, and, consequently both COVID and excess mortality in Finland raised to the 3 highest within the EU and within the OECD coutries. 89% of all COVID deaths in Finland have occurred since September 2021 when the data collection for this stúdy ended!). BMC Health Services Research. 13.3.2023. https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-023-09206-z
Statement on ‘Physical interventions to interrupt or reduce the spread of respiratory viruses’ review (Many commentators have claimed that a recently-updated Cochrane Review shows that ‘masks don’t work’, which is an inaccurate and misleading interpretation. / It would be accurate to say that the review examined whether interventions to promote mask wearing help to slow the spread of respiratory viruses, and that the results were inconclusive. Given the limitations in the primary evidence, the review is not able to address the question of whether mask-wearing itself reduces people’s risk of contracting or spreading respiratory viruses. / The review authors are clear on the limitations in the abstract: ‘The high risk of bias in the trials, variation in outcome measurement, and relatively low adherence with the interventions during the studies hampers drawing firm conclusions.’ Adherence in this context refers to the number of people who actually wore the provided masks when encouraged to do so as part of the intervention. For example, in the most heavily-weighted trial of interventions to promote community mask wearing, 42.3% of people in the intervention arm wore masks compared to 13.3% of those in the control arm. / The original Plain Language Summary for this review stated that ‘We are uncertain whether wearing masks or N95/P2 respirators helps to slow the spread of respiratory viruses based on the studies we assessed.’ This wording was open to misinterpretation, for which we apologize. While scientific evidence is never immune to misinterpretation, we take responsibility for not making the wording clearer from the outset. We are engaging with the review authors with the aim of updating the Plain Language Summary and abstract to make clear that the review looked at whether interventions to promote mask wearing help to slow the spread of respiratory viruses.). Cochrane. 11.3.2023. https://www.cochrane.org/news/statement-physical-interventions-interrupt-or-reduce-spread-respiratory-viruses-review
Long COVID: 3 years in (The acute months of the COVID-19 pandemic motivated an unprecedented response from governments, international organisations, pharmaceutical companies, and civil society. Long COVID has not received anywhere near the same level of attention or resources: the result has been widespread harm to health, societies, and economies. 3 years in, more is needed to recognise, treat, and support patients with long COVID.). Lancet. 11.3.2023.
If We Knew Then What We Know Now About Covid, What Would We Have Done Differently?
In March 2020, the virus held many mysteries. Some early assumptions didn’t hold up, while other key findings wouldn’t come until much later. If we could do it all over again… Wall Street Journal. 11.3.2023. https://www.wsj.com/articles/covid-lessons-learned-9dd5566f
March 11-20
The treatment of Long Covid and ME/CFS as FNDs in Finland and the HUS biopsychosocial Long Covid symposium have raised international criticism. Ajantasaista tietoa aiheina Long COVID, ME/CFS ja niiden liitännäissairaudet. Toipuminen tauolla. 10.3.2023. https://melc.fi/2023/03/10/me-and-long-covid-treatment-finland/comment-page-1/#comments
Opinions overtook science at HUS Long Covid symposium. Ajantasaista tietoa aiheina Long COVID, ME/CFS ja niiden liitännäissairaudet. Toipuminen tauolla. 10.3.2023. https://melc.fi/2023/03/23/opinions-overtook-science/
Here’s Why the Science Is Clear That Masks Work. NYTimes.10.3.2023. https://www.nytimes.com/2023/03/10/opinion/masks-work-cochrane-study.html
New report warns long COVID could be “mass disabling event”. It could have long-term impacts on Canada’s economy (…10-20% of people with COVID-19 develop long COVID or post-COVID condition (PCC), with symptoms including high blood pressure, an irregular heartbeat, chronic fatigue, brain fog, muscle pain, and blurred vision. “Some patients have not recovered two to three years after the initial infection and it is uncertain whether a proportion may ever fully recover,”). Insurance News. 10.3.2023. https://www.insurancebusinessmag.com/ca/news/breaking-news/new-report-warns-long-covid-could-be-mass-disabling-event-439109.aspx
Report says long COVID could impact economy and be ‘mass disabling event’ in Canada. A report released Thursday by Canada’s chief science adviser says she considers COVID-19 the “head” of the pandemic but long COVID its “tail” as the illness inflicts significant harm on individuals, their families and potentially the country’s economy. Toronto Star- 9.3.2023. https://www.thestar.com/life/health-wellness/report-says-long-covid-could-impact-economy-and-be-mass-disabling-event-in-canada/article_c31acd7e-1925-548d-b91e-dc75c4bf7c9f.html
Läkare: Vi kan inte bota postcovid, men vi kan lindra (Resultaten från postcovidmottagning på Karolinska universitessjukhuset i Huddinge är dystra. De flesta som drabbats av postcovid blir inte helt äterställda. Varje dag strömmar nya remisser in från både Stockholm och resten av landet. Vi har ingen bot, men vi kan lindra och mildra symptom, säger Chister Lidman, som är överläkare pä postcovidsmottagning). Dagens Nyheter. 8.3.2023. https://www.dn.se/insidan/lakare-vi-kan-inte-bota-postcovid-men-vi-kan-lindra/
New study finds COVID-19 didn’t have a big impact on the mental health of most people (). The Globe and Mail. 8.3.2023. https://www.theglobeandmail.com/canada/article-new-study-finds-covid-19-didnt-have-a-big-impact-on-the-mental-health/?utm_medium=Referrer:+Social+Network+/+Media&utm_campaign=Shared+Web+Article+Links
Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study (In this prospective, life-spanning, nationally representative cohort study, LRTI during early childhood was associated with almost a two times increased risk of premature adult death from respiratory disease, and accounted for one-fifth of these deaths.). Lancet. 7.3.2023. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00131-9/fulltext
Previous COVID infection linked to lower brain oxygen levels, cognitive problems: study (In a new Canadian study, researchers found that not only did participants who previously had COVID-19 perform worse on two specific cognitive tasks, but brain imaging showed that during these tasks, there was a lack of oxygen reaching the sections of the brain that would normally be fully engaged.). CTV News. 7.3.2023. https://www.ctvnews.ca/health/coronavirus/previous-covid-infection-linked-to-lower-brain-oxygen-levels-cognitive-problems-study-1.6302197
Estimating vaccine-preventable COVID-19 deaths under counterfactual vaccination scenarios in the United States (Nationally, we found that had 100% of the population became fully vaccinated during the period examined, 318,979 deaths, or approximately 50% of actual COVID-19 deaths, might have been prevented; had 85% been so, 28% might have been prevented. Across states, we found substantial variation in the proportion of avoidable COVID-19 deaths that might have been avoided at the state level, from 25% in Massachusetts to 74% in Alaska. Our findings are sobering when considering the painful deaths, the survivors’ anguish, and the diversion of scarce and expensive healthcare resources that might have been averted had peak vaccination administration efforts been maintained.). Research Square. 6.3.2023. https://www.researchsquare.com/article/rs-2618112/v1
Outpatient Treatment of COVID-19 and the Development of Long COVID Over 10 Months: A Multi-Center, Quadruple-Blind, Parallel Group Randomized Phase 3 Trial (A 42% relative decrease and 4.3% absolute decrease in the Long COVID incidence occurred in participants who received early outpatient COVID-19 treatment with metformin compared to exact-matching placebo. No effect with either ivermectin or fluvoxamine). Lancet. 6.3.2023. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4375620
YLIKUOLLEISUUS JA VAUVAKATO SUOMESSA VUONNA 2022. (Hyvä kvantitatiivinen analyysi, mutta johtopäätös rokotusten syyllisyydestä ei kestä aikasarja-analyysiä) Järjen Ääni ry. 5.3.2023. https://jarjenaani.fi/ylikuolleisuus-ja-vauvakato-suomessa-vuonna-2022/
The plasma metabolome of long COVID-19 patients two years after infection. Scientific Reports. 05.03.2023. https://www.medrxiv.org/content/10.1101/2023.05.03.23289456v1
Tens of thousands of elderly people have died without getting the care they need, charity says (Age UK cited NHS Digital figures for England which show there were 28,890 support requests for people aged 65 and over in 2021/22 where the person died without any of those services being provided. The charity said that equates to more than 500 deaths a week – more than 70 a day). Sky News. 4.3.2023. https://news.sky.com/story/tens-of-thousands-of-elderly-people-have-died-without-getting-the-care-they-need-charity-says-12825107
Cardiovascular Risks in Patients With Post–COVID-19 Condition (Entering year 4 of the COVID-19 pandemic, growing evidence calls for research, public health, and medical attention to PCC in addition to acute COVID-19 illness. DeVries and colleagues5 cast light on enduring cardiovascular risks with PCC, supporting enhanced monitoring of patients after SARS-CoV-2 infections to support early detection and intervention. More broadly, rigorous programs are needed to minimize future infections, which have consequences beyond acute COVID-19 illness, and to advance scientific and medical understanding of the pathophysiology of PCC, as well as its prevention and management.). JAMA Editorial. 3.3.2023. https://jamanetwork.com/journals/jama-health-forum/fullarticle/2802097?utm_source=twitter&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=030523#.ZATB2PfuhtQ.twitter
Covid-19: Leaked messages reveal casual policy making—and love for Whitty (The messages show that England’s chief medical officer, Chris Whitty, told Hancock on 14 April 2020 that there should be “testing of all [people] going into care homes” and “segregation whilst awaiting result.” This was a day before the government published its action plan on managing covid-19 in adult social care settings. Hancock initially said the advice “is obviously a good positive step and we must put it into the doc.” However, a message later that day to one of his special advisers said, “I do not think the community commitment adds anything and it muddies the waters.” Testing was made mandatory for people entering care homes from hospital but not for those coming from the community. Guidance stating that tests should be carried out for everyone entering care homes was not introduced until 14 August 2020. Hancock has previously claimed he put a “protective ring around care homes,” but between April and August thousands of people in care homes in England died from covid-19.). BMJ News. 3.3.2023. https://www.bmj.com/content/380/bmj.p522
Young People Are More Likely to Die of Heart Attacks Post-COVID, Study Finds. But Why? Cedars Sinai. 3.3.2023. https://www.cedars-sinai.org/newsroom/today-young-people-are-more-likely-to-die-of-heart-attacks-post-covid-study-finds-but-why/
Heart attacks and strokes late after Covid. The body of evidence expands (…based upon nearly 154,000 patients with Covid (median age 60, 90% male) from the US Department of Veteran Affairs with 2 control groups each with over 5 million people. Importantly, these were events after 30 days from infection. There was a 1.7-fold risk of heart attack and 1.6-fold increased risk of stroke, among the other adverse outcomes, as shown below, for people with Covid versus controls.). Cround Truths. 3.3.2023. https://erictopol.substack.com/p/heart-attacks-and-strokes-late-after
One-Year Adverse Outcomes Among US Adults With Post–COVID-19 Condition vs Those Without COVID-19 in a Large Commercial Insurance Database (In this cohort study of 13 435 US adults with post–COVID-19 condition (PCC) and 26 870 matched adults without COVID-19, the adults with PCC experienced increased risks for a number of cardiovascular outcomes, such as ischemic stroke. During the 12-month follow-up period, 2.8% of the individuals with PCC vs 1.2% of the individuals without COVID-19 died, implying an excess death rate of 16.4 per 1000 individuals – note, 12 mo IFR = 1,6%.). JAMA Health Forum. 3.3.2023. https://jamanetwork.com/journals/jama-health-forum/fullarticle/2802095
Bivalent booster effectiveness against severe COVID-19 outcomes in Finland, September 2022 – March 2023. (Among elderly aged 65–110 years, bivalent vaccination reduced the risk of hospitalisation and death due to COVID-19 in September–December 2022; the hazard ratios comparing exposed and unexposed ranged from 0.37 to 0.45 during the first 31–60 days since bivalent vaccination. However, in January–March 2023 the effect disappeared possibly indicating immune evasion of new SARS-CoV-2 variants, waning of vaccine effectiveness and increased presence of hybrid immunity. Among the chronically ill aged 18–64 years bivalent vaccination did not reduce the risk of severe COVID-19 outcomes) medRxiv. 2.3.2023. https://www.medrxiv.org/content/10.1101/2023.03.02.23286561v3
Brainstem volume changes in myalgic encephalomyelitis/chronic fatigue syndrome and long COVID patients (In ME/CFS, we detected positive correlations between the pons and whole brainstem volumes with “pain” and negative correlations between the midbrain and whole brainstem volumes with “breathing difficulty.” In long COVID patients a strong negative relationship was detected between midbrain volume and “breathing difficulty.” Our study demonstrated an abnormal brainstem volume in both ME/CFS and long COVID consistent with the overlapping symptoms.). Frontiers in Neuroscience. 2.3.2023.https://www.frontiersin.org/articles/10.3389/fnins.2023.1125208/full
Long COVID Now Looks like a Neurological Disease, Helping Doctors to Focus Treatments
The causes of long COVID, which disables millions, may come together in the brain and nervous system. Scientific American. 1.3.2023. https://www.scientificamerican.com/article/long-covid-now-looks-like-a-neurological-disease-helping-doctors-to-focus-treatments/
THL arvioi: Koronarokotusten tehosteannoskierrokselle ei ole tarvetta keväällä – rokotusten suoja vakavaa tautia vastaan on väestössä hyvä. THL. 1.3.2023. https://thl.fi/fi/-/thl-arvioi-koronarokotusten-tehosteannoskierrokselle-ei-ole-tarvetta-kevaalla-rokotusten-suoja-vakavaa-tautia-vastaan-on-vaestossa-hyva?redirect=%2Ffi%2F
China reports human case of H5N1 bird flu. BNO News. 1.3.2023. https://bnonews.com/index.php/2023/03/china-reports-human-case-h5n1-bird-flu/
March 1-10
Of those with long COVID at 4 months, 84% of hospital COVID patients in Sweden still had symptoms at 2 years (Linkoping University researchers in Sweden interviewed COVID-19 patients about 37 symptoms 2 years after release from the hospital from Mar 1 to May 31, 2020. The group’s initial 2021 study found that 185 of 433 hospital patients (42.7%) had lingering symptoms and activity limitations 4 months after discharge. So 32% (139 of 433) of the original group had long COVID at 2-year follow-up.). CIDRAP. 27.2.2023. https://www.cidrap.umn.edu/covid-19/those-long-covid-4-months-84-hospital-covid-patients-sweden-still-had-symptoms-2-years
US Energy Department assesses Covid-19 likely resulted from lab leak, furthering US intel divide over virus origin (Two sources said that the Department of Energy assessed in the intelligence report that it had “low confidence” the Covid-19 virus accidentally escaped from a lab in Wuhan.). CNN Politics. 27.2.2023. https://edition.cnn.com/2023/02/26/politics/covid-lab-leak-wuhan-china-intelligence/index.html?
Structural brain changes in patients with post-COVID fatigue: a prospective observational study. eClinicaMedicine. 27.2.2023. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00051-2/fulltext
SARS-CoV-2 ORF3c suppresses immune activation by inhibiting innate sensing (SARS-CoV-2 delta and kappa variants harbor premature stop codons in ORF3c demonstrating that this reading frame is not essential for efficient viral replication in vivo. In agreement with this, disruption of ORF3c did not significantly affect SARS-CoV-2 replication in CaCo-2 or CaLu-3 cells. In summary, we here identify ORF3c as an immune evasion factor that suppresses IFN-β induction, but is dispensable for efficient replication of SARS-CoV-2.). bioRxiv. 27.2.2023. https://www.biorxiv.org/content/10.1101/2023.02.27.530232v1
Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational study (Fatigue was the most common symptom in SARS survivors 18 years after discharge, with osteoporosis and necrosis of the femoral head being the main sequelae. The respiratory function and hip function scores of the SARS survivors were significantly lower than those of the controls. Physical and social functioning at 18 years was improved compared to that after 12 years but still worse than the controls. Emotional and mental health were fully recovered. Lung lesions on CT scans remained consistent at 18 years, especially in the right upper lobe and left lower lobe lesions. Plasma multiomics analysis indicated an abnormal metabolism of amino acids and lipids, promoted host defense immune responses to bacteria and external stimuli, B-cell activation, and enhanced cytotoxicity of CD8+ T cells but impaired antigen presentation capacity of CD4+ T cells.). eClinicalMedicine. 27.2.2023. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00061-5/fulltext
Tutkimus: Yli puolella suomalaisista on sekä rokotuksen että sairastetun taudin tuottamia koronaviruksen vasta-aineita. THL. 27.2.2023. https://thl.fi/fi/-/tutkimus-yli-puolella-suomalaisista-on-seka-rokotuksen-etta-sairastetun-taudin-tuottamia-koronaviruksen-vasta-aineita
Se kummallinen PEM/PESE-oire ja energiantuoton ongelmat. PEM/PESE-oire esiintyy kaikilla ME/CFS:aa sairastavilla, eikä ilman sitä voida asettaa ME/CFS-diagnoosia. Long COVIDia sairastavista PEM/PESE-oire esiintyy noin 50–70 prosentilla. 26.2.2023. https://kehonaarella.com/2023/02/26/se-kummallinen-pem-pese-oire-ja-energiantuoton-ongelmat/
The gray swan: model-based assessment of the risk of sudden failure of hybrid immunity to SARS-CoV-2 (…large jumps in viral evolution may cause failure of population immunity resulting in sudden increases in mortality. As a rise in mortality will only become apparent in the weeks following a wave of disease, reactive public health strategies will not be able to provide meaningful risk mitigation. Learning to live with the virus could thus lead to large death tolls with very little warning. Our work points to the importance of proactive management strategies for the ongoing pandemic, and to the need for multifactorial approaches to COVID-19 disease control.). medRxiv. 26.2.2023. https://www.medrxiv.org/content/10.1101/2023.02.26.23286471v2
Largest Study To Date Suggests Vaccine Lowers Post-COVID Heart Attack And Stroke Risk (Cases of major adverse cardiac events (MACEs) were observed in 12,733 patients who were unvaccinated, 160 patients who were partially vaccinated, and 1,055 patients who were fully vaccinated. Fully vaccinated patients had a 59% decreased risk of experiencing MACEs following infection than those who were unvaccinated, according to a press release on the study (per Mount Sinai Health System). After infection, patients who were partially vaccinated also appeared to have a reduced risk of MACEs. / “[We] found that, particularly among those with comorbidities, such as previous MACE, type 2 diabetes, high cholesterol, liver disease, and obesity, there is an association with a lower risk of complications,”). msn. 25.2.2023. https://www.msn.com/en-us/health/health-news/largest-study-to-date-suggests-vaccine-lowers-post-covid-heart-attack-and-stroke-risk/ar-AA17VZlX
Pathways to altered virulence of SARS-CoV-2 (… it is likely that viral evolution is subject to evolutionary drift, and it cannot be assumed that the virus will necessarily evolve to be lessvirulent,or that prior immunity will offer durable protection against severe disease. This has strong implications for public health strategies to confront the ongoing challenges presented by SARS-CoV-2and implies that there are significant risks to a strategy based on the assumption of waning virulence.). Preprints. 24.2.2023. https://osf.io/k4hb3/
Do You Have Coronaphobiaphobia? Ask Your Doctor if Notmybizumab is Right for You (Jonathan Howard). Science-Based Medicine. 24.2.2023. https://sciencebasedmedicine.org/coronaphobiaphobia/
COMMENTARY: Wear a respirator, not a cloth or surgical mask, to protect against respiratory viruses. CIDRAP UoMinnesota. 23.2.2023. https://www.cidrap.umn.edu/covid-19/commentary-wear-respirator-not-cloth-or-surgical-mask-protect-against-respiratory-viruses
SARS-CoV-2 infection results in upregulation of Plasminogen Activator Inhibitor-1 and Neuroserpin in the lungs, and an increase in fibrinolysis inhibitors associated with disease severity. ejHaem. 23.2.2023. https://onlinelibrary.wiley.com/doi/10.1002/jha2.654
Changes in SARS-CoV-2 seroprevalence and population immunity in Finland, 2020–2022. medRxiv. 23.2.2023. https://www.medrxiv.org/content/10.1101/2023.02.17.23286042v1
Direct and indirect mortality impacts of the COVID-19 pandemic in the United States, March 1, 2020 to January 1, 2022. (…the impacts of the COVID-19 pandemic on excess mortality in the US up to January 2022. The authors separate direct impacts of the pandemic from indirect impacts (disruptions), finding that most excess deaths (84%) are due to direct impacts. Moreover, in individuals under 44 years of age, indirect effects predominate in mortality from external causes and all-cause mortality.). eLife. 22.2.2023. https://elifesciences.org/articles/77562
The new scientific review on masks and Covid isn’t what you think.
A meta-analysis seeks to be the last word on the effectiveness of masks, but finding answers in science isn’t that easy. Vox. 22.2.2023. https://www.vox.com/future-perfect/2023/2/22/23609499/masks-covid-coronavirus-cochrane-review-pandemic-science-studies-infection
More Than Half Of Long Covid Patients Suffer From Organ Damage Up To One Year After Covid Infection. Forbes. 22.2.2023. https://www.forbes.com/sites/anuradhavaranasi/2023/02/22/more-than-half-of-long-covid-patients-suffer-from-organ-damage-up-to-one-year-after-covid-infection/?sh=3f22d7a41cdf
Profs. Jason Abaluck and Mushfiq Mobarak Honored for Landmark Mask Study. Abaluck and Mobarak won the Top Ten Clinical Research Achievement Award from the Clinical Research Forum for their research on the impact of community masking in preventing COVID-19 [Jason Abaluck, and Ahmed Mushfiq Mobarak are among the winners of the 2023 Top Ten Clinical Research Achievement Award for their study “Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh”]. Yale School of Management. 21.2.2023. https://som.yale.edu/story/2023/profs-jason-abaluck-and-mushfiq-mobarak-honored-landmark-mask-study
Inps, certificati di malattia da record nel 2022: +30% nel secondo semestre (Mediamente le giornate di malattia per certificato sono state 4,4 nel settore privato (contro le 5,4 del quarto trimestre 2021) e 4,2 nel settore pubblico (contro le 4,7 del 2021). Le giornate medie di malattia per ciascun lavoratore con almeno un giorno di malattia passano da 10 nel terzo trimestre 2021 a 9,5 nel terzo trimestre 2022 per il settore privato e da 10,7 a 10,1 per il settore pubblico. Per quanto riguarda invece il quarto trimestre, le giornate totali di malattia nel 2022 sono state circa 32,3 milioni nel settore privato e 10,2 milioni nel pubblico, con un incremento rispettivamente del 1% e del 7,4% rispetto all’analogo valore del 2021.). L’Economia. 21.2.2023. https://www.corriere.it/economia/lavoro/23_febbraio_21/inps-certificati-malattia-record-2022-30percento-secondo-semestre-246e4522-b1ce-11ed-8c7f-0f02d700e67e.shtml 21.2.2023.
February 21-28
Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19 (In this double-blind, randomized, placebo-controlled platform trial including 1206 US adults with COVID-19 during February 2022 to July 2022, the median time to sustained recovery was 11 days in the ivermectin group and 11 days in the placebo group. In this largely vaccinated (84%) population, the posterior probability that ivermectin reduced symptom duration by more than 1 day was less than 0.1%.). A Randomized Clinical Trial. JAMA Network. 20.2.2023. https://jamanetwork.com/journals/jama/fullarticle/2801827
Airborne transmission: a new paradigm with major implications for infection control and public health (In the longer term, the Government needs to lead with building codes in residential and commercial sectors that treat clean air provision with as much importance as earthquake safety.
The removal of non-pharmaceutical public health interventions (such as mask wearing
requirements in public spaces) makes the use of engineering controls to minimise exposure to contaminated air even more important. Improving indoor air quality will not only reduce COVID-related illness, but all morbidity related to poor air quality. With this in mind, it’s understandable that reliably maintaining high indoor air quality standards has been described as the new “sanitation). New Zealand Medical Journal. 17.2.2023. https://assets-global.website-files.com/5e332a62c703f653182faf47/63ed951a7a423147f614e18e_6028.pdf
A unique cytotoxic CD4+ T cells signature defines critical COVID-19. medRxiv. 17.2.2023. https://www.medrxiv.org/content/10.1101/2023.02.17.23286059v1
Comparative Effectiveness of BNT162b2 and NVX-CoV2373 Vaccines in Korean Adults. (Estimated risk of severe infection was 0.001 events per 1000 persons (95% CI, 0 to 0.003) for the NVX-CoV2373 (Novavax) vaccine and 0.002 events per 1000 persons (95% CI, 0.001 to 0.006) for BNT162b2 (Pfizer Biontech) vaccine). medRxiv. 16.2.2023. https://www.medrxiv.org/content/10.1101/2023.02.18.23286136v1
[Vital Statistics Reporting] Guidance for Certifying Deaths Due to Coronavirus Disease 2019 (COVID-19) Expanded in February 2023 to Include Guidance for Certifying Deaths Due to Post-acute Sequelae of COVID-19. CDC. February 2023. https://www.cdc.gov/nchs/data/nvss/vsrg/vsrg03-508.pdf
How Deadly Was China’s Covid Wave?Two months after China ended “zero Covid,” rough estimates suggest that between 1 and 1.5 million people died — far more than the official count. NYTimes. 15.2.2023. https://www.nytimes.com/interactive/2023/02/15/world/asia/china-covid-death-estimates.html
Aerosol experts provide an account of the rejection of aerosol science by the WHO. Medical News. 15.2.2023. https://www.news-medical.net/news/20230215/Aerosol-experts-provide-an-account-of-the-rejection-of-aerosol-science-by-the-WHO.aspx
Hospital Outcomes of Community-Acquired SARS-CoV-2 Omicron Variant Infection Compared With Influenza Infection in Switzerland (In this cohort study of 5212 patients hospitalized with the SARS-CoV-2 Omicron variant or influenza A or B in Switzerland, the SARS-CoV-2 Omicron variant was associated with an approximately 1.5-fold higher risk of in-hospital all-cause mortality up to day 30 compared with influenza.). JAMA. 15.2.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801464?utm_source=twitter&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=030423#.ZAOA9Rw4eMk.twitter
Mass testing to end the COVID-19 public health threat ( We here point out that mass testing (regular asymptomatic screening of the general population) is an alternative approach that can dramatically reduce cases and quickly restore economic and social activity.). Lancet Regional Health Europe. Feb. 2023. https://www.sciencedirect.com/science/article/pii/S2666776222002708
Minimising school disruption under high incidence conditions due to the Omicron variant in France, Switzerland, Italy, in January 2022 (When incidence of SARS-CoV-2 infections is high, school protocols based on reactive screening lead to a substantial and unplanned demand for testing resources, while little infection prevention is achieved. With the same resources, proactive weekly screening considerably reduces the peak of infections, limiting schooldays lost. Reactive class closure leads to large disruption with successive closures.). Eurosurveillance. February. 2023. https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.5.2200192
Covid-19: WHO treaty hopes to overcome “catastrophic failures” of pandemic response. BMJ. 14.2.2023. https://www.bmj.com/content/380/bmj.p357?
WHO abandons plans for crucial second phase of COVID-origins investigation. Sensitive studies in China were intended to pinpoint the source of the pandemic virus. Nature.14.2.2023. https://www.nature.com/articles/d41586-023-00283-y?
Verified: COVID-19 Infection Increases Diabetes Risk. (Results Also Suggest the Diabetes Risk Persists Across COVID-19 Variants, and That Upfront Vaccination May Help to Reduce Risk of Post-Infection Diabetes). Cedaes Sinai. 14.2.2023. https://www.cedars-sinai.org/newsroom/verified-covid-19-infection-increases-diabetes-risk/
Association of COVID-19 Vaccination With Risk for Incident Diabetes After COVID-19 Infection (The highest odds postinfection were for diabetes (2.35; 95% CI, 1.94-2.89; P < .001), followed by hypertension (1.54; 95% CI, 1.35-1.76; P < .001), benchmark diagnoses (1.42; 95% CI, 1.25-1.61; P < .001), and hyperlipidemia (1.22; 95% CI, 1.03-1.47; P = .03). ). JAMA. 14.2.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801415?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=021423
Why we need a deeper understanding of the pathophysiology of long COVID (The most recent estimate of people living with post-COVID-19 condition (also known as long COVID) globally has surpassed 65 million1 and, without clear diagnostic or treatment options available, this number is steadily increasing. There are more than 200 reported symptoms associated with long COVID,1 affecting virtually every organ system.). Lancet Infectious Diseases. 14.2.2023. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00053-1/fulltext
https://www.dailyrecord.co.uk/lifestyle/diabetes-symptoms-deaths-caused-disease-29944903
The Effects of SARS-CoV-2 Infection on the Cognitive Functioning of Patients with Pre-Existing Dementia (The rapid progression of dementia, the addition of further impairments/deterioration of cognitive abilities, and the increase or new appearance of white matter lesion burden suggest that previously compromised brains have little defense to withstand a new insult (i.e., ‘second hit’ like infection/dysregulated immune response, and inflammation). ‘Brain fog’ is an ambiguous terminology without specific attribution to the spectrum of post-COVID-19 cognitive sequelae. We propose a new codename, i.e. ‘FADE-IN MEMORY’ (i.e., Fatigue, decreased Fluency, Attention deficit, Depression, Executive dysfunction, slowed INformation processing speed, and subcortical MEMORY impairment).). Journal of Alzheimer’s Disease Reports. 14.2.2023. https://content.iospress.com/articles/journal-of-alzheimers-disease-reports/adr220090
Why we need a deeper understanding of the pathophysiology of long COVID. Lancet Infectious Diseases. 14.2.2023. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00053-1/fulltext
Long COVID Now Looks like a Neurological Disease, Helping Doctors to Focus Treatments. [The causes of long COVID, which disables millions, may come together in the brain and nervous system “I now think of COVID as a neurological disease as much as I think of it as a pulmonary disease, and that’s definitely true in long COVID”]. Scientific American. 14.2.2923. https://www.scientificamerican.com/article/long-covid-now-looks-like-a-neurological-disease-helping-doctors-to-focus-treatments/
Ylilääkäri: ”Suomessa kuolee nyt koko ajan enemmän väkeä” – Tämä tiedetään suomalaisten koronakuolemista ja ylikuolleisuudesta.
Tilastotietojen mukaan vuosina 2021 ja 2022 Suomessa kuoli tuhansia ihmisiä enemmän kuin edeltävinä vuosina. Mitä suomalaisten koronakuolemista nyt tiedetään? Mediuutiset. 13.2.2023. https://www.mediuutiset.fi/uutiset/mu/b7949648-9070-4e51-bd51-a648dfe3a194?ref=twitter:f632
Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei. npj Parkinson’s Disease. 13.2.2023. https://www.nature.com/articles/s41531-023-00467-3
Booster Shots May Trigger Stroke Incidents, According to CDC and FDA
An Overview of Risk and Prevention. Epoch Health. 11.2.2023. https://www.theepochtimes.com/health/booster-shots-may-trigger-stroke-incidents-according-to-cdc-and-fda_5021604.html?
February 11-20
How do we measure expected and excess deaths? National Statistical
News and insight from the Office for National Statistics (ONS). 10.2.2023. https://blog.ons.gov.uk/2023/02/10/how-do-we-measure-expected-and-excess-deaths/
Immmunisation Schedules. CDC. 10.2.2023. https://www.cdc.gov/vaccines/schedules/index.html
Koronavirus COVID-19 tilanne Suomessa. Lähde THL. Tiedot päivitetty: tartunnat ja kuolemat 9.2.2023, sairaanhoito 7.2.2023. Jätevesi päivitetty 10.2.2023. https://www.koronatilastot.fi/fi/sairaala/
Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2 (…proper crosstalk between the humoral and cellular arms of adaptive immunity has broken down in LC, and that this, perhaps in the context of persistent virus, leads to the immune dysregulation, inflammation, and clinical symptoms associated with this debilitating condition.). bioRxiv. 9.2.2023. https://pubmed.ncbi.nlm.nih.gov/36798286/
Coronavirus (COVID-19) Infection Survey technical article: Cumulative incidence of the percentage of people who have been infected with COVID-19 by variant and age, England: 9 February 2023. Analysis of the percentage of people in England who have tested positive for COVID-19 using the Coronavirus (COVID-19) Infection Survey. This survey is being delivered in partnership with the University of Oxford, the University of Manchester, the UK Health Security Agency and the Wellcome Trust. ONS. 9.2.2023. https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19infectionsurveytechnicalarticlecumulativeincidenceofthenumberofpeoplewhohavebeeninfectedwithcovid19byvariantandageengland/9february2023#data-sources-and-quality
Tutkijalääkäri ei jaa Cochranen tuoreen maskikatsauksen päätelmiä: ”Taustatutkimuksissa on monia metodologisia haasteita”. ”Maskikeskustelu ei ole koskaan kovin neutraalia. Siinä sekoittuvat fysiikka, politiikka, oletukset ja näkemykset”, Lotta Oksanen toteaa. Mediuutiset. 9.2.2023. https://www.mediuutiset.fi/uutiset/mu/769215d9-5cc3-4890-96f1-fc27b5116604
‘No one really wants to talk about COVID anymore,’ the WHO’s pandemic lead laments. But the ‘worst case’ possibility of a new coronavirus exists (There exists a popular belief that Omicron is a weakened version of the original COVID. But its generally more mild presentation is likely due, at least in part, to widespread T-cell immunity in many areas of the world. While T cells can’t stop disease, they blunt its impact, often making it appear more mild than it might in a population with virtually no immunity—like China before the lifting of “zero COVID” measures. “Omicron can cause severe disease,” Agrawal said. “It is not nature’s vaccine. ). Fortune Well. 8.2.2023. https://fortune.com/well/2023/02/08/new-coronavirus-covid-recombinant-possible-who-world-health-organization-admits-viral-evolution-covid-pandemic-omicron-zoonotic-transmission-animal-reservoir/
Young people are more likely to die of heart attacks post-COVID, study finds. But why? A recent study found that heart attacks in people ages 25 to 44 increased by 30% compared to the expected number over the first two years of the COVID-19 pandemic. Today. 8.2.2023. https://www.today.com/health/covid-heart-attack-young-people-rcna69903
Incidence and presentation of new-onset type 1 diabetes in children and adolescents from Germany during the COVID-19 pandemic 2020 and 2021: Current data from the DPV Registry (An increase in the incidences of T1D and DKA, but not of autoantibody-negative diabetes was observed during both pandemic years. Further monitoring and efforts for DKA prevention at onset are necessary.). Diabetes Res Clin Pract. 8.2.2023. https://pubmed.ncbi.nlm.nih.gov/36758641/
Usvan peitossa. Aivosumu on yleinen koronan jälkioire, mutta monet kärsivät ajattelun tahmeudesta jo ennen pandemiaa. Mistä aivosumuksi kutsutussa olotilassa on kyse? [Long COVID, Cognitive, Brain fog]. HS. 8.2.2023. https://www.hs.fi/hyvinvointi/art-2000009351625.html
Hidden harms of indoor air pollution — five steps to expose them
Dirty outdoor air might grab the headlines, but learning how pollutants inside buildings form, accumulate and affect our health is equally crucial. Nature. 8.2.2023. https://www.nature.com/articles/d41586-023-00287-8?
STM vastaa oikeuskanslerin ratkaisuun tartuntatautiasetuksesta: ”Hieman yllätti, mutta tervetullutta pohdintaa”. Oikeuskanslerin mukaan STM:n on muutettava viipymättä tartuntatautiasetusta koronan osalta. Asiasta tehtiin kaksi kantelua. Mediuutiset. 7.2.2023. https://www.mediuutiset.fi/uutiset/mu/eeedac9d-f6e3-420e-8604-21dbb14292d9?
Excess Mortality Among US Physicians During the COVID-19 Pandemic. [There were 43 (95% CI, 33-53) excess deaths per 100 000 person-years.] JAMA. 6.2.2023.https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2800889?
Yes, masks reduce the risk of spreading COVID, despite a review saying they don’t. Conversation. 6.2.2023. https://theconversation.com/yes-masks-reduce-the-risk-of-spreading-covid-despite-a-review-saying-they-dont-198992
Neurological infection and complications of SARS-CoV-2: A review (Many recent reports suggested that severe acute respiratory syndrome coronavirus 2 infections can also affect the central nervous system as well as peripheral nervous system that lead to the several neurological complications. The virus can break the blood brain barrier and enters the brain via haematological route or directly by the angiotensin-converting enzyme 2 receptors present on endothelial cells of many cerebral tissues. The neurological complications are manifested by headache, dizziness, encephalopathy, encephalitis, cerebrovascular disease, anosmia, hypogeusia, muscle damage, etc. ). Medicine. 3.2.2023. https://journals.lww.com/md-journal/fulltext/2023/02030/neurological_infection_and_complications_of.19.aspx
Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome. (The post-acute sequelae of COVID-19 present major problems for many patients, their physicians and the health-care system. They are unrelated to the severity of the initial infection, are often highly symptomatic and can occur after vaccination. Many sequelae involve cardiovascular autonomic dysfunction, with postural orthostatic tachycardia syndrome in 30% of individuals. Prognosis is unknown, and treatment is still unsatisfactory). Nature reviews cardiology. 2.2.2023. https://www.nature.com/articles/s41569-023-00842-w
Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 2 February 2023. Estimates of the prevalence of self-reported long COVID and associated activity limitation, using UK Coronavirus (COVID-19) Infection Survey data. Experimental Statistics. ONS. 2.2.2023. https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/prevalenceofongoingsymptomsfollowingcoronaviruscovid19infectionintheuk/2february2023
February 1-10
COVID Impacts: Immune Dysfunction. Detailed information and resources on the long-term health consequences of COVID-19 infection and the broad social impacts of the COVID-19 pandemic. Memorial Sloan Kettering Library. 31.1.2023. https://libguides.mskcc.org/CovidImpacts/Immune
Prevalence of Positive COVID-19 Test Results Collected by Digital Self-report in the US and Germany. JAMA. 31.1.2023. https://jamanetwork.com/journals/jamanetworkopen /fullarticle/2800848?
A pan-sarbecovirus vaccine based on RBD of SARS-CoV-2 original strain elicits potent neutralizing antibodies against XBB in non-human primates (Taken collectively, our data support that the “nonchangeable against changeable” strategy is feasible for the development of pan-sarbecovirus vaccines against sarbecoviruses, including the SARS-CoV-2 Omicron subvariants, BQ.1.1 and XBB. Considering that boost immunization plays an important role in producing bnAb responses, we suggest that the adjuvant in the first-generation subunit COVID-19 vaccines be replaced with CF501 and using it for boost immunization, which may significantly enhance the immune responses against SARS-CoV-2 and its current and future variants.). PNAS. 30.1.2023. https://www.pnas.org/doi/10.1073/pnas.2221713120
COVID-19 is a leading cause of death in children and young people in the US. Univ of Oxford. 30.1.2023. https://www.ox.ac.uk/news/2023-01-31-covid-19-leading-cause-death-children-and-young-people-us
Assessment of COVID-19 as the Underlying Cause of Death Among Children and Young People Aged 0 to 19 Years in the US. JAMA. 30.1.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800816.
These benefits will disappear when Biden ends the Covid national and public health emergencies in May. CNN Politics. 31.1.2023. https://edition.cnn.com/2023/01/30/politics/may-11-end-of-covid-and-public-health-emergencies/index.html?
Cochrane Database of Systematic Reviews: Physical interventions to interrupt or reduce the spread of respiratory viruses. Cochrane Library. 30.1.2023. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006207.pub6/full
High number of SARS-CoV-2 persistent infections uncovered through genetic analysis of samples from a large community-based surveillance study. medRxiv. 30.1.2023. https://www.medrxiv.org/content/10.1101/2023.01.29.23285160v1
Assessment of COVID-19 as the Underlying Cause of Death Among Children and Young People Aged 0 to 19 Years in the US. [aged 0 to 19 years in the US, COVID-19 ranked eighth among all causes of deaths, fifth in disease-related causes of deaths (excluding unintentional injuries, assault, and suicide), and first in deaths caused by infectious or respiratory diseases. COVID-19 deaths constituted 2% of all causes of death] JAMA. 30.1.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800816
Research to spread light on long COVID uncertainties. Long COVID is a growing social problem in Sweden and the rest of the world. We still know very little about why some are affected, and how it can be cured. “We really need more research and an investment in this,” says Anne-Marie Fors Connolly, docent of microbiology at Umeå University and physician who studies the long-term effects of COVID-19.Umeå University. 30.1.2023. https://www.umu.se/en/news/research-to-spread-light-on-long-covid-uncertainties_11713455/
Absence from work at record high as Americans feel strain from Covid (1.5 million Americans missed work because of sickness in December. Each month, more than a million people have called out sick for the past three years. In June 2022, about 7% of adult Americans had long Covid, which can affect productivity and ability to work, according to data from the Centers for Disease Control and Prevention (CDC). The last time the absentee number dipped below a million Americans was in November 2019. Last year, the trend accelerated rather than returning to normal. In 2022, workers had the most sickness-related absences of the pandemic, and the highest number since record-keeping began in 1976. In 2022, the average was 1.58 million per month, for a total of 19 million absences for the year. The largest spike was in January 2022, when 3.6 million people were absent due to illness, about triple the pre-pandemic number for that month.). Guardian. 29.1.2023. https://www.theguardian.com/world/2023/jan/29/covid-absence-workforce-health-long-covid
Miksi kuolleisuus lähti nousuun syksyllä 2021? Koronablogi [sisältää erityisesti linkkejä THL:n ja median harhaanjohtavaan tiedottamiseen]. 28.1.2023. https://koronablogi.fi/articles/miksi_kuolleisuus_lahti_nousuun_syksylla_2021.html
Comparison of Preprint Postings of Randomized Clinical Trials on COVID-19 and Corresponding Published Journal Articles. A Systematic Review. JAMA. 27.1.2023. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800857
The impact of vaccination frequency on COVID-19 public health outcomes: A model-based
analysis. medRxiv. 26.1.2023. https://www.medrxiv.org/content/10.1101/2023.01.26.23285076v1.full.pdf
COVID Virus Ventures Beyond the Lungs, Often Lodging in the Brain (The conclusion is chilling: “ … SARS-CoV-2 is capable of infecting and replicating within … many … tissues, including brain.”). DNA Science. 26.1.2023. https://dnascience.plos.org/2023/01/26/covid-virus-ventures-beyond-the-lungs-often-lodging-in-the-brain/
Incident autoimmune diseases in association with a SARS-CoV-2 infection: A matched cohort study. medRxiv. 26.1.2023. https://www.medrxiv.org/content/10.1101/2023.01.25.23285014v1
Household Transmission of Influenza A Viruses in 2021-2022 [ a significantly increased risk of household transmission of influenza A(H3N2) in 2021-2022 compared with prior seasons]. JAMA. 26.1.2023. https://jamanetwork.com/journals/jama/fullarticle/2800976
Covid-19 Infection During Pregnancy Can Damage The Placenta And The Fetus (A new study published in The Lancet Europe has found that SARS-CoV-2 infections during pregnancy are associated with placental lesions from vascular malperfusion, which can result in increased rates of fetal growth restriction, pre-labor membrane rupture, and miscarriage. Vascular damage was also observed in the organs of the fetuses via fetal MRIs.) Forbes. 25.1.2023. https://www.forbes.com/sites/williamhaseltine/2023/01/25/covid-19-infection-during-pregnancy-can-damage-the-placenta-and-the-fetus/
Antibody escape, the risk of serotype formation, and rapid immune waning: modeling the implications of SARS-CoV-2 immune evasion (In the long-term, invading variants that induce weak cross-immunity against pre-existing strains may co-circulate with those pre-existing strains. This would result in the formation of serotypes that increase disease burden, complicate SARS-CoV-2 control and raise the potential for increases in viral virulence. Less durable immunity does not drive positive selection as a trait, but such strains may transmit at high levels if they establish. Overall, our results draw attention to the importance of inter-strain cross-immunity as a driver of transmission trends and the importance of early immune evasion data to predict the trajectory of the pandemic.). medRxiv. 25.1.2023. https://www.medrxiv.org/content/10.1101/2023.01.25.23285031v1
Is science really getting less disruptive — and does it matter if it is?
A study suggesting papers and patents that change the course of science are becoming less dominant is prompting soul-searching — and lively debate about why, and what to do about it.. nature. 25.1.2023. https://www.nature.com/articles/d41586-023-00183-1?
SKANDIA: SVERIGE FÖRLORADE 71 MDR PÅ LÅNGTIDSSJUKSKRIVNINGAR 2022
Långtidssjukskrivningar i Sverige kostade samhället 71 miljarder kronor under förra året, enligt en ny rapport från Skandia. Rapporten visar dessutom att andelen sjukskrivningar till följd av psykisk ohälsa har ökat efter pandemin; under förra året uppgick kostnaden till 32,6 miljarder kronor. 2022 uppskattas andelen sjukskrivningar på grund av psykisk ohälsa ha varit 46 procent, jämfört med 45 procent 2021 och 41 procent 2020. År 2015 berodde 30 procent av långtidssjukskrivningarna på psykisk ohälsa.. Sak och Liv. 25.1.2023. https://sakochliv.se/2023/01/25/skandia-sverige-forlorade-71-mdr-pa-langtidssjukskrivningar-2022/
Suomalaisten kuolemissa uusi synkkä ennätys – tästä ylikuolleisuus johtuu. Koronavuosien aikana suomalaisia on kuollut historiallisen paljon. Pelkkä kuolleiden määrä ei kuitenkaan kerro koko totuutta paljon puhutusta ylikuolleisuudesta. Ilta=sanomat. 21.1.2023. https://www.is.fi/kotimaa/art-2000009330947.html
January 21-31
SARS-CoV-2 variant-related abnormalities detected by prenatal MRI: a prospective case–control study (Of the 38 included cases after SARS-CoV-2 infection, 20/38 (52.6%) were infected with pre-Omicron variants and 18/38 (47.4%) with Omicron. Prenatal MRIs were performed on an average of 83 days (±42.9, median 80) days after the first positive PCR test. Both pre-Omicron (P = .008) and Omicron (P = .016) groups showed abnormalities in form of a globular placenta compared to control cases. In addition, placentas in the pre-Omicron group were significantly thickened (6.35, 95% CI .02–12.65, P = .048), and showed significantly more frequent lobules (P = .046), and hemorrhages (P = .002). Fetal growth restriction (FGR) was observed in 25% (n = 5/20, P = .017) in the pre-Omicron group.). Lancet Regional Health Europe. 20.1.2023. https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(23)00005-4/fulltext#secsectitle0115
Rokote Laboratories Finland Oy kehittää nenään annettavaa koronarokotetta tiettävästi ainoana Euroopassa – antotavalla taudin torjumisessa merkittäviä hyötyjä (Koronavirus aloittaa infektion tyypillisesti ylähengitysteissä eli nenänielun limakalvoilla. Nenään annosteltavan rokotteen tarkoituksena on muodostaa vahva immuunipuolustus näille limakalvoille, jolloin viruksen lisääntyminen estetään ja infektio estyy. Jos ihminen ei infektoidu, hän ei myöskään levitä virusta,). University of Eastermn Finland. 20.1.2023. https://www.uef.fi/fi/artikkeli/rokote-laboratories-finland-oy-kehittaa-nenaan-annettavaa-koronarokotetta-tiettavasti-ainoana
Omicron Mutation Linked to Neurological Complication in Kids. healthnews.20.1.2023. https://healthnews.com/health-conditions/covid-19/omicron-subvariant-mutation-may-cause-neurological-complications-in-children/
What doctors wish patients knew about COVID-19 reinfection. AMA. 20.1.2023. https://web.archive.org/web/20230121033709/https://www.ama-assn.org/delivering-care/public-health/what-doctors-wish-patients-knew-about-covid-19-reinfection
MRI evidence of olfactory system alterations in patients with COVID-19 and neurological symptoms (Brain). Journal of Neurology. 19.1.2023. https://link.springer.com/article/10.1007/s00415-023-11561-0
Comparative effectiveness of the bivalent BA.4-5 and BA.1 mRNA-booster vaccines in the Nordic countries. medRxiv. 19.1.2023. https://www.medrxiv.org/content/10.1101/2023.01.19.23284764v1
Persistent SARS-CoV-2 infection in patients seemingly recovered from COVID-19 (SARS-CoV-2 infection can persist significantly longer than suggested by PCR-negative tests on nasopharyngeal swabs or bronchoalveolar lavage fluids. Whether the persisting infected cells have a pathogenic role in explaining the sequelae of infection in long COVID remains an outstanding question, which deserves further investigation.). Journal od Pathology. 18.1.2023. https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6035
Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration? (Treating several individuals suffering from post-COVID-19 syndrome with a nicotine patch application, we witnessed improvements ranging from immediate and substantial to complete remission in a matter of days.) Bioelectronic Medicine. 18.1.2023. https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-023-00104-7
Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: a systematic review and meta-regression. Lancet Infectious Diseases. 18.1.2023. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00801-5/fulltext
How your first brush with COVID warps your immunity. The immune system responds more strongly to the strain of a virus that it first met, weakening response to other strains. Can this ‘imprinting’ be overcome? Nature. 18.1.2023. https://www.nature.com/articles/d41586-023-00086-1
Cortical Grey matter volume depletion links to neurological sequelae in post COVID-19 “long haulers”. (Brain) BMC Neurology. 17.1.2023. https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-023-03049-1
Excess mortality dropped to 6.7% in November 2022. EuroStat. 17.1.2023. https://ec.europa.eu/eurostat/en/web/products-eurostat-news/w/Ddn-20230117-1
Tartuntojen torjunta ja unohtunut ennakointi. (This post outlines two key points missing from Finnish public discussion in 2023. It was originally published on January 16, and has been audited for its continuing relevance on August 31. The main scientific points are made here (non-pharmaceutical interventions like masks work, particularly when they’re combined with other measures; see text for explanation of non-linear compounding), here (mass testing can end the pandemic), here (international consensus we should not let the pandemic run amok), here (long covid is a biological disease) and here (novel pathogens call for a swift and prudent elimination approach).). COMPLEX SYSTEMS, HEALTH AND WELL-BEING WITH UNCERTAINTY Matti TJ Heino blog. 16.1.2023. https://mattiheino.com/2023/01/16/tartuntojen-torjunta/
Two-year follow-up of brain structural changes in patients who recovered from COVID-19: A prospective study (Brain, Cognitive). Psychiatry Research. Jan 2023. https://www.sciencedirect.com/science/article/pii/S0165178122005601
Why health-care services are in chaos everywhere. Now is an especially bad time to suffer a heart attack. Economist. 15.1.2023. https://www.economist.com/finance-and-economics/2023/01/15/why-health-care-services-are-in-chaos-everywhere
Unwanted Indoor Air Quality Effects from Using Ultraviolet C Lamps for Disinfection. Environ Sci Technol. 13.1.2023. https://pubs.acs.org/doi/10.1021/acs.estlett.2c00807#
Long COVID: major findings, mechanisms and recommendations (Long COVID is a multisystemic illness encompassing ME/CFS, dysautonomia, impacts on multiple organ systems, and vascular and clotting abnormalities. It has already debilitated millions of individuals worldwide, and that number is continuing to grow. On the basis of more than 2 years of research on long COVID and decades of research on conditions such as ME/CFS, a significant proportion of individuals with long COVID may have lifelong disabilities if no action is taken.). nature reviews microbiology. 13.1.2023. https://www.nature.com/articles/s41579-022-00846-2
Maternal mRNA covid-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants: test negative design study [maternal vaccination prottected the child for up to 6 mo.]. 12.1.2023. BMJ. https://www.bmj.com/content/380/bmj-2022-074035
Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study (This nationwide study suggests that patients with mild covid-19 are at risk for a small number of health outcomes, most of which are resolved within a year from diagnosis.). BMJ. 11.1.2023.
In sickness and in “health”: Canada’s labour market (For some sectors, the added paid sick leave is putting significant extra pressure on wage costs. This is particularly the case for some in-person industries such as mining, oil and gas, utilities, and education where wage costs are about 1.5% higher due to paid time off for employees absent all week due to illness or family matters. However, it can also impact some industries where telework is prominent, such as public administration, which has seen its wage bill increase by as much as 1% for the same reason). CIBC Economic Insights. 11.1.2023. https://economics.cibccm.com/cds?id=c2a46e48-a5b0-4f1f-8958-234031e653e7&flag=E
January 11-20
Group aiming to sabotage Whitmer’s Covid policies funded by dark money.
Non-profit affiliated with utility DTE Energy funded effort to repeal Michigan governor’s emergency order powers. The Guardian. 10.1.2023. https://www.theguardian.com/us-news/2023/jan/10/gretchen-whitmer-michigan-covid-policies-dark-money
China now publishes more high-quality science than any other nation – should the US be worried? Conversation.10.1.2023. https://theconversation.com/china-now-publishes-more-high-quality-science-than-any-other-nation-should-the-us-be-worried-192080
The safer you feel, the less safely you might behave – but research suggests ways to counteract this tendency. Conversation. 10.1.2023. https://theconversation.com/the-safer-you-feel-the-less-safely-you-might-behave-but-research-suggests-ways-to-counteract-this-tendency-190527
WHO expert: China’s COVID-19 surge could lead to deadly mutation
Dr. Dorit Nitzan: “We have to be ready and alert.” Jerusalem Post. 10.1.2022. https://www.jpost.com/conferences/article-728098
Risk of autoimmune diseases in patients with COVID-19: A retrospective cohort study. eClinicalMedicine. 10.1.2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830133/
Rokottaa vaiko eikö rokottaa – siinä pulma. Lasse Lehtosen kolumni. Uusi Suomi. 8.1.2023. https://puheenvuoro.uusisuomi.fi/lasselehtonen/rokottaa-vaiko-eiko-rokottaa-siina-pulma/
How serious is the threat of new Covid-19 variants? A surge in cases after China lifted restrictions has sparked concerns that a dangerous new strain could emerge. FT. 5.1.2023. https://www.ft.com/content/7623c671-6fc7-34e95-a177-594467a5d65e
SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study. medRxiv. 5.1.2023. https://pubmed.ncbi.nlm.nih.gov/36656776/
COVID-19 inhibits spermatogenesis in the testes by inducing cellular senescence. Frontiers in Genetics. 5.1.2023. https://www.frontiersin.org/articles/10.3389/fgene.2022.981471/full
‘Disruptive’ science has declined — and no one knows why. The proportion of publications that send a field in a new direction has plummeted over the past half-century. Nature. 4.1.2023. https://www.nature.com/articles/d41586-022-04577-5
Virukset tarttuvat lentokoneessa. Maskia kannattaa käyttää koko lentomatkan ajan, kentällä ja koneessa. HS. 2.1.2023. https://www.hs.fi/mielipide/art-2000009298876.html
Koronarokotukset vuonna 2023. Lausunto ja näyttöpohja. Työpaperi 11/2023. THL. https://www.julkari.fi/bitstream/handle/10024/146281/URN_ISBN_978-952-408-055-2.pdf?sequence=1&isAllowed=y
January 1-10
Covid-19: What is XXB.1.5 variant, accounts for over 40% cases in US?. Mint. 31.12.2022. https://www.livemint.com/news/world/covid19-what-is-xxb-1-5-variant-accounts-for-over-40-cases-in-us-11672466290618.html
Laskelmat Suomen ”huikeasta” ylikuolleisuudesta eivät kestä tarkastelua. Kun väestö vanhenee kiihtyvää vauhtia, myös kuolemia tulee väistämättä enemmän. Tätä ei monissa kansainvälisissä vertailuissa huomioida, kirjoittaa HS:n tiedetoimittaja Annikka Mutanen. HS. 31.12.2022. https://www.hs.fi/paivanlehti/31122022/art-2000009298179.html
Hoitajamitoitus ratkeaa ulkomaalaisella työvoimalla, sanoo Mehiläisen toimitusjohtaja: Suomeen olisi tuhansia tulijoita. Terveysyritys Mehiläinen aikoo tuoda Suomeen ensi vuonna tuhat ulkomaista hoiva-avustajaa. Halukkaita olisi moninkertaisesti, mutta julkinen sektori ei ole halunnut palkata heitä. Suomen Kuvalehti. 30.12.2022. https://suomenkuvalehti.fi/kotimaa/hoitajamitoitus-ratkeaa-ulkomaalaisella-tyovoimalla-sanoo-mehilaisen-toimitusjohtaja-suomeen-olisi-tuhansia-tulijoita/
Intranasal inhibitor broadly blocks SARS-CoV-2 including recent highly immunoevasive Omicron subvariants (VirX). bioRxiv. 29.12.2022. https://www.biorxiv.org/content/10.1101/2021.12.28.474326v2
Suomalaisia kuolee ennätysmääriä, mutta kiinnostaako ketään? Juha Itkonen, Taloustaito. 29.12.2022. https://www.taloustaito.fi/blogit/juha-itkonen/suomalaisia-kuolee-ennatysmaaria-mutta-kiinnostaako-ketaan/#d01014ee
Kiinaa uhkaa valtava terveyskatastrofi. Syyllinen Kiinan koronalinjan epäonnistumiseen on maan kommunistinen puolue, mutta syyllisyyttään se ei tule koskaan tunnustamaan. Helsingin Sanomat. 28.12.2022. https://www.hs.fi/paivanlehti/28122022/art-2000009291484.html
Pääkirjoitus: Tuhansia suomalaisia on kuollut liikaa – riippumaton selvitys tarvitaan. Riippumaton selvitys ylikuolleisuudesta tarvitaan, vaikka se voikin olla poliittisesti kiusallista, kirjoittaa Juha Ristamäki. Iltalehti 27.12.2022. https://www.iltalehti.fi/paakirjoitus/a/464f2586-7cb9-4453-beef-4090a02aed0a
Mid- and Long-Term Atrio-Ventricular Functional Changes in Children after Recovery from COVID-19. J Clinical Medicine. 26.12.2022. https://www.mdpi.com/2077-0383/12/1/186
China estimates 250mn people have caught Covid in 20 days
Figures presented at closed-door meeting are in stark contrast to low official case count. Financial Times. 25.12.2022. https://www.ft.com/content/1fb6044a-3050-44d8-b715-80c18ca5c9ab
Tutkijat osoittivat simppelin, mutta tehokkaan tavan välttyä sairaalalta koronatartunnassa – Suomalaiskeuhkolääkäri komppaa. Nenän huuhteleminen pian koronatartunnan jälkeen laski sairaalaan päätymisen todennäköisyyttä merkittävästi, tutkijat huomasivat.Mediuutiset. 23.12.2022. https://www.mediuutiset.fi/uutiset/mu/cde291ce-2c63-4d43-adbe-457b512250d7?
On the role of different age groups in propagating Omicron epidemics in France. [children transmit COVID] medRxiv. 23.12.2022. https://www.medrxiv.org/content/10.1101/2022.12.22.22283867v1
UK cements 10-year-partnership with Moderna in major boost for vaccines and research. Moderna to invest in mRNA research and development (R&D) in the UK, and build a state-of-the-art vaccine manufacturing centre with the ability to produce up to 250 million vaccines a year. Gov.UK Press release. 22.12.2022. https://www.gov.uk/government/news/uk-cements-10-year-partnership-with-moderna-in-major-boost-for-vaccines-and-research
What is going on with our immune cells after COVID-19 infection? Dr. Jeff Gilchrist. 22.12.2022. https://pingthread.com/thread/1605958004163084292
THL: Koronaan voi suhtautua kuin tavalliseen flunssaan. Terveyden ja hyvinvoinnin laitoksen mukaan koronavirusta koskeville erityisille ohjeille ei ole enää tarvetta. Helsingin Sanomat. 20.12.2023. https://www.hs.fi/kotimaa/art-2000009279490.html
Immune systems seriously weakened by COVID,Evolving research says COVID leaves many people at heightened risk for other infections. The Record. 20.12.2022. https://www.therecord.com/news/waterloo-region/2022/12/20/immune-systems-seriously-weakened-by-covid.html
Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium. Science Transl Med. 21.12.2022. https://www.science.org/doi/10.1126/scitranslmed.add0484
December 21-31
China reports first COVID deaths in weeks as official count questioned. Reuters. 19.12.2022. https://www.reuters.com/world/china/china-officially-reports-first-covid-deaths-weeks-virus-wave-swells-2022-12-19/
Sweden’s Pandemic Experiment. Taylor&Francis. 19.12.2022. https://www.taylorfrancis.com/books/oa-edit/10.4324/9781003289364/sweden-pandemic-experiment-sigurd-bergmann-martin-lindstr%C3%B6m
Effectiveness of the Coronavirus Disease 2019 (COVID-19) Bivalent Vaccine. [Pfizer, Moderna, mRNA]. medRxiv. 19.12.2022. https://www.medrxiv.org/content/10.1101/2022.12.17.22283625v1.full
Long-term Follow-up After Critical COVID-19. REMAP-CAP Revisited.JAMA. 16.12.2022. https://jamanetwork.com/journals/jama/fullarticle/2799872?guestAccessKey=4d7b8594-4dce-4b39-abfa-63509e71e3c4&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=121622
Onko koronakuolemia paljon, vai mihin täällä kuollaan? Suomen ylikuolleisuus on huikeaa, ja syyt ovat selvittämättä (Normaaliajan trendistä lasketut kuolemien kasvun odotusarvot vuosille 2020, 2021 ja 2022 olivat 420, 840 ja 1260, kun verrataan vuosiin juuri ennen pandemiaa. Kuolemat kuitenkin lisääntyivät 2400, 3800 ja 9200:lla, jos 2022 loppuvuosi jatkuu samanlaisena. Lukujen erotukset ovat laskennallisia ylikuolemia.). Lääkärilehti. 16.12.2022. https://worldaccordingtomatti.blog/wp-admin/post.php?post=2385&action=edit&calypsoify=1
Anna Rotkirch: Finlands covidoffer skulle inte ha ”dött i alla fall”. HBL. 16.12.2022. https://www.hbl.fi/artikel/dbbc03c1-cabb-4621-927e-47a505b75e08
Structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction (Brain, Cognitive). Annals of Clinical and Translational Neurology. 16.12.2022. https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.51710
The missing workers who are never coming back. U.S. labor force
Quarterly, Q4 2019 to Q3 2022. AXIOS. 16.12.2022. [3.2 million] https://www.axios.com/2022/12/16/the-missing-workers-who-are-never-coming-back
CLINICAL SUMMARY. Long COVID: average prevalence of 45%, with highest rate in Europe. A global meta-analysis of 194 studies finds a pooled prevalence of long COVID averaging 45% across hospitalised and nonhospitalised patients.
The pooled prevalence is highest in Europe, standing at 62.7%.
The most common self-reported symptoms are fatigue, breathlessness (dyspnoea), impaired sleep, and pain/discomfort. Univadis. 15.12.2022. https://www.univadis.com/viewarticle/long-covid-average-prevalence-of-45-with-highest-rate-in-europe-2
Select Subcommittee Releases Final Report, Culminating More Than Two Years Of Investigations Related To The Nation’s Response To The Coronavirus Crisis (The final report reveals new findings from several of the committee’s investigations—including findings related to the Trump Administration’s failure to recognize and prepare for the threat posed by the coronavirus in early 2020—and includes new information from the Select Subcommittee’s investigations into right-wing purveyors of coronavirus misinformation, and into the practices of for-profit nursing home chains and the toll on their vulnerable residents.). Select Subcommittee on the Coronavirus Crisis. 15.12.2022. https://coronavirus-democrats-oversight.house.gov/
Perspective: A Covid-19 Milestone Attained — A Correlate of Protection for Vaccines. NEJM. 15.12.2022. https://www.nejm.org/doi/full/10.1056/NEJMp2211314
SARS-CoV-2 infection and persistence in the human body and brain at autopsy (…we detected persistent SARS-CoV-2 RNA in multiple anatomic sites, including throughout the brain, as late as 230 days following symptom onset in one case. Despite extensive distribution of SARS-CoV-2 RNA throughout the body, we observed little evidence of inflammation or direct viral cytopathology outside the respiratory tract. Our data indicate that in some patients SARS-CoV-2 can cause systemic infection and persist in the body for months.). nature. 14.2.2022. https://www.nature.com/articles/s41586-022-05542-y
SARS (severe acute respiratory syndrome). NHS. 14.12.2023. https://covid19.public-inquiry.uk/wp-content/uploads/2023/07/21173155/INQ000023081.pdf
Timo Vesikarin blogi. Koronatilanne on vakaa (mutta huono). NRN. NN.12.2022. https://nrnetwork.fi/koronatilanne-on-vakaa-mutta-huono/
Taysin päivystys Acutan tilanne on kriittinen. Potilaita ei saada eteenpäin täynnä oleville erikoissairaanhoidon vuodeosastoille, jotka taas eivät saa potilaita eteenpäin perussairaanhoidon vuodeosastoille. Lääkärilehti. 14.12.2022. https://www.laakarilehti.fi/terveydenhuolto/taysin-paivystys-acutan-tilanne-on-kriittinen/?public=67e24e69e12e48d35bbd04cfab9043ad
As viral infections skyrocket, masks are still a tried-and-true way to help keep yourself and others safe. Conversation. 14.12.2022. https://theconversation.com/as-viral-infections-skyrocket-masks-are-still-a-tried-and-true-way-to-help-keep-yourself-and-others-safe-195788
The WHO estimates of excess mortality associated with the COVID-19 pandemic [Karlinsky]. nature. 14.12.2022. https://www.nature.com/articles/s41586-022-05522-2
People who skipped their COVID vaccine are at higher risk of traffic accidents, according to a new study. Fortune Well. 13.12.2022. https://fortune.com/well/2022/12/13/covid-unvaccinated-greater-risk-car-crash-traffic-accident-new-study-says-canada-government-records-pfizer-moderna/
Independent Expert Panel on effective ways of investing in health publishes opinion on the impact of the post-COVID-19 condition (long COVID) on health systems. 13.12.2022. https://ec.europa.eu/newsroom/sante/newsletter-archives/42544
Estimates of excess mortality for the five Nordic countries during the COVID-19 pandemic 2020-2021 [Coclusions: We document substantial heterogeneity and uncertainty in estimates of excess mortality. All estimates should be taken with caution in their interpretation as they miss detailed account of demographics, such as changes in the age group populations over the study period.]. Int J Epidemiol. 13.12.2022. https://academic.oup.com/ije/article/51/6/1722/6798817?login=false
6% of Irish adults have self-reported symptoms of long Covid for over three months. Irish Examiner. 12.12.2022. https://www.irishexaminer.com/news/arid-41026751.html
Helsinki avasi uudelleen koronaosaston Laakson sairaalaan. Kaksi koronaosastoa on palautettu normaalikäyttöön ja Herttoniemen varasairaala pysyy kiinni. Koronapotilaiden hoidossa käytetty Herttoniemen varasairaala sulki ovensa toukokuussa.Helsingin Sanomat 13.12.2022. https://web.archive.org/web/20221213043620/https://www.hs.fi/haku/?query=Marja+Salomaa+HS
Covid Depression Is Real. Here’s What You Need to Know. The risk of developing symptoms of depression remains high up to a year after you’ve recovered. NYTimes. 11.12.2022. https://www.nytimes.com/2022/11/12/well/long-covid-depression-symptoms-treatment.html
Americans urged to wear face masks indoors as ‘tripledemic’ hits millions
Americans across the country have been asked to wear face masks in some indoor settings over fears of a ‘tripledemic.’ Low immunity and a lack of resources is believed to be behind the problems. Mirror. 11.12.2022. https://www.mirror.co.uk/news/us-news/americans-urged-wear-face-masks-28706979
Ylikuolleisuus ja soten perverssit kannustimet. Lasse Lehtosen blogi. 11.12.2022. https://puheenvuoro.uusisuomi.fi/lasselehtonen/ylikuolleisuus-ja-soten-perverssit-kannustimet/
December 11-20
Pitkäkestoinen koronavirustauti on merkittävä kansanterveysongelma. Pienikin prosenttiosuus koronaviruksen sairastaneista tai väestöstä tarkoittaa vähintään kymmeniätuhansia suomalaisia (Pirta Hotulainen). Helsingin Sanomat. 9.12.2022. https://www.hs.fi/mielipide/art-2000009251065.html
Regeringen håller pressträff om covid-19. Expressen. 9.12.2022. https://www.expressen.se/nyheter/regeringen-haller-presstraff-om-covid-19/
Something in the Air. Germicidal UV: a tradeoff between disinfection and indoor smog. The answer will vary for different times and locations, and here we illustrate how to think about it. Jose-Luis Jimenez. 9.12.2022. https://jljcolorado.substack.com/p/germicidal-uv-a-tradeoff-between?sd=pf
Korona voi heikentää suojaa muita tauteja vastaan. Immuunijärjestelmä on infektion jälkeen heikentyneessä tilassa 3–6 kuukautta. Verkkouutiset 8.12.2022. https://www.verkkouutiset.fi/a/korona-voi-heikentaa-suojaa-muita-tauteja-vastaan/#406d5f9e
Getting China’s old people vaccinated has been slow work. It needs to speed up, fast. Economist. 8.12.2022. https://www.economist.com/china/2022/12/08/getting-chinas-old-people-vaccinated-has-been-slow-work
The number of new disability benefit claimants has doubled in a year.
The number of working-age people newly awarded disability benefits doubled between July 2021 and July 2022. This report investigates that increase. [UK] IFS. 7.12.022. https://ifs.org.uk/publications/number-new-disability-benefit-claimants-has-doubled-year.
Children at risk of strep A in England could be given preventive antibiotics. ‘Rare’ blanket measure may be used at primary schools after at least nine UK deaths from bacterial infection. Guardian. 6.12.2022. https://www.theguardian.com/society/2022/dec/06/children-risk-strep-a-england-preventive-antibiotics
Models predict massive wave of disease and death if China lifts ‘zero COVID’ policy. Country’s severe approach to pandemic is inflaming the populace, but lifting it carries huge risks. Science 6.12.2022. https://www.science.org/content/article/models-predict-massive-wave-disease-and-death-if-china-lifts-zero-covid-policy
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.. nature. 5.12.2022. https://www.nature.com/articles/s41586-022-05594-0
Risk of Type 1 Diabetes in Children is Not Increased after SARS-CoV-2 Infection: A Nationwide Prospective Study in Denmark. medRxiv. 5.12.2022. https://www.medrxiv.org/content/10.1101/2022.12.05.22283089v1
Neurologi Risto O. Roine on long covid -asiantuntija: ”Positiivista on se, että hoidolla ja kuntoutuksella potilas lähes aina edistyy”. Seura. 4.12.2022. https://seura.fi/viihde/julkkikset/neurologi-risto-o-roine-on-long-covid-asiantuntija/
Modeling the Impact of Nonpharmaceutical Interventions on COVID-19 Transmission in K-12 Schools (We find that masks and reducing contacts can greatly reduce new infections among students. Weekly screening tests also have a positive impact on disease mitigation. While self-quarantining symptomatic infections and school closures are effective measures for decreasing semester-end infections, they increase absenteeism. The model assesses different nonpharmaceutical interventions applied to K-12 schools during the pandemic and estimates their impact on COVID-19 under varying assumptions. The results are presented using parameter estimates associated with the Omicron variant, but the model is general and can be applied to different parameters. In addition, although we specify our targeted population group as K-12 schools, the conceptual model can be easily extended to implement other population groups (e.g., nursing homes or prisons) if we have a good quantitative understanding of their social contact patterns.). SMDM. 3.12.2022. https://journals.sagepub.com/doi/10.1177/23814683221140866
The Tragedy of Avoidable Covid Deaths. Comprehensive new data show just how many Americans died after vaccines became widely available — mostly in less-vaccinated states. Bloomberg. 3.12.2022. https://www.bloomberg.com/opinion/articles/2022-12-03/low-us-covid-vaccine-rates-led-to-high-death-rates-during-delta-omicron?leadSource=uverify%20wall
Heart attack deaths spike around winter holidays, expert group warns
Reducing holiday stress and taking care of your body year-round can help lower your risk. Today. 2.12.2022. https://www.today.com/health/news/heart-attack-deaths-holidays-rcna59779
Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals. Frontiers in immunology. 2.12.2022. https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034159/full
Model Evaluation of Secondary Chemistry due to Disinfection of Indoor Air with Germicidal Ultraviolet Lamps. Environ Sci Technol. 2.12,2022. https://pubs.acs.org/doi/10.1021/acs.estlett.2c00599
Kasvosuojista uutta tietoa – laaja meta-analyysi valmistui
Tutkimusaineistossa mukana lähes 400 000 henkilöä eri puolilta maailmaa.. Lääkärilehti. 2.12.2022. https://www.laakarilehti.fi/terveydenhuolto/kasvosuojista-uutta-tietoa-laaja-meta-analyysi-valmistui/?public=2c806461943bc9cb563331a3dc00d75c
Experimental Vaccines Offer Long-term Protection Against Severe COVID (“With COVID-19, young infants are one of the most vulnerable pediatric populations. This fall, we are seeing a sharp rise in hospitalizations due to respiratory virus disease in infants as the result of a confluence of SARS-CoV-2, flu, and RSV circulation,” “We should take every opportunity to provide safe and effective vaccine immunity to our youngest patients, including considering COVID-19 vaccination earlier than the currently recommended 6 months of age.” “This study emphasizes the need to get human infants immunized against SARS-CoV-2 as much as possible, as the benefits are clear and long-lasting”). Weill Cornell Medicine. 1.12.2022. https://news.weill.cornell.edu/news/2022/12/experimental-vaccines-offer-long-term-protection-against-severe-covid
Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes. nature medicine. 1.12.2022. https://www.nature.com/articles/s41591-022-02116-3
A new RCT of masks for Covid-19 is making heads spin. Critical appraisal is tough, particularly if you’ve already made up your mind Munro Report. 1.12.2022. [Hanna M. Ollila, Markku Partinen, Jukka Koskela, John Borghi, Riikka Savolainen, Anna Rotkirch, Liisa T. Laine] Face masks to prevent transmission of respiratory infections: Systematic review and meta-analysis of randomized controlled trials on face mask use [support the use of face masks particularly in a community setting and for adults]. PLOS ONE. 1.12.2022. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271517
Kukaan ei noudata STM:n rokotelinjausta. Tällä hetkellä myös ne rokotteet, joita yksityiset toimijat voisivat pistää, ovat kuntien takana.Lääkärilehti. 1.12.2022. https://www.laakarilehti.fi/terveydenhuolto/kukaan-ei-noudata-stm-n-rokotelinjausta/
Long Covid may be ‘the next public health disaster’ — with a $3.7 trillion economic impact rivaling the Great Recession. CNBC. 1.12.2022. https://www.cnbc.com/2022/11/30/why-long-covid-could-be-the-next-public-health-disaster.html
December 1-10
Study of Excipients in Delayed Skin Reactions to mRNA Vaccines: Positive Delayed Intradermal Reactions to Polyethylene Glycol Provide New Insights for COVID-19 Arm (Immediate and delayed reactions to intradermal testing (IDT) are frequently detected in patients with delayed large local reactions (DLLR). The observation of positive delayed intradermal reactions to polyethylene glycol (PEG) disclosed only in patients with DLLR reinforces a possible role of PEG in the development of these reactions. Skin testing of other excipients is of little importance in clinical practice.). Vaccines. 30.11.2022. https://www.mdpi.com/2076-393X/10/12/2048#:~:text=Immediate%20and%20delayed,in%20clinical%20practice
COVID hospitalization rates in babies as bad as for seniors amid Omicron wave, study shows. Yahoo News. 30.11.2022. https://news.yahoo.com/covid-hospitalization-rates-babies-bad-140059141.html?guccounter=1
Taloustieteen professori Antti Ripatti: Pitkittyneen koronan kustannukset nousevat miljardeihin euroihin. ”En ymmärrä miksi rokottamisen kustannuksista tehdään iso ongelma, kun me voisimme keskittyä epidemian laantumiseen”, Ripatti toteaa. Mediuutiset. 30.11.2022. https://www.mediuutiset.fi/uutiset/taloustieteen-professori-antti-ripatti-pitkittyneen-koronan-kustannukset-nousevat-miljardeihin-euroihin/9919a3ea-2cac-4438-99d9-566c90b5cf3e
Current understanding of T cell immunity against SARS-CoV-2 (compared to antibodies, T cell responses are generally less affected by the mutations of SARS-CoV-2 variants.). BMC. 29.11.2022. https://inflammregen.biomedcentral.com/articles/10.1186/s41232-022-00242-6
Disruption in seasonality, patient characteristics and disparities of respiratory syncytial virus infection among young children in the US during and before the COVID-19 pandemic: 2010-2022. medRxiv. 29.11.2022. https://www.medrxiv.org/content/10.1101/2022.11.29.22282887v1
International Conference ME/CFS and Long COVID – Treatment and Rehabilitation Conference on 7th-8th October 2022, reports (en, fr) (29th Nov 2022). Suomen lääketieteellinen ME/CFS yhdistys ry. 29.11.2022. https://slme.fi/en/international-conference-me-cfs-and-long-covid-treatment-and-rehabilitation-conference-on-7th-8th-october-2022-reports-en-fr-29th-nov-2022/
Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers, Annals of Internal Medicine. 29.11.2022. https://www.acpjournals.org/doi/10.7326/M22-1966
Endemicity Is Not a Victory: The Unmitigated Downside Risks of Widespread SARS-CoV-2 Transmission (Our findings suggest large increases in virulence for SARS-CoV-2 would result in minimal loss of transmissibility, implying that the IFR may vary freely under neutral evolutionary drift. We use an SEIRS model framework to examine the effect of hypothetical changes in the IFR on steady-state death tolls under COVID-19 endemicity. Our modeling suggests that endemic SARS-CoV-2 implies vast transmission resulting in yearly US COVID-19 death tolls numbering in the hundreds of thousands under many plausible scenarios, with even modest increases in the IFR leading to unsustainable mortality burdens. Our findings highlight the importance of enacting a concerted strategy and continued development of biomedical interventions to suppress SARS-CoV-2 transmission and slow its evolution.). MDPI Covid. 28.11.2022. https://www.mdpi.com/2673-8112/2/12/121
Keski-ikää lähestyvien naisten kuolemat lisääntyneet – koronatapaukset eivät selitä kuolleisuusluvuissa havaittua kasvua. Tiukat koronarajoitukset suojasivat aluksi ikäihmisiä, mutta omikron- ja delta-muunnokset levisivät nopeasti maskeista ja käsidesistä huolimatta. Viime vuoden loppupuolella alkanut ylikuolleisuus näkyy yli 75-vuotiaissa, muttei nuoremmissa ikäluokissa joitain poikkeuksia lukuun ottamatta. Selitykset saadaan vasta, kun kuolinsyytilastot valmistuvat, mutta THL:n tutkimusprofessori Mika Gessler kertoo ennakkoarvioita. Turun Sanomat. 27.11.2022. https://www.ts.fi/uutiset/5834558
Lasse Lehtoselta täystyrmäys Mika Salmisen puheille: ”Suomessa on ollut tänä vuonna merkittävää ylikuolleisuutta, ja todennäköisin syy sille on korona”
THL:n Mika Salminen kyseenalaisti koronakuolintilastojen luotettavuuden keskustan seminaarissa. ilta=sanomat. 27.11.2022. https://www.is.fi/kotimaa/art-2000009229995.html
THL:n Mika Salminen: Tilastot antavat väärän kuvan koronakuolleisuudesta
THL:n hyvinvointivaikuttajat-osaston johtajan Mika Salmisen mukaan Suomen koronakuolleisuus on tosiasiassa EU:n keskitasolla. Suomen koronalukujen oikeellisuus on herättänyt keskustelua aikaisemminkin. ilta=sanomat.27.11.2022. https://www.is.fi/politiikka/art-2000009229475.html
Pas de purificateur d’air pour un prof, malgré un billet du médecin
En pleine pandémie, un enseignant immunosupprimé doit se débattre pour enseigner en classe. Le Journal de Quebec. 27.11.2022. https://www.journaldequebec.com/2022/08/30/pas-de-purificateur-dair-pour-un-prof-malgre-un-billet-du-medecin
Increasing ventilation reduces SARS-CoV-2 airborne transmission in schools: a retrospective cohort study in Italy’s Marche region. Frontiers Public Health. 25.11.2022. https://www.frontiersin.org/articles/10.3389/fpubh.2022.1087087/abstract#.Y44ldlUiSw0.twitter
Toinenkin korona kuormittaa merkittävästi terveydenhuoltoa
Amerikkalaistutkimuksen mukaan toinen infektio on usein lievempi, silti komplikaatioita on enemmän niillä, jotka ovat sairastaneet koronan kahdesti verrattuna kerran sairastaneisiin.. Lääkäriulehti. 25.11.2022. https://www.laakarilehti.fi/tieteessa/toinenkin-korona-kuormittaa-merkittavasti-terveydenhuoltoa/
Lifting Universal Masking in Schools — Covid-19 Incidence among Students and Staff. NEJM. 24.11.2022. https://www.nejm.org/doi/full/10.1056/NEJMoa2211029
WHO’s departing chief scientist regrets errors in debate over whether SARS-CoV-2 spreads through air. Soumya Swaminathan says the agency should have acknowledged aerosol transmission “much earlier” but is proud of work on vaccine equity. Science. 23.11.2022. https://www.science.org/content/article/who-s-departing-chief-scientist-regrets-errors-debate-over-whether-sars-cov-2-spreads
A multinational Delphi consensus to end the COVID-19 public health threat. narure. 22.11.2022. https://www.nature.com/articles/s41586-022-05398-2
THL:n kaksoisrooli vaan jatkuu. Timo Vesikariin blogi. NRN. 22.11.2022.
Intranasal COVID-19 Vaccine Disappointing in First-in-Human Trial. JAMA 22.11.2022. https://jamanetwork.com/journals/jama/fullarticle/2798745
COVID-19 Is Linked to Detectable Brain Changes, Study Shows. TIME . 21.11.2022. https://time.com/6235600/covid-19-brain-changes-linked/
Excess mortality in England. Office for Health Improvement and Disparities. 21.10.2022 (latest]. https://app.powerbi.com/view?r=eyJrIjoiYmUwNmFhMjYtNGZhYS00NDk2LWFlMTAtOTg0OGNhNmFiNGM0IiwidCI6ImVlNGUxNDk5LTRhMzUtNGIyZS1hZDQ3LTVmM2NmOWRlODY2NiIsImMiOjh9
MRI Reveals Significant Brain Abnormalities Post-COVID. Summary: Neuroimaging study reveals significant brain changes in areas associated with language comprehension, cognition, and circadian rhythm control six months after COVID-19 infection. NeurologyNeuroscience·. 21.11.2022. https://neurosciencenews.com/post-covid-brain-21904/
November 21-30
Relation between PM2.5 pollution and Covid-19 mortality in Western Europe for the 2020–2022 period. Sci Tot Environ. 20.11.2022. https://www.sciencedirect.com/science/article/pii/S0048969722046770
Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids. nature. 20.11.2022. https://www.nature.com/articles/s41392-022-01241-2
Adapt or die: how the pandemic made the shift from EBM to EBM+ more urgent. BMJ Evidence Based Medicine [EBM]. 19.11.2022. https://ebm.bmj.com/content/27/5/253
COVID-19 and Excess All-Cause Mortality in the US and 20 Comparison Countries, June 2021-March 2022 (Finland at the top). JAMA. 18.11.2022. https://jamanetwork.com/journals/jama/fullarticle/2798990
Association of National Football League Fan Attendance With County-Level COVID-19 Incidence in the 2020-2021 Season, JAMA. 18.11.2022. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2798665
Alle ned til 18 år får tilbud om booster-vaksine. Ved å tilby vaksine til flere kan noe av smitten stanses i vinter, skriver helsedepartementet. VG Nyheter. 18.11.2022. https://www.vg.no/nyheter/innenriks/i/8JpVLE/alle-ned-til-18-aar-faar-tilbud-om-booster-vaksine
Coronavirus (COVID-19) in the UK. Gov.UK.17.11.2022 [latest update] https://coronavirus.data.gov.uk/details/cases?areaType=nation&areaName=England
Improved Neutralization of Omicron BA.4/5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent BA.4/5 Vaccine. bioRxiv. 17.11.2022. https://www.biorxiv.org/content/10.1101/2022.11.17.516898v1
COVID-19 Mortality by wave. Analysis of COVID-19 Mortality by wave, with a focus on deaths occurring during the Omicron wave. Australian Bureau of Statistics. 16.11.2022. https://www.abs.gov.au/articles/covid-19-mortality-wave
Fact Check-No evidence 40% of COVID-19 deaths in Finland were fabricated. Reuters. 16.11.2022. https://www.reuters.com/article/factcheck-deaths-finland-idUSL1N32C2IR
Koronapandemia ja kollegiaalisuus. Covid-19-pandemia on asettanut yhteiskunnat ja lääkärit monella tavalla aiemmasta poikkeaviin tilanteisiin. Pandemiaa osattiin odottaa, mutta siihen ei ehkä kuitenkaan ollut varauduttu kovin hyvin, ainakaan henkisesti. Pandemiasta on vielä paljon opittavaa. Toivottavasti tätä työtä jaksetaan nöyränä kaikissa organisaatioissa tehdä. Lääkäriliitto. 15.11.2022. https://www.laakariliitto.fi/uutiskirjeet/uutiskirjeuutiset/koronapandemia-ja-kollegiaalisuus/
Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis. BMC Medicine. 15.11.2022. https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02656-y
Moderna says new booster increases protection from omicron subvariants
The latest results from the bivalent booster are encouraging even as uptake remains low. Washington Post. 14.11.2022. https://www.washingtonpost.com/health/2022/11/14/moderna-booster-shot/
Korona leviää edelleen vanhusten osastoilla: “Jostain se pääsisi livahtamaan, vaikka he olisivat lukkojen takana”, sanoo johtajalääkäri
Koronaepidemiat kuormittavat vanhustenosastoja edelleen, ja osa tartunnan saaneista kuolee. Asiantuntijat korostavat, että vanhuksen viimeiset voimat voisi viedä yhtä lailla influenssa-, noro- tai rinovirus.. Yle Uutiset. 12.11.2022. https://yle.fi/a/3-12673129
Association between vitamin D supplementation and COVID-19 infection and mortality. Scientifric Reports, 12.11.2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653496/
Health, socioeconomic and genetic predictors of COVID-19 vaccination uptake: a nationwide machine-learning study. medRxiv. 11.11.2022. https://www.medrxiv.org/content/10.1101/2022.11.11.22282213v1
Koronarokotteista syntyi nuiva sopu. Koronarokotteita ruvetaan jakamaan nykyistä laajemmalle joukolle. Se on järkevää, vaikka lisärokotteista ei välttämättä ole kovin suurta hyötyä. Helsingin Sanomat. 11.11.2022. https://www.hs.fi/paakirjoitukset/art-2000009192538.html?share=b910a4013b9a34686a68ec17cbfaebab
November 11-20
Getting COVID-19 Multiple Times Is Risky for Your Health. Time. 10.11.2022. https://time.com/6232103/covid-19-reinfections-effects/
Half a million more people are out of the labour force because of long-term sickness. Between June and August 2022, around 2.5 million people reported long-term sickness as the main reason for economic inactivity, up from around 2 million in 2019. ONS. 10.11.2022. https://www.ons.gov.uk/employmentandlabourmarket/peoplenotinwork/economicinactivity/articles/halfamillionmorepeopleareoutofthelabourforcebecauseoflongtermsickness/2022-11-10
Paxlovid-koronaviruslääke. Tällä sivulla voit arvioida, kuulutko Paxlovid-lääkehoidon piiriin ja miten sinun tulee menetellä saadaksesi lääkkeen. HUS.https://www.hus.fi/ajankohtaista/koronavirus-covid-19/paxlovid-koronaviruslaake
Repeat COVID is riskier than first infection, study finds. Reuters. 10.11.2022. https://www.reuters.com/business/healthcare-pharmaceuticals/repeat-covid-is-riskier-than-first-infection-study-finds-2022-11-10/
Modeling COVID-19 Mortality Across 44 Countries: Face Covering May Reduce Deaths (FFP2, N95, mask, surgical). AJPM. 10.11.2022. https://www.ajpmonline.org/article/S0749-3797(21)00557-2/fulltext#%20
Acute and postacute sequelae associated with SARS-CoV-2 reinfection. (Ziyad Al-Aly. In sum, in this study of 5,819,264 individuals, we provide evidence that reinfection contributes to additional health risks beyond those incurred in the first infection including all-cause mortality, hospitalization and sequelae in a broad array of organ systems. The risks were evident in the acute and postacute phases of reinfection. The evidence suggests that for people who already had a first infection, prevention of a second infection may protect from additional health risks. Prevention of infection and reinfection with SARS-CoV-2 should continue to be the goal of public health policy.) Natutre Medicine [ Long COVID ]. 10.11.2022. https://www.nature.com/articles/s41591-022-02051-3
Myocarditis after BNT162b2 Vaccination in Israeli Adolescents. NEJM. 10.11.2022. https://www.nejm.org/doi/full/10.1056/NEJMc2207270
Outcomes of SARS-CoV-2 Reinfection. Research Square. 9.11.2022. https://www.researchsquare.com/article/rs-1749502/v1
Long-lasting Symptoms After an Acute COVID-19 Infection and Factors Associated With Their Resolution. JAMA. 9.11.2022. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2798224
Korona näyttää suuntaavan kausi-infektioksi, mutta tämä vuosi on vilauttanut uusia uhkia. Apulaisprofessori Tarja Sironen painottaa tutkimuksen ja seurannan merkitystä varautumisessa uhkiin, joista apinarokko ja päästäisten paramyksovirus ovat jo käväisseet kilauttamassa hälytyskelloa. Yle Uutiset. 8.11.2022. https://yle.fi/a/3-12668289
Siperian sulavasta ikiroudasta herää ”zombieviruksia” – Voivat olla vakava uhka myös ihmisille. Viime vuosina on löytynyt suuri määrä jättiviruksia, jotka voivat aiheuttaa tuntemattomia sairauksia. Mecdiuutiset. 8.11.2022. https://www.mediuutiset.fi/uutiset/mu/7efd5b5f-4bae-4b59-a029-2e9e2629a500?
What If COVID Reinfections Wear Down Our Immunity? Dr. Anthony Leonardi is a lightning rod for debate. If he’s right, this pandemic poses a greater threat than widely assumed. The TYEE. 7.11.2022. https://thetyee.ca/Analysis/2022/11/07/COVID-Reinfections-And-Immunity/
Kommentti: THL, nyt salaliittohöpinät sikseen ja perusteellisia vastauksia esiin. Autoa pitää ajaa niin, ettei edes anna poliisille mahdollisuutta antaa sakkoja. Samalla periaatteella pitäisi THL:nkin toimia, kirjoittaa Petri Seppä (Kiurun selvityspyyntö). ilta=sanomat. 7.11.2022. https://www.is.fi/kotimaa/art-2000009183393.html
Suomessa riskiryhmille suunnatun koronalääkkeen käyttö on osoittautunut monimutkaiseksi – uusia lääkkeitä odotetaan
Rajatuille riskiryhmille tarkoitetun koronälääke Paxlovidin käyttö on osoittautunut monimutkaiseksi. Esimerkiksi HUSin alueella lääkettä on jaettu arviolta 400 potilaalle. YLE-Uutiset 6.11.2022. https://yle.fi/a/74-20003583
Paxlovid and Long Covid. A new study sheds light on a bonus benefit after the acute phase. Ground truths. 6.11.2022. https://erictopol.substack.com/p/paxlovid-and-long-covid
Effects of Different Mask Policies in 2020: A Comparative Analysis. medRxiv. 5.11.2022. https://www.medrxiv.org/content/10.1101/2022.11.04.22281935v1.full
COVID-19 Mortality Working Group: Another month of high excess mortality in July 2022 (Australia). Actuaries Digital. 4.11.2022. https://www.actuaries.digital/2022/11/04/covid-19-mortality-working-group-another-month-of-high-excess-mortality-in-july-2022/
Antibody-Activated Endothelial Cells Increase the Risk of Blood Clots with Covid-19. Forbes. 4.11.2022. https://www.forbes.com/sites/williamhaseltine/2022/03/04/antibody-activated-endothelial-cells-increase-the-risk-of-blood-clots-with-covid-19/?sh=6cc13ce419e0
A multinational Delphi consensus to end the COVID-19 public health threat (The top three recommendations focus on whole-of-society1 action and maintaining, or in some cases returning, to a vaccines-plus approach2. First, to avoid the inefficiency and ineffectiveness of fragmented efforts, pandemic preparedness and response should adopt a whole-of-society strategy that includes multiple disciplines, sectors and actors. Second, going forward, whole-of-government approaches (such as interministry coordination) can identify, review and address resilience in health systems to make them more responsive to people’s needs. Third, all countries should adopt a vaccines-plus approach, which includes a combination of COVID-19 vaccination, other prevention measures, treatment and financial incentives such as support measures. Infection rates tend to increase when governments discontinue social measures, including non-pharmaceutical interventions, regardless of the level of vaccination). nature. 3.11.2022. https://www.nature.com/articles/s41586-022-05398-2
Excess all-cause mortality in the USA and Europe during the COVID-19 pandemic, 2020 and 2021. Scientific Reports. 3.11.2022. https://www.nature.com/articles/s41598-022-21844-7
‘Immunity debt’ is a misguided and dangerous concept. There is no evidence that an individual is worse off for having avoided earlier infection. Financial Times. 3.11.2022. https://www.ft.com/content/0640004d-cc15-481e-90ce-572328305798
SARS-ANI VIS. A Global Open Access Dataset of Reported SARS-CoV-2 Events in Animals. Complexity Science Hub, Vienna. 3.11.2022. https://vis.csh.ac.at/sars-ani/
Israeli long COVID study: 1 in 3 people fail to regain regular health months later. Spotlighting the ‘immense and evolving’ impact of COVID on human health, large study by health fund points to prevalence of symptoms including memory disturbances and muscle pain. The Times of Israel. 3.11.2022. https://www.timesofisrael.com/israeli-long-covid-study-1-in-3-people-fail-to-regain-regular-health-months-later/
Terveydenhuollon ammattilaisilta hurja epäilys: Haluaako THL sairastuttaa suomalaiset koronaan? IS:n tietojen mukaan moni asiantuntija epäilee, että THL:ssä hybridi-immuniteettitutkimus ja rokotussuositus ovat sekoittuneet keskenään ja että hybridi-immuniteettitutkimus sanelee tahdin, kun rokotussuosituksia ei laajenneta muun maailman tavoin.ilta=sanomat. 3.11.2022. https://www.is.fi/kotimaa/art-2000009176414.html
Kodeissa ja sairaalassa tehty tutkimus osoittaa: ilmahygieniasta huolehtiminen kannattaa koronatartuntojen ehkäisemiseksi. HUSin, Helsingin yliopiston, Ilmatieteen laitoksen ja Työterveyslaitoksen monitieteellisissä tutkimuksissa on selvitetty SARS-CoV-2 koronaviruksen esiintymistä koti- ja sairaalaympäristössä. HUS. 4.11.2022. https://www.hus.fi/ajankohtaista/kodeissa-ja-sairaalassa-tehty-tutkimus-osoittaa-ilmahygieniasta-huolehtiminen
If You’ve Had Covid, Watch Out for Stroke Symptoms. Several studies now show an elevated risk of heart problems during and after an infection with SARS-CoV-2. Bloomberg. 3.11.2022. https://www.bloomberg.com/opinion/articles/2022-11-03/had-covid-watch-out-for-stroke-symptoms-blood-clots-heart-attacks?leadSource=uverify%20wall
Paxlovid® (nirmatrelviiri ja ritonaviiri) erityisryhmien koronavirusinfektion varhaisessa hoidossa.
Paxlovid®-lääkitys on tehokas mahdollisimman varhain COVID-19-oireiden alun jälkeen aloitettuna ja potilaille, joilla on merkittävä vaikean koronavirustaudin riski. Pirkanmaan hyvinvointialue. 2.11.2022. https://www.pirha.fi/paxlovid-koronavirusinfektion-hoidossa
Jari Litmasen terveys romahti – ”Vajosin täysin pohjalle”. Jalkapallolegenda Jari Litmanen on kärsinyt pitkittyneen koronan oireista yli kaksi vuotta. Rakkain harrastuskin jäi. Ilta=sanomat. 2.11.2022. https://www.is.fi/jalkapallo/art-2000009172164.html
COVID-19 and diabetes — where are we now? Nature Metabolism. 1.11.2022. https://www.nature.com/articles/s42255-022-00691-w#Tab1
November 1-10
Long-COVID in patients with a history of mild or asymptomatic SARS-CoV-2 infection: a Nationwide Cohort Study. Taylor & Francis Online. 31.10.2022. https://www.tandfonline.com/doi/full/10.1080/02813432.2022.2139480
Long Covid is affecting women more than men, national survey finds. CNBC. 31.10.2022. https://www.cnbc.com/2022/10/31/long-covid-is-affecting-women-more-than-men-federal-survey-finds.html
Flu season in the US hasn’t been this bad this early in more than a decade. Now is the time to get a flu shot. CNN Health. 28.10.2022. https://edition.cnn.com/2022/10/28/health/flu-season-worse-than-normal?
Influenza vaccine: morning administering improves outcomes in older adults, women. Univadis. 28.10.2022. https://www.univadis.com/viewarticle/influenza-vaccine-morning-administering-improves-outcomes-in-older-adults-women-eda8456a-1552-36d4-abc7-a205edca80ee?utm_content=5031002&sso=true&utm_medium=email&utm_term=&ecd=mkm_ret_221029_unibow_BOWGLOBAL_5031002&uac=12477BN&utm_source=&utm_campaign=best%20of%20the%20week
Head of Turkish Medical Association is arrested after calling for investigation of army. BMJ. 27.10.2022. https://www.bmj.com/content/379/bmj.o2587?
HS:n grafiikat kertovat tiedot koronavirustilanteesta. HS:n grafiikat kertovat tiedot tartunnoista, sairaalahoidossa olevista ja kuolleista niin Suomessa kuin maailmalla. Helsingin Sanomat 27.10.2022 (päivittyvä). https://www.hs.fi/kotimaa/art-2000007983110.html
Suomessa saattaa olla jo yli 100 000 pitkäkestoiseen koronaan sairastunutta, tässä ovat yleisimmät oireet: Pitkäkestoiseen covid-19-tautiin sairastuu enemmän ihmisiä kuin siitä toipuu. Siitä huolimatta diagnoosin saaminen on yhä liian vaikeata. Vaikka suurin osa paranee taudista ajan mittaan, moni joutuu palaamaan työelämään vajaakykyisenä, pieni osa menettää työkykynsä kokonaan.Aamulehti. 27.10.2022. https://www.aamulehti.fi/koronavirus/art-2000009139124.html
Lingering cardiac involvement in previously well people after mild COVID-19. nature medicine. 26.9.2022. https://www.nature.com/articles/s41591-022-02002-y
China begins administering. PBS. 26.10 2022. https://www.pbs.org/newshour/world/china-begins-administering-inhalable-covid-19-vaccine-boosters?
THL ei ole toistaiseksi kääntymässä Lapin linjoille. Nohynek: mRNA-rokotteet estävät tartuntoja vain kohtuullisesti ja lyhyen aikaa, mutta vakavan taudin riski on eri asia. 26.10.2022. Lääkärilehti. https://www.laakarilehti.fi/terveydenhuolto/thl-ei-ole-toistaiseksi-kaantymassa-lapin-linjoille/
Is the Hygiene Hypothesis True? Did Covid shutdowns stunt kids’ immune systems? (Rhinovirus and enterovirus infections … right now, avoiding flu and COVID-19 is a priority. Those are not going to help you develop a healthy immune response, and in fact, they can do a lot of damage to the lungs during that critical developmental time. Data [show] that children that have more infections in the first 6 months to a year of life go on to have more problems). Johns Hopkins. 25.10.2022. https://publichealth.jhu.edu/2022/is-the-hygiene-hypothesis-true
Living with long Covid. (LC) Over 2,000 Guardian readers told us about their long Covid fight. Here are their stories. (Protestors march outside the White House this September to call attention to those suffering from myalgic encephalomyelitis and long Covid. The chronic condition has an array of physical and neurological symptoms, but most remain misunderstood). Guardian. 25.10.2022. https://www.theguardian.com/society/2022/oct/25/long-covid-fight-guardian-readers
Näin sairaanhoitopiirit kommentoivat työntekijöiden neljänsiä koronarokotuksia – HUSin Järvinen nostaa esille itsemääräämisoikeuden
Muut sairaanhoitopiirit pitävät THL:n suosituksia sopivana, mutta työntekijöiden joukosta on tullut toiveita lisärokotuksista. YLE Uutiset- 25.10.2022. https://yle.fi/a/74-20002374
COVID-19 Surges Linked to Spike in Heart Attacks. Cedars Sinai 24.10.2022. https://www.cedars-sinai.org/newsroom/covid-19-surges-linked-to-spike-in-heart-attacks/
SARS-CoV-2 indoor environment contamination with epidemiological and experimental investigations. Indoor AIr. 24.10.2022. https://onlinelibrary.wiley.com/doi/full/10.1111/ina.13118
COVID-19 Surges Linked to Spike in Heart Attacks. Cedars Sinai. 24.10.2022. https://www.cedars-sinai.org/newsroom/covid-19-surges-linked-to-spike-in-heart-attacks/
Cardiovascular disease and mortality sequelae of COVID-19 in the UK Biobank. BMJ. 24.10.2022. https://heart.bmj.com/content/109/2/119
Antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot. bioRxiv. 24.10.2022. https://www.biorxiv.org/content/10.1101/2022.10.22.513349v1
Tutkimus: [Remdessivir] Lääkkeestä ei ollut apua koronapotilaiden toipumiseen. Joka kuudes koronaviruspotilas oli toipunut huonosti vuoden kuluttua sairaalahoidoista. Remdesiviirilääkityksestä ei ollut apua toipumiseen. Helsingin Sanomat. 24.10.2022. https://www.hs.fi/kaupunki/art-2000009154401.html
SARS-CoV-2 indoor environment contamination with epidemiological and experimental investigations (home, hospital, Finland. Indoor Air 24.10.2022. https://onlinelibrary.wiley.com/doi/full/10.1111/ina.13118
10 myyttiä koronasta: Kuukauden tilannekatsaus. (Matti Heino). Linkedin. 22.10.2022. https://www.linkedin.com/pulse/10-myytti%C3%A4-koronasta-kuukauden-tilannekatsaus-matti-heino
Pääkirjoitus. Kiurun paluu sytytti taas koronariidat. Koronariitojen uskottiin jo olevan takana, mutta sitten Krista Kiuru (sd) palasi sosiaali- ja terveysministeriöön. Helsingin Sanomat. 22.10.2022. https://www.hs.fi/paakirjoitukset/art-2000009150304.html
Effectiveness of Monovalent mRNA Vaccines Against COVID-19–Associated Hospitalization Among Immunocompetent Adults During BA.1/BA.2 and BA.4/BA.5 Predominant Periods of SARS-CoV-2 Omicron Variant in the United States — IVY Network, 18 States, December 26, 2021–August 31, 2022. CDC MMWR. 21,10,2022, https://www.cdc.gov/mmwr/volumes/71/wr/mm7142a3.htm
Dangerous new COVID-19 variants threaten massive fall-winter surge, World Socialist Web Site. 21.10.2022. https://www.wsws.org/en/articles/2022/10/21/pers-o21.html
Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19. A Randomized Clinical Trial. JAMA. 21.10.2022. https://jamanetwork.com/journals/jama/fullarticle/2797483
October 21-30
Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndrome (Our results denote an altered and chronically aroused anti-viral profile against latent viruses in ME/CFS. SARS-CoV-2 infection even in its mild/asymptomatic form is a potent trigger for reactivation of latent herpesviruses (EBV, HHV6) and endogenous retroviruses (HERV-K), as detected by antibody fingerprints locally in the oral mucosa (saliva samples).). Frontiers Immunology. 20.10.2023. https://www.frontiersin.org/articles/10.3389/fimmu.2022.949787/full
Brain cortical alterations in COVID-19 patients with neurological symptoms. Frontiers in Neuroscience. 20.10.2022. https://www.frontiersin.org/articles/10.3389/fnins.2022.992165/full
Rokotekiista repii nyt Suomea – THL ja ylilääkärit täysin eri mieltä koronan hoidosta. Neljänsien rokotusten jakaminen aiheuttaa nyt kiistaa THL:n ja ylilääkäreiden välillä. Osa lääkäreistä pitää rokotelinjaa liian tiukkana, THL taas perustelee päätöstä rokotusten vähäisillä hyödyillä.. ilta=sanomat. 20.10 2022. https://www.is.fi/kotimaa/art-2000009142699.html
Tapio Sadeojan kolumni: Kiuru vastaan THL. THL:n perivihollinen, Krista Kiuru, palasi perhe- ja peruspalveluministeriksi mielenkiintoiseen aikaan, kirjoittaa Tapio Sadeoja.ilta=sanomat. 19.10.2022. https://www.is.fi/kotimaa/art-2000009143743.html
”En ymmärrä tätä pihtausta” – Krista Kiurulta Ylellä tiukka jyrähdys koronan hoidosta. Ministeri Kiuru soimii THL:ää nykyisistä koronalinjauksista. (Kiuru ihmetteli myös, miksei kesällä Suomeen tullutta Paxlovid-koronalääkettä käytetä nykyistä laajemmin. Lääkettä on annettu 750 henkilölle, vaikka varastossa olisi 15 000 kappaletta. En ymmärrä tätä pihtausta, Kiuru jyrähti.). ilta=sanomat. 19.10.2022. https://www.is.fi/politiikka/art-2000009144445.html
Paxlovid –lääkkeen määrääminen ja luovuttaminen koronaa (COVID-19) sairastavalle avohoitopotilaille VSSHP:ssa. Ohje ammattilaiselle. Varsinais-Suomen SHP. 18.10.2022. https://hoito-ohjeet.fi/OhjepankkiVSSHP/Paxlovid%20l%C3%A4%C3%A4kkeen%20m%C3%A4%C3%A4r%C3%A4%C3%A4minen%20ja%20luovuttaminen%20koronaa%20sairastavalle%20avohoitopotilaille%20VSSHPssa.pdf
Estimate: 10.5 Million Children Lost a Parent, Caregiver to COVID-19. JAMA Network. 18.10.2022. https://jamanetwork.com/journals/jama/fullarticle/2797407
Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial. nature communications. 18.10.2022. https://www.nature.com/articles/s41467-022-33825-5
SARS-CoV-2 vaccine and increased mýocarditis mortality risk: A poipulation based comparative study in Japan. medRxiv.18.10.2022. extension://elhekieabhbkpmcefcoobjddigjcaadp/https://www.medrxiv.org/content/medrxiv/early/2022/10/18/2022.10.13.22281036.full.pdf
If you had COVID, several of your organs could be aging 3-4 years faster, study shows, “You can start thinking about getting COVID as almost as an accelerant to aging,” Dr. Ziyad Al-Aly said. Eyewitness News. 18.10.2022. https://abc7.com/covid-study-organs-aging-covid19-long-haul/12340914/
Fauci urges US to resume long Covid research funding efforts.
Top disease expert warns against prematurely declaring victory over pandemic in interview with the Guardian (LC) Guardian. 17.10.2022. https://www.theguardian.com/society/2022/oct/17/fauci-us-funding-research-long-covid-cdc
Dr Anthony Fauci: long Covid is an ‘insidious’ public health emergency
Dr Anthony Fauci: ‘We’ve hit a wall when it comes to further resources for Covid, including long Covid.’ Composite: Exclusive: America’s top disease expert speaks to the Guardian about the dangers of long Covid and urges US Congress to avoid complacency (LC) Guardian. 17.10.2022. https://www.theguardian.com/society/2022/oct/17/fauci-interview-long-covid-risk-emergency-response-coronavirus
Can long Covid research unlock other great medical mysteries of our time?
Attention and funding for research into mononucleosis, HIV, Lyme, Ebola, Sars and other infections have historically been limited – but long Covid changed that. (LC) Guardian. 17.10.2022. https://www.theguardian.com/society/2022/oct/17/long-covid-research-unlock-medical-mysteries
Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales. Lancet. 15.10.2022. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01656-7/fulltext
IL: Ministeri Krista Kiurun mukaan koronalääkkeiden käyttöä pitäisi lisätä
Kiurun mukaan Suomessa pitäisi ylipäätään varautua koronatilanteen pahenemiseen syksyn ja talven aikana. Helsingin Sanomat. 15.10.2022. https://www.hs.fi/politiikka/art-2000009137337.html
Comparison of pandemic excess mortality in 2020–2021 across different empirical calculations. Environmental Research. NN.10.2022. https://www.sciencedirect.com/science/article/pii/S0013935122010817?via%3Dihub
Poliisi otti kiinni koronakieltäjäkoplan johtajan: Ryhmä yritti syöstä Saksan sisällissodan tilaan tuhoamalla sähkövoimaloita, suunnitteli myös ministerin kaappaamista. MTV Uutiset. 13.10.2022. https://www.mtvuutiset.fi/artikkeli/poliisi-otti-kiinni-koronakieltajakoplan-johtajan-ryhma-yritti-syosta-saksan-sisallissodan-tilaan-tuhoamalla-sahkovoimaloita-suunnitteli-myos-ministerin-kaappaamista/8548540#gs.j3apjz
Kooste koronarokotteiden haittavaikutusilmoituksista. FIMEA Päivitetty 13.10.2022, seuraava päivitys joulukuussa 2022. https://www.fimea.fi/tietoa_fimeasta/koronavirus-covid-19-/koronarokotteiden-haittavaikutusilmoitukset/kooste-koronarokotteiden-haittavaikutusilmoituksista
WHO:n pääjohtajalta kovaa puhetta long covidista: ”Kymmenien miljoonien elämä tuhoutunut”. Maailman terveysjärjestö vaatii valtioita aloittamaan kiireelliset toimet ”erittäin vakavan” kriisin kukistamiseksi. ilta=sanomat.12.10.2022. https://www.is.fi/ulkomaat/art-2000009131106.html
WHO chief urges immediate action to tackle ‘devastating’ long Covid.
Exclusive: Dr Tedros Adhanom Ghebreyesus calls for ‘sustained’ efforts to help people still experiencing ‘prolonged suffering’ (LC) . Guardian. 12.10.2022. https://www.theguardian.com/society/2022/oct/12/long-covid-who-tedros-adhanom-ghebreyesus?CMP=Share_iOSApp_Other
Flunssavirukset leviävät ensisijaisesti ilman välityksellä. Nykyisen tiedon valossa käsien ja pintojen rooli kaikkien flunssavirusten tartunnan välittäjinä on vähäinen. Helsingin Sanomat. 11.10.2022. https://www.hs.fi/mielipide/art-2000009099911.html?share=c57d8aeba9b3ef277b6e99080d8d1925
October 11-20
Brain microstructural changes and fatigue after COVID-19 (Cognitive). Frontiers in Neurology. 10.11.2022. https://www.frontiersin.org/articles/10.3389/fneur.2022.1029302/full
Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021. (Long Covid) JAMA. 10.10.2022. https://jamanetwork.com/journals/jama/fullarticle/2797443
COVID-19 Symptoms and Duration of Rapid Antigen Test Positivity at a Community Testing and Surveillance Site During Pre-Delta, Delta, and Omicron BA.1 Periods. JAMA. 10.10.2022. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2797070?
Misrepresentation and Nonadherence Regarding COVID-19 Public Health Measures. JAMA 10.10.2022. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2797071
Hanna Nohynek WHO:n strategisen rokotusasiantuntijaryhmän puheenjohtajaksi. Kolmen vuoden kausi tarjoaa aitiopaikan maailmanlaajuiseen vaikuttamiseen. Lääkärilehti 7.10.2022. https://www.laakarilehti.fi/terveydenhuolto/hanna-nohynek-who-n-strategisen-rokotusasiantuntijaryhman-puheenjohtajaksi/
The neurobiology of long COVID. Neuron/Cell. 6.10.2022. https://www.cell.com/neuron/fulltext/S0896-6273(22)00910-2
Long COVID is still disabling millions of Americans (Share of Americans with long COVID who also reported significant activity limitations, by race). AXIOS. 6.10.2022. https://www.axios.com/2022/10/06/long-covid-cdc-data-disabling
Strokes, heart attacks, sudden deaths: Does America understand the long-term risks of catching COVID? Fortune. 6.10.2022. https://fortune.com/2022/10/06/strokes-heart-attacks-sudden-death-america-long-term-risks-catching-covid-carolyn-barber/
Millaisen suojan vuoden alussa saatu kolmas koronarokote antaa tällä hetkellä? – THL:n Hanna Nohynek vastaa. Suomenmmaa. 4.10.2022. https://www.suomenmaa.fi/uutiset/millaisen-suojan-vuoden-alussa-saatu-kolmas-koronarokote-antaa-talla-hetkella-thln-hanna-nohynek-vastaa/
Protective effectiveness of prior SARS-CoV-2 infection and hybrid immunity against Omicron infection and severe disease: a systematic review and meta-regression. medRxiv. 4.10.2022. https://www.medrxiv.org/content/10.1101/2022.10.02.22280610v1
Will there be a COVID winter wave? What scientists say
Emerging variants and waning immunity are likely to push infection rates higher in the Northern Hemisphere as influenza also makes a comeback. na<ture. 3.10.2022. https://www.nature.com/articles/d41586-022-03157-x
Study Reveals Main Target of COVID-19 in Brain and Describes Effects of Virus on Nervous System.
Summary: SARS_CoV_2, the virus responsible for COVID-19 infects and replicates in astrocytes, reducing neural viability. Neuroscience News. 1.10.2022. https://neurosciencenews.com/covid-19-astrocytes-21569/
October 1-10
Excess risk for acute myocardial infarction mortality during the COVID-19 pandemic. [The excess death was most pronounced for the (25–44 years) aged decedents, 23% to 34%] J Med Virology. 29.9.2022. https://onlinelibrary.wiley.com/doi/10.1002/jmv.28187
Why you might be more likely to get long Covid if you ‘power through’ when you get virus
‘Treating Covid like a cold and thinking in 48 hours you’re ‘good to go’ is wrong. If it was me, I just wouldn’t dare.’ iNews 29.9.2022. https://inews.co.uk/news/science/likely-long-covid-rest-testing-positive-1884942
Unlike flu, COVID-19 attacks DNA in the heart: new research. brisbane times. 29.9.2022. https://www.brisbanetimes.com.au/national/queensland/unlike-flu-covid-19-attacks-dna-in-the-heart-new-research-20220929-p5bm10.html
SARS-CoV-2 infection in hamsters and humans result in lasting and unique systemic perturbations after recovery. Science Translational Medicine. 28.9.2022. https://www.science.org/doi/epdf/10.1126/scitranslmed.abq3059
SARS-CoV-2, long COVID, prion disease and neurodegeneration. Front Neurosci. 27.9.2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551214/
WHO julkaisi uudet suositukset long covidin hoitoon – Risto O. Roine: ”Ohjeistus ei tue koronan jälkitilojen käsittelyä toiminnallisena häiriönä”. WHO ei ota kantaa siihen, miten laajoja tutkimuksia potilaat tarvitsevat. Mediiuutiset 26.9.2022. https://www.mediuutiset.fi/uutiset/who-julkaisi-uudet-suositukset-long-covidin-hoitoon-risto-o-roine-ohjeistus-ei-tue-koronan-jalkitilojen-kasittelya-toiminnallisena-hairiona/3be9bbb5-e880-4b6e-bf6a-dcbdca3bb278
Impact of cross-coronavirus immunity in post-acute sequelae of COVID-19.medRxiv. 25.9.2022. https://www.medrxiv.org/content/10.1101/2022.09.25.22280335v1
Association of SARS-CoV-2 Infection With New-Onset Type 1 Diabetes Among Pediatric Patients From 2020 to 2021. JAMA. 23.9.2022. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2796649
‘I’m Dropping My COVID Hubris,’ Vows a Top Immunologist. After the virus harmed Chris Goodnow’s heart, he joined a growing chorus against reinfection complacency. (LC) TYEE. 23.9.2022. https://thetyee.ca/Analysis/2022/09/23/Top-Immunologist-Dropping-COVID-Hubris/
COVID raises risk of long-term brain injury, large U.S. study finds. KSL.com. 23.9.2022. https://www.ksl.com/article/50481186/covid-raises-risk-of-long-term-brain-injury-large-us-study-finds
Long-term neurologic outcomes of COVID-19 (Here we use the national healthcare databases of the US Department of Veterans Affairs to build a cohort of 154,068 individuals with COVID-19, 5,638,795 contemporary controls and 5,859,621 historical controls; we use inverse probability weighting to balance the cohorts, and estimate risks and burdens of incident neurologic disorders at 12 months following acute SARS-CoV-2 infection. Our results show that in the postacute phase of COVID-19, there was increased risk of an array of incident neurologic sequelae including ischemic and hemorrhagic stroke, cognition and memory disorders, peripheral nervous system disorders, episodic disorders (for example, migraine and seizures), extrapyramidal and movement disorders, mental health disorders, musculoskeletal disorders, sensory disorders, Guillain–Barré syndrome, and encephalitis or encephalopathy. We estimated that the hazard ratio of any neurologic sequela was 1.42 (95% confidence intervals 1.38, 1.47) and burden 70.69 (95% confidence intervals 63.54, 78.01) per 1,000 persons at 12 months. The risks and burdens were elevated even in people who did not require hospitalization during acute COVID-19. Limitations include a cohort comprising mostly White males.). nature medicine. 22.9.2022. https://www.nature.com/articles/s41591-022-02001-z
Long covid—an update for primary care. the BMJ 22.9.2022. https://www.bmj.com/content/378/bmj-2022-072117
COVID-19 associated with increase in new diagnoses of type 1 diabetes in youth, by as much as 72 percent, study finds (Children who were infected with COVID-19 show a substantially higher risk of developing type 1 diabetes (T1D), according to a new study that analyzed electronic health records of more than 1 million patients ages 18 and younger.). Science Daily. 23.9.2022. https://www.sciencedaily.com/releases/2022/09/220923121735.htm
SARS-CoV-2 infection and subsequent risk of type 1 diabetes in 1.2 million children. (We identified a total of 424,354 children with SARS-CoV-2 infection (of 1,202,174 children included at study start) and 990 incident cases of type 1 diabetes. The adjusted HR for type 1 diabetes at least 31 days after SARS-CoV-2 infection was 1.63 (95% CI 1.08, 2.47) in a test-negative design and 1.57 (95% CI 1.06, 2.33) in the full-cohort) EASD 2022 Stockholm. 23.9.2022. https://drive.google.com/file/d/1boUjb_pUNVcKm02Moh3jXburmTk2j-iR/view
Association of SARS-CoV-2 Infection With New-Onset Type 1 Diabetes Among Pediatric Patients From 2020 to 2021. (At 1, 3, and 6 months after infection, risk of diagnosis of T1D was greater among those infected with SARS-CoV-2 compared with those with non–COVID-19 respiratory infection (1 month: HR, 1.96 [95%CI, 1.26-3.06]; 3 months: HR, 2.10 [95% CI, 1.48-3.00]; 6 months: HR, 1.83 [95% CI, 1.36-2.44]) and in subgroups of patients aged 0 to 9 years, a group unlikely to develop type 2 diabetes, and 10 to 18 years). JAMA. 23.9.2022. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2796649
COVID-19 infections increase risk of long-term brain problems. Strokes, seizures, memory and movement disorders among problems that develop in first year after infection. Washington Univ School of Medicine. 22.9.2022. https://medicine.wustl.edu/news/covid-19-infections-increase-risk-of-long-term-brain-problems/
Yhä melkoinen mysteeri. Pitkän koronan syntymekanismia ei vieläkään tunneta. Siihen ei ole myöskään parantavaa hoitoa. Suomessa tutkimusta ja hoitoa ovat hidastaneet rahapula ja sairauden vähättely. Suomen Kuvalehti. 22.9.2022. https://suomenkuvalehti.fi/tiede-ja-teknologia/koronan-loytymisesta-on-pian-kolme-vuotta-silti-pitka-korona-hammentaa-yha-tutkijoita/
Long-term neurologic outcomes of COVID-19 [Here we use the national healthcare databases of the US Department of Veterans Affairs to build a cohort of 154,068 individuals with COVID-19, 5,638,795 contemporary controls and 5,859,621 historical controls; we use inverse probability weighting to balance the cohorts, and estimate risks and burdens of incident neurologic disorders at 12 months following acute SARS-CoV-2 infection. Our results show that in the postacute phase of COVID-19, there was increased risk of an array of incident neurologic sequelae including ischemic and hemorrhagic stroke, cognition and memory disorders, peripheral nervous system disorders, episodic disorders (for example, migraine and seizures), extrapyramidal and movement disorders, mental health disorders, musculoskeletal disorders, sensory disorders, Guillain–Barré syndrome, and encephalitis or encephalopathy. We estimated that the hazard ratio of any neurologic sequela was 1.42 (95% confidence intervals 1.38, 1.47) and burden 70.69 (95% confidence intervals 63.54, 78.01) per 1,000 persons at 12 months. The risks and burdens were elevated even in people who did not require hospitalization during acute COVID-19. Limitations include a cohort comprising mostly White males.]. naturemedicine. 22.9.2022. https://www.nature.com/articles/s41591-022-02001-z#Fig3
Hybrid immunity and strategies for COVID-19 vaccination, Lancet Infectious Diseases. 21.9.2022. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00640-5/fulltext
September 21-30
Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales. CIRCULATION. 19.9.2022. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.060785
I’ve had COVID and am constantly getting colds. Did COVID harm my immune system? Am I now at risk of other infectious diseases? Conversation 18.9.2022. https://theconversation.com/ive-had-covid-and-am-constantly-getting-colds-did-covid-harm-my-immune-system-am-i-now-at-risk-of-other-infectious-diseases-188899
COVID-19 increases risk of developing Alzheimer’s by 50-80% in older adults. News-Medical.Life Sciences. 18.9.2022. https://www.news-medical.net/news/20220918/COVID-19-increases-risk-of-developing-Alzheimers-by-50-8025-in-older-adults.aspx
Dreaded Side Effect Rears Its Ugly Head in Latest COVID Variant.
Scientists agree that we’re not doing enough to address a “silent” COVID crisis that seems to be spiraling out of control. Daily Beast. 18.9.2022. https://www.thedailybeast.com/scientists-warn-of-spike-in-long-covid-cases-across-the-united-states
Pääkirjoitus: Toiminnallisen häiriön leima haittaa long covidin ja ME-taudin hoitoa. Pitkäkestoinen korona muistuttaa oirekuvaltaan hyvin paljon ME/CFS-tautia. ME/CFS-potilaat ovat kertoneet vuosien ajan vähättelystä ja epäasiallisesta kohtelusta terveydenhuollossa. Toivottavasti tämä ei toistu long covid -potilaiden kohdalla, kirjoittaa Mediuutisten toimituspäällikkö Erpo Pakkala. Mediuutiset. 16.9.2022. https://www.mediuutiset.fi/debatti/toiminnallisen-hairion-leima-haittaa-long-covidin-ja-me-taudin-hoitoa/0c3a8976-461a-4012-b16c-1e5d62ab3185
Hundreds of Americans Will Die From COVID Today. Is this what normal now looks like? Atlantic 16.9.2022. https://www.theatlantic.com/health/archive/2022/09/us-daily-covid-death-numbers-statistics/671453/
A survey of COVID-19 in public transportation: Transmission risk, mitigation and prevention (This article presents a comprehensive survey of the current research on COVID-19 transmission mechanisms and how they relate to public transport. We critically assess literature through a lens of disaster management and survey the main transmission mechanisms, forecasting, risks, mitigation, and prevention mechanisms. Social distancing and control on passenger density are found to be the most effective mechanisms.). Multimodal Transportation. Sept. 2022. https://www.sciencedirect.com/science/article/pii/S2772586322000302
Cognitive impairment in people with previous COVID-19 infection: A scoping review. Cortex. Sept. 2022. https://www.sciencedirect.com/science/article/pii/S0010945222001691?via%3Dihub
The incidence of congenital anomalies in newborns before and during the Covid-19 pandemic (The incidence of congenital birth anomalies are significantly increased during Covid-19 pandemic compared with before Covid-19 (P value < 0.00001). The number of all types of anomalies has increased in the current pandemic, but the congenital anomalies of the central nervous system (P value = 0.04) and Genitourinary (P value = 0.03) have a larger contribution than before.). Italian Journal of Pediatrics. 15.9.2022. https://ijponline.biomedcentral.com/articles/10.1186/s13052-022-01368-6
Is covid-19 settling into a pattern? BMJ 15.9.2022. https://www.bmj.com/content/378/bmj.o2183?utm_source=etoc&utm_medium=email&utm_campaign=tbmj&utm_content=weekly&utm_term=20220916
THE IMPACTS OF COVID-19 ILLNESSES ON WORKERS. [lost participation in production and lost income, Sociodemographics and economics]. NBER Working Paper 30435. NATIONAL BUREAU OF ECONOMIC RESEARCH . Sept. 2022. w30435.pdf (nber.org)
Viruses may be ‘watching’ you – some microbes lie in wait until their hosts unknowingly give them the signal to start multiplying and kill them. Conversation 15.9.2022. https://theconversation.com/viruses-may-be-watching-you-some-microbes-lie-in-wait-until-their-hosts-unknowingly-give-them-the-signal-to-start-multiplying-and-kill-them-189949
HS:n grafiikat kertovat tiedot koronavirustilanteesta. HS:n grafiikat kertovat tiedot tartunnoista, sairaalahoidossa olevista ja kuolleista niin Suomessa kuin maailmalla. Helsingin Sanomat. 15.9.2022. https://www.hs.fi/kotimaa/art-2000007983110.html
Pitkittyneet hermosto-oireet joskus hankalia: Korona heikentää tutkitusti aivoterveyttä (Risto O Roine. Pitkittynyt korona- eli covid-19-infektio on tällä hetkellä työikäisen väestön keskeinen aivoterveyttä heikentävä tekijä. Tiedetään, että Iso-Britanniassa noin kolme prosenttia koko väestöstä sairastaa pitkittynyttä koronatautia, Yhdysvalloissa lukema on vieläkin suurempi. Kun otetaan lukuun se tosiseikka, että sairastuneiden enemmistö on pääosin työikäisiä, niin kyseessä on merkittävä kansanterveydellinen ongelma.). Aivoliitto. 14.9.2022. https://www.aivoliitto.fi/aivoterveys/artikkelit/pitkittyneet-hermosto-oireet-joskus-hankalia-korona-heikentaa-tutkitusti-aivoterveytta/#8095c4f8
Association of COVID-19 with New-Onset Alzheimer’s Disease (Risk factor for developing Alzheimer’s disease increases by 50-80% in older adults who caught COVID-19.) Journal of Altzheimers’ Disease. 13.9.2022. https://content.iospress.com/articles/journal-of-alzheimers-disease/jad220717
Saline nasal irrigation after COVID-19 diagnosis reduces hospitalization. News Medical. 13.9.2022. https://www.news-medical.net/news/20220913/Saline-nasal-irrigation-after-COVID-19-diagnosis-reduces-hospitalization.aspx
Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity. Molecular Therapy Nucleic Acids 13.9.2022. https://www.sciencedirect.com/science/article/pii/S216225312200230X
One of Long COVID’s Worst Symptoms Is Also Its Most Misunderstood
Brain fog isn’t like a hangover or depression. It’s a disorder of executive function that makes basic cognitive tasks absurdly hard. Atlantic 12.9.2022. https://www.theatlantic.com/health/archive/2022/09/long-covid-brain-fog-symptom-executive-function/671393/
September 11-20
Tartuntojen torjunta ja unohtunut ennakointi. Matti Heino, Käyttäytymisarkkitehtuuri blog. 31.8.2023. https://mattiheino.com/2023/01/16/tartuntojen-torjunta/
The Lancet Commission on lessons for the future from the COVID-19 pandemic. Lancet. 10.9.2022. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01585-9/fulltext
Jopa 70 prosenttia suomalaista on sairastanut koronan – tällainen on suoja uutta tartuntaa vastaan [THL Salminen]. MTV Uutiset. 9.9.2022. https://www.mtvuutiset.fi/artikkeli/jopa-70-prosenttia-suomalaista-on-sairastanut-koronan-tallainen-on-suoja-uutta-tartuntaa-vastaan/8508018
Heart inflammation among most common long COVID conditions in children.. Denver7. 8.9.2022. https://www.denver7.com/news/national/heart-inflammation-among-most-common-long-covid-conditions-in-children
Yhdysvaltalaistutkijat ovat löytäneet uuden vasta-aineen, joka voi nujertaa kaikki koronaviruksen muunnokset. Jos löydös päätyy rokotteeksi, se olisi tutkijoiden mukaan oikea rokotteiden Graalin malja. MTV Uutiset. 8.9.2022. https://www.mtvuutiset.fi/artikkeli/tutkijoilta-mullistava-loyto-vasta-aine-joka-voi-nujertaa-kaikki-koronaviruksen-muunnokset/8508044
What scientists have learnt from COVID lockdowns. Restrictions on social contact stemmed disease spread, but weighing up the ultimate costs and benefits of lockdown measures is a challenge. nature. 7.9.2022. https://www.nature.com/articles/d41586-022-02823-4
Critical pediatric neurological illness associated with COVID-19 (Omicron BA.2.3.7 variant) infection in Taiwan: immunological assessment and viral genome analysis in tertiary medical center (The new mutation in the S protein, which had not previously been observed but was discovered in this study, potentially explains the sudden increase in incidence of extremely adverse neurological symptoms in pediatric patients.) . Int J Infect Dis. 7.9.2022. https://www.ijidonline.com/article/S1201-9712(22)00500-8/fulltext#%20
Persistent cardiac symptoms in individuals with mild initial COVID-19. Medical News 7.9.2022. https://www.news-medical.net/news/20220907/Persistent-cardiac-symptoms-in-individuals-with-mild-initial-COVID-19.aspx
Koronaa ei kannata sairastaa uudestaan. Uusintainfektiot lisäävät niin kuoleman kuin sairaalahoitoon joutumisen riskiä pitkään akuutin taudin jälkeen, kertoo vertaisarvioimaton amerikkalaistutkimus.. Lääkärilehti. 5.9.2022. https://www.laakarilehti.fi/terveydenhuolto/koronaa-ei-kannata-sairastaa-uudestaan/
The Swedish Deception – Report. Internal emails from FOI’s question the integrity of the Swedish strategy (It’s difficult to know the extent to which one country influenced another, perhaps some found the confirmation bias they were looking for in those with similar strategy ideas. We do know that representatives of other countries, for example Sweden’s Anders Tegnell lobbied other countries to adopt his strategy throughout the pandemic, even meeting with the UK Government later in 2020. Tegnell had come under criticism early on after emails showed the epidemiologist in charge of Sweden’s strategy appearing to ask whether a higher death rate among older people might be acceptable if it led to faster herd immunity. Tegnell insists the Swedish objective was not to achieve herd immunity but rather to slow the spread of covid enough for health services to cope, however its emerged through freedom of information requests that Tegnell had deleted some of his official emails leaving gaps in the evidence trail. Lobbing for mass infection: While Swedish authorities claim they weren’t actively pursuing herd immunity, it doesn’t appear that way when looking at some of Tegnell and his colleagues lobbying in other countries during 2020). Counter Disinformation Project. 5.9.2022. https://counterdisinformationproject.substack.com/p/the-swedish-deception-report?sd=pf
Koronatilanteessa yllätyskäänne – ylilääkäri (Asko Järvinen): ”Tässä on ollut tuomiopäivän julistajia”. Koronatapausten määrä on syksyllä kääntynyt laskuun, vaikka toisin kesällä pelättiin. Iltalehti 5.9.2022. https://www.iltalehti.fi/terveysuutiset/a/31bd58ab-4d0d-4843-879a-3467ad5c75cc
Ministeriö valmistelee lakiesitystä potilaiden hengen turvaamiseksi – ministeri Aki Lindén toivoo nopeaa sopua hoitajien työkiistaan
Tehyn puheenjohtaja Millariikka Rytkönen sanoi osanneensa odottaa lain valmistelua. Sosiaali- ja terveysministeriö valmistelee nyt pikavauhdilla lakiesitystä potilasturvallisuuden varmistamiseksi työtaistelutoimien varalta. Yle Uutiset 2.9.2022. https://web.archive.org/web/20220905014625/https://yle.fi/uutiset/3-12606972
Long COVID Blood Test Receives European Approval. A diagnostic test for long COVID is set for distribution this month after receiving European approval. Medscape UK. 02.09.2022. https://web.archive.org/web/20220905010947/https://www.medscape.co.uk/viewarticle/long-covid-blood-test-receives-european-approval-2022a10022cg
September 1-10
Covid Inquiry. How covid-19 spreads: narratives, counter narratives, and social dramas (Key messages – United Kingdom
-A flawed narrative that SARS-CoV-2 was transmitted by droplets rather than being airborne became entrenched early in the pandemic
-Measures aimed at an assumed droplet pathogen (handwashing, surface cleansing, physical distancing) were over-emphasised
-Measures to reduce airborne transmission (improving indoor air quality, reducing indoor crowding and time spent indoors, and high-grade respiratory protection) were under-emphasised
-UK policy makers seemed to favour narratives from a narrow group of scientific advisers
-Consequences included care home deaths, mission critical delays in public masking, and avoidable infections of healthcare workers.). BMJ. 31.8.2022. https://www.bmj.com/content/378/bmj-2022-069940
The physics of respiratory particle generation, fate in the air, and inhalation (Lidia Morawska) nature reviews, physics. 31.8.2022. https://www.nature.com/articles/s42254-022-00506-7
Assessment of Clinical and Virological Characteristics of SARS-CoV-2 Infection Among Children Aged 0 to 4 Years and Their Household Members. JAMA 31.8.2022. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2795801?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=wklyforyou&utm_term=083122
Heikki Hiilamon kolumni: Korona-aika lietsoi professorikunnassa erikoisen ilmiön – tieteentekijät mestaroivat alalla, jota eivät tunne
Suutari pysyköön lestissään, kehottaa vanha sananlasku. Samaa voisi suositella professorikunnalle. Korona-aika opetti, että kun tieteentekijä ryhtyy kansalaisaktiiviksi, lopputulos ei ole tiedettä. Yle Uutiset. 31.8.2022. https://yle.fi/a/3-12597842
Heterogeneity in vaccinal immunity to SARS-CoV-2 can be addressed by a personalized booster strategy (…viral evolution can be expected to impact the effectiveness of vaccinal protection against severe disease, particularly for individuals with a shorter duration of immune response. One possible solution to immune heterogeneity may be more frequent boosting for individuals with a weaker immune response. A model-based approach to targeted boosting that involves the use of the ECLIA RBD assay to identify individuals whose immune response is insufficient for protection against severe disease. Vaccinal protection against severe disease is not assured and provides a path forward to reducing the risk to immunologically vulnerable individuals.). medRxiv. 30.8.2022. https://www.medrxiv.org/content/10.1101/2022.08.30.22279397v1
Graafi näyttää: Näin selkeää ylikuolleisuutta korona on Suomessa tänä vuonna aiheuttanut – muutos alkoi viime syksynä. Koronavirusepidemia on aiheuttanut ylikuolleisuutta Suomessa vuoden alusta alkaen. Ilta=Sanomat. 29.8.2022. https://www.is.fi/kotimaa/art-2000009030883.html
Sairastitko koronan? Tästä syystä joudut odottamaan neljättä rokotetta – THL:n Hanna Nohynek kertoo, miksi Suomi toimii toisin kuin WHO ja EU suosittavat (Nohynekin mukaan WHO:n ja ECDC:n suositukset eivät ole sinänsä virheellisiä: – Kansainvälisissä suosituksissa on myös mukana käytännön näkökulma ja politiikkaa. Kustannus-vaikuttavuusanalyysejä ei näissä suosituksissa ole otettu huomioon, hän sanoo.). APU. 26.8.2022. https://www.apu.fi/artikkelit/miksi-koronan-sairastanut-ei-saa-neljatta-rokotetta-thl-vastaa
Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests. Cell. 26.8.2022. https://www.cell.com/cell/fulltext/S0092-8674(22)01044-3#%20
The chronification of post-COVID condition associated with neurocognitive symptoms, functional impairment and increased healthcare utilization. Scientific reports. 25.8.2022. https://www.nature.com/articles/s41598-022-18673-z
Long-Covid: Causing “Long-Term Impact” On Australia’s Workforce Productivity. (31,000 Aussies taking sick days. With 12 per cent of people absent from work due to long-Covid, Treasurer Jim Chalmers said coronavirus has delivered ongoing ramifications. “Covid is having a long-term impact on the productivity of our workforce.”). Hit. 25.8.2022. https://www.hit.com.au/story/long-covid-causing-long-term-impact-on-australia-s-workforce-productivity-206788
Persistence, prevalence, and polymorphism of sequelae after COVID-19 in unvaccinated, young adults of the Swiss Armed Forces: a longitudinal, cohort study (LoCoMo). Lancet Infectious Diseases. 25.8.2022. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00449-2/fulltext
Saksa varautuu pahenevaan koronatilanteeseen – palauttaa maskipakon
Saksa palauttaa maskipakon pitkän matkan matkustamiseen, sairaala- ja hoitokotivierailuihin lokakuusta alkaen. Maa valmistuu näin syksyllä ja talvella pahenevaan koronatilanteeseen. Maskipakon lisäksi hallitus kaavailee koronatestipakkoa henkilöille, jotka työskentelevät sairaaloissa ja hoitokodeissa. Tällä hetkellä N-95-tyyppiset kasvomaskit ovat pakollisia lentokoneissa ja julkisissa liikenteissä. Maskipakkoa on tarkoitus jatkaa huhtikuuhun 2023 saakka. Yle Uutiset 24.8.2022. https://yle.fi/a/3-11942036/64-3-102551
Could tiny blood clots cause long COVID’s puzzling symptoms?
Scientists debate evidence for a micro-clot hypothesis that has some people pursuing potentially risky treatments. nature. 24.8.2022. https://www.nature.com/articles/d41586-022-02286-7
Milloin liki vuosi sitten rokotettu lääkäri saa boosterin? THL vetoaa pitkäkestoiseen suojaan vakavaa koronatautia vastaan ja hybridi-immuniteettiin. Lääkärilehti. 24.8.2022. https://www.laakarilehti.fi/terveydenhuolto/milloin-liki-vuosi-sitten-rokotettu-laakari-saa-boosterin/?utm_medium=newsletter
Coronavirus World Map: Tracking the Global Outbreak. New York Times. Accessed 24.8.2022. https://www.nytimes.com/interactive/2021/world/covid-cases.html
Fragmented outbreak data will lead to a repeat of COVID-19. To break the vicious cycle of patchy understanding and poor virus control, we need to talk about privacy. nature. 23.8.2022. https://www.nature.com/articles/d41586-022-02268-9
Työsuojelun yhteistoiminta ja riskien arvioinnin päivitys on edelleen tärkeää.
Koulujen alettua myös erilaiset tartuntataudit ovat levinneet. OAJ muistuttaa, että korona edellyttää edelleen muun muassa riskien arviointia päiväkodeissa, kouluissa ja oppilaitoksissa. OAJ. 23.8.2022. https://www.oaj.fi/ajankohtaista/uutiset-ja-tiedotteet/2022/tyosuojelun-yhteistoiminta-ja-riskienarvioinnin-paivitys-on-edelleen-tarkeaa/
Distinguishing features of Long COVID identified through immune profiling (Marked differences were noted in specific circulating myeloid and lymphocyte populations relative to matched control groups, as well as evidence of elevated humoral responses directed against SARS-CoV-2 among participants with Long COVID. Further, unexpected increases were observed in antibody responses directed against non-SARS-CoV-2 viral pathogens, particularly Epstein-Barr virus. Analysis of circulating immune mediators and various hormones also revealed pronounced differences, with levels of cortisol being uniformly lower among participants with Long COVID relative to matched control groups). medRxiv. 9.8.2022. https://www.medrxiv.org/content/10.1101/2022.08.09.22278592v1
Clinical Features and Burden of Postacute Sequelae of SARS-CoV-2 Infection in Children and Adolescents. JAMA Network. 22.8.2022. https://jamanetwork.com/journals/jamapediatrics/fullarticle/2795569
Children’s Risk of Suicide Increases on School Days. Unlike in adults, suicide risk among children is lowest during the summer and higher during the school year. Understanding these patterns can help prevent and treat suicidality. Scientific American. 22.8.2022. https://www.scientificamerican.com/article/childrens-risk-of-suicide-increases-on-school-days/
Ylilääkäri: Jos olet kipeä, sinulla on todennäköisesti korona. Verkkouutiset. 22.8.2022. https://www.verkkouutiset.fi/a/ylilaakari-jos-olet-kipea-sinulla-on-todennakoisesti-korona/#1debac39
Rates of COVID-19 Cases and Deaths by Vaccination Status. CDC COVID Data Tracker. Accessed 22.8.2022. https://covid.cdc.gov/covid-data-tracker/#rates-by-vaccine-status
Apinarokko. THL. Accessed 22.8.2022. https://thl.fi/fi/web/infektiotaudit-ja-rokotukset/taudit-ja-torjunta/taudit-ja-taudinaiheuttajat-a-o/apinarokko
What were the historical reasons for the resistance to recognizing airborne transmission during the COVID-19 pandemic (Jimenez, Morawska, et al.)? Indoor Air. 21.8.2022. https://onlinelibrary.wiley.com/doi/10.1111/ina.13070
August 21-31
The NHS is being squeezed in a vice. Financial Times. 20.8.2022. https://www.ft.com/content/f36c5daa-9c14-4a92-9136-19b26508b9d2
Pandemic management requires exposure science (MJJantunen). Environment International. 20.8.2022. https://www.sciencedirect.com/science/article/pii/S016041202200397X?via%3Dihub https://doi.org/10.1016/j.envint.2022.107470
Which COVID boosters to take and when: a guide for the perplexed
A diverse menu of vaccine options leaves people searching for the best route to protection. Nature. 19.8.2022. https://www.nature.com/articles/d41586-022-02221-w
Coronavirus (COVID-19) Infection Survey, UK: 19 August 2022. Percentage of people testing positive for coronavirus (COVID-19) in private residential households in England, Wales, Northern Ireland and Scotland, including regional and age breakdowns. Office for National Statistics (ONS/UK). accessed 19.8.2022. https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/coronaviruscovid19infectionsurveypilot/19august2022
Asiantuntija (Markku Broas) ihmettelee THL:n koronapuheita: ”Suomi ei yksin voi julistaa pandemiaa päättyneeksi”. THL ilmoitti koronaviruksen siirtyneen endeemiseen vaiheeseen. Maailman terveysjärjestön mielestä pandemia jatkuu yhä. Suomen Kuvalehti. 19.8.2022. https://suomenkuvalehti.fi/kotimaa/asiantuntija-ihmettelee-thln-koronapuheita-suomi-ei-yksin-voi-julistaa-pandemiaa-paattyneeksi/
Time-dependent recovery of brain hypometabolism in neuro-COVID-19 patients (Cognitive). Eur J Nucl Med Molec Imag. 19.8.2022. https://link.springer.com/article/10.1007/s00259-022-05942-2
Scientists Discover “Weak Spot” Across All Major Covid Variants: Study
The weakness can be targeted by neutralising antibodies, potentially paving the way for treatments that would be universally effective across Covid variants, researchers said. NDTV. 19.8.2022. https://www.ndtv.com/world-news/scientists-discover-weak-spot-across-all-major-covid-variants-study-3268899
Health expert warns of spike in monkeypox cases amid shortage of vaccines
Four UK Chief Medical Officers agreed vaccine deployment should be prioritised where there are localised outbreaks. Wales Online 18.8.2022. https://www.walesonline.co.uk/news/health/monkeypox-vaccine-symptoms-cases-contact-24787594
ANYWHERE BUT HERE. China now insists the pandemic didn’t start within its borders. Its scientists are publishing a flurry of papers pointing the finger elsewhere. Science. 18.8.2022. https://www.science.org/content/article/pandemic-start-anywhere-but-here-argue-papers-chinese-scientists-echoing-party-line
Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort study. Lancet Respiratory Medicine. 18.8.2022. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00226-0/fulltext?fs=e&s=cl
COVID-19: respirator masks cut SARS-CoV-2 infections by >40%. JAMA Network Open. 18.8.2022. https://www.univadis.com/viewarticle/covid-19-respirator-masks-cut-sars-cov-2-infections-by-40-ccc791d1-4826-3288-a6ae-ff773bde8950
CDC director announces shake-up, citing COVID mistakes. LA Times. 17.8.2022. https://www.latimes.com/world-nation/story/2022-08-17/cdc-director-announces-organization-shake-up
How much virus does a person with COVID exhale? New research has answers. One ‘superspreader’ with Omicron shed 1,000 times as much viral RNA as those with Alpha or Delta. Nature. 17.8.2022. https://www.nature.com/articles/d41586-022-02202-z
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients (Risks of the common psychiatric disorders returned to baseline after 1–2 months (mood disorders at 43 days, anxiety disorders at 58 days) and subsequently reached an equal overall incidence to the matched comparison group (mood disorders at 457 days, anxiety disorders at 417 days). By contrast, risks of cognitive deficit (known as brain fog), dementia, psychotic disorders, and epilepsy or seizures were still increased at the end of the 2-year follow-up period. Post-COVID-19 risk trajectories differed in children compared with adults: in the 6 months after SARS-CoV-2 infection, children were not at an increased risk of mood (HR 1·02 [95% CI 0·94–1·10) or anxiety (1·00 [0·94–1·06]) disorders, but did have an increased risk of cognitive deficit, insomnia, intracranial haemorrhage, ischaemic stroke, nerve, nerve root, and plexus disorders, psychotic disorders, and epilepsy or seizures (HRs ranging from 1·20 [1·09–1·33] to 2·16 [1·46–3·19]). Unlike adults, cognitive deficit in children had a finite risk horizon (75 days) and a finite time to equal incidence (491 days). A sizeable proportion of older adults who received a neurological or psychiatric diagnosis, in either cohort, subsequently died, especially those diagnosed with dementia or epilepsy or seizures. Risk profiles were similar just before versus just after the emergence of the alpha variant (n=47 675 in each cohort). Just after (vs just before) the emergence of the delta variant (n=44 835 in each cohort), increased risks of ischaemic stroke, epilepsy or seizures, cognitive deficit, insomnia, and anxiety disorders were observed, compounded by an increased death rate. With omicron (n=39 845 in each cohort), there was a lower death rate than just before emergence of the variant, but the risks of neurological and psychiatric outcomes remained similar.). Lancet Psychiatry. 17.8.2022. https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(22)00260-7/fulltext
Public health taxonomy for social listening on monkeypox conversations
For use in infodemic monitoring and insights generation. WHO Technical Document. 17.8.2022. https://www.who.int/publications/m/item/public-health-taxonomy-for-social-listening-on-monkeypox-conversations?et_rid=35361131&et_cid=4430550
Blood abnormalities found in people with Long Covid. Study implicates lack of key hormone, battle-weary immune cells, and reawakened viruses. Science. 16.8.2022. https://www.science.org/content/article/blood-abnormalities-found-people-long-covid?fbclid=IwAR0-9UxAil5AfnRfhmgLqWTJgcjYiscWeXNchLW07fVjOhky4AbgThYm7cg#.Yv3pboUQQN4.facebook
Tuore tutkimus antoi huolestuttavia tuloksia koronan uusintatartunnoista – Apulaisylilääkäri: Pandemia ei ole ohi- Yhdysvaltalaistutkimus on vielä vertaisarvioimaton. Sen vahvuutena on kuitenkin suuri aineisto, Husin apulaisylilääkäri sanoo. Mediuutiset. 16.8.2022. https://www.mediuutiset.fi/uutiset/tuore-tutkimus-antoi-huolestuttavia-tuloksia-koronan-uusintatartunnoista-apulaisylilaakari-pandemia-ei-ole-ohi/496876c5-e77b-4996-a12b-19356b8d5af8
Tutkimus osoitti ensimmäistä kertaa, että yhteys matalan sosioekonomisen aseman ja koronasairastavuuden välillä rajoittui ainoastaan maahanmuuttajataustaiseen väestöön. Helsingin Uutiset. 16.8.2022. https://www.helsinginuutiset.fi/paikalliset/4790216
Healthcare Workers Who Wear Better Masks Get Less COVID. — Observational study affirms better odds of dodging infection by wearing a respirator mask. MedpageToday. 15.8.2022. https://www.medpagetoday.com/infectiousdisease/covid19/100227
Group Life COVID-19 Mortality. Survey Report. AUGUST | 2022. [Estimated reported Group Life claim incidence rates were up 20.0% on a seasonally-adjusted basis compared to 2017–2019 reported claims. USA, America] SOA Research Institute. NN.8.2022.
Green zoning: An effective policy tool to tackle the Covid-19 pandemic., Health Policy. NN.8.2022. https://www.sciencedirect.com/science/article/pii/S0168851021001585
Group Life COVID-19 Mortality Survey Report. SOA Research Institute. NN.8.2022. https://www.soa.org/4a368a/globalassets/assets/files/resources/research-report/2022/group-life-covid-19-mortality-03-2022-report.pdf.
Vanhempia kiellettiin tapaamasta vastasyntynyttä vauvaansa Mikkelissä – koronakanteluita tehty jo yli 3000. Eduskunnan oikeusasiamiehelle ja valtioneuvoston oikeuskanslerille on tehty yhteensä yli 3 000 koronaan tavalla tai toisella liittyvää kantelua. Iltalehti kysyi apulaisoikeusasiamies Pasi Pölöseltä ja oikeuskansleri Tuomas Pöystiltä, mitä kantelut ovat koskeneet ja kuinka virallinen Suomi on selvinnyt pandemiasta. Iltalehti.14.8.2022. https://www.iltalehti.fi/kotimaa/a/dae3e5c1-0571-4bf7-a194-ac5e9dd2840f?utm_source=iltalehti.fi&utm_medium=email&utm_campaign=email_il_uutiskirje
Non-pharmaceutical Interventions and Social Distancing as Intersubjective Care and Collective Protection. Asian Bioethics Review. 13.8.2022. https://link.springer.com/article/10.1007/s41649-022-00212-7
Pandemia ei ole ohi, maskit käyttöön, apulaisylilääkäri kehottaa – uusi koronatartunta voi olla edellistä vaikeampi, uusi tutkimus kertoo
Tuore yhdysvaltalaistutkimus antaa syytä vältellä uutta koronatartuntaa edelleenkin. Iltalehti. 13.8.2022. https://www.iltalehti.fi/terveysuutiset/a/927fa44b-fcc7-4658-b57f-b8f53a0c6366
Seinäjoen keskussairaala on ollut niin täynnä, että naistentautien osastolle on sijoitettu miehiä – koronapotilaita hoidetaan ympäri sairaalaa.
Keskussairaala on ollut täynnä lähes koko kesän. Heikentyneestä koronatilanteesta huolimatta pandemiaosastoa ei aiota avata.YLE Uutiset. 12.8.2022. https://yle.fi/uutiset/3-12573331
Ei vähänkään oireisena kouluun, käsiä pestään armotta – katso tästä vinkit koronaturvalliseen koulunalkuun. Koulut avaavat ovensa ympäri Suomea tämän ja ensi viikon aikana. Maskit ja karanteenit ovat pitkälti eilispäivää, mutta jotkin koronavuosien käytännöt pysyvät. YLE Uutiset. 12.8.2022. https://yle.fi/uutiset/3-12572153
It can feel safer to block out contradictory information that challenges a belief. Cognitive biases and brain biology help explain why facts don’t change minds. The Conversation. 11.8.2022. https://theconversation.com/cognitive-biases-and-brain-biology-help-explain-why-facts-dont-change-minds-186530
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients. PNAS. 11.8.2022. https://www.pnas.org/doi/full/10.1073/pnas.2200960119
August 11-20
Distinguishing features of Long COVID identified through immune profiling. medRxiv. 10.8.2022. https://www.medrxiv.org/content/10.1101/2022.08.09.22278592v1
Hallitus varautuu laittamaan ravintolat ja tapahtumat taas kiinni koronan takia – oikeusoppinut: “Kestämätön himmeli”. Perustuslakiasiantuntija Pauli Rautiaisen mielestä toistaiseksi voimassa olevien lakien sijaan nyt täytyisi keskittyä rakentamaan pysyvää tartuntatautilakia. Iltalehti. 9.8.2022. https://www.iltalehti.fi/politiikka/a/b39698aa-f62a-4d29-b0ad-fb2e8f852e83
Distinguishing features of Long COVID identified through immune profiling. medRxiv. 9.8.2022. https://www.medrxiv.org/content/10.1101/2022.08.09.22278592v1
Long COVID: which symptoms can be attributed to SARS-CoV-2 infection? Lancet. 6.8.2022. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01385-X/fulltext
Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study [Long COVID] Lancet. 6.8.2022. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01214-4/fulltext#seccestitle130
Post-Covid-19 Symptoms and Conditions Among Children and Adolescents – United States, March 1, 2020-January 31, 2022. CDC MMWR. 5.8.2022. https://www.cdc.gov/mmwr/volumes/71/wr/mm7131a3.htm
Long COVID, Cognitive Impairment, and the Stalled Decline in Disability Rates. FEDS Notes. 5.8.2022. https://www.federalreserve.gov/econres/notes/feds-notes/long-covid-cognitive-impairment-and-the-stalled-decline-in-disability-rates-20220805.htm
Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies. nature. Communications biology. 5.8.2022. https://www.nature.com/articles/s42003-022-03739-5
Comparative evaluation results of SARS-CoV-2 antigen rapid diagnostic tests passing the sensitivity criteria (in alphabetical order of manufacturers), Germany, 2020–2021 (n = 96). accessed 5.8.2022. https://www.eurosurveillance.org/content/table/10.2807/1560-7917.ES.2021.26.44.2100441.t1?fmt=ahah&fullscreen=true
Itävaltaa järkyttää koronarokotuksia kannattaneen lääkärin peruuttamaton ratkaisu kuukausien vihakampanjan jälkeen
Koronatoimien puolesta kampanjoineen Lisa-Maria Kellermayrin kuolema sai tuhannet osoittamaan mieltään Itävallassa. Liittopresidentti Alexander Van der Bellen tuomitsi jyrkästi vihan lietsomisen lääkäriä kohtaan. Ilta=sanomat. 4.8.2022. https://www.is.fi/ulkomaat/art-2000008982689.html
Blood clots, heart problems, kidney failure: COVID creates a higher risk for rare pediatric health problems, new CDC study finds. Fortune. 4.8.2022. https://fortune.com/2022/08/04/covid-creates-higher-risk-kids-children-pediatric-blood-clots-kidney-failure-heart-problems-type-1-diabetes/
Samhällsnytta före individens rättigheter i Sveriges coronastrategi.
Syftet med den svenska coronastrategin har varit att skydda institutioner snarare än individer. Det menar Per Bauhn, professor i praktisk filosofi vid Linnéuniversitetet. Han har utvärderat Sveriges hantering av pandemin i ett bidrag till en internationell samlingsvolym om etik och pandemihantering. Linnéuniversitetet. 3.8.2022. https://lnu.se/mot-linneuniversitetet/aktuellt/nyheter/2022/samhallsnytta-fore-individens-rattigheter-i-sveriges-coronastrategi/
Das sieht der Entwurf für Corona-Maßnahmen ab dem Herbst vor
Der vorgeschlagene Katalog könnte ab Oktober bis April nächsten Jahres gelten. Dieser sieht verpflichtende Basismaßnahmen vor und Möglichkeiten für die Länder. Der Tagesspiegel. 3.8.2022. https://www.tagesspiegel.de/politik/lauterbach-und-buschmann-einig-das-sieht-der-entwurf-fuer-corona-massnahmen-ab-dem-herbst-vor/28570952.html
Tracking Covid-19’s global spread. The disease has spread to every continent and case numbers continue to rise. CNN health. 3.8.2022 Update. https://edition.cnn.com/interactive/2020/health/coronavirus-maps-and-cases/
Heart disease after COVID: what the data say. Some studies suggest that the risk of cardiovascular problems, such as a heart attack or stroke, remains high even many months after a SARS-CoV-2 infection clears up. Researchers are starting to pin down the frequency of these issues and what is causing the damage. Nature. 2.8.2022. https://www.nature.com/articles/d41586-022-02074-3
Why the Chair of the Lancet’s COVID-19 Commission Thinks The US Government Is Preventing a Real Investigation Into the Pandemic. Current Affairs. 2.8.2022. https://www.currentaffairs.org/2022/08/why-the-chair-of-the-lancets-covid-19-commission-thinks-the-us-government-is-preventing-a-real-investigation-into-the-pandemic
Association of Receiving a Fourth Dose of the BNT162b Vaccine With SARS-CoV-2 Infection Among Health Care Workers in Israel. JAMA. 2.8.2022. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2794864
Varautuminen koronatilanteen jatkumiseen kasvatuksessa ja koulutuksessa 1.8.2022. Opetushallitus. https://www.oph.fi/fi/kehittaminen/varautuminen-koronatilanteen-jatkumiseen-kasvatuksessa-ja-koulutuksessa-182022
Evolution of SARS-CoV-2 Shedding in Exhaled Breath Aerosols. medRxiv. 1.8.2022. https://www.medrxiv.org/content/10.1101/2022.07.27.22278121v2.full
New trial shows nasal spray reduces infection of covid-causing virus by 62%. A new clinical trial led by Queen Mary University of London and Barts Health researchers has shown that the pHOXWELL nasal spray can reduce infection with SARS-CoV-2 – the virus that causes Covid-19 – by 62%. [Study published iun J Clinical Virology] Queen Mary University of London. 1.8.2022. https://www.qmul.ac.uk/media/news/2022/smd/new-trial-shows-nasal-spray-reduces-infection-of-covid-causing-virus-by-62-.html
August 1-10
The Efficacy of Facemasks in the Prevention of COVID-19: A Systematic Review. medRxiv. 31.7.2022. https://www.medrxiv.org/content/10.1101/2022.07.28.22278153v1
Initial strategy of vaccinating only known monkeypox contacts was ‘doomed to failure’ in the US, experts say. CNN health. 31.7.2022. https://edition.cnn.com/2022/07/30/health/monkeypox-vaccination-strategy/index.html
Spain reports first monkeypox-related death in Europe. CNN. 30.7.2022. https://edition.cnn.com/2022/07/29/europe/spain-first-monkeypox-death-europe-intl-hnk/index.html
Is COVID prematurely aging our immune systems? Repeated SARS-CoV-2 infections may be prematurely aging human immune systems, research suggests. National Post. 30.7.2022. https://nationalpost.com/health/is-covid-prematurely-aging-our-immune-systems
Why The BMJ will no longer report on unsubstantiated press releases. BMJ. 28.7.2022. https://www.bmj.com/content/378/bmj.o1878
Onko korona nyt pysyvästi keskuudessamme? THL:n Salminen: “Sen kanssa joudutaan elämään ainakin allekirjoittaneen loppuiän”. Koronavirus on tullut keskuuteemme jäädäkseen. THL:n Mika Salminen totesi keskiviikkona pandemian muuttuneen koronaendemiaksi. Mitä endeemisellä taudilla oikein tarkoitetaan? MTV-Uutiset 28.7.2022. https://www.mtvuutiset.fi/artikkeli/onko-korona-on-nyt-pysyvasti-keskuudessamme-thl-n-salminen-sen-kanssa-joudutaan-elamaan-ainakin-allekirjoittaneen-loppuian-verran/8477606#gs.87ezjh
Raju pettymys! Koronan jälkioireet päättävät Maria Huntingtonin kauden
Seitsenottelija oli jo valittu Münchenin EM-kisoihin. Ilta=Sanomat. 28.7.2022. https://www.is.fi/yleisurheilu/art-2000008971328.html
Jari Litmanen kertoo Iltalehdelle, että hänen terveytensä romahti puoleksitoista vuodeksi: ”Elämäni oli pitkään selviytymistaistelua”. Jari Litmanen sairastui koronavirustautiin heti ensimmäisessä aallossa. Vasta nyt hän tuntee Iltalehden mukaan olevansa voimissaan. Litmanen kertoo nukkuneensa pahimmillaan päivittäin kahdet päiväunet. Helsingin Sanomat. 28.7.2022. https://www.hs.fi/urheilu/art-2000008971090.html?share=ff2d27fd5903f64ef9fdbf58200fea67
THL:n Mika Salminen: Talvella edessä kunnon epidemia. Laitoksen mukaan koronavirus on siirtymässä pandemiasta endemiaan.Verkkouutiset. 27.7.2022. https://www.verkkouutiset.fi/a/thln-mika-salminen-talvella-edessa-kunnon-epidemia/#1debac39
Jopa 10 000 henkeä on voinut selvitä rokotusten ansiosta tänä vuonna, arvioi Mika Salminen ja sanoo, että pandemiasta on siirrytty endemiaan. THL on kerännyt yli 4400 kuolintodistusta, joissa koronavirusinfektio on kirjattu kuolinsyyksi tai kuolemaan vaikuttaneeksi tekijäksi. Yle-uutiset. 27.7.2022. https://yle.fi/a/3-12552244
Long COVID and the labour market. Institute for Fiscal Studies. 27.7.2022. https://ifs.org.uk/publications/16121
Wuhanin villieläintori oli koronapandemian alkujuuri, sanovat kaksi uutta tutkimusta. Torilla myytiin muun muassa eläviä punakettuja, mäyriä ja supikoiria. Helsingin Sanomat. 27.7.2022. https://www.hs.fi/tiede/art-2000008968992.html?share=60f33bf3557b3ad84f863b830791776f
Tapio Sadeojan kolumni: On vain yksi totuus ja se on THL:n totuus. Miksi THL on vähätellyt neljänsien rokotuksien merkitystä, kysyy Tapio Sadeoja. Ilta=Sanomat. 27.7.2022. https://www.is.fi/kotimaa/art-2000008968379.html
Onko apinarokko sittenkään vain seksitauti? Esitimme tämän ja kahdeksan muuta kysymystä virologille. Helsingin yliopiston virologian professori Olli Vapalahti muistuttaa, että apinarokko voi tarttua läheisessä kontaktissa myös pisaratartuntana. Pienille lapsille tauti on erityisen vaarallinen. YLE Uutiset. 26.7.2022. https://yle.fi/uutiset/3-12551225
The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic (Pekar et al. found that genomic diversity before February 2020 comprised two distinct viral lineages, A and B, which were the result of at least two separate cross-species transmission events into humans (see the Perspective by Jiang and Wang). The precise events surrounding virus spillover will always be clouded, but all of the circumstantial evidence so far points to more than one zoonotic event occurring in Huanan market in Wuhan, China, likely during November–December 2019.). Science. 26.7.2022. https://www.science.org/doi/10.1126/science.abp8715
The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2. (Pekar et al.) 26.7.2022. https://www.science.org/doi/10.1126/science.abp8337
Reproduction number of monkeypox in the early stage of the 2022 multi-country outbreak. medRxiv. 26.7.2022. https://www.medrxiv.org/content/10.1101/2022.07.26.22278042v1
Professorin mukaan Suomi on herännyt jälkijunassa pitkittyneen koronataudin riskeihin: “Britanniassa on noin sata hoitoon erikoistunutta klinikkaa”. Arviot pitkittyneen koronataudin esiintyvyydestä vaihtelevat. Kansallista tutkimusta aiheesta ei vielä ole saatavilla. YLE Uutiset. 26.7.2022. https://yle.fi/uutiset/3-12561417
Isolation facilities for covid-19: towards a person centred approach. The BMJ. 26.7.2022. https://www.bmj.com/content/378/bmj-2021-069558
How long is COVID infectious? What scientists know so far. Those with SARS-CoV-2 are often advised to isolate for only a few days. But evidence is mounting that some people can continue to pass on the virus for much longer. Nature. 26.7.2022. https://www.nature.com/articles/d41586-022-02026-x
The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic. Science. 26.7.2022. https://www.science.org/doi/10.1126/science.abp8715
The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2. Science 26.7.2022. https://www.science.org/doi/10.1126/science.abp8337
Symptoms and risk factors for long COVID in non-hospitalized adults. nature medicine. 25.7.2022. https://www.nature.com/articles/s41591-022-01909-w
THL:n Salminen kehottaa päättäjiä harkitsemaan terveydenhuollon resurssien lisäämistä – “Koronaan ei voida ikuisesti suhtautua toisin kuin muihin tauteihin”. Mika Salminen toivoo, että terveydenhuollon kapasiteettia vahvistettaisiin, jottei yhteiskuntaa tarvitsisi niin herkästi sulkea terveydenhuollon kantokyvyn turvaamisen nimissä. Salminen vertaa koronaa RS-virukseen, joka on toistuva riesa lapsille ja vanhuksille.Mika Salminen toivoo, että terveydenhuollon kapasiteettia vahvistettaisiin, jottei yhteiskuntaa tarvitsisi niin herkästi sulkea terveydenhuollon kantokyvyn turvaamisen nimissä. Salminen vertaa koronaa RS-virukseen, joka on toistuva riesa lapsille ja vanhuksille. Keskipohjanmaa. 25.7.2022. https://www.keskipohjanmaa.fi/uutinen/629659
Preventive Medication for COVID-19 Infection. JAMA. 25.7.2022. https://jamanetwork.com/journals/jama/fullarticle/2794799?guestAccessKey=be88b5a6-16ab-4c8e-9b4a-30a2c91f95d1&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=072522
WHO declares monkeypox a public health emergency of international concern. CNN health. 23.7.2022. https://edition.cnn.com/2022/07/23/health/monkeypox-who-intl/index.html
Korona pitäisi poistaa yleisvaarallisten tartuntatautien joukosta, sanoo THL:n Salminen – näin vastaa STM. MTV Uutiset. 23.7.2022. https://www.mtvuutiset.fi/artikkeli/korona-pitaisi-poistaa-yleisvaarallisten-tartuntatautien-joukosta-sanoo-thl-n-salminen-nain-vastaa-stm/8473888#gs.6qtyrc
Mid-term MRI evaluation reveals microstructural white matter alterations in COVID-19 fully recovered subjects with anosmia presentation (Brain, Cognitive). SAGE. 23.7.2022. https://journals.sagepub.com/doi/10.1177/17562864221111995
Government must act now to ensure pupils’ learning is not disrupted in September. Ministers must use the summer break to prepare for Covid surge. Unison. 22.7.2022. https://www.unison.org.uk/news/2022/07/government-must-act-now-to-ensure-pupils-learning-is-not-disrupted-in-%E2%80%8Bseptember/
THL:n Mika Salminen listaa viisi syytä, miksi on hyvä, etteivät poliitikot tai mielipidevaikuttajat päätä rokotuksista. Salminen kirjoittaa THL:n blogikirjoituksessaan pitävänsä Suomen nykyistä järjestelmää onnistuneena. Heksingin Sanomat. 22.7.2022. https://www.hs.fi/kaupunki/art-2000008962148.html
Rokotusohjelma ei voi perustua mielipiteisiin. THL Blogi. 22.7.2022. https://blogi.thl.fi/rokotusohjelma-ei-voi-perustua-mielipiteisiin/
Euroopassa on käynnissä uusi koronavirusaalto – EU:n tartuntatautiviraston mukaan nousu jatkuu vielä viikkoja. Euroopan tartuntatautivirasto seuraa tarkasti uutta Intiasta löytynyttä varianttia. Virasto arvioi, että päivitettyjä koronavirusrokotteita saadaan loppusyksystä. YLE Uutiset 22.7.2022. https://yle.fi/uutiset/3-12545135
As new variant spreads, a crucial drug to protect the most vulnerable goes vastly underused. STAT. 22.7.2022. https://www.statnews.com/2022/07/22/evusheld-covid-drug-for-immunocompromised-underused/
Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection. NEJM. 21.7.2022. https://worldaccordingtomatti.blog/wp-admin/post.php?post=2385&action=edit
July 21-31
Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines. Science. 19.7.2022. https://www.science.org/doi/10.1126/science.abq0203
As Omicron rages on, scientists have no idea what comes next. A rapid succession of subvariants is the new normal—but a completely new variant could still emerge. Science. 19.7.2022. https://www.science.org/content/article/omicron-rages-scientists-have-no-idea-what-comes-next
A seven point plan to suppress covid infections and reduce disruptions. BMJ. 19.7.2022. https://www.bmj.com/content/378/bmj.o1793
Preliminary public health considerations for COVID-19 vaccination strategies in the second half of 2022. ECDC. 18.7.2022. https://www.ecdc.europa.eu/sites/default/files/documents/Preliminary-public-health-considerations-%20COVID-19-vaccination-2022.pdf
Tutkimus: Pfizerin ja Modernan rokotteet antavat pitkäaikaisimman suojan koronaa vastaan. Tuoreen yhdysvaltalaistutkimuksen mukaan mRNA-rokotteet antavat lähes kolme kertaa pidemmän suojan kuin adenovirusvektorirokotteet tai koronatartunta. YLE Uutiset. 18.7.2022. https://yle.fi/uutiset/3-12540734
Editorials: The NHS is not living with covid, it’s dying from it, BMJ. 18.7.2022. https://www.bmj.com/content/378/bmj.o1779
An Examination of SARS-CoV-2 Transmission Based on Classroom Distancing in Schools With Other Preventive Measures in Place—Missouri, January–March 2021 (In 3 school districts in Missouri with moderate to high rates of community SARS-CoV-2 transmission, no transmission was documented in close contacts seated at desks at least 3 ft apart. These results support CDC school guidance16 indicating that student classroom density can be safely increased by reducing the minimum physical distancing to 3 ft when other recommended prevention strategies are applied, including wearing face masks. Implementation of this guidance will support in-person education for K-12 students.). Public Health Reports. 16.7.2022. https://journals.sagepub.com/doi/10.1177/00333549221109003
MTV: Sauli Niinistö arvioi, että Suomessa vallitsee koronatietoisuuden puute: ”Se vaatii niitä maskeja ja vähän harkintaa”. Sauli Niinistö vetoaa nyt suomalaisiin ja korostaa, että etenkin riskiryhmäläisten tartuttamista on vältettävä. Kauppalehti. 16.7.2022. https://www.kauppalehti.fi/uutiset/mtv-sauli-niinisto-arvioi-etta-suomessa-vallitsee-koronatietoisuuden-puute-se-vaatii-niita-maskeja-ja-vahan-harkintaa/8c9a52ee-a38d-4198-91e5-9e5684400304
2-[18F]-FDG PET for imaging brain involvement in patients with long COVID: perspective of the EANM Neuroimaging Committee. Eur J Nucl Med and Molec Imag. 16.7.2022. https://link.springer.com/article/10.1007/s00259-022-05913-7
Omikron jyllää Kiinassa mittavista sulkutoimista huolimatta.
Koronatartuntojen hillitsemiseksi Kiina käyttää koronasulkuja, pitkiä karanteeniaikoja sekä massatestauksia, vaikka toimet ovat käyneet raskaiksi maan taloudelle. Ilta=Sanomat. 16.7.2022. https://www.is.fi/ulkomaat/art-2000008949177.html
Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review (Cognitive). J Nucl Med. NN.7.2022. https://jnm.snmjournals.org/content/63/7/971
The durability of natural infection and vaccine-induced immunity against future infection by SARS-CoV-2. PNAS. 15.7.2022. https://www.pnas.org/doi/10.1073/pnas.2204336119
Kansanedustaja sai tarpeekseen: THL pitäisi uudistaa kokonaan.
Terhi Koulumies korostaa, että kansanterveysviranomaisen toiminta pitäisi rahoittaa täysin verorahoin. Verkkouutiset. 15.7.2022. https://www.verkkouutiset.fi/a/kansanedustaja-sai-tarpeekseen-thl-pitaisi-uudistaa-kokonaan/#6d0bdcea
Six-month sequelae of post-vaccination SARS-CoV-2 infection: A retrospective cohort study of 10,024 breakthrough infections. Brain Behaviour Immunity. NN.7.2022. https://www.sciencedirect.com/science/article/pii/S0889159122001118
Koronarokotusten vaikuttavuus Suomessa. Tervetuloa THL:n kuutioraportointiin! THL Update. 14.7.2022. https://sampo.thl.fi/pivot/beta/fi/epirapo/covid19inci/fact_epirapo_covid19inci?row=inciagegroup-639348&column=quadrimestermonth-642723&filter=measure-639168&filter=incivacstatus-669813
Brain fog after COVID-19 has similarities to ‘chemo brain,’ Stanford-led study finds. Stanford Medicine13.6.2022. https://neuroscience.stanford.edu/news/brain-fog-after-covid-19-has-similarities-chemo-brain-stanford-led-study-finds
Provisional COVID-19 Deaths by HHS Region, Race, and Age. CDC. Update 13.7.2022. https://data.cdc.gov/NCHS/Provisional-COVID-19-Deaths-by-HHS-Region-Race-and/tpcp-uiv5
THL:n selvitys: iäkkäät riskiryhmäläiset hyötyvät selvästi eniten neljännestä koronarokotteesta. THL. 13.7.2022. https://thl.fi/fi/-/thl-n-selvitys-iakkaat-riskiryhmalaiset-hyotyvat-selvasti-eniten-neljannesta-koronarokotteesta
COVID-19 Reinfections May Be Common—But They’re Not Harmless. TIME. 13.7.2022. https://time.com/6196814/covid-19-reinfections-omicron-risks/?
Effectiveness of a fourth dose of mRNA COVID-19 vaccine against all-cause mortality in long-term care facility residents and in the oldest old: A nationwide, retrospective cohort study in Sweden. Lancet. 13.7.2022. https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(22)00162-4/fulltext
Have new COVID variants changed what we know about surface transmission? San Francisco Chronicle 13.7.2022. https://www.sfchronicle.com/bayarea/pandemicproblems/article/covid-surface-transmission-17300795.php
SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trial (Overall, mean SARS-CoV-2 RNA concentrations (6·96 log10 copies/mL in the NONS group and 7·16 log10 copies/mL in the placebo group) were comparable at baseline. Primary endpoint mean treatment difference SARS-CoV-2 RNA change from baseline to the end of treatment (EOT) was -0·52 copies/mL (SE 0·202, 95% CI -0·92 to -0·12; p = 0·010) with NONS compared to placebo. Secondary endpoint assessments demonstrated a greater proportion of patients receiving NONS (82·8%) cleared SARS-CoV-2 (RT-PCR negative) by EOT compared to placebo (66·7%, p = 0·046), with no virus RNA detected a median of four days earlier compared to placebo (three vs seven days; p = 0·044).). Lancet Regional Health Southeast Asia. 12.7.2023. https://doi.org/10.1016/j.lansea.2022.100036 https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(22)00046-4/fulltext
Long covid patients travel abroad for expensive and experimental “blood washing”. Feature BMJ. 12.7.2022. https://www.bmj.com/content/378/bmj.o1671
COVID-19’s impact on the brain: Immune response may cause damage. Previous research links COVID-19 infection to brain issues, such as “brain fog” and neurological issues.
In a very small cadaver study, researchers from the National Institutes of Health found that antibodies created by the body in response to COVID-19 infection can cause damage to blood vessels in the brain, causing neurological symptoms.
Scientists believe the discovery of antibody-driven immune complexes on endothelial cells in the brain suggests immune-modulating therapies may help long COVID patients. Medical News Today. 12.7.2022. https://www.medicalnewstoday.com/articles/covid-19s-impact-on-the-brain-immune-response-may-cause-damage?
Statement on the twelfth meeting of the International Health Regulations (2005) Emergency Committee regarding the coronavirus disease (COVID-19) pandemic. WHO 12.7.2022. https://www.who.int/news/item/12-07-2022-statement-on-the-twelfth-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemic
Excess Mortality during the Pandemic: The Role of Health Insurance. The White House. 12.7.2022. https://www.whitehouse.gov/cea/written-materials/2022/07/12/excess-mortality-during-the-pandemic-the-role-of-health-insurance/
Kymsote keskeyttää toistaiseksi 12–69-vuotiaiden riskiryhmään kuuluvien 4. koronarokotukset. KymSoten koronainfo. 12.7.2022. https://korona.kymsote.fi/kymsote-keskeyttaa-toistaiseksi-12-69-vuotiaiden-riskiryhmaan-kuuluvien-4-koronarokotukset/
BA.5, Chapter 2. Significant updates from the previous BA.5 story. Eric Topol. Ground Truths. 11.7.2022. https://erictopol.substack.com/p/ba5-chapter-2
Undercounted Covid-19 cases leave US with a blind spot as BA.5 variant becomes dominant. CNN Health. 11.7.2022. https://edition.cnn.com/2022/07/11/health/ba-5-hidden-covid-case-increase/index.html
EU kehottaa jäsenvaltioita antamaan välittömästi neljännen koronarokotteen yli 60-vuotiaille – Suomi aikoo antaa piikit vasta syyskuussa. THL ei ole vielä ehtinyt perehtyä uuden EU-suosituksen taustoihin. Helsingin Sanomat. 11.7.2022. https://www.hs.fi/kotimaa/art-2000008938641.html?share=97c9021486e54028bbcfd9e2920cf013
July 11-20
Rapid improvement in severe long COVID following perispinal etanercept. Curr Med Res Opin 10.7.2022. https://pubmed.ncbi.nlm.nih.gov/35791687/
Huippututkijat: paremmalla ilmanvaihdolla olisi mahdollista torjua hengitysteitse leviäviä epidemioita. Tutkijoiden tekemien laskelmien perusteella tehostetulla ja oikein suunnatulla sisäilmanvaihdolla riski saada hengitysteitse leviävä tauti, kuten Covid-19, laskisi 20 prosentista 5 prosenttiin. YLE-Uutiset. 10.7.2022. https://yle.fi/uutiset/3-12518229?
Rokotettavien määrä – Kuinka monta ihmistä pitää rokottaa, jotta yksi koronan vuoksi tapahtunut erikoissairaalahoitojakso estyisi? Työpaperi 32/2022. THL https://www.julkari.fi/bitstream/handle/10024/144815/URN_ISBN_978-952-343-896-5.pdf?sequence=1&isAllowed=y
Huolestuttava uusi tutkimus koronasta: Jokainen uusi tartunta voikin olla edellistä kohtalokkaampi. Terveydenhuollossa on syytä varautua lähivuosina hoitamaan koronan aiheuttamia pitkäaikaishaittoja, kuten sydäntauteja ja veritulppia, varoittaa Husin diagnostiikkajohtaja Lasse Lehtonen. Ilta=Sanomat. 9.7.2022. https://www.is.fi/kotimaa/art-2000008931452.html
SARS-CoV-2 Omicron Variant Sub-Lineages BA.4 and BA.5: Evidence and Risk Assessment. [Evidence shows that SARS-CoV-2 reinfection adds risk of all-cause mortality, hospitalization and adverse health outcomes during acute and post-acute SARS-CoV-2 reinfection, and that the risk and burden may increase in a graded manner according to the number of infections. The evidence that SARS-CoV-2 can cause immune dysregulation is increasing. Reducing the risk of SARS-CoV-2 infection and reinfection could reduce overall burden of death and disease in Ontario during the pandemic and longer-term.] Public Health Ontario. 8.7.2022. https://www.publichealthontario.ca/-/media/Documents/nCoV/voc/2022/07/evidence-brief-ba4-ba5-risk-assessment-jul-8.pdf?sc_lang=en
The effect of COVID certificates on vaccine uptake, health outcomes, and the economy. nature 8.7.2022. https://www.nature.com/articles/s41467-022-31394-1?s=09
Long COVID and symptom trajectory in a representative sample of Americans in the first year of the pandemic. Scientific Reports. 8.7.2022. https://www.nature.com/articles/s41598-022-15727-0
Rokotuskeskus rauhoittelee keskustelua koronadisinformaation jakamisesta: Lääkärit katsovat yksittäisiä potilaita, THL koko väestöä. Asiantuntijat ovat eri mieltä koronarokotusten antamisesta. THL on laajentamassa neljännen rokotteen antamista loppukesästä. Infektiolääkärit haluavat, että rokotukset aloitettaisiin heti.YLE Uutiset. 8.7.2022. https://yle.fi/uutiset/3-12529809?
Covid’s chronic effects loom increasingly large. Despite fewer severe cases, the sheer volume of infections means hundreds of thousands are unwell for the long term. Financial Times. 8.7.2022. https://www.ft.com/content/63dcc4d1-8b53-4110-bd44-10e3d1d98585
The Economy Could Have a Long Case of Long Covid. Lingering symptoms for millions of people may place a prolonged drag on economic activity and pose problems for life insurers and healthcare providers. WSJ. 8.7.2022. https://www.wsj.com/articles/the-economy-could-have-a-long-case-of-long-covid-11657272619?st=nax9wf2motn897s&reflink=desktopwebshare_permalink
Australian medical authorities order Zero-COVID activist Dr David Berger to undertake “education” program or be deregistered. World Socialist Web Site. 8.7.2022. https://www.wsws.org/en/articles/2022/07/08/aakm-j08.html?s=03
AHPPC statement on COVID-19 winter update and ongoing health protection measures to support our community. The Australian Health Protection Principal Committee (AHPPC) continues to closely monitor the COVID-19 pandemic situation, drawing upon international and local evidence. Australian Government, Dept of Health and Aged Care. 8.7.2022. https://www.health.gov.au/news/ahppc-statement-on-covid-19-winter-update-and-ongoing-health-protection-measures-to-support-our-community
Opinion The worst virus variant just arrived. The pandemic is not over. Washington Post. 7.7.2022. https://www.washingtonpost.com/opinions/2022/07/07/worst-virus-variant-just-arrived-pandemic-is-not-over/
Pääkirjoitus: Korona ”loppui” kun Kiuru lähti. Heti kun koronaministeri Kiuru lähti sairauslomalle, loppui hallituksessa koronan pelko, mutta kevät ja kesä ovat näyttäneet, ettei korona ole kadonnut mihinkään, kirjoittaa Iltalehden toimittaja Kreeta Karvala. Iltalehti 7.7.2022. https://www.iltalehti.fi/paakirjoitus/a/0e08075e-513a-4709-bc5c-d1ac22444210
Tuomas Aivelo: Koronaviruksen uusinta aaltoa ei tarvitse odotella, se on jo alkanut. Omikronin BA.5-alamuunnos on levinnyt Euroopassa nopeasti, mutta on vaikea ennustaa, kuinka korkeaksi sen aiheuttama tartunta-aalto Suomessa nousee. Iltalehti 7.7.2022. https://www.iltalehti.fi/kotimaa/a/c6631197-9a03-43ca-96e8-e716eda3c3f6
The Truth About COVID Reinfections, Now That There Are New Variants
A viral article paints a picture where we’re constantly sick. Here’s what’s actually going on. (Slate trashes TYEE). Slate. 7.7.2022. https://slate.com/technology/2022/07/covid-reinfection-omicron-wave-forever-plague.html
Effects of Previous Infection and Vaccination on Symptomatic Omicron Infections. New England Journal of Medicine. 7.7.2022. https://www.nejm.org/doi/full/10.1056/NEJMoa2203965
Duration of immune protection of SARS-CoV-2 natural infection against reinfection in Qatar. medRxiv. 7.7.2022. https://www.medrxiv.org/content/10.1101/2022.07.06.22277306v1
How long and effective does a mask protect you from an infected person who emits corona virus-laden particles: by implementing physics-based modeling. medRxiv. 6.7.2022. https://www.medrxiv.org/content/10.1101/2022.07.05.22277221v1
Waning of SARS-CoV-2 vaccine-induced immunity: A systematic review and secondary data analysis. medRxiv. 6.7.2022. https://www.medrxiv.org/content/10.1101/2022.07.04.22277225v1
Long covid -asiantuntijaryhmä: Työkyvyttömyysaallon sijaan edessä tuottavuuden lasku
Neurologian professori Risto O. Roine arvioi, että Suomessa pitkittyneen koronataudin tapauksia voi olla jopa kymmenen kertaa virallisia lukuja enemmän. Helsingin Sanomat. 6.7.2022. https://www.hs.fi/visio/art-2000008919913.html
Korona, joka ei katoa. Edes lieväoireisen koronatartunnan jälkeen ei voi huokaista helpotuksesta, koska miljoonille ihmisille taudista on jäänyt lamauttavia oireita kuukausiksi ja vuosiksi, sanoo Akiko Iwasaki, yksi maailman johtavista koronatutkijoista. HS Vision haastattelussa hän kertoo näkemyksensä siitä, mitä tällä hetkellä tiedetään koronaviruksen aiheuttamista pitkäaikaisista oireista. Helsingin Sanomat. 6.7.2022. https://www.hs.fi/visio/art-2000008873226.html
Covid-19 reinfections may increase the likelihood of new health problems. CNN Health. 5.7.2022. https://edition.cnn.com/2022/07/05/health/covid-reinfection-risk/index.html
Now That BA.5 Is Dominant, Stopping It Will Be Difficult. TIME. 5.7.2022. https://time.com/6193890/ba-5-omicron-dominant/
Get Ready for the Forever Plague. Public health officials’ COVID complacency has opened the door to new illnesses and devastating long-term damage (Canada). The TYEE 4.7.2022. https://thetyee.ca/Analysis/2022/07/04/Get-Ready-Forever-Plague/
Medici famiglia: mai visti tanti casi di covid. Intervenire subito o si rischia la tempesta perfetta. All’Aifa l’appello a modificare il protocollo per la somministrazione degli antivirali, alla politica di investire decisamente sulle quarte dosi. L’intervista di Gerardo D’Amico a Silvestro Scotti. RAI News. 4.7.2022. Medici famiglia: mai visti tanti casi di covid. Intervenire subito o si rischia la tempesta perfetta (rainews.it)
Covid: 84.700 positivi, 63 morti. 118, aumentano i casi di polmonite
Tasso di positività al 26%. Responsabile servizio Emergenza: per le polmoniti responsabile la più recente delle sottovarianti di Omicron, BA.5. ANSA Cronaca. 3.7.2022. https://www.ansa.it/sito/notizie/cronaca/2022/07/02/covid-84.700-positivi-63-morti.-118-aumentano-i-casi-di-polmonite_14b3783f-bb72-41bd-8dcd-f52cf6ea8c5e.html
Infektioylilääkäri kritisoi kovin sanoin THL:n linjauksia: ”Vakavien tautien vähentämiseen on olemassa keino”. Markku Broas toivoo, että rokotteista ja koronan aiheuttamista kuolemista keskusteltaisiin enemmän. Ilta=Sanomat. 2.7.2022. https://www.is.fi/kotimaa/art-2000008921572.html
Kansanedustaja vaatii selvitystä koronakuolleisuudesta – ”Miksi ihmisten ei anneta suojautua tältä hankalalta taudilta?” Pia Kauma epäilee, onko valmistautuminen syksyn korona-aaltoon riittävää. Hän nostaa esiin myös neljännet koronarokotteet. Uusi Suomi. 2.7.2022. https://www.uusisuomi.fi/uutiset/kansanedustaja-vaatii-selvitysta-koronakuolleisuudesta-miksi-ihmisten-ei-anneta-suojautua-talta-hankalalta-taudilta/f5660af1-48e5-4dd6-9382-160dcde2b05e
Aki Lindén tivaa THL:ltä vastausta rokotekysymykseen: ”Mitä erityisperusteita Suomessa on?” Ministeri Aki Lindén on vaatinut jo kolme kuukautta, että neljänsiä koronarokotteita annettaisiin nykyistä enemmän. Koronatartuntojen ja sairaalassa olevien määrä on Suomessa jälleen nousussa. Ilta=Sanomat. 2.7.2022. https://www.is.fi/politiikka/art-2000008921639.html
Comparisons of all-cause mortality between European countries and regions: 28 December 2019 to week ending 1 July 2022
Comparisons of all-cause excess mortality on a weekly basis since the start of the coronavirus (COVID-19) pandemic. Measures include relative age-standardised mortality rates and relative cumulative age-standardised mortality rates. ONS. 1.7.2022. https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/articles/comparisonsofallcausemortalitybetweeneuropeancountriesandregions/latest
Opinion: Monkeypox—not doing enough is not an option. bmj. 1.7.2022. https://www.bmj.com/content/378/bmj.o1631?
WHO concerned about first cases of monkeypox in children. The organization warns that overall cases in Europe have tripled in the last two weeks, although it has not yet declared the outbreak a global health emergency. El Pais. 1.7.2022. https://english.elpais.com/science-tech/2022-07-01/who-concerned-about-first-cases-of-monkeypox-in-children.html
Immunity and infectivity in covid-19. bmj. 1.7.2022. https://www.bmj.com/content/378/bmj-2020-061402 https://www.bmj.com/content/378/bmj-2020-061402/rapid-responses
Covid-19: Brazil is recording a fifth of all deaths of under 5s. bmj. 1.7.2022. https://www.bmj.com/content/378/bmj.o1634?
Where’s the herd immunity? Our research shows why Covid is still wreaking havoc. ‘Living with the virus’ is proving much harder than the early vaccine success suggested: this fight is far from over. Guardian. 1.7.2022. https://www.theguardian.com/commentisfree/2022/jul/01/herd-immunity-covid-virus-vaccine?
COVID-19 reinfection could be worse than first thought. 9News. 1.7.2022. https://www.9news.com.au/national/covid-19-second-and-third-infections-could-be-worse-than-first-time/66eef293-a9c1-4f1a-bbc2-ca4ab5e5cf02
Association Between BNT162b2 Vaccination and Long COVID After Infections Not Requiring Hospitalization in Health Care Workers. JAMA. 1.7.2022. https://jamanetwork.com/journals/jama/fullarticle/2794072
Novavax is part of the FDA’s COVID-19 booster debate, but its vaccine still hasn’t been authorized. The experimental shot played a front-and-center role during this week’s debate about how best to update the COVID-19 vaccines to better protect against omicron. MarketWatch. 1.7.2022. https://www.marketwatch.com/story/novavax-is-part-of-the-fdas-covid-19-booster-debate-but-its-vaccine-still-hasnt-been-authorized-11656528348
July 1-10
An Agent-Based Model to Support Infection Control Strategies at School (The significance of risk reduction through the policies assessed here is of potential relevance for public health authorities and school administrators both at a local and national level. Implementation of standard preventive measures such as mask-wearing and environmental ventilation should be considered necessary in phases of low viral circulation. Active preventive measures such as screening campaigns can be seen as additional measures to be implemented to reduce the viral transmission in the school environment during high viral circulation period to avoid massive school closures.). Journal of Artificial Societies and Social Simulation. 30.6.2022. https://www.jasss.org/25/3/2.html
Long distance airborne transmission of SARS-CoV-2: rapid systematic review. bmj. 29.6.2022. https://www.bmj.com/content/377/bmj-2021-068743
Airborne SARS-CoV-2 (Time for an indoor air revolution). Editorial. bmj. 29.6.2022. https://www.bmj.com/content/377/bmj.o1408
Novavax COVID vaccine surprisingly effective against all Omicron variants. New Atlas, 29.6.2022. https://newatlas.com/science/novavax-covid19-vaccine-omicron-booster/
Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection. NEJM. 29.6.2022. https://www.nejm.org/doi/full/10.1056/NEJMc2202092
First reported case of a person getting COVID from a cat. Scientists in Thailand have established that a tabby passed SARS-CoV-2 to a veterinary surgeon — although such cases of cat-to-human transmission are probably rare. nature. 29.6.2022. https://www.nature.com/articles/d41586-022-01792-y
Bad news for Paxlovid? Coronavirus can find multiple ways to evade COVID-19 drug. Lab studies identify resistance mutations in SARS-CoV-2’s protease, and some circulating variants have them. Science. 29.6.2022. https://www.science.org/content/article/bad-news-paxlovid-coronavirus-can-find-multiple-ways-evade-covid-19-drug?
U.S. FDA advisers recommend change to COVID vaccine composition for fall. Reuters. 29.6.2022. https://www.reuters.com/business/healthcare-pharmaceuticals/us-fda-advisers-meet-discuss-design-future-covid-vaccines-2022-06-28/
BioNTech, Pfizer to start testing universal vaccine for coronaviruses. [Germany’s BioNTech, Pfizer’s partner in COVID-19 vaccines, said the two companies would start tests on humans of next-generation shots that protect against a wide variety of coronaviruses in the second half of the year. Their experimental work on shots that go beyond the current approach include T-cell-enhancing shots, designed to primarily protect against severe disease if the virus becomes more dangerous, and pan-coronavirus shots that protect against the broader family of viruses and its mutations.] Reuters. 29.6.2022. https://www.reuters.com/business/healthcare-pharmaceuticals/biontech-pfizer-starting-testing-universal-coronavirus-vaccine-h2-2022-06-29/
Ensimmäinen tablettimuotoinen koronalääke saapunut Suomeen − tarkoitettu vain vakavan taudin riskiryhmään kuuluville. Tarkat kriteerit on täytettävä ja kotitesti varmistettava laboratoriossa. Mediuutiset. 29.6.2022. https://www.mediuutiset.fi/uutiset/ensimmainen-tablettimuotoinen-koronalaake-saapunut-suomeen-tarkoitettu-vain-vakavan-taudin-riskiryhmaan-kuuluville/eae0f676-6feb-4e09-aa6d-cf5d287b9482
Tapio Sadeojan kolumni: Tuhansia kuollut koronaan Suomessa? Kaikki harhaa vaan on. 4 832 kuollut koronaan. Juhannukseen mennessä tilastoihin ehtineenä, kirjoittaa Tapio Sadeoja. Ilta=Sanomat. 29.6.2022. https://www.is.fi/kotimaa/art-2000008912785.html
How long does SARS-CoV-2 stay in the body? BMJ. 28.6.2022. https://www.bmj.com/content/377/bmj.o1555
Up to one in six people with COVID-19 report long COVID symptoms.
One in six (17%) middle-aged people who report being infected by SARS-CoV-2 also report long COVID symptoms, while this falls to one in 13 (7.8%) among younger adults who reported having Covid-19, according to a new study led by King’s and UCL.Kings College London News Centre. 28.6.2022. https://www.kcl.ac.uk/news/up-to-one-in-six-people-covid-19-long-covid-symptoms
New Study: COVID-19 May Cause or Accelerate Neurological Diseases. BioSpace. 28.6.2022. https://www.biospace.com/article/research-suggests-covid-19-patients-at-higher-risk-of-parkinson-s-alzheimer-s-stroke-and-bleeding/
Over half of people with Long Covid for two years are declared unfit to work. DutchNews.nl. 28.6.2022. https://www.dutchnews.nl/news/2022/06/over-half-of-people-with-long-covid-for-two-years-are-declared-unfit-to-work/
Australia must plan now for a significant burden of disease and disability due to Long COVID
Apinarokko uhkaa jäädä kiertämääön ihmisiin (Tuomas Aivelo). TIEDE. 29.6.2022. https://www.tiede.fi/blogit/kaiken-takana-loinen/apinarokko-uhkaa-jaada-kiertamaan-ihmisiin
The BA.5 story. The takeover by this Omicron sub-variant is not pretty. Eric Topol. Ground Truths. 27.6.2022. https://erictopol.substack.com/p/the-ba5-story
COVID-19 could put us at a greater risk of neurodegenerative diseases and stroke. Analysis of nearly one million Danish health records has found patients who tested positive for COVID-19 were subsequently more likely to be diagnosed with Alzheimer’s disease, Parkinson’s disease and stroke. Science Focus. 25.6.2022. https://www.sciencefocus.com/news/covid-19-could-put-us-at-a-greater-risk-of-neurodegenerative-diseases-and-stroke
What doctors wish patients knew about wearing N95 masks. AMA. 24.6.2022. https://www.ama-assn.org/delivering-care/public-health/what-doctors-wish-patients-knew-about-wearing-n95-masks
Laaja tutkimus: koronarokotteet estivät lähes 20 miljoonaa kuolemaa vuoden aikana. Tutkijoiden mukaan noin 600 000 kuolemaa lisää olisi voitu estää, jos Maailman terveysjärjestön WHO:n tavoite rokottaa 40 prosenttia kaikkien maiden väestöstä viime vuoden loppuun mennessä olisi toteutunut. Helsingin Sanomat. 24.6.2022. https://www.hs.fi/ulkomaat/art-2000008906484.html?share=6ad15524f38aedba1af41699a9a33705
COVID-19 positive patients at higher risk of developing neurodegenerative disorders, new study shows. Medical Press. 24.6.2022. https://medicalxpress.com/news/2022-06-covid-positive-patients-higher-neurodegenerative.html
Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infectious Diseases. 23.6.2022. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00320-6/fulltext
Global Life Expectancy Falls for First Time Since 1950s Due to Covid. Global life expectancy has fallen for the first time since the 1950s following the Covid-19 pandemic, according to new analysis. The analysis, published by the ONE Campaign, has found that global life expectancy has fallen 1.64 years between 2019 and 2021. Bloomberg. 23.6.2022. https://www.bloomberg.com/news/articles/2022-06-22/global-life-expectancy-falls-for-first-time-since-records-began-due-to-covid-19
STM: Laajamittaiselle koronan testaus- ja jäljitystoiminnalle ei ole enää tarvetta. Strategian tavoitteena on jatkossa ehkäistä riskiryhmäläisten koronatartuntoja, ohjata vaikeaoireiset potilaat hoidon piiriin ja turvata terveydenhuollon kantokyky. Ilta=Sanomat. 23.6.2022. https://web.archive.org/web/20220623054457/https://www.is.fi/kotimaa/art-2000008903640.html
THL muuttaa rokotussuosituksiaan todennäköisesti syksyllä. Osa varastossa olevista rokotteista saattaa olla silloin jo vanhentunut. Suomenmaa. 23.6.2022. https://web.archive.org/web/20220623190609/https://www.suomenmaa.fi/uutiset/thl-muuttaa-rokotussuosituksiaan-todennakoisesti-syksylla/
Long-COVID in children and adolescents: a systematic review and meta-analyses. Scientific Reports, 23.6.2022. https://www.nature.com/articles/s41598-022-13495-5
China’s first mRNA vaccine is close — will that solve its COVID woes?
Researchers say a highly effective jab will help to avoid hospitals getting overwhelmed, but probably won’t end the country’s ‘zero COVID’ policy. Nature. 22.6.2022. https://www.nature.com/articles/d41586-022-01690-3
PAXLOVID-LÄÄKEHOIDON KOHDENTAMINEN COVID-19-INFEKTION HOIDOSSA Paxlovid-lääkitys on tehokas mahdollisimman varhain covid-19-oireiden alun jälkeen aloitettuna ja potilaille, joilla on merkittävä vaikean koronavirustaudin riski. Lääkityksen kohdentaminen on ohjeistettu näillä periaatteilla. Ennen hoitoa diagnoosi on varmistettava terveydenhuollossa tehtävällä PCR-testillä. Hoito tulee aloittaa 5 vrk:n kuluessa oireiden alkamisesta. STM. 22.6.2022. https://www.vsshp.fi/fi/sairaanhoitopiiri/media-tiedotteet-viestinta/tiedotteet/Documents/Ohje%20Paxlovid-hoidon%20kohdentamisesta.pdf
A reinfection red flag. Why a new report is so troubling (Eric Topol). Ground Truths. 22.6.2022. https://erictopol.substack.com/p/a-reinfection-red-flag
Gut microbiota from patients with mild COVID-19 cause alterations in mice that resemble post-COVID syndrome. Research Square. 22.6.2022. https://www.researchsquare.com/article/rs-1756189/v1
Long COVID symptoms in SARS-CoV-2-positive children aged 0–14 years and matched controls in Denmark (LongCOVIDKidsDK): a national, cross-sectional study. Lancet. 22.6.2022. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(22)00154-7/fulltext
Despite Access to Federal COVID-19 Funds to Optimize Ventilation, Most Schools Use Lower-Cost Strategies. JAMA Health Forum. 21.6.2022. doi:10.1001/jamahealthforum.2022.2501
There’s more & more evidence accumulating that COVID-19 causes a chronic illness in many, and that this correlates with virus persistence in tissues. We should really start thinking about this as an illness where virus persists chronically in a significant proportion of people. [Dr. Deepti Gurdasani]. The Reader. 21.6.2022. https://threadreaderapp.com/thread/1539174805198479360.html
June 21-30
Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2. Lancet. 18.6.2022. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00941-2/fulltext
“We Have to Get Out of This Phase”: Ashish Jha on the Future of the Pandemic. President Biden’s COVID czar talks about his public-health philosophy, his Twitter threads, his unlikely path to the White House, and where we go from here. New Yorker. 18.6.2022. https://www.newyorker.com/news/the-new-yorker-interview/we-have-to-get-out-of-this-phase-ashish-jha-on-the-future-of-the-pandemic
Monitoring occurrence of SARS-CoV-2 in school populations: A wastewater-based approach. (Children transmit COVID in communities) PLOS One. 17.6.2022. https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0270168
Covid infections up after Platinum Jubilee celebrations. BBC. 17.6.2022. https://www.bbc.com/news/health-61839777
Outcomes of SARS-CoV-2 Reinfection. Research Square 17.6.2022. https://assets.researchsquare.com/files/rs-1749502/v1/
The covid waves continue to come. Omicron continues to drive waves of covid infections, writes Christina Pagel, but let’s not give up trying to control transmission. bmj. 17.6.2022. https://www.bmj.com/content/377/bmj.o1504?
Outcomes of SARS-CoV-2 Reinfection [US Veterans study, 0…1…2…3 infections]. Research Square. 17.6.2022. https://www.researchsquare.com/article/rs-1749502/v1
Reactogenicity, immunogenicity and breakthrough infections following heterologous or fractional second dose COVID-19 vaccination in adolescents (Com-COV3): A randomised controlled trial (Neutralising antibodies against Omicron BA.1 and BA.2 were higher after NVXCoV2373 than a two-dose 30µg BNT162b2 schedule. The lowest rate of SARS-CoV-2 breakthrough infections occurred in participants who received NVXCoV2373 as their second dose.) J Infect. 16.6.2023. https://www.journalofinfection.com/article/S0163-4453(23)00330-4/fulltext
Nature Index Annual Tables 2022: China’s research spending pays off
Experts say the country’s strong scientific performance is likely to be sustained in the coming years. nature. 16.6.2022. https://www.nature.com/articles/d41586-022-01669-0
Koronajohtajana tunnetuksi tullut Mika Salminen vaihtaa tehtävää. Kaleva. 16.6.2022. https://www.kaleva.fi/koronajohtajana-tunnetuksi-tullut-mika-salminen-va/4694403?s=03
Koronakriisin hoitoa johtanut Mika Salminen siirtyy uusiin tehtäviin – ”Ei pitäisi kohahduttaa”. Salminen ei usko, että muutos kohahduttaa suomalaisia. ”Minähän olen tässä ollut vain kasvot, jotta THL:n asiantuntijat saavat tehdä rauhassa työtään koronan torjumiseksi.””Nyt puhutaan siitä, että koronaan pitäisi varautua syksyä varten, se on väärä ajattelutapa. Meidän pitää sopeutua siihen, että korona on täällä. Nyt on sopiva aika jättää akuutti vaihe taakse. Koronaa hoidetaan siinä missä muitakin tarttuvia tauteja.”. Helsingin Sanomat. 16.6.2022. https://www.hs.fi/kotimaa/art-2000008889186.html
CLUES TO LONG COVID. Scientists strive to unravel what is driving disabling symptoms. Science. 16.6.2022. https://www.science.org/content/article/what-causes-long-covid-three-leading-theories
Long covid -diagnoosien määrä räjähti Suomessa – Rokotukset eivät pelastaneetkaan pitkittyneeltä koronalta. Helsingin Uutoiset 16.6.2022. https://www.helsinginuutiset.fi/paikalliset/4672874
Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae. medRxiv.16.6.2022. https://www.medrxiv.org/content/10.1101/2022.06.14.22276401v1
Life expectancy in racial and ethnic groups in the USA. Lancet. 16.6.2022. The Lancet | The best science for better lives
Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19. nature communications. 15.6.2022. https://www.nature.com/articles/s41467-022-30932-1.epdf
Ylilääkäreiden kannanotto Kainuun hyvinvointialueen organisaatiomuutoksiin: henkilöstöä on kuultu, mutta ei kuunneltu – “tapa on Kainuun soten kannalta vakavasti haitallinen”. Kainuun Sanomat. 15.6.2022. https://www.kainuunsanomat.fi/artikkeli/ylilaakareiden-kannanotto-kainuun-hyvinvointialueen-organisaatiomuutoksiin-henkilostoa-on-kuultu-mutta-ei-kuunneltu-tapa-on-kainuun-soten-kannalta-vakavasti-haitallinen-220160025/
Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial (Viraleze nasal spray against COVID and other virus infections). Scientific Reports. June 2022. DOI:10.1038/s41598-022-14601-3 https://www.researchgate.net/publication/361382162_Astodrimer_sodium_antiviral_nasal_spray_for_reducing_respiratory_infections_is_safe_and_well_tolerated_in_a_randomized_controlled_trial
Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs. Highlights: •mRNA vaccines promote sustained synthesis of the SARS-CoV-2 spike protein. •The spike protein is neurotoxic, and it impairs DNA repair mechanisms. •Suppression of type I interferon responses results in impaired innate immunity. •The mRNA vaccines potentially cause increased risk to infectious diseases and cancer. •Codon optimization results in G-rich mRNA that has unpredictable complex effects. Food and ChemicAL Toxicology. nn.6.2022. Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings. Molecular Psychiatry. 14.6.2022. https://www.nature.com/articles/s41380-022-01632-5
Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings. Molecular Psychiatry. 14.6.2022. https://www.nature.com/articles/s41380-022-01632-5
Omicron infection is a poor booster of COVID-19 immunity. People infected with the Omicron variant show poor immune boosting against future SARS-CoV-2 infection. Imperial College, London. 14.6.2022. https://www.imperial.ac.uk/news/237315/omicron-infection-poor-booster-covid-19-immunity/
Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure. Science 14.6.2022. https://www.science.org/doi/10.1126/science.abq1841
Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae. MedRxiv. 14.6.2022. https://doi.org/10.1101/2022.06.14.22276401
People who caught Covid in first wave get ‘no immune boost’ from Omicron. Study of triple vaccinated people also says Omicron infection does little to reduce chance of catching variant again. Guardian. 14.6.2022. https://www.theguardian.com/world/2022/jun/14/people-who-caught-covid-in-first-wave-get-no-immune-boost-from-omicron?CMP=Share_iOSApp_Other
Risk of Alzheimer’s Disease Following Influenza Vaccination: A Claims-Based Cohort Study Using Propensity Score Matching. Journal orf Alzheimer’s Disease. 13.6.2022. https://content.iospress.com/articles/journal-of-alzheimers-disease/jad220361#ref020
Japan Has Fewest Covid-19 Deaths Per Capita in OECD, New Data Show
Widespread mask-wearing and relatively little obesity in East Asia are cited for low mortality rate, but lessons remain elusive. WSJ. 13.6.2022. https://www.wsj.com/articles/japan-has-fewest-covid-19-deaths-per-capita-in-oecd-new-data-show-11655116829
Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurohttps://www.nature.com/articles/s41467-022-30932-1logical symptoms in COVID-19. nature communications. 13.6.2022.
Relax, This Isn’t the Future of Japanese Tourism. It’s easy to be frustrated with Japan’s slow reopening, but the country needs to learn to let down its guard first. Bloomberg. 13.6.2022. https://www.bloomberg.com/opinion/articles/2022-06-12/relax-tourism-to-japan-is-not-becoming-like-north-korea#xj4y7vzkg
Covid is making flu and other common viruses act in unfamiliar ways. Washington Post. 13.6.2022. https://www.washingtonpost.com/health/2022/06/13/covid-flu-rsv-viruses/
Yle: Husin johtajaylilääkäri varoittaa kesän koronakuolemista – ”Kehitys voi olla varsin huolestuttava”. Markku Mäkijärvi pitää kesäkuukausia tartuntojen kannalta riskialttiina, koska ihmiset liikkuvat ja lomailevat paljon. Ilta=Sanomat. 13.6.2022. https://www.is.fi/kotimaa/art-2000008881999.html
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. •Respiratory COVID induces CSF cytokine elevation and microglial reactivity •CCL11 activates hippocampal microglia and impairs neurogenesis •Respiratory COVID causes persistent loss of oligodendrocytes and myelinated axons •Respiratory influenza causes similar but less persistent cellular dysregulation. cell. 12.6.2022. DOI:https://doi.org/10.1016/j.cell.2022.06.008
June 11-20
‘More work’ to be done’: Key takeaways from the WHO report on origins of the Covid-19 pandemic. CNN World. 10.6.2022. https://edition.cnn.com/2022/06/10/china/who-covid-pandemic-origins-report-intl-hnk/index.html?
Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms (Brain, Cognitive) Brain. 9.6.2022. https://academic.oup.com/brain/article/145/9/3203/6604299?login=false
Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy. JAMA. 9.6.2022. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2793178
FDA decision on Novavax’s Covid shots could be delayed to review changes in manufacturing. CNBC. 9.6.2022. https://www.cnbc.com/2022/06/09/fda-decision-on-novavaxs-covid-shots-could-be-delayed-.html
Study Finds Previous Covid-19 Infection Doesn’t Protect Children From Omicron. Forbes. 9.6.2022. https://www.forbes.com/sites/williamhaseltine/2022/06/09/study-finds-previous-covid-19-infection-doesnt-protect-children-from-omicron/?sh=49cf6e9e1176
The occurrence of hyperactivated platelets and fibrinaloid microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Research Square. 8.6.2022. https://www.researchsquare.com/article/rs-1727226/v1
The COVID Event Horizon. How many COVID infections will you have in your lifetime? There’s probably a limit. Medium. 8.6.2022. https://medium.com/@socialcreature/the-covid-event-horizon-37dc504bf503
Concordance of SARS-CoV-2 RNA in Aerosols From a Nurses Station and in Nurses and Patients During a Hospital Ward Outbreak. JAMA. 8.6.2022. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2793153?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=070322
Hallitus laatii pelisääntöjä syksyn korona-aallon varalle – Koronapassilla ei enää voisi kiertää rajoituksia, jos niihin turvaudutaan. Hallitus kerää lausuntoja tartuntatautilakiin ehdotetuista muutoksista. Mediuutiset 8.6.2022. https://www.mediuutiset.fi/uutiset/mu/9f7492b9-942f-4298-b4e8-3ea828ea8161
New York Times: Leviääkö apinarokko ilmassa? Yhdysvaltain tautikeskus suosittelee maskia apinarokkopotilaalle ja hänen perheenjäsenilleen, aerosolitartunnoista puhutaan kuitenkin varoen. Lääkärilehti. 8.6.2022. https://www.laakarilehti.fi/terveydenhuolto/new-york-times-leviaako-apinarokko-ilmassa/?
Osa long covid -potilaista täyttää ME/CFS:n diagnostiset kriteerit – Molempien hoidossa ja kuntoutuksessa korostuu yksilöllisyys ja moniammatillinen yhteistyö. Covid-19-pandemia tulee todennäköisesti lisäämään merkittävästi ME/CFS-potilaiden määrää, kirjoittavat Hanna Markkula, Tuuli Latvala ja Eveliina Leinonen. Mediuutiset. 7.6.2022. https://www.mediuutiset.fi/debatti/osa-long-covid-potilaista-tayttaa-me-cfsn-diagnostiset-kriteerit-molempien-hoidossa-ja-kuntoutuksessa-korostuu-yksilollisyys-ja-moniammatillinen-yhteistyo/c6ca5347-41a1-48bc-aa33-2d721d246e4a
BA.5-variantin osuus yli kolminkertaistunut viikossa Husin alueella
Rokotusten ja aiemmin sairastetun koronan tuomaa suojaa kiertävä variantti yleistyy nopeasti. Lääkärilehti. 7.6.2022. https://www.laakarilehti.fi/terveydenhuolto/ba.5-variantin-osuus-yli-kolminkertaistunut-viikossa-husin-alueella/?
Nirmatrelvir Resistant SARS-CoV-2 Variants with High Fitness in Vitro. bioRxiv. 7.6.2022. https://www.biorxiv.org/content/10.1101/2022.06.06.494921v1
The substitutions L50F, E166A and L167F in SARS-CoV-2 3CLpro are selected by a protease inhibitor in vitro and confer resistance to nirmatrelvir. bioRxiv. 7.6.2022. https://www.biorxiv.org/content/10.1101/2022.06.07.495116v1
U.S. CDC removes mask recommendation from monkeypox travel notice to avoid confusion. Reuters. 7.6.2022. https://www.reuters.com/world/us/us-cdc-removes-mask-recommendation-monkeypox-travel-notice-avoid-confusion-2022-06-07/
Reducing SARS-CoV-2 in Shared Indoor Air. JAMA Wiewpoint. 7.6.2022. https://jamanetwork.com/journals/jama/fullarticle/2793289
Covid-19: Doctor who sold hydroxychloroquine as “magic bullet” treatment is jailed. bmj. 6.6.2022. https://www.bmj.com/content/377/bmj.o1395?=&utm_source=adestra&utm_medium=email&utm_campaign=usage&utm_content=daily&utm_term=text
Suomessa on varastossa yli 3 miljoonaa koronarokotetta – ylilääkäri kommentoi. Suomen suuret koronarokotevarastot ovat monen tekijän summa. Iltalehti. 6.6.2022. https://www.iltalehti.fi/terveysuutiset/a/1a472435-f0dd-4758-8cbf-a1aef16b9cc0
What Our COVID-19 Response Can Teach Us About Dealing With Monkeypox. TIME. 6.6.2022. https://view.newsletters.time.com/?qs=9cb58f3b3de900675050d37e9b6ffb7f1046c9a1ae9705166182eecc6f650ee06006c91f5ac2b1d08814c8613a974a32c9e21a0b23c631e31989e7d00123d09625d8bc616f83a350777fe2b0696e294c&fbclid=IwAR3-zUmfPNK1KYaybI8s8IhOaAfQRaxLWEvhiiJNJCZOBTphHED9CZ0Hb9k
Short-term Mortality Fluctuations. HMD Short-Term Human Mortality Database. 6.6.2022. https://mpidr.shinyapps.io/stmortality/ HMD Finland Total population https://www.mortality.org/Country/Country?cntr=FIN
How Swedish authorities worked to export “herd immunity” to other countries. The following is a submission to the Global Workers’ Inquest into the COVID-19 Pandemic from anti-COVID activists Keith Begg and Virpi Flyg on the efforts of the Swedish government to export its “herd immunity” strategy of mass infection to countries throughout the world. Begg is a communications specialist from Ireland who holds both Irish and Swedish citizenship, and the founder of Media Watchdogs of Sweden. Flyg is a writer, translator, and social media influencer from Finland. World Socioalist Web Site. 5.6.2022. https://www.wsws.org/en/articles/2022/06/06/swed-j06.html
Suomalaistutkijat alkavat etsiä kiivaasti long covidin alatyyppejä – diagnoosien määrä on jopa nelinkertaistunut lyhyessä ajassa
Helsingin yliopistollisen sairaalan johtaman tutkimushankkeen tavoitteena on selvittää koronavirusinfektion jälkeisten pitkäaikaisten oireiden eli long covidin taustalla olevia mekanismeja.YLE Uutiset. 4.6.2022. https://yle.fi/uutiset/3-12468334
Long COVID-19 in children: an Italian cohort study. (Our study demonstrates that Long COVID-19 is a reality in pediatric age and could involve even patients with mild or no acute symptoms. The results stress the importance of monitoring primary care pediatric patients after acute COVID-19 infection and the relevance of vaccination programs in pediatric population, also in order to avoid the consequences of Long COVID-19 syndrome.). Italian Journal of Pediatrics. 3.6.2022. https://ijponline.biomedcentral.com/articles/10.1186/s13052-022-01282-x
Can long Covid lead to death? A new analysis suggests it could
The CDC is beginning to look at death certificates that indicate more than 100 people who died had long Covid. Politico. 3.6.2022. https://www.politico.com/news/2022/06/03/can-long-covid-lead-to-death-a-new-analysis-suggests-it-could-00036845
Omicron subvariant drives spike in cases and deaths in Portugal
Europe faces prospect of further Covid measures later in the year as share of Omicron BA.5 cases rise in Portugal and Germany. Guardian. 3.6.2022. https://www.theguardian.com/world/2022/jun/03/omicron-covid-subvariant-drives-spike-in-cases-and-deaths-in-portgual?CMP=Share_iOSApp_Other
Covid Is Way More Lethal to Kids Than The Flu (In the US, nearly six times more kids and teens died from Covid in one year than did from the flu, according to a new analysis of pediatric mortality data.). Bloomberg. 3.6.2022. https://www.bloomberg.com/news/newsletters/2022-06-03/coronavirus-daily-covid-is-more-lethal-to-kids-than-the-flu
Lasse Lehtoselta kritiikkiä THL:n rokotussuosituksista: ”Hifistelyä” – näkee myös asiakastyytyväisyyden vaarantuvan. Helsingin ja Uudenmaan sairaanhoitopiirin diagnostiikkajohtaja ja terveysoikeuden professori Lasse Lehtonen antaa kritiikkiä THL:n tänään päivittämästä rokotussuosituksesta. Demokraatti. 2.6.2022. https://demokraatti.fi/lasse-lehtoselta-kritiikkia-thln-rokotussuosituksista-hifistelya-nakee-myos-asiakastyytyvaisyyden-vaarantuvan
Yli 80-vuotiaiden ylikuolleisuudella ei selvää yhteyttä tehosterokotusten myöhäiseen aloitukseen. FaktaBaari. 2.6.2022. https://www.faktabaari.fi/fakta/yli-80-vuotiaiden-ylikuolleisuudella-ei-selvaa-yhteytta-tehosterokotusten-myohaiseen-aloitukseen/
Why did Covid disappear from our collective consciousness so quickly?
Brigid Delaney. Guardian. 2.6.2022. https://www.theguardian.com/commentisfree/2022/jun/03/why-did-covid-disappear-from-our-collective-consciousness-so-quickly
Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine. NEJM. 2.6.2022. https://www.nejm.org/doi/full/10.1056/NEJMoa2201300
Covid-19: Two million people in the UK are estimated to be experiencing long covid, says ONS. bmj. 1.6.2022. https://www.bmj.com/content/377/bmj.o1391?
Why does viral RNA sometimes persist after recovery from acute infections? PLOS Biology. 1.6.2022. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001687
People still afraid of catching COVID-19 are costing the U.S. economy billions of dollars. Head Topics US. 1.6.2022. https://headtopics.com/us/people-still-afraid-of-catching-covid-19-are-costing-the-u-s-economy-billions-of-dollars-32517926
COVID death tolls: scientists acknowledge errors in WHO estimates
Researchers with the World Health Organization explain mistakes in high-profile mortality estimates for Germany and Sweden.. nature. 1.6.2022. https://www.nature.com/articles/d41586-022-01526-0/
Hyvästi, Koronavilkku! Sovellus lopetti toimintansa – Sen kautta tehtiin 64 000 tartuntailmoitusta. Mediuutiset. 1.6.2022. https://www.mediuutiset.fi/uutiset/mu/f72367c1-f0c0-41c1-b36d-82457a0bdf7b?ref=newsletter:e718&utm_source=uutiskirje%40mediuutiset.fi&utm_medium=email&utm_campaign=MU-Uutiskirje-laakari
Great Barrington julkilausuma eli miten fossiilisten polttoaineiden teollisuuden lobbarit kaappasivat keskustelun koronatorjunnasta. GBD Blog. June 2022. https://docs.google.com/document/d/1eLRKtkRg5fnHFs_cgarZWIzsFE6Seya39oCVExD76Kk/mobilebasic
June 1-10
During the Omicron Wave, Death Rates Soared for Older People
Last year, people 65 and older died from Covid at lower rates than in previous waves. But with Omicron and waning immunity, death rates rose again. New York Times. 31.5.2022. https://www.nytimes.com/2022/05/31/health/omicron-deaths-age-65-elderly.html
Mask wearing in community settings reduces SARS-CoV-2 transmission (We resolve conflicting results regarding mask wearing against COVID-19. Most previous work focused on mask mandates; we study the effect of mask wearing directly. We find that population mask wearing notably reduced SARS-CoV-2 transmission (mean mask-wearing levels corresponding to a 19% decrease in R). We use the largest wearing survey (n = 20 million) and obtain our estimates from regions across six continents. We account for nonpharmaceutical interventions and time spent in public, and quantify our uncertainty.). PNAS. 31.5.2022. https://www.pnas.org/doi/10.1073/pnas.2119266119
Living with covid cannot save lives, but research can. BMJ. 30.5.2022. https://www.bmj.com/content/377/bmj.o1361
Monitoring for SARS-CoV-2 drug resistance mutations in broad viral populations. bioRxiv. 30.5.2022. https://www.biorxiv.org/content/10.1101/2022.05.27.493798v1
COVID-19: Infektionen hinterlassen bei Kindern keinen Antikörperschutz vor Omikron. 30.5.2022. https://www.aerzteblatt.de/nachrichten/134653/COVID-19-Infektionen-hinterlassen-bei-Kindern-keinen-Antikoerperschutz-vor-Omikron?utm_source=dlvr.it&utm_medium=twitter
Secretoglobin family 1D member 2 (SCGB1D2) protein inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease. bioRxiv. 28.5.2022. https://www.biorxiv.org/content/10.1101/2022.05.27.493784v1
A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021. medRxiv.27.5.2022. https://pubmed.ncbi.nlm.nih.gov/35664995/
COVID-19 in 2022—The Beginning of the End or the End of the Beginning? JAMA. 27.5.2022. https://jamanetwork.com/journals/jama/fullarticle/2793011?
Aktuell veckorapport om influensa: Denna rapport publicerades den 26 maj 2023 och redovisar influensaläget vecka 19–20 (8–21 maj). Uppdaterad 27 juli 2023 med korrigering av datakälla för Region Norrbottens vaccinationstäckning. Folkhälsomyndigheten. 26.5.2023. https://www.folkhalsomyndigheten.se/folkhalsorapportering-statistik/statistik-a-o/sjukdomsstatistik/influensa-veckorapporter/aktuell-veckorapport-om-influensa/
SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 subvariants evolved to extend antibody evasion. bioRxiv. 26.5.2022. https://doi.org/10.1101/2022.05.26.493517
Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5. bioRxiv. 26.5.2022. https://doi.org/10.1101/2022.05.26.493539
On the Trail of Long COVID. TIME. 26.5.2022. https://view.newsletters.time.com/?qs=7655bc242c5b342e5fb155e57cad97209b4badce519bcf744c4012e3ac96471e53f513725b0c4e0158e7cea04ca0ad76012970bcb2e05b541e8b6b0551b0dc6822cf87e979b88be24d3847588b973482&fbclid=IwAR0C8kVgWIbRoWIjs3dNxUWWu4yIvjbAElOvNVeAdAuYjIheN40UFKBGKrE
Evusheld long-acting antibody combination retains neutralising activity against Omicron variants BA.4 and BA.5, according to new study from University of Oxford. AstraZeneca. 25.5.2022. https://www.astrazeneca.com/media-centre/medical-releases/evusheld-long-acting-antibody-combination-retains-neutralising-activity-omicron-variants-ba4-ba5-according-new-study-university-oxford.html
Long COVID after breakthrough SARS-CoV-2 infection. Nature Medicine. 25.5.2022. https://www.nature.com/articles/s41591-022-01840-0
Long COVID risk falls only slightly after vaccination, huge study shows
Results suggest that vaccines offer less protection against lingering symptoms than expected. Nature. 25.5.2022. https://www.nature.com/articles/d41586-022-01453-0
Kuolleisuus on kasvanut, mutta THL ei tingi neljänsien koronarokotteiden ikärajasta – “En uskonut silmiäni”, sanoo Maijaliisa Aho, 72
Moni ikäihminen odottaa muutoksia rokotusten ikärajoihin. Asiantuntijat ovat erimielisiä, eikä Kansallisen rokotusasiantuntijaryhmän päätöskään ollut yksimielinen.YLE Uutiset. 25.5.2022. https://yle.fi/uutiset/3-12461806
Suomen ensimmäinen apinarokkotartunta hyvin todennäköinen. HUSissa on todettu aikuisella miespotilaalla orthopox-ryhmään kuuluvan viruksen aiheuttama tartunta. Apina- ja isorokkovirukset ovat orthopoxviruksia. Lopullinen varmistus apinarokkotartunnasta saadaan, kun näytteen sekvensointi valmistuu loppuviikolla. STT Info (HUS). 25.5.2022. https://www.sttinfo.fi/tiedote/suomen-ensimmainen-apinarokkotartunta-hyvin-todennakoinen?publisherId=23980819&releaseId=69942501
Risk of blood clots in lung doubled for COVID survivors: US study. MedicalXpress. 25.5.2022. https://medicalxpress.com/news/2022-05-blood-clots-lung-covid-survivors.html
Researchers Find a Pathway to Prevent COVID Infection. Medscape. 25.5.2022. https://www.medscape.com/viewarticle/974617?
Post–COVID Conditions Among Adult COVID-19 Survivors Aged 18–64 and ≥65 Years (As more persons are exposed to and infected by SARS-CoV-2, reports of patients who experience persistent symptoms or organ dysfunction after acute COVID-19 and develop post-COVID conditions have increased.COVID-19 survivors have twice the risk for developing pulmonary embolism or respiratory conditions; one in five COVID-19 survivors aged 18–64 years and one in four survivors aged ≥65 years experienced at least one incident condition that might be attributable to previous COVID-19.). CDC MMRW. 24.5.2022. https://www.cdc.gov/mmwr/volumes/71/wr/mm7121e1.htm
Why the Air at the Gym May Be More Likely to Spread Covid. A new study found exercisers expel a shocking number of tiny aerosol particles when they are working hard. New York Times. 24.5.2022. https://www.nytimes.com/2022/05/24/well/move/covid-gym-air.html
Post-COVID C+onditions Among Adult COVID-19 Survivors Aged 18-64 and >65 Years – United States, March 2020-November 2021. CDC MMWR. 24.5.2022. https://www.cdc.gov/mmwr/volumes/71/wr/mm7121e1.htm
Aerosol particle emission increases exponentially above moderate exercise intensity resulting in superemission during maximal exercise. 23.5.2022. PNAS. https://www.pnas.org/doi/10.1073/pnas.2202521119
As Monkeypox Cases Rise, Nations Are Urged to Examine Vaccine Stores
The United States has stockpiled millions of doses of two smallpox vaccines, also effective against monkeypox. But the outbreaks so far are clustered in other countries. New York Times. 23.5.2022. https://www.nytimes.com/2022/05/23/health/monkeypox-vaccines.html?referringSource=articleShare
COVID-19 symptoms and duration of direct antigen test positivity at a community testing and surveillance site, January 2021-2022. medRxiv. 23.5.2022. https://www.medrxiv.org/content/10.1101/2022.05.19.22274968v1
How Rapid Reinfection Has Changed the Covid Fight. New variants can infect people who had Covid-19 as recently as a few months ago. The Mew Republic. 23.5.2022. https://newrepublic.com/article/166573/reinfection-ba2-omicron-covid
Where is the next SARS-CoV-2 variant of concern?. Lancet. 21.5.2022. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00743-7/fulltext
Widening of inequalities in COVID- 19 years of life lost from 2020 to 2021: a Scottish Burden of Disease Study. JECH. 21.5.2022.https://jech.bmj.com/content/jech/early/2022/05/24/jech-2022-219090.full.pdf
May 21-31
School Masking Policies and Secondary SARS-CoV-2 Transmission. AAP Publications. 20.5.2022. https://publications.aap.org/pediatrics/article/149/6/e2022056687/185379/School-Masking-Policies-and-Secondary-SARS-CoV-2?autologincheck=redirected
Excess Mortality in Massachusetts During the Delta and Omicron Waves of COVID-19. JAMA. 20.5.2022. https://jamanetwork.com/journals/jama/fullarticle/2792738?
Child hepatitis cases up to almost 200, say public health officials. ‘It’s important that parents know the likelihood of their child developing hepatitis is extremely low’ says UKHSA. Independent. 20.5.2022. https://www.independent.co.uk/news/health/child-hepatitis-public-health-b2083855.html
Monkeypox in Australia: what is it and how can we prevent the spread? The Conversation. 20.5.2022. https://theconversation.com/monkeypox-in-australia-what-is-it-and-how-can-we-prevent-the-spread-183526
So, Have You Heard About Monkeypox? A new viral outbreak is testing whether the world has learned anything from COVID. Atlantic. 20.5.2022. https://www.theatlantic.com/health/archive/2022/05/monkeypox-outbreak-covid-pandemic/629920/
SARSCoV2 variants of concern and variants under investigation in England Technical briefing 42. UK Health Security Agency. 20.5.2022. extension://elhekieabhbkpmcefcoobjddigjcaadp/https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1077180/Technical-Briefing-42-20May2022.pdf
Families Live in Fear as Long-Haul Covid Afflicts More Children
A hospital in Ohio creates a new clinic to treat those patients. Bloomberg. 19.5.2022. https://www.bloomberg.com/news/articles/2021-05-19/long-haul-covid-kids-coronavirus-proving-more-serious-risk-to-children#xj4y7vzkg
Want to prevent pandemics? Stop spillovers. Decision-makers discussing landmark agreements on health and biodiversity must include four actions to reduce the risk of animals and people exchanging viruses. Nature. 19.5.2022. https://media.nature.com/original/magazine-assets/d41586-022-01312-y/d41586-022-01312-y.pdf
Ensimmäinen poliotapaus 30 vuoteen on vahvistettu Mosambikissa – Virus hävitettiin Afrikasta jo kertaalleen. Maailman terveysjärjestön (WHO) Afrikan-aluejohtaja Matshidiso Moeti totesi uuden löydöksen olevan ”erittäin huolestuttava”. Helsingin Sanomat. 19.5.2022. https://www.hs.fi/ulkomaat/art-2000008830045.html
Korona aiheuttaa edelleen runsaasti poissaoloja työpaikoilta – korvaushakemuksia on niin paljon jonossa, että Kela palkkaa 50 uutta käsittelijää. S-ryhmässä alkuvuosi oli haastava omikronin viedessä työntekijöitä sairauslomille. Pandemian aikana koronapoissaolot ovat pakottaneet jopa sulkemaan yksittäisiä S-ryhmän liikkeitä tai lyhentämään aukioloa. YLE Uutiset. 19.5.2022. https://yle.fi/uutiset/3-12450525
STM: Hoivakodeissa on vielä keväällä edessä koronakuolemia – Uusi tartunta-aalto syksyllä tai talvella todennäköinen. Suomessa koronakuolemien ja tartuntojen määrä on kuitenkin laskenut maaliskuun korkeista luvuista. Helsingin Sanomat. 19.5.2022. https://www.hs.fi/kotimaa/art-2000008826106.html
Apinarokko on isorokon varjo. (Aivelo) Tiede. 19.5.2022. https://www.tiede.fi/blogit/kaiken-takana-loinen/apinarokko-isorokon-varjo
Neutralization Escape by the SARS-CoV-2 Omicron Variants BA.2.12.1 and BA.4/BA.5 medRxiv. 19.5.2022. https://www.medrxiv.org/content/10.1101/2022.05.16.22275151v1
Kannattaako koronarokotusta enää ottaa? Tähän ihmisryhmään kuuluvien ei ole vielä syytä mennä kolmannelle piikille, kertoo THL:n Hanna Nohynek. Helsingin Uutiset. 18.5.2022. https://www.helsinginuutiset.fi/paikalliset/4612645
Erkenntnisse zu Covid-Infektionen: Warum manche Menschen kein Corona hatten. Während der Omikron-Welle haben sich Millionen Menschen mit Sars-CoV-2 infiziert. Manche hatten aber bisher noch nie ein positives Testergebnis. Woran kann das liegen? BaZ Wissen. 18.5.2022. https://www.bazonline.ch/warum-manche-menschen-kein-corona-hatten-318416937600?
The pandemic’s true health cost: how much of our lives has COVID stolen? Researchers are trying to calculate how many years have been lost to disability and death. (DALY) Nature. 18.5.2022. https://www.nature.com/articles/d41586-022-01341-7?
Monkeypox – United Kingdom of Great Britain and Northern Ireland. WHO. 18.5.2022. https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON383
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak. STAT. 18.5.2022. https://www.statnews.com/2022/05/18/spain-portugal-report-monkeypox-cases-raising-specter-of-wider-outbreak/?
Onko kesä peruttu? Tehoavatko rokotteet? Viisi kysymystä ja vastausta Suomeen rantautuneesta uudesta omikronvariantista
Turun yliopistollinen keskussairaala kertoi keskiviikkona löytäneensä potilaalta Suomen ensimmäisen Etelä-Afrikan omikronvariantin. YLE Uutiset. 18.5.2022. https://yle.fi/uutiset/3-12451831
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination. nature.18.5.2022. https://www.nature.com/articles/s41586-022-04865-0.
Omicron Infection Induces Low-Level, Narrow-Range SARS-CoV-2 Neutralizing Activity. Lancet. 16.5.2022. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4099400
Coronavirus may be linked to cases of severe hepatitis in children. Reuters. 16.5.2022. https://www.reuters.com/business/healthcare-pharmaceuticals/coronavirus-may-be-linked-cases-severe-hepatitis-children-2022-05-16/
The Answer to Stopping the Coronavirus May Be Up Your Nose. New York Times. 16.5.2022. https://www.nytimes.com/2022/05/16/opinion/covid-nasal-vaccine.html
Just how accurate are rapid antigen tests? Two testing experts explain the latest data. The Conversation. 16.5.2022. https://theconversation.com/just-how-accurate-are-rapid-antigen-tests-two-testing-experts-explain-the-latest-data-180405?
Avohilmo: Perusterveydenhuollon avohoidon ICD-10 – käyntisyyt. THL jatkuvasti päivittyvä? https://sampo.thl.fi/pivot/prod/fi/avo/perus06/summary_icd1001?alue_0=11810&alue_1=&alue_2=&palvelumuoto_0=33780&ammattiryhm%C3%A4_0=30664&ik%C3%A4luokat_0=109987&sukupuoli_0=11936&mittari_0=100050&drill-diagnoosi=11
How Australia Saved Thousands of Lives While Covid Killed a Million Americans. The United States and Australia share similar demographics, but their pandemic death rates point to very different cultures of trust. New York Times. 15.5.2022. https://www.nytimes.com/2022/05/15/world/australia/covid-deaths.html?referringSource=articleShare
Long-term Neuropsychiatric Complications and 18F-FDG-PET Hypometabolism in the Brain From Prolonged Infection of COVID-19. Alzheimer Disease. April-June. 2022. https://journals.lww.com/alzheimerjournal/Abstract/2022/04000/Long_term_Neuropsychiatric_Complications_and.12.aspx
Multivariate profile and acute-phase correlates of cognitive deficits in a COVID-19 hospitalised cohort. eClinicalMedicine. NN.5.2022. https://www.sciencedirect.com/science/article/pii/S258953702200147X
Post COVID-19 pulmonary fibrosis; a meta-analysis study. Annals of Medicine and Surgery. NN.5.2022. https://www.sciencedirect.com/science/article/pii/S2049080122003508
SARS-CoV-2 Infection May Present as Acute Hepatitis in Children. Ped Inf Dis J. NN.5.2022. https://journals.lww.com/pidj/fulltext/2021/05000/sars_cov_2_infection_may_present_as_acute.38.aspx
Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens. Lancet Gastroent&Hepatol. 14.5.2022. https://www.sciencedirect.com/science/article/pii/S2468125322001662
Elevated liver enzymes and bilirubin following SARS-CoV-2 infection in children under 10. medRxiv. 14.5.2022. https://www.medrxiv.org/content/10.1101/2022.05.10.22274866v1
Mistä ylikuolleisuusluvut johtuvat? Koronapandemia on sosiaalilääketieteellinen tauti, jonka ilmaantuvuuteen ja haittoihin vaikuttavat niin lääketieteelliset kuin sosiaalisetkin tekijät. Mielipidekirjoitus. Helsingin Sanomat. 14.5.2022. https://www.hs.fi/mielipide/art-2000008812081.html
Tracking covid-19 excess deaths across countries. In many parts of the world, official death tolls undercount the total number of fatalities. Economist. 13.5.2022. https://www.economist.com/graphic-detail/coronavirus-excess-deaths-tracker
You Could Catch Covid Again. And Again. And Even Again. As the virus surges through the US yet again, some people are catching it for a second, third or even fourth time. Bloomberg. 13.5.2022. https://www.bloomberg.com/news/articles/2022-05-13/can-i-get-covid-twice-covid-surges-again-in-us-with-reinfections-rising?
Protecting Children Against Omicron. JAMA. 13.5.2022. https://jamanetwork.com/journals/jama/fullarticle/2792526?guestAccessKey=dce928b5-79bb-4785-978d-20cc768a93cb&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=051322
Epidemiological update: SARS-CoV-2 Omicron sub-lineages BA.4 and BA.5. ECDC. 13.5.2022. https://www.ecdc.europa.eu/en/news-events/epidemiological-update-sars-cov-2-omicron-sub-lineages-ba4-and-ba5
NICE outlines steps needed to put ME/CFS guideline into practice. NICE has today, International ME Awareness Day (Thursday, 12 May 2022) published its implementation statement which sets out the practical steps needed to put its recent guideline on the diagnosis and management of myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome (ME/CFS) into. National Institute for Health and Care Excellence. 12.5.2022. https://www.nice.org.uk/news/article/nice-outlines-steps-needed-to-put-me-cfs-guideline-into-practice
Premature ageing of the immune system may be one cause of long covid. New Scientist. 12.5.2022. https://www.newscientist.com/article/mg25033343-000-premature-ageing-of-the-immune-system-may-be-one-cause-of-long-covid/
High population burden of Omicron variant (B.1.1.529) is associated with the emergence of severe hepatitis of unknown etiology in children. Int J Infect Dis. 12.5.2022. https://www.ijidonline.com/article/S1201-9712(22)00290-9/fulltext
Sairaanhoitopiiri suosittaa neljänsiä koronarokotteita nyt myös yli 70-vuotiaille kotihoidon tai omaishoidon piirissä oleville – Tampere aloittaa heti
Jo aiemmin neljänsiä rokotuksia on suositeltu yli 80-vuotiaille. YLE Uutiset. 12.5.2022. https://yle.fi/uutiset/3-12441549
“Koronakuolleisuuden voimakas kasvu jäänyt pimentoon”, sanoo HUSin Lasse Lehtonen – Suomi saattaa tätä menoa kiilata Ruotsin ohi
Lehtosen mukaan väärä tilannekuva voi vähentää ihmisten hakeutumista tehosterokotuksiin. YLE Uutiset. 12.5.2022. https://yle.fi/uutiset/3-12440967
Akuutteja maksatulehduksia havaittu useissa Euroopan maissa, ei yhteyttä koronavirukseen – Suomessa ei viitteitä tapausten lisääntymisestä. Keski-Uusimaa. 12.5.2022. https://www.keski-uusimaa.fi/paikalliset/4600549
Japanese researcher suggests ties between omicron variant and severe hepatitis in children, Japan Times. 12.5.2022. https://www.japantimes.co.jp/news/2022/05/12/national/science-health/japanese-researcher-omicron-hepatitis-children/
Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study. Lancet. Respiratory Medicine. 11.5.2022. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00126-6/fulltext
Huippujulkaisu The Lancet julkaisi tietoa Suomen hurjasta ylikuolleisuudesta koronavuosina – Mikä on totuus lukujen takana? THL:n ylilääkäri Tuija Leinon mukaan todellisuudessa vain osassa kuolemista koronatauti on perimmäinen kuolinsyy. ”Osassa tauti on osavaikutus, pienessä osassa ei sitäkään”, hän sanoo. Helsingin Sanomat. 11.5.2022. https://www.hs.fi/kotimaa/art-2000008803767.html
May 11-20
THL:n kaksoisrooli rokotteiden tutkimuksessa ja hankinnassa sai oikeuskanslerin vaatimaan riippumattomuuden vahvistamista. SSS.fi. 10.5.2022. https://www.sss.fi/2019/05/oikeuskansleri-vaatii-rokotetutkimuksen-ja-hankintojen-selkeampaa-erottamista-thln-toiminnassa/
Fulminant onset COVID-19: predictors and outcome. BMJ Postgraduate Medical Journal. 10.5.2022. https://pmj.bmj.com/content/early/2022/05/10/postgradmedj-2022-141724
Suun kautta otettavia koronalääkkeitä ei toiveista huolimatta ole saatu Suomeen – neuvottelut junnaavat tai lisänäyttöä vaaditaan
Tuore tutkimustulos kertoo, että koronalääkkeistä remdesiviiri vähentää varmasti kuolleisuutta varhain aloitettuna. Suomalaisprofessori toivoo, että lääkkeitä käyttöönotettaessa niiltä vaadittaisiin laajempaa tutkimusnäyttöä. YLE-Uutiset. 10.5.2022. https://yle.fi/uutiset/3-12430354?utm_source=social-media-share&utm_medium=social&utm_campaign=ylefiapp
Are COVID surges becoming more predictable? New Omicron variants offer a hint. Omicron relatives called BA.4 and BA.5 are behind a fresh wave of COVID-19 in South Africa, and could be signs of a more predictable future for SARS-CoV-2. Nature. 10.5.2022. https://www.nature.com/articles/d41586-022-01240-x?
Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar. medRxiv. 10.5.2022. https://www.medrxiv.org/content/10.1101/2022.05.09.22274802v1.full
New versions of Omicron are masters of immune evasion. Vaccines and prior infection still prevent severe disease from new SARS-CoV-2 strains. Science. 10.5.2022. https://www.science.org/content/article/new-versions-omicron-are-masters-immune-evasion
Covid-19: Fourth dose of mRNA vaccines is safe and boosts immunity, study finds. BMJ. 10.5.2022. https://www.bmj.com/content/377/bmj.o1170?
Feature: How Hong Kong’s vaccination missteps led to the world’s highest covid-19 death rate. Omicron has taken Hong Kong from having one of the lowest covid-19 death rates in the world to having the highest daily death rate per capita. A key reason for this is the island’s handling of vaccination. BMJ. 9.5.2022. https://www.bmj.com/content/377/bmj.o1127?
The route back to 2% inflation − speech by Michael Saunders (impact of COVID & Long COVID on workforce) 9.5.2022. https://www.bankofengland.co.uk/speech/2022/may/michael-saunders-speech-at-the-resolution-foundation-event
Surviving the pandemic is only half the battle: ‘Long COVID’ could affect a billion in just a few years. Fortune. 8.5.2022. https://fortune.com/2022/05/08/surviving-pandemic-half-the-battle-long-covid-growing-public-health-crisis-could-affect-a-billion-in-just-a-few-years/
Suomi kärkisijoilla koronakuolleisuustilastossa – Lasse Lehtonen: ”Epäonnistumiseen on vaikuttanut viisi tekijää”. Kauppalehti. 8.5.2022. https://www.kauppalehti.fi/uutiset/suomi-karkisijoilla-koronakuolleisuustilastossa-lasse-lehtonen-epaonnistumiseen-on-vaikuttanut-viisi-tekijaa/d9ec49a7-8766-46b5-a2a0-f7e737ea4a9c?ref=whatsapp:6978
Estimates of excess mortality for the five Nordic countries during the Covid-19 pandemic 2020-2021. medRxiv. 7.5.2022. https://www.medrxiv.org/content/10.1101/2022.05.07.22274789v1.full.pdf
Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 6 May 2022
Estimates of the prevalence of self-reported long COVID and associated activity limitation, using UK Coronavirus (COVID-19) Infection Survey data. Office of National Statistics. 6.5.2022. https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/prevalenceofongoingsymptomsfollowingcoronaviruscovid19infectionintheuk/6may2022
Omicron as severe as other COVID variants -large U.S. study. Reuters. 6.5.2022. https://www.reuters.com/business/healthcare-pharmaceuticals/omicron-severe-previous-covid-variants-large-study-finds-2022-05-05/
Persistent white matter changes in recovered COVID-19 patients at the 1-year follow-up. Brain. 5.5.2022. https://academic.oup.com/brain/article/145/5/1830/6464331?login=false
Why India’s real Covid toll may never be known. BBC News. 5.5.2022. https://www.bbc.com/news/world-asia-india-60981318
Näin 4. koronarokotuksen suositus laajenee – Mika Salminen: Suomeen tulossa rauhallinen kesä. Laajennuksella pyritään estämään heikossa kunnossa olevien tartuntoja. Asiantuntijat odottavat kesästä rauhallista, mutta epidemia nostanee päätään taas syksyllä. Uusi Suomi. 5.5.2022. https://www.uusisuomi.fi/uutiset/nain-4-koronarokotuksen-suositus-laajenee-mika-salminen-suomeen-tulossa-rauhallinen-kesa/565bef5e-613d-4f62-b23f-b0cb7b4aa53c
SARS-CoV-2 and its variants, but not Omicron, induces severe thymic atrophy and impaired T cell development. Research Square. 5.5.2022. https://www.researchsquare.com/article/rs-1581769/v1
Long COVID or Post-COVID Conditions. CDC. 5.5.2022. https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html
Tehohoidon tilannekuva: COVID-19 teho-osastoilla. Kansallinen tehohoidon koordinoiva toimisto Kuopion yliopistollinen sairaala. Raportti 4.5.2022. https://www.psshp.fi/documents/194344/209627/Tehohoidon+tilannekuva+-+Koordinoivan+toimiston+raportti+2022_05_04.pdf/32c19e78-75ca-02dd-14bc-c50965ae4a04
Mitä maskien hyödyistä oikeasti tiedetään? Maskisuositus päättyi, mutta maski kannattaisikin vaihtaa hengityksensuojaimeen, jos haluaa välttää koronan. Lääkärilehti. 4.5.2022. https://www.laakarilehti.fi/terveydenhuolto/mita-maskien-hyodyista-oikeasti-tiedetaan/?public=e5870728c558cf14d30dff51e32e1935
The Children Left Behind by Long Covid. As the world pretends the pandemic is over, at least a half-million children in the U.S. are struggling with the mysterious disease. Bloomberg. 4.5.2022. https://www.bloomberg.com/news/features/2022-05-04/long-covid-in-kids-has-effects-that-last-beyond-hospital
Lasting brain impacts of severe COVID-19 equivalent to 20 years of ageing (Analysis of the data revealed COVID-19 survivors were less accurate and had slower response times than the matched control population. These deficits were still detectable when the patients were following up six months later. / The effects were strongest for those who required mechanical ventilation. By comparing the patients to 66,008 members of the general public, the researchers estimate that the magnitude of cognitive loss is similar on average to that sustained with 20 years ageing, between 50 and 70 years of age, and that this is equivalent to losing 10 IQ points. / Survivors scored particularly poorly on tasks such as verbal analogical reasoning, a finding that supports the commonly-reported problem of difficulty finding words. They also showed slower processing speeds, which aligns with previous observations post COVID-19 of decreased brain glucose consumption within the frontoparietal network of the brain, responsible for attention, complex problem-solving and working memory, among other functions.). Imperial College. 3.5.2022. https://www.imperial.ac.uk/news/236034/lasting-brain-impacts-severe-covid-19-equivalent/
Long COVID: As much as 75% of hospital patients still not ‘fully recovered’. -Researchers followed around 2,000 people who were hospitalized due to a COVID-19-related illness. Of the participants, only 1 in 4 reported feeling fully recovered a year after they were released from the hospital.
Some factors the researchers believe contributed to a poorer outcome include obesity and requiring the use of a ventilator during their hospital stay. MedicalNewsToday. 3.5.2022. https://www.medicalnewstoday.com/articles/long-covid-as-much-as-75-of-hospital-patients-still-not-fully-recovered
SARS-CoV-2 Omicron Variant is as Deadly as Previous Waves After Adjusting for Vaccinations, Demographics, and Comorbidities. Research QSARS-CoV-2 Omicron Variant is as Deadly as Previous Waves After Adjusting for Vaccinations, Demographics, and Comorbidities. Research Square. 2.5.2022. https://www.researchsquare.com/article/rs-1601788/v1
Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses [Marjukka Myllärniemi]. Lancet. 2.5.2022. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00519-0/fulltext
Postacute COVID-19 is Characterized by Gut Viral Antigen Persistence in Inflammatory Bowel Diseases. Gastroenterology. 1.5.2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057012/
Inflammasome activation in infected macrophages drives COVID-19 pathology. bioRxiv. 1.5.2022. https://www.biorxiv.org/content/10.1101/2021.09.27.461948v2
May 1-10
Fulminant onset COVID- 19: predictors and outcome. BMJ. 30.4.2022. extension://elhekieabhbkpmcefcoobjddigjcaadp/https://pmj.bmj.com/content/postgradmedj/early/2022/05/10/postgradmedj-2022-141724.full.pdf
The 4 physician groups leading the political antivax movement. A physician-led attack on public health is being mediated by the Big 4: The Great Barrington Declaration, America’s Front Line Doctors, Frontline Critical Care Alliance, and the Unity Project. MisinformationKills’s Newsletter. 30.4.2022. https://misinformationkills.substack.com/p/the-4-physician-groups-leading-the?s=r
Protection against Omicron re-infection conferred by prior heterologous SARS-CoV-2 infection, with and without mRNA vaccination. medRxiv. 29.4.2022.https://globalnews.ca/news/8688590/long-covid-symptoms-children/ https://www.medrxiv.org/content/10.1101/2022.04.29.22274455v1.full
Heart Problems after COVID-19. Johns Hopkins Medicine. 28.4.2022. https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/heart-problems-after-covid19
Multivariate profile and acute-phase correlates of cognitive deficits in a COVID-19 hospitalised cohort (COVID-19 survivors were less accurate (G_SScore=-0.53SDs) and slower (G_RT=+0.89SDs) in their responses than expected compared to their matched controls. Acute illness, but not chronic mental health, significantly predicted cognitive deviation from expected scores (G_SScore (p=0.0037) and G_RT (p = 0.0366)). The most prominent task associations with COVID-19 were for higher cognition and processing speed, which was qualitatively distinct from the profiles of normal ageing and dementia and similar in magnitude to the effects of ageing between 50 and 70 years of age. A trend towards reduced deficits with time from illness (r∼=0.15) did not reach statistical significance.). eClinicalMedicine. 28.4.2022. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00147-X/fulltext
Long-term mortality following SARS-CoV-2 infection: A national cohort study from Estonia. Lancet Regional Health Europe, 28.4.2022. https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(22)00087-4/fulltext
South Africa is being hit hard by COVID again. Here is what that means for the US. It’s too soon to know whether the BA.4 and BA.5 omicron variants will take off in the U.S. as they are in South Africa. But some experts are anxious. USA Today. 28.4.2022. https://eu.usatoday.com/story/news/health/2022/04/28/south-africa-omicron-ba-4-ba-5-what-means-us/9553483002/
Monitoring SARS-CoV-2 in air and on surfaces and estimating infection risk in buildings and buses on a university campus. Journal of Exposure Science & Environmental Epidemiology. 27.4.2022. https://www.nature.com/articles/s41370-022-00442-9
Public health impact of covid-19 vaccines in the US: observational study. BMJ 27.4.2022. https://www.bmj.com/content/377/bmj-2021-069317
What Is “Brain Fog” and Cognitive Dysfunction in Long COVID? After recovering from the initial COVID infection, many people are experiencing a symptom that is difficult to explain, yet it may be one of the most life-changing and debilitating symptoms they experience. Cognitive dysfunction, often described as “brain fog,” affects how easy it is to think and make decisions. Unfortunately, these cognitive changes are a common symptom associated with many chronic conditions, including Long COVID. RTHm. 26.4.2022. https://rthm.com/what-is-brain-fog-and-cognitive-dysfunction-in-long-covid/
Critical weaknesses in shielding strategies for COVID-19. PLOS Global Public Health. 26.4.2022. https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000298
Moderna’s new COVID-19 booster protects better against Omicron and other variants. MedicalNewsToday. 25.4.2022. https://www.medicalnewstoday.com/articles/modernas-new-covid-19-booster-protects-better-against-omicron-other-variants?
Resistance to recognizing airborne transmission of SARS-CoV-2 may be rooted in historical error. (Neha Mathur) News Medical 25.8.2022. https://www.news-medical.net/news/20220825/Resistance-to-recognizing-airborne-transmission-of-SARS-CoV-2-may-be-rooted-in-historical-error.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=covid_19_newsletter_1_september_2022
COVID-19 and the Brain: The Neuropathological Italian Experience on 33 Adult Autopsies. MDPI (Biomolecules) 25.4.2022. https://www.mdpi.com/2218-273X/12/5/629
Investigation into acute hepatitis of unknown aetiology in children in England. Technical briefing. UK Health Security Agency, 25.4.2022. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1071198/acute-hepatitis-technical-briefing-1_4_.pdf
Coronavirus (COVID-19) deaths worldwide per one million population as of April 26, 2022, by country https://www.statista.com/statistics/1104709/coronavirus-deaths-worldwide-per-million-inhabitants/
A rampage through the body. The lungs are ground zero, but COVID-19 also tears through organ systems from brain to blood vessels. Science. 24.4.2022. https://www.science.org/doi/10.1126/science.368.6489.356
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study (LC). Lancet Respiratory Medicine. 23.2.2022. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00127-8/fulltext
SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients. JMCB. 22.4.2022. https://academic.oup.com/jmcb/article/14/4/mjac021/6572370
Brain Imaging Changes in Patients Recovered From COVID-19: A Narrative Review (Cognitive). Frontiers in Neuroscience. 22.4.2022. https://www.frontiersin.org/articles/10.3389/fnins.2022.855868/full
WHO recommends highly successful COVID-19 therapy (Paxlovid) and calls for wide geographical distribution and transparency from originator. WHO. 22.4.2022. https://www.who.int/news/item/22-04-2022-who-recommends-highly-successful-covid-19-therapy-and-calls-for-wide-geographical-distribution-and-transparency-from-originator
Longest known COVID-19 infection – 505 days – described by UK researchers
One of the first occult COVID infections is also described (…evidence that new Covid variants may arise in immunocompromised individuals and present details of one of the first occult Covid infections (cases where the patient was thought to have cleared the virus, with negative testing to show that, but is subsequently found to have had an ongoing infection).). EurekAlert. 21.4.2022. https://www.eurekalert.org/news-releases/950412
An mRNA vaccine with a twist—it copies itself—protects against COVID-19. Company’s limited data release backs promise of new, lower dose vaccine designed to be easier to distribute and cheaper. Science. 21.4.2022. https://www.science.org/content/article/mrna-vaccine-twist-it-copies-itself-protects-against-covid-19?
Everything You Need to Know About the Hepatitis Outbreak Among Children. Is the number of cases in Israel unusually high, what are the symptoms of the disease and is it linked to the coronavirus? Haaretz explains. Haaretz. 21.4.2022. https://www.haaretz.com/israel-news/everything-you-need-to-know-about-the-hepatitis-outbreak-among-children-1.10754895
Israel Examining 12 Cases of Kids’ Hepatitis After WHO Warning
After 84 cases of hepatitis in children were discovered in the U.K. without a known cause, Israel begins monitoring similar cases in hopes of finding an explanation for the recent surge. Haaretz. 21.4.2022. https://www.haaretz.com/israel-news/israel-examining-12-cases-of-kids-hepatitis-after-who-warning-1.10752779
Policy stringency and mental health during the COVID-19 pandemic: a longitudinal analysis of data from 15 countries. Lancet Public Health. 21.4.2022. https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(22)00060-3/fulltext
Kaksi kokenutta lääkäriä vaatii neljänsiä rokotteita entistä nuoremmille – viidessä kuukaudessa koronakuolemia on ollut Suomessa yli 2300. HUSin Eeva Ruotsalainen ja Länsi-Pohjan Markku Broas vaativat neljänsien rokotteiden ikärajan laskemista pikaisella aikataululla. Näin on tehty myös useissa muissa maissa. YLE Uutiset. 21.4.2022. https://yle.fi/uutiset/3-12412961
April 21-30
In-person schooling and associated COVID-19 risk in the United States over spring semester 2021. Science Advances. 20.4.2022. https://www.science.org/doi/10.1126/sciadv.abm9128
Ruotsin valtionepidemiologi Anders Tegnell ei saanutkaan töitä WHO:sta. Rokotteiden saannin turvaamiseen liittyvän työpaikan oli tarkoitus sijaita WHO:n päämajassa Sveitsin Genevessä. Helsinngin Sanomat. 20.4.2022. https://www.hs.fi/ulkomaat/art-2000008763814.html
Maskeista luovutaan Helsingin seudun joukkoliikenteessä – Finnair tarkastelee maskivaatimustaan lähiaikoina. Helsingin seudun liikenne luopuu yleisestä maskisuosituksesta. Helsingin Sanomat. 20.4.2022. https://www.hs.fi/kaupunki/art-2000008763129.html
The Link Between COVID-19 And Erectile Dysfunction. (Erectile dysfunction, or ED. Preliminary studies show about a 20% increase in the incidence of erectile dysfunction in men who have had COVID-19 compared to men who haven’t had COVID-19). Henry Ford Health. 19.4.2022. https://www.henryford.com/blog/2022/04/covid-and-erectile-dysfunction
UK to have slowest growth of G7 nations in 2023, says IMF. PM’s claims that Britain has strongest rebound in group undermined by fund’s latest economic forecast (COVID pandemic). Financial Times. 19.4.2022. https://www.ft.com/content/4ac7e454-5a0c-4094-90af-fb54404d45a0
THL:n Mika Salminen tokaisi Ylellä työterveydestä ”suosittu mutta typerä”– ja palautetta vyöryy. Mika Salmisen mielestä terveydenhuoltojärjestelmän pitäisi olla kaikille sama riippumatta siitä, käykö ihminen töissä. Mediuutiset. 19.4.2022. https://www.mediuutiset.fi/uutiset/mu/dd510566-85d2-4472-9165-4e1e81db3909
Global COVID-19 Death Toll May Be Triple the Reported Deaths. JAMA. 19.4.2022. https://jamanetwork.com/journals/jama/fullarticle/2791213?
Pulmonary fibrosis seen in half of COVID-19 survivors. Univadis. 18.4.2022. https://www.univadis.com/viewarticle/pulmonary-fibrosis-seen-in-half-of-covid-19-survivors-76f7a96b-ee38-31c8-9986-f9aa25b835a3?
Six-month sequelae of post-vaccination SARS-CoV-2 infection: A retrospective cohort study of 10,024 breakthrough infections. Brain Behaviour and Immunity. 18.4.2022. https://reader.elsevier.com/reader/sd/pii/S0889159122001118?
Dose-response modelling of endemic coronavirus and SARS-CoV-2: human challenge trials reveal the individual variation in susceptibility. medRxiv. 16.4.2022. https://doi.org/10.1101/2022.04.07.22273549; t
Global Prevalence of Post COVID-19 Condition or Long COVID: A Meta-Analysis and Systematic Review. J Infect Dis. 16.4.2022. https://pubmed.ncbi.nlm.nih.gov/35429399/
Vaccines are no match for long Covid. Treating it is science’s next great challenge. Guardian. 16.4.2022. https://www.theguardian.com/commentisfree/2022/apr/16/vaccines-long-covid-science?CMP=Share_AndroidApp_Other
Protocol for isolation and analysis of small volatile microbiome metabolites from human or mouse samples.STAR Protocols 15.4.2022. https://star-protocols.cell.com/protocols/1569?twclid=2-6ci34ce4rrh3velfxq0m1y76w
Pitkäkestoinen ylikuolleisuusanomalia 2022. Rönning & Guldbransen. April 2022. https://jarjenaani.fi/wp-content/uploads/2022/04/Ylikuolleisuusanomalia2021-1.pdf
Even mild COVID-19 can cause your brain to shrink. Recent brain imaging shows the disease can cause physical changes equivalent to a decade of aging and trigger problems with attention and memory. Exactly why is still a mystery. National Geographic. 15.4.2022. https://www.nationalgeographic.com/magazine/article/even-mild-covid-19-can-cause-your-brain-to-shrink?
Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland. WHO. 15.4.2022. https://www.who.int/emergencies/disease-outbreak-news/item/acute-hepatitis-of-unknown-aetiology—the-united-kingdom-of-great-britain-and-northern-ireland
FDA authorizes first Covid-19 breath test. CNN health. 15.4.2022. https://edition.cnn.com/2022/04/14/health/covid-breath-test/index.html?
Modelling COVID-19 in school settings to evaluate prevention and control protocols (In the context of schools as well, reactive protocols are not able to make significant impacts because waiting for symptomatic cases to be detected corresponds to a lack of anticipation of the spread dynamics. Moreover, at high incidence, reactive testing imposes a large number of tests but in an unanticipated way, thus causing shortages and delays [19]. Iterative screening protocols instead detect both presymptomatic and asymptomatic cases, can be planned efficiently and would constitute moreover an epidemic surveillance tool that allows detecting the beginning of a new wave in a timely fashion.). Anaesthesia Critical Care & Pain Medicine, April 2022. https://www.sciencedirect.com/science/article/pii/S2352556822000285?via%3Dihub
Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21. Lancet. 14.4.2022. https://www.thelancet.com/action/showPdf?pii=S0140-6736%2821%2902796-3
Hundreds are still dying from Covid every day. Why is Paxlovid sitting on shelves? The supply of Pfizer’s highly effective antiviral pill has rapidly increased, but many physicians still aren’t prescribing it. NBCNews.14.4.2022. https://www.nbcnews.com/health/health-news/covid-antiviral-pill-paxlovid-underused-supply-rcna24200
COVID-19 Autopsies Reveal Underreporting of SARS-CoV-2 Infection and Scarcity of Co-infections. Frontiers in Medicine. 14.4.2022. https://www.frontiersin.org/articles/10.3389/fmed.2022.868954/full
SARS-CoV-2 Actively Infects And Kills Lymphoid Cells. Forbes. 14.4.2022. https://www.forbes.com/sites/williamhaseltine/2022/04/14/sars-cov-2-actively-infects-and-kills-lymphoid-cells/?sh=2c22257786b8
Potilaan Lääkärilehti: Neurologian professorin mukaan koronatartunnan välttely on yhä järkevää, Koronatartunnan välttely on neurologian professorin Risto O. Roineen mukaan edelleen järkevää. Roine kommentoi asiaa Potilaan lääkärilehdessä. Kaleva. 14.4.2022. https://www.kaleva.fi/potilaan-laakarilehti-neurologian-professorin-muka/4521049
SARS-CoV-2 Actively Infects And Kills Lymphoid Cells. Forbes. 14.4.2022. https://www.forbes.com/sites/williamhaseltine/2022/04/14/sars-cov-2-actively-infects-and-kills-lymphoid-cells/?sh=cf4122486b89
Unmasked Facies. JAMA. 14.4.2022. https://jamanetwork.com/journals/jama/fullarticle/2791316
Omikron BA.2 on nyt yleisin jätevesien koronavirusmuunnos Koronaviruksen RNA:n kokonaismäärä Suomen jätevesissä on edelleen korkealla tasolla. Mediuutiset. 13.4.2022. https://www.mediuutiset.fi/uutiset/mu/00b5d440-733e-49df-aa28-c181927582c6
Statement on the eleventh meeting of the International Health Regulations (2005) Emergency Committee regarding the coronavirus disease (COVID-19) pandemic. WHO. 13.4.2022. https://www.who.int/news/item/13-04-2022-statement-on-the-eleventh-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemic
COVID-19: “THE ELIMINATION OF THE VIRUS IS ALWAYS POSSIBLE”
Interview with Yaneer Bar-Yam. World Health Network. 12.4.2022. https://www.worldhealthnetwork.global/yaneer-interview
Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection. Clinical Advances. 12.4.2022. https://www.cell.com/med/fulltext/S2666-6340(22)00167-2
COVID-19: Current cases. Information about confirmed and probable cases of COVID-19 in New Zealand. Ministry of Health. 11.4.2022. https://www.mediuutiset.fi/uutiset/mu/d12f17a8-a11a-4aad-a02a-8c47c99a4834
NHS chiefs call for return of masks and limits on indoor mixing. The NHS Confederation wants a return to mask use. Health chiefs want the government to reconsider its ‘living with Covid plan’ and are urging a return to mask use, accusing No10 of abandoning “any interest in Covid whatsoever.” LBC. 11.4.2022. https://www.lbc.co.uk/news/nhs-chiefs-call-for-return-of-masks-and-limits-on-indoor-mixing/
Postmortem Assessment of Olfactory Tissue Degeneration and Microvasculopathy in Patients With COVID-19. JAMA Neurology. 11.4.2022. https://jamanetwork.com/journals/jamaneurology/fullarticle/2790735
Aivot ottavat koronasta osumaa. Korona ei vanhenna aivoja kymmentä vuotta, vaan kohutussa brittitutkimuksessa havaittiin sen aiheuttavan volyymikatoa aivojen etualaosassa etenkin iäkkäillä. Lääkärilehti. 11.4.2022. https://www.laakarilehti.fi/terveydenhuolto/aivot-ottavat-koronasta-osumaa/
Japan’s Low-Key Covid Campaign Has Lessons for China
The strident efforts in the People’s Republic are in stark contrast to the restrained but more sustainable efforts by its old rival to the east. Bloomberg. 11.4.2022. https://www.bloomberg.com/opinion/articles/2022-04-10/japan-s-low-key-covid-campaign-is-more-sustainable-than-china-s-all-out-efforts
April 11-20
Tutkimukset osoittavat, että vähintään 30 prosenttia Suomen väestöstä on saanut koronatartunnan – THL:n Salminen: Osuus voi olla vielä tätäkin isompi. Tutkimukset perustuvat satunnaisotantaan, jossa on tarkasteltu verinäytteistä löydettyjä vasta-aineita. Löydetyt määrät ovat paljon virallisia tartuntalukuja suuremmat, ja tämäkin arvio on vain minimimäärä. YLE Uutiset. 10.4.2022. https://yle.fi/uutiset/3-12424610
Erikoislääkäri Maria Juusela pohtii, pitäisikö meillä olla itsenäinen koronapandemian seurantalaskuri? Juusela myös ihmettelee, missä viipyvät päätökset ikäihmisten 4. rokotteista ja kolmas rokotekierros 12–17-vuotiaille? MediUutiset. 10.4.2022. https://www.mediuutiset.fi/uutiset/mu/d12f17a8-a11a-4aad-a02a-8c47c99a4834
Notes from the Field: SARS-CoV-2 Omicron Variant Infection in 10 Persons Within 90 Days of Previous SARS-CoV-2 Delta Variant Infection — Four States, October 2021–January 2022. CDC Morbidity and Mortality Weekly Report. 8.4.2022. https://www.cdc.gov/mmwr/volumes/71/wr/mm7114a2.htm
Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis. Lancet. 8.4.2022. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00484-6/fulltext
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation. Nature. 8.4.2022. https://www.nature.com/articles/s41586-022-04702-4
”Tästä tulee tauti muiden joukossa” – Koronaepidemiassa ei ole näkynyt laantumisen merkkejä, mutta asiantuntijat toivovat, että kevään epidemiahuippu olisi jo saavutettu. ”Todennäköisesti neljänsiin rokotuksiin tullaan menemään myöskin nuoremmissa ikäryhmissä, mutta ajoitus ja ajankohta täytyy määrittää tarkan seurantatiedon perusteella”, sanoi Taneli Puumalainen sosiaali- ja terveysministeriöstä. Helsingin Sanomat. 7.4.2022. https://www.hs.fi/kotimaa/art-2000008733903.html
Korona piinaa jatkossakin: “Suurin osa tulee sairastamaan monta kertaa elämänsä aikana” (Mika Salminen). MTV Uutiset. 7.4.2022. https://www.mtvuutiset.fi/artikkeli/korona-piinaa-jatkossakin-suurin-osa-tulee-sairastamaan-monta-kertaa-elamansa-aikana/8397892#gs.9jqtea
The Latest on Long Covid Research with Dr. Iwasaki. YouTube. 7.4.2022. https://www.youtube.com/embed/CF4j-EVPlPU
Use of face masks did not impact COVID-19 incidence among 10–12-year-olds in Finland. medRxiv. 7.4.2022. https://www.medrxiv.org/content/10.1101/2022.04.04.22272833v1
Covid-19: Symptomatic infection with omicron variant is milder and shorter than with delta, study reports. BMJ. 7.4.2022. https://www.bmj.com/content/377/bmj.o922
COVID-19 Linked to Increased Risk of Blood Clots Even Months Later: What to Know. A new study finds that people who had COVID-19 are at increased risk for blood disorders months after their illness.
This may be due to inflammation from the illness.
Getting vaccinated can help protect people from developing blood clots or bleeding disorders after COVID-19. HealthLine. 6.4.2022. https://www.healthline.com/health-news/covid-19-linked-to-increased-risk-of-blood-clots-even-months-later-what-to-know
Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study. BMJ. 6.4.2022. https://www.bmj.com/content/377/bmj-2021-069590
Post COVID-19 pulmonary fibrosis; a meta-analysis study. Ann Med Surg. 6.4.2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983072/
Why the WHO took two years to say COVID is airborne. Early in the pandemic, the World Health Organization stated that SARS-CoV-2 was not transmitted through the air. That mistake and the prolonged process of correcting it sowed confusion and raises questions about what will happen in the next pandemic. Nature. 6.4.2022. https://www.nature.com/articles/d41586-022-00925-7#:~:text=Early%20in%20the%20pandemic%2C%20the,happen%20in%20the%20next%20pandemic.
What triggers severe COVID? Infected immune cells hold clues. Studies have revealed that infected immune cells prompt a massive inflammatory response. Nature. 6.4.2022. https://www.nature.com/articles/d41586-022-00925-7?
Long Covid-19 may remain a chronic condition for millions. CNN. 6.4.2022. https://edition.cnn.com/2022/04/06/health/long-covid-19-what-it-is/index.html?utm_term=1649773240313cb7d3e794e8f&utm_source=cnn_04.12.22+Results+are+In&utm_medium=email&bt_ee=PEXLei5P3p%2BiG1z4Yln2Auu78mQi6iafOQnIivqIAJmUfotwGi0zJPx41Ek%2Fpfri&bt_ts=1649773240315
Exhaled CO2 as a COVID-19 Infection Risk Proxy for Different Indoor Environments and Activities. National Library of Medicine. (Environ Sci Technol Lett) 5.4.2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043197/
Protection by a Fourth Dose of BNT162b2 against Omicron in Israel. NEJM. 5.4.2022. https://www.nejm.org/doi/full/10.1056/NEJMoa2201570?query=recirc_mostViewed_railB_article
Koronapotilaita on kuollut kolmessa kuukaudessa enemmän kuin koko viime vuonna – THL:n Salmisen mukaan keinot suunnan kääntämiseksi ovat vähissä. Lähes kaikki koronavirukseen kuolevat suomalaiset ovat jo valmiiksi sairaita, kertoo johtava asiantuntija Sirkka Goebeler THL:sta. (ei oikein keinoja ole, Mika Salminen THL:stä toteaa, että koronakuolemien määrä alkaa laskea viimeistään kun tapausmäärät lähtevät laskuun). Helsingin Sanomat. 4.4.2022. https://www.hs.fi/kotimaa/art-2000008723113.html
Glasses and risk of COVID-19 transmission – analysis of the Virus Watch Community Cohort study. medRxiv. 4.4.2022. https://www.medrxiv.org/content/medrxiv/early/2022/04/04/2022.03.29.22272997.full.pdf
Bars, cinemas, gyms: Belgium agrees on ‘ventilation plan’ for public places. The Brussels Times. 4.4.2022. https://www.brusselstimes.com/belgium-news/214866/bars-cinemas-gyms-belgium-agrees-on-ventilation-plan-for-public-places?s=03
Cardiac impairment in Long Covid 1-year post-SARS-CoV-2 infection. medRxiv. 4.4.2022. https://www.medrxiv.org/content/10.1101/2022.04.03.22272610v1
Prof Jeremy Nicholson: the link between Long Covid and heart disease. RNZ. 2.4.2022. https://www.rnz.co.nz/national/programmes/saturday/audio/2018836711/prof-jeremy-nicholson-the-link-between-long-covid-and-heart-disease
What Is The Omicron XE Variant And Why Are Scientists Concerned About Its Rapid Transmission Rate? Medriva. 2.4.2022. https://medriva.com/what-is-the-omicron-xe-variant-and-why-are-scientists-concerned-about-their-rapid-transmission-rates-fueling-the-uk/
What Drives Post-COVID Cognitive Changes? — New research hints at why COVID brain fog may persist. Medpage Today. 1.4.2022. https://www.medpagetoday.com/neurology/generalneurology/97981
Projecting COVID-19 Mortality as States Relax Nonpharmacologic Interventions. JAMA Health Forum. 1.4.2022. https://jamanetwork.com/journals/jama-health-forum/fullarticle/2790812?
Incidence Rates and Clinical Outcomes of SARS-CoV-2 Infection With the Omicron and Delta Variants in Children Younger Than 5 Years in the US. JAMA Pediatrics. 1.4.2022. https://jamanetwork.com/journals/jamapediatrics/fullarticle/2790793?
Analyysi: Korona yhdisti tiedemaailman, Venäjän hyökkäys rikkoi sen jälleen – tieteellä ei ole varaa uuteen kylmään sotaan. Venäjän hallitus on kieltänyt tutkijoitaan osallistumasta kansainvälisiin konferensseihin ja länsimaiset tiedeyhteisöt boikotoivat venäläisiä. Sota on monella alalla katkaissut tutkimuksen, joka luotti yhtenäiseen maailmaan, kirjoittaa toimittaja Johannes Blom. YLE-Uutiset. 1.4.2022. https://yle.fi/uutiset/3-12384327?
Projecting COVID-19 Mortality as States Relax Nonpharmacologic Interventions [no path to the end of the COVID-19 pandemic that avoided difficult trade-offs between prolonged NPIs and increased COVID-19 mortality]. JAMA. 1.4.2022. https://jamanetwork.com/journals/jama-health-forum/fullarticle/2790812
April 1 – 10
Coronavirus Hong Kong: ‘Omicron strain causes 7 times more deaths among hospitalised children than influenza’. Study from University of Hong Kong also found 15 per cent of children hospitalised with Omicron BA.2 had developed neurological complications
But research team says recorded 0.35 per cent fatality rate likely an ‘overestimate’, as many children with mild symptoms stay at home instead of going to hospital. South China Morning Post. 31.3.2022. https://www.scmp.com/news/hong-kong/article/3172633/coronavirus-hong-kong-omicron-strain-causes-7-times-more-deaths
Diabetes risk rises after COVID, massive study finds
Even mild SARS-CoV-2 infections can amplify a person’s chance of developing diabetes, especially for those already susceptible to the disease. Nature. 31.3.2022. https://www.nature.com/articles/d41586-022-00912-y
How Japan survived covid-19. BMJ. 31.3.2022. https://www.bmj.com/content/376/bmj.o778
Koronakuolemia voitaisiin estää antamalla neljäs annos nopeasti myös alle 80-vuotiaille, sanovat HUSin asiantuntijat. Tehosteannokset olisivat tarpeen erityisesti 70-79-vuotiaiden ikäryhmälle. YLE_Uutiset. 31.3.2022. https://yle.fi/uutiset/3-12384691
SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death. Scientific Reports. 31.3.2022. https://www.nature.com/articles/s41598-022-09410-7
Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults. Nature Medicine. 31.3.2022. https://www.nature.com/articles/s41591-022-01780-9
Column: Did Sweden beat the pandemic by refusing to lock down? No, its record is disastrous (The Swedish government, they report, deliberately tried to use children to spread COVID-19 and denied care to seniors and those suffering from other conditions.
The government’s goal appeared geared to produce herd immunity — a level of infection that would create a natural barrier to the pandemic’s spread without inconveniencing middle- and upper-class citizens; the government never set forth that goal publicly, but internal government emails unearthed by the Swedish press revealed that herd immunity was the strategy behind closed doors.
Explicit or not, the effort failed. “Projected ‘natural herd-immunity’ levels are still nowhere in sight,” the researchers wrote, adding that herd immunity “does not seem within reach without widespread vaccinations” and “may be unlikely” under any circumstances.). Los Angeles Times. 31.3.2022. https://www.latimes.com/business/story/2022-03-31/sweden-covid-policy-was-a-disaster
Diabetes risk rises after COVID, massive study finds. Even mild SARS-CoV-2 infections can amplify a person’s chance of developing diabetes, especially for those already susceptible to the disease. Nature. 31.3.2022. https://www.nature.com/articles/d41586-022-00912-y?
Can you get Covid twice in one month? How soon you can recatch coronavirus and if you can get Omicron again. Omicron has been shown to typically cause less serious illness, but also brings with it an increased risk of reinfection. iNews/Health. 30.3.2022. https://inews.co.uk/news/health/covid-can-get-twice-month-how-soon-catch-coronavirus-again-what-reinfection-explained-1443820
Rapid increase in SARS-CoV-2 seroprevalence during the emergence of Omicron variant, Finland. medRxiv. 30.3.2022. https://www.medrxiv.org/content/10.1101/2022.03.25.22272952v1
Omikron säilyy muovipinnalla pidempään kuin muut koronavariantit, jopa 193 tuntia – Myös ihmisiholla se sinnittelee pisimpään. Kaksi tuoretta aasialaista tutkimusta vertailee koronaviruksen omikron-variantin poikkeuksellista kykyä säilyä erilaisilla pinnoilla elossa. Mediuutiset. 30.3.2022. https://www.mediuutiset.fi/uutiset/mu/1c7262b3-4ebd-43b5-bda3-fd9052f4d743?ref=newsletter:65ee&utm_source=uutiskirje%40mediuutiset.fi&utm_medium=email&utm_campaign=MU-Uutiskirje-laakari
Effect of Early Treatment with Ivermectin among Patients with Covid-19. NEJM. 30.3.2022. https://www.nejm.org/doi/full/10.1056/NEJMoa2115869
Asiantuntijat: Korona ei muutu ehkä koskaan tavalliseksi kausiflunssaksi – tästä se johtuu. Asiantuntijat suhtautuvat epäillen siihen, että koronaviruksesta olisi ainakaan lähiaikoina tulossa ihmisille lievä ja vaaraton tauti. Ilta=sanomat. 30.3.2022. https://www.is.fi/kotimaa/art-2000008714148.html
Cholera, Key facts:
Most of those infected will have no or mild symptoms and can be successfully treated with oral rehydration solution.
A global strategy on cholera control, Ending Cholera: a global roadmap to 2030, with a target to reduce cholera deaths by 90% was launched in 2017.
Researchers have estimated that each year there are 1.3 to 4.0 million cases of cholera, and 21 000 to 143 000 deaths worldwide due to cholera (1)
Cholera is an acute diarrhoeal disease that can kill within hours if left untreated.
Provision of safe water and sanitation is critical to prevent and control the transmission of cholera and other waterborne diseases.
Severe cases will need rapid treatment with intravenous fluids and antibiotics.
Oral cholera vaccines should be used in conjunction with improvements in water and sanitation to control cholera outbreaks and for prevention in areas known to be high risk for cholera. WHO. 30.3.2022. https://www.who.int/news-room/fact-sheets/detail/cholera
Older adults can get second coronavirus booster to strengthen waning protection. Washington Post. 29.3.2022. https://www.washingtonpost.com/health/2022/03/29/fda-authorizes-second-booster-shot/
F.D.A. Allows Second Coronavirus Boosters for Everyone 50 and Older
People in the age group can get the additional shot at least four months after their first booster. Those 12 and older with certain immune deficiencies are also eligible. New York Times. 29.3.2022. https://www.nytimes.com/2022/03/29/us/politics/second-coronavirus-booster-shot.html?referringSource=articleShare
White House Reverts to Air Hygiene in latest efforts to thwart coronavirus. It is pushingh strategies, such as better wir filters in schools and businesses, to help thwart the virus. Washingtonm Post. 29.3.2022. https://www.washingtonpost.com/health/2022/03/29/white-house-covid-strategy-indoor-air-quality/
Risk of SARS-CoV-2 reinfections in children: a prospective national surveillance study between January, 2020, and July, 2021, in England. Lancet. 28.3.2022. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(22)00059-1/fulltext
Molecular consequences of SARS-CoV-2 liver tropism. Nature Metabolism. 28.3.2022. https://www.nature.com/articles/s42255-022-00552-6.
SvD: Förvirring kring Tegnells nya jobb på WHO – jobbet finns inte. HBL. 28.3.2022. https://www.hbl.fi/artikel/forvirring-kring-tegnells-nya-jobb-pa-who-jobbet-finns-inte/?
Huge Study Finds Second COVID-19 Booster is ‘Life-saving’ for Over 60s. Health Policy Watch. 28.3.2022. https://healthpolicy-watch.news/95297-2/
Fourth Vaccine Reduces Risk of Dying From COVID by 78 Percent, Israeli Study Finds. As omicron’s BA.2 variant is fueling a spike in COVID-19 infections, the latest large-scale study by an Israeli HMO suggests that a fourth dose reduces both the risk of infection and severe illness. Haaretz. 26.3.2022. https://www.haaretz.com/israel-news/fourth-vaccine-reduces-risk-of-dying-from-covid-by-78-percent-israeli-study-finds-1.10700268
What to know about flying during the COVID-19 pandemic. Medical News Today. 28.3.2022. https://www.medicalnewstoday.com/articles/flying-during-covid
Fourth Vaccine Reduces Risk of Dying From COVID by 78 Percent, Israeli Study Finds. As omicron’s BA.2 variant is fueling a spike in COVID-19 infections, the latest large-scale study by an Israeli HMO suggests that a fourth dose reduces both the risk of infection and severe illness. Haaretz. 26.3.2022. https://www.haaretz.com/israel-news/fourth-vaccine-reduces-risk-of-dying-from-covid-by-78-percent-israeli-study-finds-1.10700268
SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses. Lancet. 25.3.2022. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00383-X/fulltext
Can drugs reduce the risk of long COVID? What scientists know so far
Researchers are trying to establish whether existing COVID-19 vaccines and treatments can prevent lasting symptoms. nature. 25.3.2022. https://www.nature.com/articles/d41586-022-00823-y?fbclid=IwAR0rO3bh97jIMiIucaYJHf5yhtOTpWE7vFFDveiEUnT8dZE-CWDSS2FL3Ng
Evusheld (tiksagevimabi/silgavimabi) Yleistiedot Evusheld-valmisteesta sekä siitä, miksi se on hyväksytty EU:ssa (COVID-19 ehkäisylääke). EMA. 25.3.2022. https://www.ema.europa.eu/en/documents/overview/evusheld-epar-medicine-overview_fi.pdf
SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids. Stem Cell Reports. 24.3.2022. https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(22)00104-7
Second Booster Vaccine and Covid-19 Mortality in Adults 60 to 100 Years Old. Research Square. 24.3.2022. https://assets.researchsquare.com/files/rs-1478439/v1/24514bba-2c9d-4add-9d8f-321f610ed199.pdf?c=1648141784
Long Covid could create a generation affected by disability, expert warns. Guardian. 23.3.2022. https://www.bloomberg.com/news/newsletters/2022-06-03/coronavirus-daily-covid-is-more-lethal-to-kids-than-the-flu.
Evaluation of airborne transmission risk in university towns based on IEQ surveys. National Library of Medicine. (Energy and Built Environment) 23.3.2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942440/
Burden of PCR-Confirmed SARS-CoV-2 Reinfection in the U.S. Veterans Administration, March 2020 – January 2022. medRxiv. 23.3.2022. https://www.medrxiv.org/content/10.1101/2022.03.20.22272571v1.full.pdf
Robust, persistent adaptive immune responses to SARS-CoV-2 in the oropharyngeal lymphoid tissue of children. Research Square. 23.4.2022. https://www.researchsquare.com/article/rs-1276578/v1
Visual interpretation of brain hypometabolism related to neurological long COVID: a French multicentric experience. Eur J Nucl and Molec Imag. 23.3.2022. https://link.springer.com/article/10.1007/s00259-022-05753-5
Airborne transmission: Are CO2 monitors a long term solution or “pandemic hack?” BMJ. 23.3.2022. https://www.bmj.com/content/376/bmj.o736?
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020. Lancet. 22.3.2022. https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(21)00052-1/fulltext#:~:text=There%20was%20a%20strong%20geographical,SARS%2DCoV%2D2%20antibodies
Editor’s Pick: Thromboembolic Storm in the Recovering Stage of COVID-19: A Case Report. EMJ. 22.3.2022. https://www.emjreviews.com/flagship-journal/article/eds-pick-thromboembolic-storm-in-the-recovering-stage-of-covid-19-a-case-report-j190121/
Evaluation of science advice during the COVID-19 pandemic in Sweden. Nature / Humanities & Sociall Sciences Communications. 22.3.2022. https://www.nature.com/articles/s41599-022-01097-5
Italian study shows ventilation can cut school COVID cases by 82%. Reuters. 22.3.2022. https://www.reuters.com/world/europe/italian-study-shows-ventilation-can-cut-school-covid-cases-by-82-2022-03-22/
Effectiveness of a second BNT162b2 booster vaccine against hospitalization and death from COVID-19 in adults aged over 60 years. Nature Medicine. 22.3.2022. https://www.nature.com/articles/s41591-022-01832-0_reference.pdf
Neutralizing antibodies to SARS-CoV-2 Omicron variant after third mRNA vaccination in health care workers and elderly subjects. Wiley Online Library. 21.3.2022. https://onlinelibrary.wiley.com/doi/10.1002/eji.202149785
Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals. Gov.UK. 21.3.2022. https://www.gov.uk/government/publications/myocarditis-and-pericarditis-after-covid-19-vaccination/myocarditis-and-pericarditis-after-covid-19-vaccination-guidance-for-healthcare-professionals
March 21-31
Communicable Disease Threats Report. Week 11, 12-18 March 2023. ECDC. 20.3.2023. https://www.ecdc.europa.eu/sites/default/files/documents/communicable-disease-threats-report-week-11-2023.pdf
Ivermectin Didn’t Reduce Covid-19 Hospitalizations in Largest Trial to Date
Patients who got the antiparasitic drug didn’t fare better than those who received a placebo. Wall Street Journal. 18.3.2022. https://www.wsj.com/articles/ivermectin-didnt-reduce-covid-19-hospitalizations-in-largest-trial-to-date-11647601200
Omicron survives longer on some surfaces, studies find. That may help explain why it’s more contagious, but it’s no reason to panic. CNN Health. 18.3.2022. https://edition.cnn.com/2022/03/18/health/omicron-surfaces-studies/index.html?
Infektiolääkäri kirjoitti kriittisen kirjan koronan hoidosta – Rajoitukset aiheuttaneet vakavia terveysongelmia ja taloudellisia tappioita.
Uutuuskirja koronapandemiasta Suomessa: Taudin torjuntakeinot aiheuttaneet vakavia terveydellisiä ja taloudellisia haittoja. Kirjan mukaan paljossa on onnistuttu, mutta pelon lietsominen ja ylimitoitetut rajoitukset ajoittaisine täyssulkuineen ovat aiheuttaneet vakavia terveysongelmia ja taloudellisia tappioita. Mediuutiset. 17.3.2022. https://www.mediuutiset.fi/uutiset/mu/a6ea7482-cf62-4c5e-b245-c63603c7a8f7?
FACT SHEET: Biden Administration Launches Effort to Improve Ventilation and Reduce the Spread of COVID-19 in Buildings. White House. 17.3.2022. https://www.whitehouse.gov/briefing-room/statements-releases/2022/03/17/fact-sheet-biden-administration-launches-effort-to-improve-ventilation-and-reduce-the-spread-of-covid-19-in-buildings/
‘Heartbreaking’: How long COVID is impacting children. Global News. 17.3.2022. https://globalnews.ca/news/8688590/long-covid-symptoms-children/
America Is Zooming Through the Pandemic Panic-Neglect Cycle. All epidemics trigger the same Sisyphean cycle of panic and neglect. Even so, that cycle isn’t meant to spin this quickly. Atlantic. 17.3.2022. https://www.theatlantic.com/health/archive/2022/03/congress-covid-spending-bill/627090/
‘Heartbreaking’: How long COVID is impacting children. Global News. 16.3.2022. https://globalnews.ca/news/8688590/long-covid-symptoms-children/
Global Prevalence of Post COVID-19 Condition or Long COVID: A Meta-Analysis and Systematic Review. J Infect Dis. 16.3.2022. https://pubmed.ncbi.nlm.nih.gov/35429399/ COMPLETE https://watermark.silverchair.com/jiac136.pdf
1 in 4 symptomatic children get long COVID, a new study finds. What are the symptoms? EuroNewsNext. 16.3.2022. https://www.euronews.com/next/2022/03/15/long-covid-has-been-found-in-1-in-4-symptomatic-children-a-new-study-finds-what-are-the-sy
Fevers, convulsions seen more in children during omicron wave: Japan Pediatric Society. The Mainichi. 16.3.2022. https://mainichi.jp/english/articles/20220316/p2a/00m/0na/006000c
Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study. Lancet. 16.3.2022. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00462-7/fulltext
Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa. Science 15.3.2022. https://www.science.org/doi/10.1126/science.abn4947
International Multi-Center Study Confirms Stroke Risk in Younger Healthier COVID-19 Patients. The largest study on severe stroke and COVID-19 published to date found even moderate COVID-19 infection increased risk of death in younger, healthier stroke patients. New wise. 15.3.2022. https://www.newswise.com/coronavirus/international-multi-center-study-confirms-stroke-risk-in-younger-healthier-covid-19-patients/?article_id=767147
Cognitive decline and brainstem hypometabolism in long COVID: A case series. Brain and Behaviour. 15.3.2022. https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.2513
THE COLOR OF CORONAVIRUS:
COVID-19 DEATHS BY RACE AND ETHNICITY IN THE U.S. APM Research Lab. 15.3.2022. https://www.apmresearchlab.org/covid/deaths-by-race
Airborne Transmission of SARS-CoV-2 Delta Variant within Tightly Monitored Isolation Facility, New Zealand (Aotearoa). Emerging Infectious Diseases. March 2022. https://doi.org/10.3201/eid2803.212318
Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis. Brain, Behaviour, and Immunity. March 2022. https://www.sciencedirect.com/science/article/pii/S0889159121006516
COVID and the Heart: It Spares No One. Research now tells us that COVID doesn’t discriminate when it comes to heart problems. (…anyone infected with COVID is at higher risk for heart issues—including clots, inflammation, and arrhythmias—a risk that persists even in relatively healthy people long after the illness has passed.) Johns Hopkins. 14.3.2022. https://publichealth.jhu.edu/2022/covid-and-the-heart-it-spares-no-one
Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity. Nature Reviews. Microbiology. 14.3.2022. ttps://www.nature.com/articles/s41579-022-00722-z
Effect of Sotrovimab on Hospitalization or Death Among High-risk Patients With Mild to Moderate COVID-19. A Randomized Clinical Trial. JAMA. 14.3.2022. https://jamanetwork.com/journals/jama/fullarticle/2790246?
Long COVID in Children and Adolescents: A Systematic Review and Meta-analyses. medRxiv. 13.3.2022. https://www.medrxiv.org/content/10.1101/2022.03.10.22272237v1
One-third of all US child Covid deaths occurred during Omicron surge.
Children seem to be facing increasing risks as mask mandates are abandoned and vaccination rates stall. Guardian. 11.3.2022. https://www.theguardian.com/world/2022/mar/11/us-child-covid-deaths-omicron-surge?CMP=Share_iOSApp_Other
ACE2-independent infection of T lymphocytes by SARS-CoV-2. Nature. 11.3.2022. https://www.nature.com/articles/s41392-022-00919-x
March 11-20
We cannot afford to repeat these four pandemic mistakes. BMJ. 10.3.2022. https://www.bmj.com/content/376/bmj.o631
Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21. Lancet. 10.3.2022. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02796-3/fulltext
Mandatory masking in schools reduced COVID-19 cases during Delta surge. NIH-funded study compared more than 1.1 million students across nine states. NIH News Releases. 10.3.2022. https://www.nih.gov/news-events/news-releases/mandatory-masking-schools-reduced-covid-19-cases-during-delta-surge?
Comparison of Seroconversion in Children and Adults With Mild COVID-19 (These findings suggest that serology may provide a less reliable marker of prior SARS-CoV-2 infection in children and support strategies to protect children against COVID-19, including vaccination). JAMA. 9.3.2022. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789845
Koronan tarttuminen pinnoilta tai lentokoneesta on epätodennäköistä, rauhoittelevat asiantuntijat. Se on aina hyvä muistaa, että normaali elämä ei ole laboratorio. Turun Sanomat. 9.3.2022. https://www.ts.fi/uutiset/4886888
Perspectives: The “Wolf” Is Indeed Coming: Recombinant “Deltacron” SARS-CoV-2 Detected. CCDC Weekly. 9.3.2022. https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2022.054
School Masking Policies and Secondary SARS-CoV-2 Transmission. Pediatrics. 9.3.2022. https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2022-056687/185379/School-Masking-Policies-and-Secondary-SARS-CoV-2
Sveriges statsepidemiolog Anders Tegnell slutar – får jobb hos WHO. Hufvudstadsbladet. 9.3.2033. https://www.hbl.fi/artikel/sveriges-statsepidemiolog-anders-tegnell-slutar-far-jobb-hos-who/
SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature. 7.3.2022. https://www.nature.com/articles/s41586-022-04569-5
How does COVID-19 affect patients with idiopathic pulmonary fibrosis (A previous multinational study analyzed the in-hospital mortality of 161 patients with ILD hospitalized with COVID-19 and revealed that 42.2% of patients had idiopathic pulmonary fibrosis (IPF). A similar study has been conducted in the United States, which also reports that patients with ILD are more susceptible to severe COVID-19 as compared to those without ILD. Another study has shared a similar observation that COVID-19 patients with fibrotic ILD exhibited a higher mortality rate compared to non-fibrotic ILD. / There remains a limited amount of evidence on the outcome of COVID-19 patients with IPF. )? News Medical & Lie Sciences. 6.3.2022. https://www.news-medical.net/news/20220306/How-does-COVID-19-affect-patients-with-idiopathic-pulmonary-fibrosis.aspx
Aamulehti: Aki Lindén huolissaan koronarokotustahdin hiipumisesta.
Aki Lindén muistuttaa Aamulehdessä, että koronaa on edelleen liikkeellä. Iltalehti. 5.3.2022. https://www.iltalehti.fi/koronavirus/a/a554622b-41ec-4f0d-82ef-f64b7d73bfa8
The indirect effect of mRNA-based COVID-19 vaccination on healthcare workers’ unvaccinated household members. nature communications. 4.3.2022. https://www.nature.com/articles/s41467-022-28825-4
The Challenge of Debunking Health Misinformation in Dynamic Social Media Conversations: Online Randomized Study of Public Masking During COVID-19. J Med Internet Res. 2.3.2022. https://pubmed.ncbi.nlm.nih.gov/35156933/
The White House unveils a new Covid strategy, but it will need congressional funding. NewYork Times. 2.3.2022. https://www.nytimes.com/live/2022/03/02/world/covid-19-tests-cases-vaccine?referringSource=articleShare#biden-announces-initiative-to-pair-coronavirus-tests-with-treatment
How ventilation, filtration, and humidity may prevent coronavirus transmission. Medical News Today. 2.3.2022. https://www.medicalnewstoday.com/articles/how-ventilation-filtration-and-humidity-may-prevent-coronavirus-transmission
Molecular imaging findings on acute and long-term effects of COVID-19 on the brain: A systematic review. JNM. 1.3.2022. https://jnm.snmjournals.org/content/early/2022/02/17/jnumed.121.263085
THL:n Mika Salminen: Koronapandemia on lähestymässä loppuaan – “Olen optimistinen sen suhteen, että tää oli nyt tässä”. MTV Uutiset. 3.3.2022. https://www.mtvuutiset.fi/artikkeli/thl-n-mika-salminen-koronapandemia-on-lahestymassa-loppuaan-olen-optimistinen-sen-suhteen-etta-taa-oli-nyt-tassa/8368112
March 1 – 10
Shared Narrative – Analysis on Finnish Socio-Educational Policy and National Broadcasting (YLE) Literacy during COVID-19 Variants 2021. Jyrki Loima. International Journal of Education and Literacy Studies. 28.2.2022. https://www.researchgate.net/publication/358263637_Shared_Narrative_-_Analysis_on_Finnish_Socio-Educational_Policy_and_National_Broadcasting_YLE_Literacy_during_COVID-19_Variants_2021
Koronapandemian alkuperä yhä varmempi: tutkimusten mukaan tartunnat lähtivät eläintorilta kahteen otteeseen, väli-isäntänä saattoi olla supikoira
Kahdessa kansainvälisessä ja yhdessä kiinalaisessa tutkimuksessa on saatu vahvaa näyttöä siitä, että SARS-CoV-2 tarttui torilla myydyistä eläimistä. Hypoteesi laboratoriosta viruksen syntypaikkana hiipuu. YLE Uutiset 28.2.2022. https://yle.fi/uutiset/3-12336380?utm_source=newsletter&utm_medium=email&utm_campaign=scienceweekly&utm_content=2022-03-06
Wuhan market was epicentre of pandemic’s start, studies suggest
Report authors say that the coronavirus SARS-CoV-2 jumped to people from animals sold at the market on two occasions in late 2019 — but some scientists want more definitive evidence. Nature. 27.2.2022. https://www.nature.com/articles/d41586-022-00584-8?
Assessing the impact of SARS-CoV-2 prevention measures in Austrian schools using agent-based simulations and cluster tracing data (In conclusion, we find that different types of schools require different combinations of preventive measures. The ideal mix of mitigation measures needs to be more stringent in secondary schools than in primary schools, and needs to preferentially focus on teachers as sources of infection. Even under strict prevention measures, larger clusters in schools will still occur at regular intervals when the incidence in the general population is high enough. However, in this work we have shown that when keeping schools open during the COVID-19 pandemic a calculable risk can be achieved by a combination of stringently enforced measures which can be successively relaxed as larger portions of the population become vaccinated.). nature communications. 27.1.2022. https://www.nature.com/articles/s41467-022-28170-6
The role of outdoor and indoor air quality in the spread of SARS-CoV-2: Overview and recommendations by the research group on COVID-19 and particulate matter (RESCOP commission). National Library of Medicine. (Environ Res) 26.2.2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881809/
Comparative effectiveness of N95, surgical or medical, and non-medical facemasks in protection against respiratory virus infection: A systematic review and network meta-analysis. Wiley Online Library. 26.2.2022. https://onlinelibrary.wiley.com/doi/10.1002/rmv.2336
Slutbetänkande SOU 2022:10. Coronakommissionen.. 25.2.2022. https://coronakommissionen.com/publikationer/slutbetankande-sou-2022-10/
Sverige under pandemin. Volym 1. Samhällets, företagens och enskildas ekonomi. Slutbetänkande av Coronakommissionen. Stockholm 2022. Statens Offentliga Uträdningar SOU 2022:10. 25.2.2022. extension://elhekieabhbkpmcefcoobjddigjcaadp/https://coronakommissionen.com/wp-content/uploads/2022/02/sverige-under-pandemin-volym-1_webb-slutbetankande.pdf
Sverige under pandemin. Volym 2. Förutsättningar, vägval och utvärdering. Slutbetänkande av Coronakommissionen. Stockholm 2022. Statens Offentliga Uträdningar SOU 2022:10. 25.2.2022. extension://elhekieabhbkpmcefcoobjddigjcaadp/https://coronakommissionen.com/wp-content/uploads/2022/02/sverige-under-pandemin-volym-2_webb-slutbetankande.pdf
Sverige under pandemin. Summary in English. Slutbetänkande av Coronakommissionen. Stockholm 2022. Statens Offentliga Uträdningar SOU 2022:10. 25.2.2022. extension://elhekieabhbkpmcefcoobjddigjcaadp/https://coronakommissionen.com/wp-content/uploads/2022/02/summary_20220225.pdf
Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage. medRxiv. 25.2.2022. https://doi.org/10.1101/2022.02.24.22271440
Käännettä parempaan ei koronatilanteessa vielä nähdä – teho-osastolla tilanne oli perjantaina Satakunnassa koko epidemian pahin. Perjantaina hoidossa oli lyhyen ajan jopa viisi koronapotilasta yhtä aikaa. Se on enemmän kuin kertaakaan koko epidemian aikana. Satakunnan kansa. 25.2.2022. https://www.satakunnankansa.fi/koronavirus/art-2000008644315.html
Hus: Kasvomaskisuositus jatkunee vielä kuukausia. Husin Markku Mäkijärven mukaan suojautuminen koronavirustartuntoja vastaan vain korostuu, kun rajoituksia puretaan ja ihmisten kohtaamiset lisääntyvät. Helsingin Sanomat. 25.2.2022. https://www.hs.fi/kaupunki/art-2000008636704.html
NIH launches new initiative to study “Long COVID”. The NIH Director. 23.2.2022. https://www.nih.gov/about-nih/who-we-are/nih-director/statements/nih-launches-new-initiative-study-long-covid
Koronatartunnat ovat hidastaneet koronarokotustahtia. Koronarokotuksia annetaan nyt vain kymmenes osa siitä, mitä annettiin vuoden alussa. YLE Uutiset. 23.2.2022. https://yle.fi/uutiset/3-12329829
Coronavirus vaccine protection was much weaker against omicron, data shows. Washington Post. 23.2.2022. https://www.washingtonpost.com/health/interactive/2022/vaccine-omicron-effectiveness/?itid=hp_pandemic
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications. 23.2.2022. https://www.nature.com/articles/s41467-022-28371-z
REVIEW ARTICLE. A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications. Biochemical Journal. 23.2.2022. https://portlandpress.com/biochemj/article/479/4/537/230829/A-central-role-for-amyloid-fibrin-microclots-in
Long-term follow-up of dynamic brain changes in patients recovered from COVID-19 without neurological manifestations (Cognitive), JCI Insight. 22.2.2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876627/
Persisting pulmonary dysfunction in pediatric post-acute Covid-19. medRxiv. 22.2.2022. https://www.medrxiv.org/content/10.1101/2022.02.21.22270909v1
When Finland Decided to Open Up: A Behavioural Scientist’s Perspective. Matti TJ Heino. And Out Come the Systems -blog. 21.2.2022. https://mattiheino.com/2022/02/21/let-me-be-your-deja-vu/
February 21 – 28
Hemliga dokument avslöjar strategin. Svenska Dagbladet. 20.2.2022. https://www.svd.se/hemliga-dokument-avslojar-strategin
Opinion: After the pandemic, long covid may unleash a tidal wave of health troubles. Washington Post. 20.2.2022. https://www.washingtonpost.com/opinions/2022/02/20/long-covid-may-unleash-health-troubles-after-pandemic/
How Long Covid Exhausts the Body. New York Times. 19.2.2022. https://www.nytimes.com/interactive/2022/02/19/science/long-covid-causes.html
We’ll Have Herd Immunity by April. Covid cases have dropped 77% in six weeks. Experts should level with the public about the good news. Wall Street Journal. 18.2.2022. https://www.wsj.com/articles/well-have-herd-immunity-by-april-11613669731
Vil at koronasyke barn skal gå på skolen. Barn som kan smitte andre med korona kan være på skolen dersom allmenntilstanden er god. Regjeringen har gjort denne lettelsen i tiltak av hensyn til barn og unge. NRK. 18.2.2022. https://www.nrk.no/norge/vil-at-koronasyke-barn-skal-ga-pa-skolen-1.15857082
Uusi koronatrendi: Lapsipotilaiden määrä sairaaloissa kasvaa Ruotsissa ja Norjassa – tutkimuksen mukaan lapset herkempiä omikronille kuin deltalle
Yhdysvaltalaistutkimuksen mukaan omikroniin sairastuneet lapset joutuivat sairaalahoitoon nelinkertaisesti deltamuunnokseen verrattuna. YLE -Uutiset. 18.2.2022. https://yle.fi/uutiset/3-12322753
Uusi koronatrendi: Lapsipotilaiden määrä sairaaloissa kasvaa Ruotsissa ja Norjassa – tutkimuksen mukaan lapset herkempiä omikronille kuin deltalle
Yhdysvaltalaistutkimuksen mukaan omikroniin sairastuneet lapset joutuivat sairaalahoitoon nelinkertaisesti deltamuunnokseen verrattuna. YLE Uutiset. 18.2.2022. https://yle.fi/uutiset/3-12322753
As BA.2 subvariant of Omicron rises, lab studies point to signs of severity. CNN Health.18.2.2022. https://edition.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html
Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022. CDC MMWR. 18.2.2022. https://www.cdc.gov/mmwr/volumes/71/wr/mm7107e2.htm?s_cid=mm7107e2_w
‘I’m an Olympic Athlete. Due to Long COVID, Now I Struggle to Walk Up a Flight of Stairs’. For COVID-19 long haulers, recovery is slow. New research may, however, explain their suffering and point to new avenues for treatment. Everyday Health. 18.2.2022. https://www.everydayhealth.com/coronavirus/mitochondrial-dysfunction-may-be-to-blame-in-long-covid-19/
Estimates of SARS-CoV-2 Omicron Variant Severity in Ontario, Canada. JAMA. 17.2.2022. https://jamanetwork.com/journals/jama/fullarticle/2789408?
US has suffered more than 1m excess deaths during pandemic, CDC finds
The latest statistic hints at the breadth of Covid-19’s impact on health in the United States. Guardian 17.2.2022. https://www.theguardian.com/world/2022/feb/17/us-excess-deaths-pandemic-cdc
Estimates of SARS-CoV-2 Omicron Variant Severity in Ontario, Canada. JAMA. 17.2.2022. https://jamanetwork.com/journals/jama/fullarticle/2789408
Do masks really harm kids? Here’s what the science says. As more states drop mask mandates, experts explain why keeping them on in schools is still a smart move for families and teachers. National Geographic 17.2.2022. https://www.nationalgeographic.com/science/article/do-masks-really-harm-kids-heres-what-the-science-says
Koronavirustippoja laitettiin vapaaehtoisten nenään – tulokset yllättivät. Miksi toiset ovat alttiimpia tartunnalle kuin toiset, ihmettelevät tutkijat. Ilta=sanomat. 17.2.2022. https://www.is.fi/kotimaa/art-2000008620645.html
Grafiikat näyttävät selkeän käänteen epidemian vaarallisuudessa tammikuussa – katso oman ikäryhmäsi tiedot. Vaikka tartuntojen ilmaantuvuus moninkertaistui tammikuussa, kuolemien ilmaantuvuus jopa laski joissain ryhmissä, selviää THL:n uusista tiedoista. Helsingin Sanomat. 17.2.2022. https://www.hs.fi/kotimaa/art-2000008617430.html?
STM:n ja THL:n tilannekatsaus koronavirustílanteesta. Valtioneuvosto. 17.2.2022. https://stm.fi/documents/1271139/110045675/STM+THL+VM+mediainfo17.2.22.FINAL.pdf/
Pandemics disable people — the history lesson that policymakers ignore
Influenza, polio and more have shown that infections can change lives even decades later. Why the complacency over possible long-term effects of COVID-19?. Nature. 16.2.2022. https://www.nature.com/articles/d41586-022-00414-x?
The Effectiveness Of Government Masking Mandates On COVID-19 County-Level Case Incidence Across The United States, 2020 (…observational study of matched cohorts from 412 US counties between March 21 and October 20, 2020, we estimated the association between county-level public masking mandates and daily COVID-19 case incidence. On average, the daily case incidence per 100,000 people in masked counties compared with unmasked counties declined by 25 percent at four weeks, 35 percent at six weeks, and 18 percent across six weeks postintervention. The beneficial effect varied across regions of different population densities and political leanings. The most concentrated effects of masking mandates were seen in urban counties; the benefit of the mandates was potentially stronger within Republican-leaning counties. Although benefits were not equally distributed in all regions, masking mandates conferred benefit in reducing community case incidence during an early period of the COVID-19 pandemic.). Health Affairs. 16.2.2022. https://www.healthaffairs.org/doi/10.1377/hlthaff.2021.01072
Risks of mental health outcomes in people with covid-19: cohort study. BMJ. 16.2.2022. https://www.bmj.com/content/376/bmj-2021-068993?
Modeling the Transmission of COVID-19: Impact of Mitigation Strategies in Prekindergarten-Grade 12 Public Schools, United States, 2021 (Based on our model, layering mitigation strategies and contact tracing can limit the number of cases that may occur from transmission in schools. Schools in communities with substantial levels of community spread will need to be more vigilant to ensure adherence of mitigation strategies to minimize transmission. Our results show that for school administrators, teachers, and parents to provide the safest environment, it is important to utilize multiple mitigation strategies and contract tracing that reduce SARS CoV-2 transmission by at least 69%. This will require training, reinforcement, and vigilance to ensure that the highest level of adherence is maintained over the entire school term.). Journal of Public Health Management and Practice. Jan/Feb. 2022. https://journals.lww.com/jphmp/abstract/2022/01000/modeling_the_transmission_of_covid_19__impact_of.7.aspx
Mass testing to end the COVID-19 public health threat (While the world awaits and hopes for new and more effective vaccines, we need tools in the toolbox that can effectively control transmission of rapidly spreading new variants, especially if more pathogenic. Otherwise, we may face significant disruptions and enormous costs due to repeated waves of illness, with each wave increasing the numbers of workers thrown out of the workforce from long term health effects. Lockdowns, due to their social restrictions and high short-term economic costs, are no longer the best available option. We here point out that mass testing (regular asymptomatic screening of the general population) is an alternative approach that can dramatically reduce cases and quickly restore economic and social activity.). Lancet Regional Health Europe. Feb.2023. https://www.sciencedirect.com/science/article/pii/S2666776222002708
Mask Effectiveness for Preventing Secondary Cases of COVID-19, Johnson County, Iowa, USA. CDC Emerging Infectious Diseases. Feb 2022. https://wwwnc.cdc.gov/eid/article/28/1/21-1591_article
Increased Potency and Breadth of SARS-CoV-2 Neutralizing Antibodies After a Third mRNA Vaccine Dose. bioRxiv. 15.2.2022. https://www.biorxiv.org/content/10.1101/2022.02.14.480394v1
”Det mest anständiga är att åtalet läggs ner”. Jag var en av dem som erbjöds förmånen att bli testad, skriver Sven Britton, professor emeritus, om att åtal väckts för en testning för bestämning av antikroppar mot sars-cov-2. (1 kommentar). Dagens Medicin. 15.2.2022. https://www.dagensmedicin.se/opinion/debatt/det-mest-anstandiga-ar-att-atalet-laggs-ner/
Persistent SARS-CoV-2 Nucleocapsid Protein Presence in the Intestinal Epithelium of a Pediatric Patient 3 Months After Acute Infection. JPGN Reports. Feb.2022. https://journals.lww.com/jpgnr/fulltext/2022/02000/persistent_sars_cov_2_nucleocapsid_protein.9.aspx
Ilmahygienia suojaa koronatartunnoilta. Ilmavälitteisen tartunnan riskiä voidaan vähentää tieteen ja teknologian tuomien ratkaisujen avulla. Lääkärilehti. 14.2.2022. https://www.laakarilehti.fi/kliininen-tyo/ilmahygienia-suojaa-koronatartunnoilta/?public=c118ba0e51b2a0f8429a4b19c5e7a7df
CDC: COVID-19 Booster Effectiveness Wanes After Four Months.
The agency also finds that third shots prevented hospitalizations during the Omicron wave.The Scientist. 14.2.2022. https://www.the-scientist.com/news-opinion/cdc-covid-19-booster-effectiveness-wanes-after-four-months-69703?
FEATURE: Reduced brain function, immune disorder a possibility of “long COVID”. Kyodo News. 14.2.2022. https://english.kyodonews.net/news/2022/02/263518f1cd8b-feature-reduced-brain-function-immune-disorder-a-possibility-of-long-covid.html
Persistence, prevalence, and polymorphism of sequelae after COVID-19 in young adults. [testosterone] medRxiv. 13.2.2022. https://doi.org/10.1101/2022.02.11.22270836
Tutkijat varoittavat pandemian jälkeisestä sydänpommista: Riskit koholla vielä vuosi infektion jälkeen. MTV-Uutiset 12.2.2021. https://www.msn.com/fi-fi/terveysjafitness/hyvinvointi/tutkijat-varoittavat-pandemian-j%C3%A4lkeisest%C3%A4-syd%C3%A4npommista-riskit-koholla-viel%C3%A4-vuosi-infektion-j%C3%A4lkeen/ar-AATJ1uJ?ocid=winp-sf
Effectiveness of Face Mask or Respirator Use in Indoor Public Settings for Prevention of SARS-CoV-2 Infection — California, February–December 2021 (Face masks or respirators (N95/KN95s) effectively filter virus-sized particles in laboratory settings. The real-world effectiveness of face coverings to prevent acquisition of SARS-CoV-2 infection has not been widely studied. Consistent use of a face mask or respirator in indoor public settings was associated with lower odds of a positive SARS-CoV-2 test result (adjusted odds ratio = 0.44). Use of respirators with higher filtration capacity was associated with the most protection, compared with no mask use.). CDC MMWR. 11.2.2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830622/
Desinfioivaa UV-valaistusta voidaan käyttää myös ihmisten läsnä ollessa. Covid-19-pandemia on vauhdittanut UV-valoon perustuvan desinfiointiteknologian kehitystä ja käyttöönottoa. Mediuutiset. 11.2.2022. https://www.mediuutiset.fi/uutiset/mu/50a72e39-7b3c-402b-8d5a-92170a0ebcc5?
Huolestuttava tieto: Koronan uskotaan lisänneen huomattavasti lasten 1. tyypin diabetesta Suomessa – “Mitään vastaavaa ei ole nähty”. MTV Uutiset. 11.2.2022. https://www.mtvuutiset.fi/artikkeli/lasten-diabetes-tapaukset-lisaantyneet-lahes-kolmanneksella-asiantuntija-voidaan-ajatella-etta-covid-jouduttaisi-tautiprosessin-etenemista/8353508
Academics: Viral Evolution Scenarios, 10 February 2022. Gov.UK. 11.2.2022. https://www.gov.uk/government/publications/academics-viral-evolution-scenarios-10-february-2022
THL: Koronastrategiaan muutos – Neljäs annos ensisijaisesti vain riskiryhmille. Neljäs rokoteannos ei toisi merkittävää lisähyötyä koko väestölle. Suoja vakavalta taudilta säilyy hyvänä kolmannen annoksen jälkeen myös omikrontartunnoissa. Sosiaali- ja terveydenhuollon henkilöstön rokotukset ovat yhä lääketieteellisesti perusteltuja. Mediuutiset. 11.2.2022. https://www.mediuutiset.fi/uutiset/thl-koronastrategiaan-muutos-neljas-annos-ensisijaisesti-vain-riskiryhmille/c1ff347d-76fc-40c8-b79b-e11ea5bcf9db
February 11 – 20
In unvaccinated pregnant women, Covid can cause deadly harm to babies. Though rare, Covid during pregnancy can increase a woman’s risk of stillbirth (“We have never seen this level of destruction from an infectious illness before. It rendered the placenta unfit to carry out its duties,” said Dr. David Schwartz, a perinatal pathologist in private practice in Atlanta, who led the study. “These fetuses and newborns died from asphyxiation due to lack of oxygen.”). NBC News. 10.2.2023. https://www.nbcnews.com/health/health-news/covid-stillbirths-coronavirus-can-severely-damage-placenta-pregnant-wo-rcna15534
Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico. (Novavax NVX-CoV2373 was safe and effective for the prevention of Covid-19. Most breakthrough cases were caused by contemporary variant strains.) N Engl J Med. 10.2.2022.
How well do vaccines protect against Omicron? What the data shows. Gov.UK. 10.2.2022. https://ukhsa.blog.gov.uk/2022/02/10/how-well-do-vaccines-protect-against-omicron-what-the-data-shows/
Weekly death statistics [31 European Countries]. Eurostat. 10.2.2021. https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Weekly_death_statistics#Data_sources
Heart-disease risk soars after COVID — even with a mild case
Massive study shows a long-term, substantial rise in risk of cardiovascular disease, including heart attack and stroke, after a SARS-CoV-2 infection. Nature. 10.2.2022. https://www.nature.com/articles/d41586-022-00403-0
Risk of persistent and new clinical sequelae among adults aged 65 years and older during the post-acute phase of SARS-CoV-2 infection: retrospective cohort study. BMJ. 9.2.2022. https://www.bmj.com/content/376/bmj-2021-068414
Long COVID Might be Taking Toll on Health Care Workforce (Long COVID appears to be worsening the labor shortage in the United States, and the health care industry—which has lost 20% of workers over the pandemic—could be particularly hard hit.). Infection Control Today. 9.2.2022. https://www.infectioncontroltoday.com/view/long-covid-might-be-taking-toll-on-health-care-workforce
Omicron Has Been Found in Deer—That Should Worry Us. TIME. 9.2.2022. https://time.com/6146253/omicron-deer-covid-19/
Analyysi: Nämä 10 ristiriitaa ovat hiertäneet THL:n ja STM:n välejä
Kreeta Karvala. THL ja STM ovat olleet eri linjoilla useista keskeisistä koronatoimista yli kaksi vuotta jatkuneen koronakriisin aikana, kirjoittaa Iltalehden Kreeta Karvala. Iltalehti 8.2.2022. https://www.iltalehti.fi/politiikka/a/20a69937-d9c9-47b4-9c33-c6b420fe1ea6
Perspective SARS-CoV-2 infections in children: Understanding diverse outcomes. Immunity (Cell). 8.2.2022. https://www.cell.com/action/showPdf?pii=S1074-7613%2822%2900043-7
Tyypin 1 diabetes on lisääntynyt korona-aikana Helsingissäkin. Syy on epäselvä ja vaatii lisätutkimuksia, mutta koronapandemiaan on ajallinen yhteys. Lääkärilehti. 8.2.2022. https://www.laakarilehti.fi/tieteessa/tyypin-1-diabetes-on-lisaantynyt-korona-aikana-helsingissakin/?
Estimating the effect of non-pharmaceutical interventions to mitigate COVID-19 spread in Saudi Arabia (The IBM-KSA results scenarios showed the high effectiveness of mask-wearing, physical distancing, and contact tracing in controlling the spread of the disease. Without NPIs, the KSA could have reported 4,824,065 (95% CI: 3,673,775–6,335,423) cases by June 2021. The IBM-KSA showed that mandatory mask-wearing and physical distancing saved 39,452 lives (95% CI: 26,641–44,494). In-person education without personal protection during teaching would have resulted in a high surge of COVID-19 cases. Compared to scenarios with no personal protection, enforcing mask-wearing and physical distancing in schools reduced cases, hospitalizations, and deaths by 25% and 50%, when adherence to these NPIs was set to 50% and 70%, respectively. The IBM-KSA also showed that a quarantine imposed on international travelers reduced the probability of outbreaks in the country.). BMC Medicive. 7.2.2022. https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02232-4
Long-term cardiovascular outcomes of COVID-19. Nature Medicine. 7.2.2022. https://www.nature.com/articles/s41591-022-01689-3
Host genomes for the unique SARS-CoV-2 variant leaked into Antarctic soil metagenomic sequencing data. Research Square. 7.2.2022. https://www.researchsquare.com/article/rs-1330800/v1
Antihistamines for Postacute Sequelae of SARS-CoV-2 Infection. The Journal for Nurse Practitioners. 7.2.2022. https://www.sciencedirect.com/science/article/pii/S155541552100547X
Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples, Nature Biomedical Engineering. 7.2.2022. https://www.nature.com/articles/s41551-021-00833-7?
Päivittyvä seuranta: Sairaanhoitopiirit tyrmäävät koululaisten säännöllisen kotitestauksen | Australia avaa rajansa helmikuun lopulla | Turkin presidentillä koronatartunta
Kerromme uusimmat tiedot koronaviruksesta tässä artikkelissa. YLE-Uutiset. 7.2.2022. https://yle.fi/uutiset/3-11942036?utm_source=social-media-share&utm_medium=social&utm_campaign=ylefiapp
Brief incubation, high viral shedding: COVID-19 human challenge trial results. Medical News Today. 4.2.2022. https://www.medicalnewstoday.com/articles/brief-incubation-high-viral-shedding-covid-19-human-challenge-trial-results?
Effectiveness of Face Mask or Respirator Use in Indoor Public Settings for Prevention of SARS-CoV-2 Infection — California, February–December 2021. CDC Morbidity and Mortality Weekly Report. 4.2.2022. https://www.cdc.gov/mmwr/volumes/71/wr/mm7106e1.htm
Alzheimer’s-like changes found in COVID patients’ brains; flu shot, mRNA booster safe together. Reuters. 4.2.2022. https://www.reuters.com/business/healthcare-pharmaceuticals/alzheimers-like-changes-found-covid-patients-brains-flu-shot-mrna-booster-safe-2022-02-04/
How a nondescript box has been saving lives during the pandemic – and revealing the power of grassroots innovation. The Conversation 3.2.2022. https://theconversation.com/how-a-nondescript-box-has-been-saving-lives-during-the-pandemic-and-revealing-the-power-of-grassroots-innovation-176779?
Complications Following SARS-CoV-2 Infection in Victoria, Australia: A Record Linkage Study. SSRN (Lancet). 3.2.2022. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4025054
SARS-CoV-2 Infections in Close Contacts of Positive Cases in the Olympic and Paralympic Village at the 2021 Tokyo Olympic and Paralympic Games. JAMA. 3.2.2022. https://jamanetwork.com/journals/jama/fullarticle/2788895?
Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness. OLOS One. 3.2.2022. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263069
Tutkimus: Koronavirus voi tarttua yhdestä pisarasta. Tutkijoiden mukaan kokeiden perusteella tehtiin rohkaisevia havaintoja. Iltalehti. 3.2.2022. [ep’äeettinen tutkimus] https://www.iltalehti.fi/ulkomaat/a/4db7f55f-75d2-401b-9fab-bed077f38095
Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK. ONS. 3.2.2021. https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/datasets/alldatarelatingtoprevalenceofongoingsymptomsfollowingcoronaviruscovid19infectionintheuk?s=09
Fungal Diseases and COVID-19 (The most commonly reported fungal infections in patients with COVID-19 include aspergillosis, invasive candidiasis, and mucormycosis (sometimes called by the misnomer ”black fungusexternal icon.” Fungal infections resistant to antifungal treatment have also been described in patients with severe COVID-19). CDC. 2.3.2023. https://www.cdc.gov/fungal/covid-fungal.html
Miksi rajoituksia puretaan, vaikka koronakuolemia kirjataan yhä kymmeniä viikossa? – ”Ei voida ajatella, että kukaan ei saa Suomessa koskaan kuolla mihinkään”, sanoo THL:n Salminen. Yhä pienempi osa koronatartunnan saaneista kuolee tautiin. Aamulehti. 2.2.2022. https://www.aamulehti.fi/koronavirus/art-2000008583714.html
Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge. [Alexander van Assendelft: an unethical human experiment] Research Square. 1.2.2022. https://www.researchsquare.com/article/rs-1121993/v1
Model-Estimated Association Between Simulated US Elementary School-Related SARS-CoV-2 Transmission, Mitigation Interventions, and Vaccine Coverage Across Local Incidence Levels. JAMA. 1.2.2022. https://pubmed.ncbi.nlm.nih.gov/35157056/
Moni uskoo, että Suomessa on tiukemmat koronarajoitukset kuin muualla – tarkistimme faktat, ja asia on lähes päinvastoin. Tämä juttu kertoo, miten Suomen tämänhetkiset rajoitukset vertautuvat Tanskaan, Saksaan, Englantiin ja Italiaan. Tällä hetkellä yhteiskuntaa avataan osassa Euroopan maita Suomea rivakammin. YLE-Uutiset. 1.2.2022. https://yle.fi/uutiset/3-12297246?utm_source=newsletter&utm_medium=email&utm_campaign=newsdaily&utm_content=2022-02-02
Koronakuolemien määrä kasvaa nopeasti – kysyimme, miksi THL laskee lukuihin muitakin kuin selkeitä koronataudin aiheuttamia kuolemia. Koronaan liittyvien kuolemien määrä ylittää pian 2 000:n rajapyykin. Suurin kuolleisuus on iäkkäillä rokottamattomilla. THL kirjaa koronakuolemiksi kuolemat, jotka ovat tapahtuneet 30 vuorokauden aikana tartunnasta. YLE-Uutiset. 1.2.2022. https://yle.fi/uutiset/3-12296560?utm_source=newsletter&utm_medium=email&utm_campaign=newsdaily&utm_content=2022-02-02
High Rates of Rapid Antigen Test Positivity After 5 days of Isolation for COVID-19. medRxiv. 1.2.2022. https://www.medrxiv.org/content/10.1101/2022.02.01.22269931v1.full.pdf
Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge. In Review.1.2.2022. https://www.researchsquare.com/article/rs-1121993/v1
February 1 – 10
It’s a delusion to think mass spread of Omicron will end the pandemic.Globe and Mail. 31.1.2022. https://www.theglobeandmail.com/opinion/article-its-a-delusion-to-think-mass-spread-of-omicron-will-end-the-pandemic/
Transmission of SARS-CoV-2 Omicron VOC subvariants BA.1 and BA.2: Evidence from Danish Households. medRxiv. 30.1.2022. https://www.medrxiv.org/content/10.1101/2022.01.28.22270044v1.full
Russia Sees Record Population Decline As Excess Deaths Hit 1M. Russia experienced its largest population decline in 2021 since the end of the Soviet Union. Moscow Times. 29.1.2022. https://www.themoscowtimes.com/2022/01/28/russias-pandemic-excess-death-toll-almost-1m-a76194
37,000 People Already Received 4th Vaccination in Hungary. Hungary today. 28.1.2022. https://hungarytoday.hu/coronavirus-covid-19-vaccines-fourth-dose-jab-booster/
Covid-19: Antibody “signature” could predict risk of long covid. BMJ. 28.1.2022. https://www.bmj.com/content/376/bmj.o245?
The COVID Project: Coronavirus in Kids Tracking and Education Project. 28.1.2022. https://www.covkidproject.org/
Nämä keinot ovat vanhentuneet koronan torjunnassa, professori sanoo – tässä pätevät
Moni lotraa edelleen käsidesin kanssa, vaikka oleellisempaa omikronin leviämisen ehkäisemisessä olisi maskin käyttäminen oikein. Iltalehti. 28.1.2022. https://www.iltalehti.fi/terveysuutiset/a/4beeae55-439a-4367-8762-24239d61be4a?
Coronaviruset hänger ofta kvar i inomhusluften – forskare uppmanar oss att vrida upp luftkonditioneringen och att använda luftrenare. Svenska YLE. 28.1.2022. https://svenska.yle.fi/a/7-10012085
Läkare med postcovid: Jag saknar den jag var. Detta är min berättelse om postcovid och den är varken unik eller allmängiltig, skriver läkaren Lisa Norén som har postcovid och är aktiv i nätverket Läkare till läkare. Hon tar upp Hanne Kjöllers uppmärksammade artiklar om postcovid och avfärdar att det är en kultursjukdom. Hon menar att sjukdomen är komplex och därför krävs det läkare med postcovidkompetens. Kvartal. 27.1.2022. https://kvartal.se/artiklar/lakare-med-postcovid-jag-saknar-den-jag-var/
THL:n Mika Salminen pohjoiselle valmiustoimikunnalle: Alueelliset toimijat ovat onnistuneet torjumaan koronaa hyvin. Pohjois-Suomen alueellinen valmiustoimikunta kokoontui alkuviikolla uudistuneessa kokoonpanossa ylijohtaja Terttu Savolaisen johdolla. Asiantuntijavieraana oli THL:n terveysturvallisuusosaston johtaja, professori Mika Salminen, joka kiitti alueellisia toimijoita erinomaisesta onnistumisesta koronapandemian torjunnassa. Mun Oulu. 27.1.2022. https://www.munoulu.fi/artikkeli/-/id/thl-n-mika-salminen-pohjoiselle-valmiustoimikunnalle-alueelliset-toimijat-ovat-onnistuneet-torjumaan-koronaa-hyvin
Uusi normaali koittaa kesään mennessä, sanoo THL:n Mika Salminen – tätä se tarkoittaa. Kaikki merkit viittaavat siihen, että uusi normaali on kulman takana: se tarkoittaa ensi kesänä suurten ja perinteisten kesäfestivaalien paluuta. Iltalehti. 27.1.2022. https://www.iltalehti.fi/koronavirus/a/cd4b87e6-19e4-4f0e-8603-5b4f727c372a
Asiantuntijan mukaan olemme koronapandemian loppuvaiheilla, mutta sinänsä korona ei koskaan lopu. Koronapandemia päättyy eri paikoissa eri aikaan, mutta epidemiologi Jussi Sanen mukaan pandemiassa ollaan jo loppuvaiheilla. HUSin apulaisylilääkäri Eeva Ruotsalainen ei kuitenkaan halua olla ylioptimistinen.YLE-Uutiset. 27.1.2022. https://yle.fi/uutiset/3-12288922?
Turkulainen hammastahna-suuvesi covid-19-infektiota vastaan sai patentin Yhdysvalloissa.
Yhtiön mukaan koronaa vastaan toimiva hammastahna-suuvesi perustuu elimistön oman kemiallisen puolustusmekanismin vahvistamiseen. Mediuutiset. 27.1.2022. https://www.mediuutiset.fi/uutiset/mu/8f2511e1-86f7-499e-8195-d9c95ea05583?
The Covid Resilience Ranking. The Best and Worst Places to Be as We Learn to Live With Covid. Bloomberg. 27.1.2022. https://www.bloomberg.com/graphics/covid-resilience-ranking/?
Implication of COVID-19 on Erythrocytes Functionality: Red Blood Cell Biochemical Implications and Morpho-Functional Aspects. Int J Mol Sci. 27.1.2022. https://www.mdpi.com/1422-0067/23/4/2171/htm
A second version of omicron is spreading. Here’s why scientists are on alert. NPR. 27.1.2022. https://www.npr.org/sections/goatsandsoda/2022/01/27/1076123109/new-covid-variant-omicron-ba-2
Satasairaalan henkilöstöllä todettu runsaasti koronatartuntoja – Leikkauksia joudutaan perumaan. Kiireelliset toimenpiteet ja päivystysleikkaukset toteutetaan poikkeustilanteesta huolimatta normaalisti. Satakunnan Kansa. 26.1.2022. https://www.satakunnankansa.fi/koronainfo/art-2000008569067.html
Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta 2 variants. medRxiv. 26.1.2022. https://www.medrxiv.org/content/10.1101/2022.01.25.22269794v1.full.pdf
When will the COVID-19 pandemic end? 4 essential reads on past pandemics and what the future could bring. The Conversation. 26.1.2022. https://theconversation.com/when-will-the-covid-19-pandemic-end-4-essential-reads-on-past-pandemics-and-what-the-future-could-bring-175587?
Alueelliset toimijat ovat onnistuneet torjumaan koronaa, totesi Mika Salminen Pohjois-Suomen alueellisessa valmiustoimikunnassa.
Pohjois-Suomen alueellinen valmiustoimikunta kokoontui 25.1.2022 uudistuneessa kokoonpanossa ylijohtaja Terttu Savolaisen johdolla. Asiantuntijavieraana oli Terveyden ja hyvinvoinnin laitoksen terveysturvallisuusosaston johtaja, professori Mika Salminen, joka kiitti alueellisia toimijoita erinomaisesta onnistumisesta koronapandemian torjunnassa. Aluehallintovirasto. 25.1.2022. https://www.sttinfo.fi/tiedote/alueelliset-toimijat-ovat-onnistuneet-torjumaan-koronaa-totesi-mika-salminen-pohjois-suomen-alueellisessa-valmiustoimikunnassa?publisherId=69818103&releaseId=69930577
The Real-time Assessment of Community Transmission (REACT) programme is one of the largest, most significant pieces of research looking at how the COVID-19 pandemic is progressing in England. Imperial College. 25.1.2022. https://www.imperial.ac.uk/medicine/research-and-impact/groups/react-study/real-time-assessment-of-community-transmission-findings/
The study is being carried out by a world-class team of scientists, clinicians and researchers at Imperial College London, in partnership with Ipsos MORI, and was commissioned by the Department of Health and Social Care. Explore our study’s findings below.
Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants. medRxiv. 25.1.2022. https://www.medrxiv.org/content/10.1101/2022.01.25.22269794v1.full.pdf
Close relatives of MERS-CoV in bats use ACE2 as their functional receptors, bioRxiv.25.1.2022. https://www.biorxiv.org/content/10.1101/2022.01.24.477490v1.full.pdf
COVID-19: endemic doesn’t mean harmless. Rosy assumptions endanger public health — policymakers must act now to shape the years to come. Nature. 24.1.2022. https://www.nature.com/articles/d41586-022-00155-x
Parties may lead to his downfall, but is this the worst of what Johnson has done? BMJ. 24.1.2022. https://www.bmj.com/content/376/bmj.o196?
Multiple early factors anticipate post-acute COVID-19 sequelae. Cell. 24.1.2022. https://www.cell.com/cell/fulltext/S0092-8674(22)00072-1#figs1
Disease severity during SARS-COV-2 reinfection: a nationwide study. J of Infection. 24.1.2022. https://www.journalofinfection.com/article/S0163-4453(22)00010-X/fulltext
COVID-19: endemic doesn’t mean harmless. Rosy assumptions endanger public health — policymakers must act now to shape the years to come. Nature. 24.1.2022. https://www.nature.com/articles/d41586-022-00155-x
T cell apoptosis characterizes severe Covid-19 disease. Cell death and differentiation. 22.1.2022. https://www.nature.com/articles/s41418-022-00936-x
Variation in excess all-cause mortality by age, sex, and province during the first wave of the COVID-19 pandemic in Italy. Scientific Reports. 20.1.2022. https://www.nature.com/articles/s41598-022-04993-7
Functional evaluation of the P681H mutation on the proteolytic activation of the SARS-CoV-2 variant B.1.1.7 (Alpha) spike. iScience. 21.1.2022. https://www.sciencedirect.com/science/article/pii/S2589004221015595?
“Hengitysilma paremmaksi ja FFP2-maskit kasvoille” – fysiikka ei erehdy, koronan torjunnassa on otettava uusi askel. Pandemian alkuvaiheessa monet asiantuntijat ja poliitikot uskoivat vahvasti myyttiin, etteivät virukset leviä ensisijaisesti hengitysilmassa vaan kosketustartunnan kautta. Fyysikot toivat kuitenkin jo pandemian alkuvaiheessa esille, että korona leviää voimakkaimmin nimenomaan hengitysilmassa. Virusta täytyykin jatkossa torjua rokotusten ohella ennen kaikkea hengitysilman laatuun keskittymällä, kirjoittaa apulaisprofessori Ville Vuorinen. MustRead. 21.1.2022. https://www.mustread.fi/artikkelit/hengitysilma-paremmaksi-ja-ffp2-maskit-kasvoille-fysiikka-ei-erehdy-koronan-torjunnassa-on-otettava-uusi-askel/?
Ville Vuorinen: Hengitysilman parantaminen on avain pandemian torjuntaan. Korona leviää ilmateitse, ja siksi sitä ei pysäytetä käsien pesulla, sanoo apulaisprofessori Ville Vuorinen. Paukut pitäisi pistää ilmahygieniaan, ja siinä tarvitaan sekä tehokasta ilmanvaihtoa että oikeanlaisia maskeja. A” Uutiset 21.1.2022. https://www.aalto.fi/fi/uutiset/ville-vuorinen-hengitysilman-parantaminen-on-avain-pandemian-torjuntaan
January 21 – 31
Outpatient treatment of Covid-19 and the development of Long Covid over 10 months: A
2 multi-center, quadruple-blind, parallel group randomized phase 3 trial. SSEN. 20.1.2022. https://deliverypdf.ssrn.com/delivery.php?ID=767068083087001028017106089075000103054050034080045061126006095094000092113122092124011002034032054015113005121112075072068114107041047029074101005084064101099029104051055083096082005015113108088014082123075109010030097096020093084111010090066083127102&EXT=pdf&INDEX=TRUE
From pandemic to endemic? What 2022 might mean for COVID-19. World Economic Forum. 19.1.2022. https://www.weforum.org/agenda/2022/01/covid-19-pandemic-2022-what-next-expert-voices-from-davos/
Rapid vigilance and episodic memory decrements in COVID-19 survivors. Brain Communications. 19.1.2022. https://academic.oup.com/braincomms/article/4/1/fcab295/6511053?login=false
Ilmanvaihto-ohjeistus varhaiskasvatuksen, opetuksen ja koulutuksen tilojen käytöstä vastaaville. THL. 19.1.2021. https://thl.fi/fi/web/ymparistoterveys/sisailma/koronavirus-ja-sisailman-turvallisuus/ilmanvaihto-ohjeistus-varhaiskasvatuksen-opetuksen-ja-koulutuksen-tilojen-kaytosta-vastaaville
Differences in environmental stability among SARS-CoV-2 variants of concern: Omicron has higher stability. bioRxiv. 19.1.2022. https://www.biorxiv.org/content/10.1101/2022.01.18.476607v1.full
SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses. Cell. 19.1.2022. https://www.cell.com/cell/fulltext/S0092-8674(22)00069-1#relatedArticles
Biden Will Give Away Free N95 Masks at Pharmacies and Health Centers. TIME. 19.1.2022. https://time.com/6140223/biden-free-n95-masks/?utm_medium=email&utm_source=sfmc&utm_campaign=newsletter+coronavirus+default+ac&utm_content=+++20220119+++body&et_rid=149179605&lctg=149179605
Respiratory viruses that hijack immune mechanisms may have Achilles’ heel. Phys.org. 18.1.2022. https://phys.org/news/2022-01-respiratory-viruses-hijack-immune-mechanisms.html
Incidence of Type 1 Diabetes in Children and Adolescents During the COVID-19 Pandemic in Germany: Results From the DPV Registry. Diabetes Care. 17.1.2022. https://diabetesjournals.org/care/article-abstract/doi/10.2337/dc21-0969/139385/Incidence-of-Type-1-Diabetes-in-Children-and?redirectedFrom=fulltext
Israel Finds Fourth COVID Booster is only ‘Partially Effective,’ Vast Majority of Hospitalised Omicron Patients Are Unvaccinated. Health Policy Watch. 17.1.2022. https://healthpolicy-watch.news/israel-fourth-covid-booster-ineffective/
Tamperelaisyritys sai luvan koronakeksinnölleen: puhallustesteri antaa alle minuutissa tiedon koronatartunnasta. Suomessa kehitetty puhallustesteri mittaa uloshengityksestä koronainfektion aiheuttamia yhdisteitä. YLE-Uutiset. 17.1.2022. https://yle.fi/uutiset/3-12273307?
Kannanotto: Valmiuslaki ei takaa terveydenhuollon kantokykyä. Nuorten Lääkärien Yhdistys. 17.1.2022. https://www.nly.fi/kannanotto-valmiuslaki-ei-takaa-terveydenhuollon-kantokykya/
Time to upgrade from cloth and surgical masks to respirators? Your questions answered. The Converesation. 17.1.2022. https://theconversation.com/time-to-upgrade-from-cloth-and-surgical-masks-to-respirators-your-questions-answered-174877
Hengityssuojaimet toimivat, vaikka jotkut muuta väittävätkin [Ari Laaksonen]. Kaleva. 16.1.2022. https://www.kaleva.fi/hengityssuojaimet-toimivat-vaikka-jotkut-muuta-vai/4249701
Excess mortality in 2020-2021 % change compared with 2016-2019 average. Eurostat Statistics explained. nn.1.2022. https://ec.europa.eu/eurostat/statistics-explained/index.php?title=File:Excess_Mortality_Update_DEC2021GIF.gif
Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study. Lancet Infectious Diseases. NN.1.2022. https://www.sciencedirect.com/science/article/pii/S1473309921004606
With COVID-19, Air Is Both the Problem and the Solution. SARS-CoV-2 can linger in the air. Dealing with it can be relatively easy, but first, we have to admit we have a problem McGill. 15.1.2022. https://www.mcgill.ca/oss/article/covid-19/covid-19-air-both-problem-and-solution
One in nine recent virus cases in Israel are reinfections — report. High proportion of those who recovered and were then reinfected were at least partially vaccinated; officials believe confirmed daily cases will reach 100,000 in coming days. Times of Israel. 15.1.2022. https://www.timesofisrael.com/one-in-nine-recent-virus-cases-in-israel-are-reinfections-report/
A LITERATURE REVIEW AND META-ANALYSIS OF THE EFFECTS OF LOCKDOWNS ON COVID-19 MORTALITY. Studies in Applied Economics. NN.1.2022. extension://elhekieabhbkpmcefcoobjddigjcaadp/https://sites.krieger.jhu.edu/iae/files/2022/01/A-Literature-Review-and-Meta-Analysis-of-the-Effects-of-Lockdowns-on-COVID-19-Mortality.pdf
Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure. Science 14.1.2022. https://www.science.org/doi/10.1126/science.abq1841
Risk for Newly Diagnosed Diabetes >30 Days After SARS-CoV-2 Infection Among Persons Aged <18 Years — United States, March 1, 2020–June 28, 2021 (SARS-CoV-2 infection is associated with worsening of diabetes symptoms, and persons with diabetes are at increased risk for severe COVID-19. SARS-CoV-2 infection might also induce newly diagnosed diabetes. Persons aged <18 years with COVID-19 were more likely to receive a new diabetes diagnosis >30 days after infection than were those without COVID-19 and those with prepandemic acute respiratory infections. Non–SARS-CoV-2 respiratory infection was not associated with an increased risk for diabetes.). CDC MMWR. 14.1.2022. https://www.cdc.gov/mmwr/volumes/71/wr/mm7102e2.htm
Weekly epidemiological update: Omicron variant of concern (VOC) – week 2 (data as of 13 January 2022) EU/EEA. ECDC. 14.1.2022. https://www.ecdc.europa.eu/en/news-events/weekly-epidemiological-update-omicron-variant-concern-voc-week-2-data-13-january-2022
COVID-19 starkly increases pregnancy complications, including stillbirths, among the unvaccinated, Scottish study shows. Separate study finds timing of infection during pregnancy predicts prematurity. Science. 14.1.2022. https://www.science.org/content/article/covid-19-starkly-increases-pregnancy-complications-including-stillbirths-among?
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection (Combinations of the inflammatory mediators IFN-β, PTX3, IFN-γ, IFN-λ2/3 and IL-6 associated with LC with 78.5–81.6% accuracy.). nature immunology. 13.1.2022. https://www.nature.com/articles/s41590-021-01113-x
Covid-19: Peak of viral shedding is later with omicron variant, Japanese data suggest. BMJ. 13.1.2022. https://www.bmj.com/content/376/bmj.o89
Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer’s dementia. Alzheimer’s Association. 13.1.2022. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12556
Covid-19: Peak of viral shedding is later with omicron variant, Japanese data suggest. BMJ. 13.1.2022. https://www.bmj.com/content/376/bmj.o89
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection. Nature Immunology. 13.1.2022. https://www.nature.com/articles/s41590-021-01113-x
Hospital length of stay for COVID-19 patients: a systematic review and meta-analysis (Length of Stay, LoS, in Hospital. Europe 15.31 (9.03-21.59) days). Multidiscip Respir Med. 12.1.2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472334/
The effectiveness of vaccination against long COVID. A rapid evidence briefing. UK Health Security Agency. 12.1.2022. https://ukhsa.koha-ptfs.co.uk/cgi-bin/koha/opac-retrieve-file.pl?id=fe4f10cd3cd509fe045ad4f72ae0dfff
Covid-19 control measures and common paediatric infections. BMJ. 12.1.2022. https://doi.org/10.1136/bmj.n3093
Analyzing natural herd immunity media discourse in the United Kingdom and the United States. [Great Barrington Declaration, False balance in media coverage]. PLOS Global Public Health. 12.1.2022. https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000078
Indirect effects of the covid-19 pandemic on childhood infection in England: population based observational study. BMJ. 12.1.2022. https://doi.org/10.1136/bmj-2021-067519
Why we need to wear better masks. [Risk of COVID-19 infection between infected and non-infected individuals with different mask combinations – N95 ] AXIOS. 11.1.2022. https://www.axios.com/2022/01/11/n95-mask-protection-covid
Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain. bioRxiv. 10.1.2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764721/
Slow the Spread? Speeding It May Be Safer. Tamping down on Omicron may increase the risk of an ‘antigenic shift’ to a far deadlier supervariant. Wall Street Journal. 10.1.2022. https://www.wsj.com/articles/speeding-it-may-be-safer-omicron-mandates-antigenic-drift-shift-covid-supervariant-mask-social-distancing-lockdown-vaccine-11641847062
The Dynamics of SARS-CoV-2 Infectivity with Changes in Aerosol. Microenvironment. medRxiv. 10.1.2022. https://www.medrxiv.org/content/10.1101/2022.01.08.22268944v1.full.pdf
Covid loses 90% of ability to infect within 20 minutes in air – study
Exclusive: Findings highlight importance of short-range Covid transmission. The Guardian. 11.1.2022. https://www.theguardian.com/world/2022/jan/11/covid-loses-90-of-ability-to-infect-within-five-minutes-in-air-study
WHO: Jatkuvissa tehosterokotuksissa ei järkeä
Maailman terveysjärjestön mukaan tarvitaan rokote, joka ehkäisee tartuntoja. Iltalehti. 11.1.2022. https://www.iltalehti.fi/ulkomaat/a/5ca307c8-7c15-4476-a361-b544d3b9e77e?
January 11 – 20
Slow the Spread? Speeding It May Be Safer. Tamping down on Omicron may increase the risk of an ‘antigenic shift’ to a far deadlier supervariant. WSJ Opinnon. 10.1.2022. https://www.wsj.com/articles/speeding-it-may-be-safer-omicron-mandates-antigenic-drift-shift-covid-supervariant-mask-social-distancing-lockdown-vaccine-11641847062
The Dynamics of SARS-CoV-2 Infectivity with Changes in Aerosol Microenvironment. medRxiv. 10.1.2022. https://www.medrxiv.org/content/10.1101/2022.01.08.22268944v1
Infectious viral load in unvaccinated and vaccinated patients infected with SARS-CoV-2 WT, Delta and Omicron. MedRxiv. 10.1.2022. https://www.medrxiv.org/content/10.1101/2022.01.10.22269010v1
Liikuntaväki huolissaan lasten harrastusten rajoituksista – THL:n Tervahauta: Hyödyt vähäiset, haitat suuret. Viranomaisten toimia pidetään poukkoilevana ja rajoituskaavailuja epäreiluina lasten ja nuorten kannalta. Lajiliittojen johtajat pelkäävät koko ikäluokan menettämistä. YLE-Uutiset. 8.1.2022. https://yle.fi/uutiset/3-12263002?
Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain. bioRxiv. 10.1.2022. https://www.biorxiv.org/content/10.1101/2022.01.07.475453v1.full
Efficacy of face masks, neck gaiters and face shields for reducing the expulsion of simulated cough-generated aerosols. Aerosol Science & Technology. 7.1.2022. https://www.tandfonline.com/doi/full/10.1080/02786826.2020.1862409
Hospitals Are in Serious Trouble. Omicron is inundating a health-care system that was already buckling under the cumulative toll of every previous surge. Atlantic. 7.1.2022. https://www.theatlantic.com/health/archive/2022/01/omicron-mild-hospital-strain-health-care-workers/621193/
STM:n asiantuntijaryhmä: Korona voi ilmetä pitkäkestoisena joka toisella aikuisella – HS seurasi tiedotustilaisuutta. Uupumus, hengenahdistus ja kognitiiviset häiriöt yleisiä oireita. Helsingin Sanomat. 7.1.2022. https://www.hs.fi/kotimaa/art-2000008523531.html
Immunity against Omicron from breakthrough infection could be a matter of timing. Laboratory studies hint that a longer interval between vaccination and infection is better than a shorter one. Nature. 7.1.2022. https://www.nature.com/articles/d41586-022-00004-x?
Risk Factors for Severe COVID-19 Outcomes Among Persons Aged ≥18 Years Who Completed a Primary COVID-19 Vaccination Series — 465 Health Care Facilities, United States, December 2020–October 2021. CDC Morbidity and Mortality Weekly Report. 7.1.2022. https://www.cdc.gov/mmwr/volumes/71/wr/mm7101a4.htm
How to Think About Covid Data Right Now. New York Times. 7.1.2022. https://www.nytimes.com/interactive/2022/01/07/us/covid-data-explained.html
Higher viral load and infectivity increase risk of aerosol transmission for Delta and Omicron variants of SARS-CoV-2. Swiss Medical Weekly. 6.1.2021. https://smw.ch/article/doi/smw.2022.w30133
Virologian professori: Maskien käyttö on nyt tärkeämpää kuin koskaan – Tilanne pääkaupunkiseudulla ”kuin Lontoossa”. Uusi Suomi. 6.1.2022. https://www.uusisuomi.fi/uutiset/virologian-professori-maskien-kaytto-on-nyt-tarkeampaa-kuin-koskaan-tilanne-paakaupunkiseudulla-kuin-lontoossa/488a3898-2b85-4b5a-ab09-edb16d5ad59f
Comprehensive Chemosensory Psychophysical Evaluation of Self-reported Gustatory Dysfunction in Patients With Long-term COVID-19. A Cross-sectional Study. JAMA Network. 6.1.2022. https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2787787?
A National Strategy for the “New Normal” of Life With COVID. JAMA Network. 6.1.2022. https://jamanetwork.com/journals/jama/article-abstract/2787944
Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome. BMJ / Gut. 5.1.2022. https://gut.bmj.com/content/early/2022/01/05/gutjnl-2021-325989
South African scientist thinks she may have solved the mystery of long COVID-19, which afflicts 100M people. A recent study by Resia Pretorius and her team at Stellenbosch University in South Africa suggests that long COVID-19 may be triggered by microclots. The Hill. 5.1.2022. https://thehill.com/changing-america/well-being/medical-advances/588443-south-african-scientist-thinks-she-may-have
Association between vaccination status and reported incidence of post-acute COVID-19 symptoms in Israel: a cross-sectional study of patients tested between March 2020 and November 2021. medRxiv. 5.1.2022. https://www.medrxiv.org/content/10.1101/2022.01.05.22268800v2
Practical Indicators for Risk of Airborne Transmission in Shared Indoor Environments and Their Application to COVID-19 Outbreaks. Environmental Science & Technology. 5.1.2022. https://doi.org/10.1021/acs.est.1c06531
Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19. @IanRicksecker, A Duke pathology study in Singapore “detected SARS-CoV-2 .. in the colon, appendix, ileum, haemorrhoid, liver, gallbladder and lymph nodes .. suggesting widespread multiorgan involvement of the viral infection.” The same study found “evidence of residual virus in .. tissues during the convalescent phase, up to 6 months after recovery, in a non-postmortem setting,” suggesting that “a negative swab result might not necessarily indicate complete viral clearance from the body.” Gut. 5.1.2022. gut.bmj/content/gutjnl-2021-324280.full.pdf
Discordant SARS-CoV-2 PCR and Rapid Antigen Test Results. When Infectious: A December 2021 Occupational Case Series. medRxiv. 5.1.2022. Discordant SARS-CoV-2 PCR and Rapid Antigen Test Results When Infectious: A December 2021 Occupational Case Series (medrxiv.org)
By wearing face masks in schools, students protect their learning, families and long-term health. Flawed or unrepresentative studies promote the view that masks are ineffective or harmful. But at times when Covid case rates are high, they’re one of our best options. iNews. 5.1.2022. https://inews.co.uk/opinion/by-wearing-face-masks-in-schools-students-protect-their-learning-families-and-long-term-health-1381627
Practical Indicators for Risk of Airborne Transmission in Shared Indoor Environments and Their Application to COVID-19 Outbreaks. Environ Sci Technol. 5.1.2022. https://pubs.acs.org/doi/10.1021/acs.est.1c06531
Early Israeli findings show fivefold boost from fourth COVID vaccine dose. CIDRAP, University of Minnesota. 4.1.2022. https://www.cidrap.umn.edu/news-perspective/2022/01/early-israeli-findings-show-fivefold-boost-fourth-covid-vaccine-dose
Viikoittaiset tilastot kuolleista julkaistaan jatkossa kerran kuukaudessa. Tilastokeskus. 4.1.2022. https://www.stat.fi/uutinen/viikoittaiset-tilastot-kuolleista-julkaistaan-jatkossa-kerran-kuukaudessa
Long Covid: why do some people have symptoms months after infection? Researchers say more than 100m suffer ill effects for at least 12 weeks. Financial Times. 4.1.2022. https://www.ft.com/content/ed89cad2-6f82-44f0-b01d-c4490e4a7372?shareType=nongift
A framework for reconstructing SARS-CoV-2 transmission dynamics using excess mortality data. (Iran) medRxiv. 4.1.2022. https://www.medrxiv.org/content/10.1101/2021.10.04.21264540v2.full.pdf
Mapping the antigenic diversification of SARS-CoV-2. medRxiv. 3.1.2022. https://www.medrxiv.org/content/10.1101/2022.01.03.21268582v1
Covid-19: An urgent call for global “vaccines-plus” action. BMJ. 3.1.2022. https://www.bmj.com/content/376/bmj.o1
Superspreading: Insufficient ventilation led to a probable long-range airborne transmission of SARS-CoV-2 on two buses. Buiding and Environment. NN.1.2022. https://www.sciencedirect.com/science/article/pii/S0360132321008118?via%3Dihub
The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism. @IanRicksecker, Luckily, the University of Glasgow found that “Whilst Delta is optimised for fusion at the cell surface, Omicron .. achieves entry through endosomal fusion. This switch .. offers [an] explanation for [its] reduced syncytia formation.”1.1.2022. https://t.co/lsAwufl6dl
What is an N95 respirator? N95DECON Publications. 2022. https://www.n95decon.org/publications
Satunnaistetut, pragmaattiset monikeskustutkimukset ovat parantaneet COVID-19-taudin hoitoa. Duodecim. Jan 2022. https://www.duodecimlehti.fi/duo16524
2022 January 1 – 10
Tutkija HS:lle: Tällainen on koronan “superimmuniteetti”
Rokotetutkimuskeskuksen johtajan (Mikko Rämet) mukaan immuniteetti voi vaikuttaa jopa koko elämän ajan. Verkkouutiset. 31.12.2021. https://www.verkkouutiset.fi/a/tutkija-hslle-tallainen-on-koronan-superimmuniteetti/#8abf9fd5
Are People Optimistically Biased about the Risk of COVID-19 Infection? Lessons from the First Wave of the Pandemic in Europe. Int J Environ Res Public Health. 31.12.2021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744599/
Studies suggest why omicron is less severe: It spares the lungs. The Seattle Times. 31.12.2021. https://www.seattletimes.com/nation-world/studies-suggest-why-omicron-is-less-severe-it-spares-the-lungs/
Travelers infected one another across hallway in Covid-19 quarantine facility, New Zealand research shows. CNN Travel. 31.12.2021. https://edition.cnn.com/2021/12/30/health/new-zealand-covid-facility-transmission/index.html
Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infection. @IanRicksecker, Those warnings have since been proven by discovery of autoimmune features. This study of 177 Los Angeles healthcare workers found that all had persistent self-attacking antibodies at least 6 months after infection, regardless of illness severity. J Translational Medicine. 30.12.2021. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-03184-8
Covid-19: Is it safe to reduce the self-isolation period? BMJ. 30.12.2021. https://www.bmj.com/content/375/bmj.n3164?
Taiwan rejects US CDC guidance on 5-day quarantine. Some Omicron cases still infectious up to 12 days after testing positive. Taiwan News. 30.12.2021. https://www.taiwannews.com.tw/en/news/4393548
Rekord bei Corona-Neuinfektionen. Die Pandemie erreicht in der Schweiz und weltweit einen neuen Höhepunkt. Mehr als 17’600 Ansteckungen innert 24 Stunden – und das dürfte erst der Anfang einer riesigen Welle in der Schweiz sein. Welche Länder ebenfalls stark betroffen sind. BaZ. 29.12.2021. https://www.bazonline.ch/die-pandemie-erreicht-in-der-schweiz-und-weltweit-einen-neuen-hoehepunkt-318445720632?
The SARS-CoV-2 B.1.1.529 Omicron virus causes attenuated infection and disease in mice and hamsters. Research Square. 29.12.2021. https://www.researchsquare.com/article/rs-1211792/v1
Omikron voi todella olla lievempi – Tutkija: Ihan huippua. Akatemiatutkijan mukaan uusi virusmuunnos ei ilmeisesti pääse leviämään yhtä tuhoisasti keuhkoissa kuin aiempi delta. Verkkouutiset. 29.12.2021. https://www.verkkouutiset.fi/omikron-voi-todella-olla-lievempi-tutkija-ihan-huippua/#773fc543
HUSin ylilääkäri ehdottaa erillisten koronasairaaloiden perustamista Suomeen. Ylilääkäri Eero Hirvensalon mukaan sairaalat olisi mahdollista perustaa terveydenhuollon niukoista resursseista huolimatta, jos mukana olisi useita toimijoita ja soveltuvilta osin yksityinen terveydenhuolto. YLE Uutiset. 29.12.2021. https://yle.fi/uutiset/3-12248864?
Can COVID-19 alter your personality? Here’s what brain research shows. Alzheimer’s, Parkinson’s, and traumatic brain injury can cause changes in behavior by altering brain anatomy. Now it seems the coronavirus can too. National Geographic. 29.12.2021. https://www.nationalgeographic.com/science/article/can-covid-19-alter-your-personality-heres-what-brain-research-shows?cmpid=org=ngp::mc=social::src=twitter::cmp=editorial::add=tw20211229science-sciencecovidpersonalitydisorder&linkId=146317189
CDC shortens recommended Covid-19 isolation and quarantine time. CNN Health. 28.12.2021. https://edition.cnn.com/2021/12/27/health/cdc-covid-quarantine-isolation-shortened-recommendation/index.html?
Intranasal inhibitor blocks omicron and other variants of SARS-CoV-2. Research Square. 28.12.2021. https://www.researchsquare.com/article/rs-1196079/v1
Going viral: How Covid changed science forever – The perfect storm (2021)
Jonathan Van-Tam is joined by leading experts to reveal the secrets of contagion and the mathematics of disease. The Royal Institution. 28.12.2021. https://www.rigb.org/explore-science/explore/video/going-viral-how-covid-changed-science-forever-invisible-enemy-2021
Combined triple treatment of fibrin amyloid microclots and platelet pathology in individuals with Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) can resolve their persistent symptoms. @IanRicksecker, [COVID-19] also causes microclots: “Fibrin(ogen) amyloid microclots and platelet hyperactivation [were] observed in [Long COVID] patients,” in this work by Stellenbosch University of South Africa, which also explored potential treatments. Research Square. 28.12.2021. https://www.researchsquare.com/article/rs-1205453/v1
Risk of Cardiovascular Events after Covid-19: a double-cohort study. (@IanRicksecker) Oregon Health & Science University found that “symptomatic or asymptomatic SARS-CoV-2 infection is associated with increased risk of [fatal] cardiovascular outcomes and has causal effect on all-cause mortality.” medRxiv. 27.12.2021. https://doi.org/10.1101/2021.12.27.21268448
Omicron infection enhances neutralizing immunity against the Delta variant. medRxiv. 27.12.2021. https://www.medrxiv.org/content/10.1101/2021.12.27.21268439v1.full
Emeritusprofessori: Visiiri suojaa koronalta kuin aurinkolasit HIV:lta. Verkkouutiset. 27.12.2021. https://www.verkkouutiset.fi/emeritusprofessori-visiiri-suojaa-koronalta-yhta-hyvin-kuin-aurinkolasit-hivlta/#773fc543
Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact. medRxiv. 27.12.2021. https://www.medrxiv.org/content/10.1101/2020.12.24.20248802v2
Coronavirus Can Persist for Months After Traversing Body. BloombergQuint. 26.12.2021. https://www.bloombergquint.com/coronavirus-outbreak/coronavirus-can-persist-for-months-after-traversing-entire-body.
The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters. bioRxiv. 26.12.2021. https://www.biorxiv.org/content/10.1101/2021.12.24.474086v1
Aerosol generation during general anesthesia is comparable to coughing: An observational clinical study. Acta Anesthesiologica Scandinavica. 24.12.2021. https://onlinelibrary.wiley.com/doi/10.1111/aas.1402
SARS-CoV-2 variants of concern and variants under investigation in England. Technical briefing 33. UK Health Security Agency. 23.12.2021. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1043807/technical-briefing-33.pdf
Covid-19: Early studies give hope omicron is milder than other variants. BMJ. 23.12.2021. https://www.bmj.com/content/375/bmj.n3144?
Helsinki GSE:n Tilannehuoneen selvitys: Rokotukset suojaavat lapsia tehokkaasti tartunnoilta – 11-vuotiailla jopa kaksinkertainen määrä tartuntoja 12-vuotiaisiin verrattuna. Helsinki Graduate School of Economics. 23.12.2021. https://www.helsinkigse.fi/corona/helsinki-gsen-tilannehuoneen-selvitys-rokotukset-suojaavat-lapsia-tehokkaasti-tartunnoilta-11-vuotiailla-jopa-kaksinkertainen-maara-tartuntoja-12-vuotiaisiin-verrattuna/
Coronavirus disease (COVID-19): How is it transmitted? How does COVID-19 spread between people? WHO. 23.12.2021. https://www.who.int/news-room/questions-and-answers/item/coronavirus-disease-covid-19-how-is-it-transmitted
How The Koch Network Hijacked The War On COVID. As Omicron surges, a shadowy institute filled with fringe doctors appears to be part of big business’ two-year strategy to legitimize attacks on pandemic interventions.The Lever. 22.12.2021. https://www.levernews.com/how-the-koch-network-hijacked-the-war-on-covid/
Medical technologies have been central to US pandemic response – but social behaviors matter just as much. The Conversation. 22.12.2021. https://theconversation.com/medical-technologies-have-been-central-to-us-pandemic-response-but-social-behaviors-matter-just-as-much-171587?
Kannattaako oireettoman tehdä kotitesti? Pitääkö lapset testata ennen isovanhempien tapaamista? 10 kysymystä ja vastausta toisesta koronajoulusta. Turun yliopiston virusopin professori Ilkka Julkusen mukaan kotitestejä voi hyvin käyttää lieväoireisessa taudissa. Kotitestistä saatuun negatiiviseen tulokseen pitää kuitenkin suhtautua pienellä varauksella. Helsingin Sanomat. 22.12.2021. https://www.hs.fi/hyvinvointi/art-2000008492207.html
11 Early Signs of Dementia. healthline. 22.12.2021. https://www.healthline.com/health/dementia/early-warning-signs
How The Koch Network Hijacked The War On Covid [As Omicron surges, a shadowy institute filled with fringe doctors appears to be part of big business’ two-year strategy to legitimize attacks on pandemic interventions.GBD, Trump]. CMD. 22.12.2021. https://www.exposedbycmd.org/2021/12/22/how-the-koch-network-hijacked-the-war-on-covid/
What now for Sweden and covid-19? BMJ. 22.12.2021. https://www.bmj.com/content/375/bmj.n3081?
Covid News: What the U.S. Vaccination Campaign Looks Like One Year On. Pfizer said a combination of pills reduced the risk of hospitalization and death by 89 percent if given within three days of the onset of symptoms. New York Times. 21.12.2021. https://www.nytimes.com/live/2021/12/14/world/covid-omicron-vaccines#pfizer-covid-pill-paxlovid
WHO:n suomalaisasiantuntija kutsui omikronia ”mahdollisesti jopa evoluution joululahjaksi” – selittää nyt sanojaan (– Kaikki toistaiseksi olemassa oleva tosielämän data (ei mallit) eri maista vahvistaa mitä E-Afrikasta kuultiin aiemmin. Omikron ei ole katastrofi, mahdollisesti jopa evoluution joululahja. Jos nyt aikuiset taas kiusaa lapsia ja mm. sulkee kouluja niin tuleepahan varsinainen jälkipeli, Jussi Sane tviittasi.).Iltalehti. 21.12.2021. https://www.iltalehti.fi/kotimaa/a/06ef60d0-03b7-4b82-a9af-dc70c75d9e84
In world first, Israel set to give 4th COVID shot to over 60s, at-risk groups. Hailing recommendation by panel of health experts, Bennett orders swift roll-out of extra vaccine booster for people over 60, immunocompromised and health care workers. The Times of Israel. 21.12.2021. https://www.timesofisrael.com/health-ministry-panel-recommends-fourth-covid-shot-for-at-risk-groups/?
Viranomainen määräsi yleisötilaisuudet säppiin – Kirkko vetää omaa linjaa: joulukirkot järjestetään. “Älytön päätös tässä vaiheessa.” Salon seurakunnassa kritisoidaan tuomiokapitulin ohjetta. Kirkon mukaan uskonnon harjoittaminen auttaa ihmisiä jaksamaan pandemiassa. Suomen Kuvalehti. 21.12.2021. https://suomenkuvalehti.fi/jutut/kotimaa/viranomainen-maarasi-yleisotilaisuudet-sappiin-kirkko-vetaa-omaa-linjaa-joulukirkot-jarjestetaan/?
Koronarajoitukset kiristymässä. Useat alueet ovat tiedottaneet rajoitussuosituksista. Lääkärilehti. 21.12.2021. https://www.laakarilehti.fi/ajassa/ajankohtaista/koronarajoitukset-kiristymassa/?public
December 21 – 31
SARS-CoV-2 infection and persistence throughout the human body and brain. Research Square. 20.12.2021. https://doi.org/10.21203/rs.3.rs-1139035/v1
Avoin kirje päättäjille: Omikronin torjunta vaatii kiireellisiä rajoitustoimia. Eroonkoronasta. 20.12.2021. https://www.eroonkoronasta.fi/avoin-kirje-paeaettaejille-omikronin-torjunta-vaatii-kiireellisiae-rajoitustoimia/#s_allekirjoittajat
SARS-CoV-2 infection and persistence throughout the human body and brain. Research Square. 20.12.2021. https://assets.researchsquare.com/files/rs-1139035/v1_covered.pdf?c=1640020576
Teholla 63 koronapotilasta – tehohoidon koordinaattorit: Hallituksen tehtävä rajuja päätöksiä ja heti. Professori Matti Reinikainen arvioi, että Suomeen vasta tuloaan tekevä omikron työllistää sairaaloita arvioitua enemmän. Etelä-Afrikassa virus on jyllännyt nuorten keskuudessa. YLE-Uutiset. 20.12.2021. https://yle.fi/uutiset/3-12239558?
Multisystem Inflammatory Syndrome in Children by COVID-19 Vaccination Status of Adolescents in France. JAMA Network. 20.12.2021. https://jamanetwork.com/journals/jama/fullarticle/2787495
Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity. nature. 18.12.2021. https://www.nature.com/articles/s41467-021-27040-x
Ministeri Krista Kiuru: Hätäjarrusta on päätettävä jo ensi viikolla ja rajoitustoimia on lisättävä merkittävästi. Kiuru toivoo, että Italian tapaan Suomi alkaa vaatia myös eurooppalaisilta ennen maahan tuloa otettua koronatestitodistusta. Perhe- ja peruspalveluministeri Krista Kiurulla (sd) on tapana varoitella koronatilanteesta, mutta tällä kertaa hän on jopa Kiuru-mittarilla tarkasteltuna äärimmäisen huolestunuta. Helsingin Sanomat. 18.12.2021. https://www.hs.fi/politiikka/art-2000008474448.html
Status på omikron-varianten (B.1.1.529) pr. Statens Serum Institut finder et stadigt stigende antal omikron tilfælde i Danmark. Samlet er der nu fundet 11.559 tilfælde af smitte med virus-varianten omikron. Alle fakta om forekomsten af omikron i Danmark udsendes nu i en daglig rapport. Statens SerumInstitut. 17.12.2021. https://www.ssi.dk/aktuelt/nyheder/2021/status-pa-omikron-varianten-b11529-pr-171221
Omicron largely evades immunity from past infection or two vaccine doses. Imperial College. 17.12.2021. https://www.imperial.ac.uk/news/232698/omicron-largely-evades-immunity-from-past/
How Omicron Evades Natural Immunity, Vaccination, And Monoclonal Antibody Treatments. Forbes. 17.12.2021. https://www.forbes.com/sites/williamhaseltine/2021/12/17/how-omicron-evades-natural-immunity-vaccination-and-monoclonal-antibody-treatments/?sh=d4e595f60e08
CDC recommends Pfizer, Moderna vaccines over J&J’s. CNN Health. 17.12.2021. https://edition.cnn.com/2021/12/16/health/johnson-vaccine-acip-recommendation-mrna-preferred/index.html
Vaccine inequality may undermine the booster programme. BMJ. 17.12.2021. https://www.bmj.com/content/375/bmj.n3118
Why Paxlovid is a Just-in-Time Breakthrough. The first potent anti-Covid pill will be a big help. Ground truths. 16.12.2023. https://erictopol.substack.com/p/why-paxlovid-is-a-just-in-time-breakthrough
Huonossa sisäilmassa koronatartunnan voi saada minuuteissa – tehokas tuuletus laskee riskiä luultua enemmän, kertoo VTT:n tuore tutkimus. Mitä enemmän huonetilassa on viruksia, sitä suurempi on riski taudin leviämisestä. Tuulettamalla viruspitoisuudet tippuvat tutkijoiden mukaan jopa 90 prosenttia. YLE-Uutiset. 16.12.2021. https://yle.fi/uutiset/3-12231997?
Report 48 – The value of vaccine booster doses to mitigate the global impact of the Omicron SARS-CoV-2 variant. Imperial College. 16.12.2021. https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-48-global-omicron/
The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice. @IanRicksecker The virus appears to be able to cross the blood-brain barrier and cause significant neurological damage. The ability of the spike protein to cross the blood-brain barrier was demonstrated in mice at the University of Washington. Nature Neuroscience. 16.12.2021. https://doi:10.1038/s41593-020-00771-8.
Report 49 – Growth, population distribution and immune escape of Omicron in England. Imperial College. 16.12.2021. https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-49-Omicron/
Missed shots: Science revisits its 2020 Breakthrough of the Year. The COVID-19 vaccine rollout was a spectacular success—and a stunning tragedy. Science. 16.12.2021. https://www.science.org/content/article/missed-shots-science-revisits-its-2020-breakthrough-year?
Impacts of K-12 school reopening on the COVID-19 epidemic in Indiana, USA (There is now a growing body of evidence that school closures contributed to mitigating the first wave of the epidemic and, as we have shown, may have contributed to the resurgence of SARS-CoV-2 during fall 2020. Our study adds to this evidence, and suggests an even greater impact of school reopening than several other studies. This is due in part to our assumption that asymptomatic and symptomatic infections contribute similarly to transmission, and in part to our model’s ability to capture chains of transmission within schools and extending out into the community. Our study echoes several modeling studies in emphasizing the importance of reducing school operating capacity to impede transmission. As schools grapple with COVID-19 going forward, results such as these provide an important basis for motivating the adoption and sustainment of reduced school operating capacity and adherence to face-mask requirements in schools. As we demonstrated, these actions are highly consequential for those directly linked to schools and for the communities in which they are embedded.). Epidemics. December. 2021. https://www.sciencedirect.com/science/article/pii/S1755436521000396?via%3Dihub
A tantalizing clue to why omicron is spreading so quickly. NPR. 15.12.2021. https://www.npr.org/sections/goatsandsoda/2021/12/15/1064597592/a-tantalizing-clue-to-why-omicron-is-spreading-so-quickly
HKUMed finds Omicron SARS-CoV-2 can infect faster and better than Delta in human bronchus but with less severe infection in lung. HKU Faculty of Medicine News. 15.12.2021. https://www.med.hku.hk/en/news/press/20211215-omicron-sars-cov-2-infection
Covid-19: Long covid symptoms among hospital inpatients show little improvement after a year, data suggest. BMJ. 15.12.2021. https://www.bmj.com/content/375/bmj.n3092?=&utm_source=adestra&utm_medium=email&utm_campaign=usage&utm_content=daily&utm_term=text
U.S. study suggests vaccines may be ineffective against Omicron without booster. Reuters. 15.12.2021. https://www.reuters.com/business/healthcare-pharmaceuticals/us-study-suggests-covid-19-vaccines-may-be-ineffective-against-omicron-without-2021-12-14/?
Assessment of the further emergence of the SARS-CoV-2 Omicron VOC in the context of the ongoing Delta VOC transmission in the EU/EEA, 18th update. ECDC. 15.12.2021. https://www.ecdc.europa.eu/en/publications-data/covid-19-assessment-further-emergence-omicron-18th-risk-assessment
Pohjois-Pohjanmaalla tahallista koronalle altistumista: ”Liittyy luultavasti koronapassiin”. Kallion kuntayhtymä kertoo huolestuttavasta koronailmiöstä. Iltalehti. 15.12.2021. https://www.iltalehti.fi/koronavirus/a/8ec31170-683e-470c-a3db-091fbc205f23?
THL haluaa rajoille kireämmän linjan kuin hallitus suunnittelee – Ruotsikin on omikronin riskimaa. Valtioneuvosto on päättämässä huomenna torstaina matkustusrajoitusten kiristämisestä. Sisäministeri Mikkonen sanoo, että hallituksessa on keskusteltu myös sisärajatarkastusten palauttamisesta. YLE-Uutiset. 15.12.2021. https://yle.fi/uutiset/3-12231096
REVIEW: How Common is Long COVID in Children and Adolescents? Pediat Incfext Dis J. Dec.2021. https://journals.lww.com/pidj/fulltext/2021/12000/how_common_is_long_covid_in_children_and.20.aspx
Evidence for a mouse origin of the SARS-CoV-2 Omicron variant. Journal of Genetics and Genomics. Dec.2021. https://www.sciencedirect.com/science/article/pii/S1673852721003738
Final data on pills to treat Covid-19 holds strong against hospitalization and death, Pfizer says. CNN Health. 14.12.2021. https://edition.cnn.com/2021/12/14/health/pfizer-paxlovid-pills-covid-treatment/index.html?
Pfizer’s Covid Pill Works Well, Company Confirms in Final Analysis. The treatment, called Paxlovid, is likely to work against Omicron and could be available in the United States before the end of the year. New York Times. 14.12.2021. https://www.nytimes.com/2021/12/14/health/pfizer-covid-19-pill-paxlovid.html?
Sairaalapomot eivät näe hätäjarrulle tarvetta hoidon kuormituksen takia – johtajalääkäri: “vaikuttavin toimi olisi puuttuminen ravintoloiden aukioloihin”
Koronan omikronmuunnoksen tulevaa vaikutusta sairaaloiden kuormitukseen ei vielä tiedetä. Sosiaali- ja terveysministeriö valmistautuu rajoitusten tiukentamiseen, mutta kahden sairaanhoitopiirin johtajat arvioivat, että toistaiseksi hätäjarrun käytölle ei ole tarvetta. YLE-Uutiset. 14.12.2021. https://yle.fi/uutiset/3-12229385
Pääministeri Marin: Kolmansien rokotusten antamista vauhditettava – ”Työterveydenhuoltoa voitaisiin hyödyntää laajemmin”. Hallitus käsittelee koronatilannetta neuvottelussaan ensi viikon tiistaina 21. joulukuuta. Ilta=sanomat. 14.12.2021. https://www.is.fi/politiikka/art-2000008474610.html
Ministeri Kiuru: Maahantulorajoitukset kiristyvät – kolmansiin rokotuksiin on pyydetty apua puolustusvoimilta
Tänään kokoontunut sote-ministeriryhmä on tehnyt hallitukselle esityksen rajatoimien kiristämisestä sekä lisäavusta kunnille rokotusten järjestämistä varten. YLE-Uutiset. 14.12.2021. https://yle.fi/uutiset/3-12230314
Hollanti sulkee koulut etuajassa koronan takia. Hollannissa koululaiset pääsevät joululomalle viikkoa aiemmin heikentyneen koronatilanteen takia.Iltalehti. 14.12.2021. https://www.iltalehti.fi/ulkomaat/a/e41dd356-07b6-4a15-810a-93921e9794bb
Covid-19: Almost 100 ICU staff from Malaga hospital test positive after Christmas lunch. BMJ. 14.12.2021. https://www.bmj.com/content/375/bmj.n3085?
Why do Covid boosters offer greater protection against Omicron? Studies show three jabs are more effective than two as manufacturers work on variant-specific vaccines. Financial Times. 14.12.2021. https://www.ft.com/content/8a6a0ec8-fd07-49cd-a3f5-386a06269a5c
Merck’s COVID pill loses its lustre: what that means for the pandemic. Molnupiravir was initially heralded by public-health officials as a game-changer for COVID-19, but full clinical-trial data showed lower-than-expected efficacy. Nature. 13.12.2021. https://www.nature.com/articles/d41586-021-03667-0?
Christopher Ruhm Summarizes the COVID-19 Pandemic’s Impact on US Mortality. NBER 13..12.2021. https://www.nber.org/affiliated-scholars/researchspotlight/christopher-ruhm-summarizes-covid-19-pandemics-impact-us-mortality
Meet the Vaccine Scientists: TIME’s Heroes of the Year. TIME. 13.12.2021. https://view.newsletters.time.com/?
Where I Live, No One Cares About COVID. Outside the world inhabited by the professional classes in a handful of major metropolitan areas, many Americans are leading their lives as if COVID is over. Atlantic. 13.12.2021. https://www.theatlantic.com/ideas/archive/2021/12/where-i-live-no-one-cares-about-covid/620958/
COVID-19-tutkimuskatsaus 13/2021. Valtioneuvosto. 13.12.2021. https://julkaisut.valtioneuvosto.fi/handle/10024/163688
Risikovurdering af omikron. Statens Seruminstitut. 12.12.2021. https://covid19.ssi.dk/-/media/arkiv/subsites/covid19/risikovurderinger/risikovurdering_omikron_121221_ssi.pdf?la=da
HUS: Neljä kymmenestä teho-osastolla hoidetuista koronapotilaista ei ollut palannut työhön tai harrastukseen kolme kuukautta kotiutumisen jälkeen. Teho-osastolle joutuneiden koronapotilaiden keski-ikä on koko epidemian ajalta 57 vuotta. Nuorempien ikäryhmien osuus tehohoidossa olevista koronapotilaista on kasvanut. YLE Uutiset. 11.12.2021. https://yle.fi/uutiset/3-12225995
Modelling the potential consequences of the Omicron. SARS-CoV-2 variant in England. 11.12.2021. https://cmmid.github.io/topics/covid19/reports/omicron_england/report_11_dec_2021.pdf
December 11 – 20
South Africa: early data suggest Omicron is more transmissible but less severe. The Conversation. 10.12.2021. https://theconversation.com/south-africa-early-data-suggest-omicron-is-more-transmissible-but-less-severe-173517?
Uusi tutkimus: tässä ajassa kaksi koronarokotetta ottaneiden suoja tartuntaa vastaan heikkenee. Koronarokotteiden teho hiipuu kolmen kuukauden jälkeen. Ilta=sanomat. 10.12.2021. https://www.is.fi/terveys/art-2000008464942.html?
Lopettaako Suomi rokotteiden tilaamisen? Hallitukselta vaaditaan vastauksia. Kokoomuksen Terhi Koulumies kysyy, aikooko Suomi todellakin peruuttaa rokotetilauksiaan. Verkkouutiset. 10.12.2021. https://www.verkkouutiset.fi/lopettaako-suomi-rokotteiden-tilaamisen-hallitukselta-vaaditaan-vastauksia/#773fc543
The Hunt for a Single Shot to Defeat Omicron and All Coronaviruses. While the science is still in its early stages, the hardest part about developing a super-vaccine for all coronaviruses could be finding a way to pay for it. Bloomberg. 9.12.2021. https://www.bloomberg.com/news/features/2021-12-09/could-a-one-shot-coronavirus-vaccine-protect-you-from-all-variants
Alarm as almost 20% of South Africa’s healthcare workers contract Covid. Mail&Guardian. 9.12.2021. https://mg.co.za/coronavirus-essentials/2021-12-09-alarm-as-almost-20-of-south-africas-healthcare-workers-contract-covid/
16- and 17-year-olds are now eligible for a Pfizer/BioNTech Covid-19 vaccine booster. CNN Health. 9.12.2021. https://edition.cnn.com/2021/12/09/health/covid-booster-adolescents-fda-authorization/index.html?
STM huolestui Suomen kouluista ja lasten tartuntojen noususta – vetoomus THL:lle. WHO kehotti koronatoimiin peruskouluissa. STM huolestui Suomen tilanteesta ja vetoaa nyt THL:ään. Uusi Suomi. 9.12.2021. https://www.uusisuomi.fi/uutiset/stm-huolestui-suomen-kouluista-ja-lasten-tartuntojen-noususta-vetoomus-thllle/c1dd0e38-6941-44ca-a929-381ca8b4f7ea
Corona infections and air quality. More infections in poorly ventilated classrooms. Indoor air quality has an influence on how many corona virus infections occur there. This has now been shown for the first time in a pilot project involving Empa researchers in 150 primary school classrooms in Graubünden. The analysis also showed that the air quality in many classrooms is poor. The study concluded that regular ventilation of classrooms is therefore very important, even in winter months. EMPA. 9.12.2021. https://www.empa.ch/web/s604/covid-and-co2
Study shows benefit of regular classroom ventilation classroom. A Swiss study has found that poorly ventilated school classrooms record up to six times as many Covid-19 cases compared with those which are regularly aired. SwissInfo. 9.12.2021. https://www.swissinfo.ch/eng/society/study-shows-benefit-of-regular-classroom-ventilation/47179498
Ensimmäiset merkit omikronin kyvystä väistää rokotussuoja ilmi – Melatoniinista ja D-vitamiinista nyt apu pandemian hallintaan? (Mikko Paunio). Uusi Suomi. 8.12.2021. https://puheenvuoro.uusisuomi.fi/mikkopaunio/ensimmaiset-merkit-omikronin-kyvysta-vaistaa-rokotussuoja-ilmi-melatoniinista-ja-d-vitamiinista-nyt-apu-pandemian-hallintaan/
Pfizer antoi ensimmäisen arvion koronarokotteensa tehosta omikronmuunnosta vastaan. Kolmas annos Comirnaty-rokotetta herättää alustavien tulosten mukaan lupaavan paljon vasta-aineita omikronvarianttia vastaan. Mediuutiset. 8.12.2021. https://www.mediuutiset.fi/uutiset/mu/a4697e4f-84b6-45c1-8c32-dd112e1b581e?ref=newsletter:66d0&utm
Pfizer, BioNTech vaccine neutralises Omicron with three shots. Reuters. 8.12.2021. https://www.reuters.com/business/healthcare-pharmaceuticals/biontech-pfizer-say-test-shows-3-doses-vaccine-neutralise-omicron-2021-12-08/
PFIZER AND BIONTECH PROVIDE UPDATE ON OMICRON VARIANT. Pfizer. 8.12.2021. https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-provide-update-omicron-variant
Scientists Discover Harder-to-Detect Version of Omicron. Bloomberg. 8.12.2021. https://www.bloomberg.com/news/articles/2021-12-08/australia-finds-new-omicron-lineage-in-arrival-from-south-africa?cmpid=BBD120821_BIZ&utm_medium=email&utm_source=newsletter&utm_term=211208&utm_campaign=bloombergdaily
Tanska sulkee koulut. Aiemmin Tanska kertoi, että omikron leviää koko yhteiskunnassa. Iltalehti. 8.12.2021. https://www.iltalehti.fi/ulkomaat/a/55748a61-25a4-4f07-ade8-c03eb3c64d3d
Tallinnan-laivalta pääsi kävelemään suoraan Helsinkiin, vaikka kuulutus varoitti koronapassin tarkastuksesta. Katajanokan terminaalissa Helsingissä ei tarkastettu koronapasseja matkustajilta vaan jaettiin vanhentunutta ohjetta koronatestiin menemisestä. HS. 8.12.2021. https://www.hs.fi/kaupunki/art-2000008460200.html?share=583b747344b857ca56a08ac8b1522f47
COVID-19 Community Response Framework v4.0. New Zealand Government. 8.12.2021. https://www.health.govt.nz/system/files/documents/pages/covid-19_community_protection_framework_v4.0_8_dec_2021.pdf
Omicron coronavirus variant partly evades Pfizer vaccine’s protection, study shows. CNN Health. 8.12.2021. https://edition.cnn.com/2021/12/07/health/omicron-variant-pfizer-vaccine-south-africa-study/index.html
Omikronin vakavat tapaukset lisääntyvät räjähdysmäisesti. Verkkouutiset. 8.12.2021. https://www.verkkouutiset.fi/omikronin-vakavat-tapaukset-lisaantyvat-rajahdysmaisesti/#7e9b2b60
Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and monoclonal antibodies. medRxiv. 8.12.2021. https://www.medrxiv.org/content/10.1101/2021.12.07.21267432v1.full.pdf
Soomest sisse toodud haigusjuhtude arv kasvab. 8.12.2021. https://www.err.ee/1608429296/soomest-sisse-toodud-haigusjuhtude-arv-kasvab
Omikron paljasti leviämisensä saloja: Se on lainannut geneettistä koodia tavalliselta flunssalta. Koronan sairastaminen näyttää suojaavaan uudelta koronatartunnalta kolme kertaa huonommin, jos tartuttaja on deltamuunnoksen sijasta omikron. Mediuutiset. 8.12.2021. https://www.mediuutiset.fi/uutiset/mu/82024ba4-be86-433f-ad9d-c7783cbb8bad
Frequency of Neurologic Manifestations in COVID-19. A Systematic Review and Meta-analysis. Neurology. 7.12.2022. https://n.neurology.org/content/97/23/e2269
Persistence of clinically relevant levels of SARS-CoV2 envelope gene subgenomic RNAs in non-immunocompromised individuals. International Journal of Infectious Diseases. 7.12.2021. https://www.ijidonline.com/article/S1201-9712(21)01206-6/fulltext
An upper bound on one-to-one exposure to infectious human respiratory particles. PLOS One. 7.12.2021. https://www.pnas.org/content/118/49/e2110117118
Anders Tegnell svarade på läsarnas frågor om corona. Expressen. 7.12.2021. https://www.expressen.se/nyheter/anders-tegnell-svarar-pa-dina-fragor-om-corona-/
Omicron variant of SARS-CoV-2 harbors a unique insertion mutation of putative viral or human genomic origin. OSF Preprints. 7.12.2021. https://osf.io/f7txy/
FHI: Alvorlig situasjon, men lite sannsynlig at omikron gir mer alvorlig sykdom. Det er ingen sikre tegn på at smittesituasjonen er i ferd med å snu. Folkehelseinstituttet (FHI) forventer en betydelig forverring for sykehusene selv om omikron trolig ikke gir mer alvorlig sykdom.NRK 7.12.2021. https://www.nrk.no/norge/fhi_-alvorlig-situasjon_-men-lite-sannsynlig-at-omikron-gir-mer-alvorlig-sykdom-1.15761037
Monet maat antavat jo keppiä rokottamattomille – Tässä lista 11 valtion käyttämistä kovista keinoista. Useat maat iskevät rokottamattomille sanktioita, kertoo uutistoimisto Bloomberg. Kovien keinojen joukossa ovat esimerkiksi lihavat sakot ja lomautukset. Mediuutiset. 7.12.2021. https://www.mediuutiset.fi/uutiset/monet-maat-antavat-jo-keppia-rokottamattomille-tassa-lista-11-valtion-kayttamista-kovista-keinoista/aed61f0a-b5ea-43d5-b1af-d9724675ff2c
Science Brief: Community Use of Masks to Control the Spread of SARS-CoV-2. CDC. 6.12.2021. https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/masking-science-sars-cov2.html#anchor_1634654779910
Sollen auch Geimpfte und Genesene Maske tragen? Vielerorts gilt wieder Maskenpflicht. Eine neue Studie zeigt: FFP2-Masken schützen weit besser als medizinische Masken. Was Sie dazu wissen sollten. BaZ. 6.12.2021. https://www.bazonline.ch/sollen-auch-geimpfte-und-genesene-maske-tragen-447605008512
Use of Masks to Control the Spread. CDC COVID-10. 6.12.2021. https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/masking-science-sars-cov2.html
Omicron can reset the World’s Covid Strategy. Bloomberg. 5.12.2021. https://www.bloomberg.com/opinion/articles/2021-12-05/omicron-is-unavoidable-but-it-s-not-time-to-give-in-to-covid-panic
Prognosis. Initial Hospital Data in Omicron Epicenter Shows Milder Disease. Most patients in Covid wards have not been oxygen dependent. This seems different from earlier waves where fewer vaccinated. Bloomberg. 5.12.2021. https://www.bloomberg.com/news/articles/2021-12-05/initial-hospital-data-in-omicron-epicenter-shows-milder-disease?cmpid=BBD120621_MKT&utm_medium=email&utm_source=newsletter&utm_term=211206&utm_campaign=markets
Tshwane District Omicron Variant Patient Profile – Early Features. SAMRC. 4.12.2021. https://www.samrc.ac.za/news/tshwane-district-omicron-variant-patient-profile-early-features
Covid-19: Antibody boost after third dose varies greatly by vaccine, study finds. BMJ. 3.12.2021. doi: https://doi.org/10.1136/bmj.n3011
NHS forecasts 230,000 extra cases of PTSD in England due to Covid. Post-traumatic stress disorder diagnoses likely be among domestic abuse victims, care workers and the bereaved. Guardian. 3.12.2021. https://www.theguardian.com/society/2021/dec/03/nhs-forecasts-230000-extra-cases-of-ptsd-in-england-due-to-covid?utm_term=Autofeed&CMP=twt_gu&utm_medium&utm_source=Twitter#Echobox=1638513650
COVID-19: Omicron has ‘substantial’ ability to evade immunity from previous coronavirus infection. Researchers at the National Institute for Communicable Diseases (NICD) warn their finding has important public health implications. Sky News. 3.12.2021. https://news.sky.com/story/covid-19-omicron-has-substantial-ability-to-evade-immunity-from-previous-coronavirus-infection-12484840
Disorders of Consciousness Associated With COVID-19
A Prospective Multimodal Study of Recovery and Brain Connectivity. Neurology. 3.12.2021. https://n.neurology.org/content/98/3/e315.long
KORONAVIRUS ON TAPPANUT KAHDEN VUODEN AIKANA JO YLI VIISI MILJOONAA IHMISTÄ. MUTTA MITEN SE SAI ALKUNSA? VASTA NYT SUURI SALAISUUS ALKAA RATKETA. HS Kuukausiliite.12. 3.12.2021. https://www.hs.fi/kuukausiliite/art-2000008369960.html?share=6e9bd8e471f70562f7ded6e3bbcaff37
Disorders of Consciousness Associated With COVID-19. A Prospective Multimodal Study of Recovery and Brain Connectivity (Cognitive). Neurology. 3.12.2021. https://n.neurology.org/content/98/3/e315
Koronavirus leviää ilmateitse – onko sillä merkitystä?
On hämmästyttävää, miten vähän on varmaa tietoa siitä, millä lailla yleiset ylähengitysteiden tartuntataudit tarttuvat. Lyhyessä ajassa on käynyt selväksi, että aiemmin tunnettujen kosketus- ja pisaratartuntamekanismien lisäksi aerosolivälitteinen leviäminen on yleistä (1,2). Usein näiden reittien erottaminen ei ole helppoa. Infektoitunut voi tartuttaa vieressä seisovan terveen henkilön kaikilla kolmella tavalla. Kaukana tartunnan saaneesta olevat eivät voi saada tartuntatautia kosketus- tai pisaratartuntana – jäljelle jää siis aerosolitartunta.Lääkärilehti. 3.12.2021. https://www.laakarilehti.fi/ajassa/paakirjoitukset-tiede/koronavirus-leviaa-ilmateitse-ndash-onko-silla-merkitysta/?utm_medium=newsletter&utm_source=uk&utm_campaign=uk48pe-2021&m=NDA3NDYsZjg0YjM5MTczMzZhYWI4MDQ1YWIyMzMxOGU3YTcwNmM%3D
COVID-19 vaccine surveillance report. Week 48. UK Health Security Agency. 3.12.2021.